The effects of amantadine on traumatic brain injury outcome: a double-blind, randomized, controlled, clinical trial.

Abstract:

INTRODUCTION:Amantadine, as a dopamine receptor agonist, may stimulate and help the recovery of the nervous system after traumatic brain injury (TBI). METHODS:We performed this study as a double-blind, randomized, controlled clinical trial with target population including all patients with TBI who scored nine or lower on the Glasgow Coma Scale (GCS), admitted to our hospital between January 2013 and April 2014. The protocol included administration of the drug (placebo or amantadine) for 6 weeks and patient evaluation using the GCS and FOUR score on the first, third and seventh days after the drug was started. After 6 months from starting study drug, the patients were evaluated on the Mini-Mental State Examination, Glasgow Outcome Study, Disability Rating Scale and Karnofsky Performance Scale. RESULTS:We included 40 patients in the study. The mean age of the patients was 36.77 ± 18.21. As an only important finding, the amantadine group registered an important rise between the first and the seventh day of study drug (∆GCS7-GCS1) with p-value = 0.044. CONCLUSION:Based on our findings during the first week and the 6 months (since starting drug) follow-ups, prescribing amantadine did not lead to reportable effects on the patients' level of consciousness, memory, disability, cognition, mortality and performance.

journal_name

Brain Inj

journal_title

Brain injury

authors

Ghalaenovi H,Fattahi A,Koohpayehzadeh J,Khodadost M,Fatahi N,Taheri M,Azimi A,Rohani S,Rahatlou H

doi

10.1080/02699052.2018.1476733

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

1050-1055

issue

8

eissn

0269-9052

issn

1362-301X

journal_volume

32

pub_type

杂志文章,随机对照试验
  • Botulinum toxin type A in the treatment of children and adolescents with an acquired brain injury.

    abstract:PRIMARY OBJECTIVE:To describe clinical experience using botulinum toxin type A (BTX-A) in children with acquired brain injury. RESEARCH DESIGN:Single centre, open label, pilot study. METHODS AND PROCEDURES:Twenty-one patients were randomized to three groups according to impairment severity and treatment objectives. ...

    journal_title:Brain injury

    pub_type: 杂志文章,随机对照试验

    doi:10.1080/02699050400013675

    authors: van Rhijn J,Molenaers G,Ceulemans B

    更新日期:2005-05-01 00:00:00

  • Impaired decision-making after traumatic brain injury: the Iowa Gambling Task.

    abstract:SUMMARY:The aim of the present study was to use the Iowa Gambling Task (IGT) to investigate differences in decision-making (DM) between patients who sustained TBI and healthy subjects, while controlling for age, education and gender. METHODS:A hundred and ten participants, half of whom had severe or mild TBI, complete...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2014.896943

    authors: Cotrena C,Branco LD,Zimmermann N,Cardoso CO,Grassi-Oliveira R,Fonseca RP

    更新日期:2014-01-01 00:00:00

  • Golf cart associated traumatic brain injury.

    abstract::Object: Although contact sport-related head injuries are frequently reported, golf cart accidents may have significant consequences including severe traumatic brain injury (TBI) or head injury. As no standardized regulations exist, this mechanism may be underreported. Methods: A retrospective review of TBI or cranial ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2019.1642516

    authors: Simpson B,Shepard S,Kitagawa R

    更新日期:2019-01-01 00:00:00

  • The development of the therapeutic working alliance, patients' awareness and their compliance during the process of brain injury rehabilitation.

    abstract:PURPOSE:To examine the development and interaction of the therapeutic alliance, patients' compliance and awareness during the process of brain injury rehabilitation and the role of demographic and injury related variables in this process. Subjects were 86 patients who underwent a holistic neuropsychological outpatient ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050600664772

    authors: Schönberger M,Humle F,Teasdale TW

    更新日期:2006-04-01 00:00:00

  • A standardization study of the Czech version of the Mississippi Aphasia Screening Test (MASTcz) in stroke patients and control subjects.

    abstract:PRIMARY OBJECTIVE:To assess the criterion and construct validity and inter-rater reliability of the Czech version of the Mississippi Aphasia Screening Test (MASTcz). RESEARCH DESIGN:Prospective evaluation of consecutive inpatients admitted to the stroke unit of a university hospital within 60 days of onset of a unilat...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050802372190

    authors: Kostálová M,Bártková E,Sajgalíková K,Dolenská A,Dusek L,Bednarík J

    更新日期:2008-09-01 00:00:00

  • Self-reported symptoms during post-mild traumatic brain injury in acute phase: influence of interviewing method.

    abstract:PRIMARY OBJECTIVE:To examine the role played by two interviewing methods used in the evaluation of acute self-reported symptoms after a mild traumatic brain injury (mTBI). METHOD AND PROCEDURES:A cohort of 354 mTBI-adult participants was recruited over a period of 36 months in emergency rooms of five Canadian trauma h...

    journal_title:Brain injury

    pub_type: 杂志文章,多中心研究

    doi:10.3109/02699052.2010.531881

    authors: Villemure R,Nolin P,Le Sage N

    更新日期:2011-01-01 00:00:00

  • Correlates of invalid neuropsychological test performance after traumatic brain injury.

    abstract:PRIMARY OBJECTIVE:To investigate external correlates of invalid test performance after traumatic brain injury, as assessed by the California Verbal Learning Test - Second Edition (CVLT-II) and Word Memory Test (WMT). RESEARCH DESIGN:Consecutive 2-year series of rehabilitation referrals with a diagnosis of traumatic br...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050701253129

    authors: Donders J,Boonstra T

    更新日期:2007-03-01 00:00:00

  • Anoxic encephalopathy: a neurobehavioural study in rehabilitation.

    abstract::This study examined an operational conditioning paradigm designed to train procedural learning channels in a patient with anoxic encephalopathy. Prior to treatment the patient had been incontinent to bowel and bladder incontinent, minimally participant in daily activities and aggressive toward staff and residents for ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/026990597123115

    authors: Goldberg KB,Ellis DW

    更新日期:1997-10-01 00:00:00

  • Self-awareness following traumatic brain injury and implications for rehabilitation.

    abstract:PRIMARY OBJECTIVE:Many studies investigating self-awareness following traumatic brain injury (TBI) have been conducted more than 2 years post-injury, thereby providing limited information regarding the implications of insight for rehabilitation. The present study aimed to investigate awareness of deficits in a group of...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050110103274

    authors: Port A,Willmott C,Charlton J

    更新日期:2002-04-01 00:00:00

  • Parental alcohol misuse is a powerful predictor for the risk of traumatic brain injury in childhood.

    abstract:BACKGROUND:Although the positive relationship between parental alcohol use and children's injuries is well established, it is not known whether parental alcohol misuse is a risk factor for traumatic brain injuries (TBIs) of their children and whether subjects with childhood TBI have hazardous drinking habits in adolesc...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050701553221

    authors: Winqvist S,Jokelainen J,Luukinen H,Hillbom M

    更新日期:2007-09-01 00:00:00

  • Neurologically-related sequelae associated with mild traumatic brain injury.

    abstract:OBJECTIVE:Mild traumatic brain injury (mTBI) accounts for more than 75% of traumatic brain injuries every year. This study examines the temporal association between non-blast mTBI and the onset of neurologic sequelae to illuminate risks of post-concussive syndrome, epilepsy and chronic pain. METHODS:A large historical...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2014.989904

    authors: Webb TS,Whitehead CR,Wells TS,Gore RK,Otte CN

    更新日期:2015-01-01 00:00:00

  • Dual effects of heme oxygenase-1 on astrocyte injury induced by hemin in vitro.

    abstract:PRIMARY OBJECTIVE:The purpose of this study was to investigate the effects of heme oxygenase-1 (HO-1) on astrocyte injury induced by hemin. RESEARCH DESIGN:Primary astrocytes were isolated from Sprague Dawley rat pups and cultured in vitro. The expression of HO-1 was induced by hemin in a quantitative fashion and the ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2015.1084648

    authors: Chen H,Wang X,Zhao Q,Zhang Z,Ye X,Hua F,Cui G

    更新日期:2016-01-01 00:00:00

  • Zolpidem induces paradoxical metabolic and vascular changes in a patient with PVS.

    abstract:INTRODUCTION:Zolpidem is a non-benzodiazepine drug used for the therapy of insomnia, which has selectivity for stimulating the effect of GABA-A receptors. Recently, a paradoxical arousing effect of zolpidem in patients with severe brain damage has been repeatedly reported. METHODS:A placebo-controlled magnetic resonan...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2013.794961

    authors: Rodriguez-Rojas R,Machado C,Alvarez L,Carballo M,Estevez M,Perez-Nellar J,Pavon N,Chinchilla M,Carrick FR,DeFina P

    更新日期:2013-01-01 00:00:00

  • A further study on the sustained attention response to task (SART): the effect of age, gender and education.

    abstract::The present study aimed to investigate the potential effect of age, gender and education upon the theoretically sound measure of sustained attention--Sustained Attention Response to Task (SART)--amongst a control sample and patients with traumatic brain injury (TBI). The SART is a simple and brief computer-assisted pr...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050110034325

    authors: Chan RC

    更新日期:2001-09-01 00:00:00

  • The good-old-days bias and post-concussion syndrome symptom reporting in a non-clinical sample.

    abstract:PRIMARY OBJECTIVE:To investigate the good-old-days bias, a psychosocial factor associated with post-concussion syndrome (PCS). STUDY DESIGN:Repeated measures comparison of PCS symptoms reported 6 months prior (retrospectively) and currently. A non-clinical sample was used to determine if this bias is a general recall ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2012.666367

    authors: Sullivan KA,Edmed SL

    更新日期:2012-01-01 00:00:00

  • Neuropsychological assessment and the Disability Rating Scale (DRS): a concurrent validity study.

    abstract::Assessment of current level of functioning among clients with traumatic brain injury (TBI) often guides the establishment of realistic outcome goals for post-acute rehabilitation. Further, data generated from neuropsychological testing provide a clinician with a better understanding of a client's pattern of cognitive ...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/026990500413740

    authors: Neese LE,Caroselli JS,Klaas P,High WM Jr,Becker LJ,Scheibel RS

    更新日期:2000-08-01 00:00:00

  • Tolerance of a virtual reality intervention for attention remediation in persons with severe TBI.

    abstract:OBJECTIVE:To evaluate the feasibility of applying virtual reality and robotics technology to improve attention in patients with severe traumatic brain injury (TBI) in the early stages of recovery. METHODS:A sample of TBI patients (n=18, aged 19-73) who were receiving acute inpatient rehabilitation completed three-dime...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2010.551648

    authors: Larson EB,Ramaiya M,Zollman FS,Pacini S,Hsu N,Patton JL,Dvorkin AY

    更新日期:2011-01-01 00:00:00

  • Interpretive risks: the use of the Hopkins Symptom Checklist 90-Revised (SCL 90-R) with brain tumour patients.

    abstract::Patients with brain tumours often report distress. Interpretive problems ensue when measures normed on healthy persons are utilized to quantify distress. This study investigated potentially spurious elevations on the Hopkins Symptom Checklist 90 Revised (SCL 90-R). Responses of 17 patients were obtained prior to aggre...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/026990598122674

    authors: Kaplan CP,Miner ME,Mervis L,Newton H,McGregor JM,Goodman JH

    更新日期:1998-03-01 00:00:00

  • Higher haemoglobin levels and dedicated trauma admission are associated with survival after severe traumatic brain injury.

    abstract:BACKGROUND:Prevention of secondary brain injury is a key component of acute management of patients with severe traumatic brain injury (TBI). Haemoglobin concentration may have an impact on optimization of cerebral oxygenation. Patients with TBI may best be served by an organized trauma service. The objective is to dete...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2015.1004558

    authors: Baltazar GA,Pate AJ,Panigrahi B,Sharp A,Smith M,Chendrasekhar A

    更新日期:2015-01-01 00:00:00

  • Effects of CC-chemokine receptor 5 on ROCK2 and P-MLC2 expression after focal cerebral ischaemia-reperfusion injury in rats.

    abstract:OBJECTIVE:CC-chemokine receptor 5 (CCR5) plays a pivotal role in reperfusion after stroke. This study assessed and confirmed the effects of CCR5 in experimental stroke via regulation of ROCK/P-MLC pathway. METHODS:Male Sprague Dawley (SD) rats were randomly divided into sham group, ischaemia-reperfusion group (I/R gro...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2015.1129557

    authors: Li L,Zhi D,Shen Y,Liu K,Li H,Chen J

    更新日期:2016-01-01 00:00:00

  • Robotic gait training in patients with impaired consciousness due to severe traumatic brain injury.

    abstract:PRIMARY OBJECTIVE:This prospective controlled non-randomized study investigated the effects of robotic gait training on electroencephalographic (EEG) brain activity in patients with impaired consciousness due to severe traumatic brain injury (TBI). METHODS:Twelve TBI patients and 14 healthy controls underwent a single...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2011.607782

    authors: Lapitskaya N,Nielsen JF,Fuglsang-Frederiksen A

    更新日期:2011-01-01 00:00:00

  • Patient correlates of caregivers' distress and family functioning after traumatic brain injury.

    abstract::This study examined the relationship of patient variables to caregiver distress and family functioning after TBI in 62 families. An extension of Kreutzer et al. 1994 (in press), the present investigation used four categories of predictor variables: indices of injury severity, neuropsychological tests, neurobehavioural...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699059409150974

    authors: Kreutzer JS,Gervasio AH,Camplair PS

    更新日期:1994-04-01 00:00:00

  • Suspiciously slow: timed digit span as an embedded performance validity measure in a sample of veterans with mTBI.

    abstract:OBJECTIVE:To explore the utility of Timed Digit Span (TDS) as an embedded performance validity test (PVT) in a sample of veterans with mild traumatic brain injury (mTBI). We hypothesize that TDS will predict PVT failure on an established stand-alone measure (Trial 1 of the Test of Memory Malingering; TOMM). METHODS:TD...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2018.1553311

    authors: Gabel NM,Waldron-Perrine B,Spencer RJ,Pangilinan PH,Hale AC,Bieliauskas LA

    更新日期:2019-01-01 00:00:00

  • Indicators of complicated mild TBI predict MMPI-2 scores after 23 years.

    abstract:PRIMARY OBJECTIVE:Research suggests that post-concussive syndrome may become persistent after mild traumatic brain injury (mTBI). The aim of this study was to investigate determinants of subjective complaints, characteristic for post-concussive syndrome, 23 years after mTBI. RESEARCH DESIGN:The study was a follow-up a...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050902748349

    authors: Hessen E,Nestvold K

    更新日期:2009-03-01 00:00:00

  • Dynamic changes in white matter following traumatic brain injury and how diffuse axonal injury relates to cognitive domain.

    abstract::Objective: The goal is to evaluate longitudinally with diffusion tensor imaging (DTI) the integrity of cerebral white matter in patients with moderate and severe DAI and to correlate the DTI findings with cognitive deficits. Methods: Patients with DAI (n = 20) were scanned at three timepoints (2, 6 and 12 months) afte...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699052.2020.1859615

    authors: Grassi DC,Zaninotto AL,Feltrin FS,Macruz FBC,Otaduy MCG,Leite CC,Guirado VMP,Paiva WS,Santos Andrade C

    更新日期:2021-01-28 00:00:00

  • Neuropsychiatric interventions with head injured children and adolescents.

    abstract::With increasing numbers of surviving head injured children and adolescents, there is a growing need to provide child neuropsychiatric services as a necessary component for their comprehensive rehabilitation. This paper discusses the critical role child psychiatry should have in pediatric head injury rehabilitation and...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699058709034443

    authors: Parmelee DX,O'Shanick GJ

    更新日期:1987-07-01 00:00:00

  • Conversation-based assessment of social cognition in adults with traumatic brain injury.

    abstract:PRIMARY OBJECTIVE:The purpose of this study was to characterize performance of individuals with traumatic brain injury (TBI) on a novel video-based test, the Video Social Inference Test (VSIT). The VSIT was designed to capture social inference processes that would be engaged in daily conversations. The test required bo...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050802027059

    authors: Turkstra LS

    更新日期:2008-05-01 00:00:00

  • Multiple indicators model of long-term mortality in traumatic brain injury.

    abstract:OBJECTIVE:To examine the prognostic ability of protein S100B, neuron-specific enolase (NSE) and glial fibrillary acid protein (GFAP) for prediction of 1-year mortality in patients with traumatic brain injury (TBI) in relation to clinical and radiological characteristics of TBI. METHODS:Brain injury was quantified in 8...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2012.694567

    authors: Gradisek P,Osredkar J,Korsic M,Kremzar B

    更新日期:2012-01-01 00:00:00

  • Perseveration of traumatic re-experiencing in PTSD; a cautionary note regarding exposure based psychological treatments for PTSD when head injury and dysexecutive impairment are also present.

    abstract::This case study describes the psychological treatment of a man with co-existing PTSD, head injury and mild dysexecutive impairment. It describes the detrimental consequences when the re-experiencing of a traumatic event appears to have become a perseverated response. In this case, the perseveration meant that the most...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.1080/02699050110088263

    authors: King NS

    更新日期:2002-01-01 00:00:00

  • 'We are the forgotten victims': Perspectives of adult siblings of persons with traumatic brain injury.

    abstract:PRIMARY OBJECTIVE:This study determined how the lives of a cross-national sample of adult siblings had changed since their brothers and sisters incurred a traumatic brain injury. RESEARCH DESIGN:A total of 272 participants provided responses to the question, 'How is your life different since your sibling had a TBI?' R...

    journal_title:Brain injury

    pub_type: 杂志文章

    doi:10.3109/02699052.2010.514317

    authors: Degeneffe CE,Olney MF

    更新日期:2010-01-01 00:00:00