Abstract:
PURPOSE::To describe the patterns of regression of choroidal melanoma after treatment with plaque brachytherapy. METHODS::Retrospective interventional case series including 170 consecutive patients treated with 103Pd eye plaque radiation for choroidal melanoma. Outcome measures were changes in tumor thickness, surface characteristics, tumor vascularity, ultrasonography, fluorescein angiography, optical coherence tomography, and histopathology. RESULTS::The mean initial tumor thickness was 3.9 mm (median 2.8 mm; range 2-11.3 mm) that decreased to 1.7 mm (median 1.2 mm; range 0-7.1 mm) after plaque brachytherapy. On imaging, tumors were pigmented in 51% ( n = 86/170), amelanotic in 10% ( n = 17/170), and variably pigmented in 39% ( n = 67/170). Tumor pigmentation increased in 64% ( n = 106/166), decreased in 18% ( n = 30/166), and was unchanged in 18% ( n = 30/166). Of the 120 that demonstrated intrinsic vascularity, 10% ( n = 12/120) had decreased tumor-related vascularity and 90% ( n = 108/120) showed complete resolution. Subretinal fluid was present in 34% ( n = 58/170) of eyes at presentation. Of them, 15% (9; n = 9/58) had persistent SRF at last follow-up. On ultrasound imaging, 88% ( n = 149/170) tumors presented with low to moderate internal reflectivity of which 61% ( n = 91/149) showed increased reflectivity on regression. We noted a crescendo-decrescendo fluctuation in the presence of orange pigment lipofuscin along with complete resolution of drusenoid retinal pigment epithelial detachments. In the entire series of 170 patients, there was 0.5% (1) failure of local control, 2% (4) secondary enucleations, and 6% (10) patients developing metastasis. CONCLUSION::Findings related to choroidal melanoma regression after 103Pd plaque brachytherapy included decreased intrinsic tumor vascularity, decreased tumor-related subretinal fluid, increased pigmentation, specific changes in orange pigment lipofuscin and resolution of drusenoid retinal pigment epithelial detachments, as well as decreased tumor thickness with an increase in internal reflectivity on ultrasound.
journal_name
Eur J Ophthalmoljournal_title
European journal of ophthalmologyauthors
Maheshwari A,Finger PTdoi
10.1177/1120672118776146subject
Has Abstractpub_date
2018-11-01 00:00:00pages
722-730issue
6eissn
1120-6721issn
1724-6016journal_volume
28pub_type
杂志文章abstract:PURPOSE:To study sex differences in corneal biomechanical parameters in Egypt as regards to corneal hysteresis (CH), corneal resistance factor (CRF), Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated intraocular pressure (IOPcc). METHODS:This is a cross-sectional observational study that include...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000572
更新日期:2015-09-01 00:00:00
abstract:PURPOSE:To report the long-term surgical outcome of vitrectomy for cystoid macular edema due to nonischemic central retinal vein occlusion (CRVO). METHODS:A retrospective chart review of 25 consecutive eyes (25 patients) with cystoid macular edema due to nonischemic CRVO treated with vitrectomy was performed. All pati...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210601600609
更新日期:2006-11-01 00:00:00
abstract:PURPOSE:To evaluate the use of 10/0 polyester (Mersilene) sutures for closure of small corneal incision after congenital cataract surgery. METHODS:The authors retrospectively reviewed the medical records of 58 cases (42 patients) who underwent congenital cataract extraction and intraocular lens implantation between 19...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210801800114
更新日期:2008-01-01 00:00:00
abstract:PURPOSE:To report clinical and confocal microscopy features of late-onset Candida albicans keratitis after Descemet stripping automated keratoplasty (DSAEK). METHODS:We performed clinical and confocal scan on a patient who underwent DSAEK and phacoemulsification for Fuchs endothelial dystrophy and cataract. RESULTS:A...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/EJO.2011.6228
更新日期:2011-07-01 00:00:00
abstract:PURPOSE::To describe a case of Posterior Keratoconus (keratoconus posticus); its clinical condition, corneal, refractive response to intracorneal ring implantation (MyoRing), anterior segment optical coherence tomography findings; and micro incisional cataract surgery outcome. METHODS::Case report. RESULTS::The case ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672118787436
更新日期:2019-01-01 00:00:00
abstract::The primary aim of this study was to summarize and illustrate the main structural cross-sectional optical coherence tomography findings encountered after vitreoretinal surgery for rhegmatogenous retinal detachment. This was a non-systematic review of literature on structural cross-sectional optical coherence tomograph...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1177/1120672120911334
更新日期:2020-07-01 00:00:00
abstract:PURPOSE:Good binocular potential has been a fundamental defining characteristic of acute acquired concomitant esotropia (AACE) type II. The purpose of this study was to ascertain the clinical features and surgical outcome in children with AACE type II who underwent repeated surgery for the sake of binocularity. METHOD...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067211002000301
更新日期:2010-05-01 00:00:00
abstract:PURPOSE:To establish the real localization of rifabutin-related corneal deposits in a patient with human immunodeficiency virus (HIV) infection by in vivo HRT II confocal microscopy with related clinicopathologic implications. METHODS:Observational case report. After Siena University Institutional Review Board approva...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210901900327
更新日期:2009-05-01 00:00:00
abstract:PURPOSE:To asses visual quality after bilateral implantation of the Acri.LISA 366D intraocular lens (IOL) (Carl Zeiss Meditec) in patients with high and low-moderate myopia. METHODS:A total of 304 eyes of 152 patients had bilateral implantation of the Acri.LISA 366D IOL. The patients were divided into 2 groups: low-mo...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067211002000111
更新日期:2010-01-01 00:00:00
abstract:PURPOSE:Leber hereditary optic neuropathy (LHON) is recognized as the most common cause of isolated blindness in young men. The current study was designed to test whether LHON as a mitochondrial disease is associated with vascular functional alterations characterized by aortic elastic properties during echocardiography...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210801800225
更新日期:2008-03-01 00:00:00
abstract:PURPOSE:To assess the long-term results of viscotrabeculotomy in infants with primary congenital glaucoma and to compare its outcome with conventional trabeculotomy. PATIENTS AND METHODS:A prospective randomized comparative study included infants with primary congenital glaucoma younger than 2 years. Patients were div...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120922453
更新日期:2020-05-26 00:00:00
abstract:PURPOSE:To evaluate the anatomic success rate, visual acuity (VA) changes, and complications of 23-G vitrectomy without associated scleral procedures for the treatment of primary rhegmatogenous retinal detachment (PRRD). METHODS:Patients diagnosed with PRRD were considered for inclusion. Patients with evidence of pr...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000234
更新日期:2013-05-01 00:00:00
abstract:PURPOSE:Dacryocystorhinostomy (DCR) is the standard surgical treatment for adult nasolacrimal duct obstruction. There have been relatively few studies of closed nasolacrimal duct intubation in adults. The aim of this study was to determine rates of anatomic patency following this procedure. METHODS:The authors carried...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210701700402
更新日期:2007-07-01 00:00:00
abstract:PURPOSE:While elevated intraocular pressure (IOP) is a major risk factor for glaucoma, only about 1% of patients with 25 mmHg develop the condition each year. Since a sizeable proportion of the ganglion cells are already lost when the visual field losses are apparent, the aim is to identify patients with elevated IOP i...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,评审
doi:10.1177/112067210101102s05
更新日期:2001-07-01 00:00:00
abstract:PURPOSE:To assess and investigate the relationship between diurnal variations in intraocular pressure (IOP) and biomechanical properties of cornea. METHODS:Sixty-two healthy volunteers were recruited. Corneal compensated IOP (IOPcc), Goldmann-correlated IOP (IOPg), corneal resistance factor (CRF), and corneal hysteres...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210901900518
更新日期:2009-09-01 00:00:00
abstract::In myopia patients, Rh and acid phosphatase were typed in two groups: group 1 consisted of 214 patients with low myopia (-6 D or less); group 2 of 124 patients with high myopia (more than -6 D). Statistical analysis of the markers showed a good Hardy-Weinberg equilibrium for both groups. In the Rh system there was a s...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1992-10-01 00:00:00
abstract:OBJECTIVE:To evaluate the effect of chronicity on the size of the ostium after external dacryocystorhinostomy (DCR) with intubation. METHODS:Design: A retrospective chart review of patients who underwent external DCR with intubation over 10 years from January 2003 at a tertiary hospital. All patients were recruited an...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/1120672120976044
更新日期:2020-11-24 00:00:00
abstract:PURPOSE:The main purpose of this prospective study was to compare the efficacy, local tolerance, and safety of topical lomefloxacin 0.3% and topical ofloxacin 0.3% in the treatment of acute bacterial conjunctivitis. PATIENTS AND METHODS:Forty patients with acute bacterial conjunctivitis were included in a randomized, ...
journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:
更新日期:1999-10-01 00:00:00
abstract:PURPOSE:To evaluate the effect of oral prednisolone on visual outcomes and complications of scleral buckling (SB) in phakic eyes with acute rhegmatogenous retinal detachment (RRD). METHODS:In a randomized double-blind placebo-controlled trial, patients with acute RRD underwent SB. The treatment group received 1 mg/kg ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.1177/112067211002000224
更新日期:2010-03-01 00:00:00
abstract:PURPOSE:To evaluate the changes in retinal nerve fiber layer thickness (RNFLT), ganglion cell layer thickness (GCLT), retinal thickness (RT), and subfoveal choroidal thickness (SFCT) in eyes that received pars plana vitrectomy (PPV) with internal limiting membrane (ILM) peeling for idiopathic macular hole (IMH) and to ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000851
更新日期:2017-05-11 00:00:00
abstract::Blood flow in various tissues of the body shows spontaneous variations. The purpose of this study was to analyze variations over time in the blood flow of the optic nerve head. Blood flow was measured by the laser Doppler flowmeter (LDF) in 12 healthy volunteers, and analyzed by spectral Fourier analysis. The LDF tech...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:
更新日期:1997-10-01 00:00:00
abstract:PURPOSE:Transforming growth factor-beta1 (TGF-beta1) is thought to play a pivotal role in the regulation of the wound healing process after glaucoma filtering surgery. The aim of the present study was to investigate whether platelet-derived growth factor isoforms (PDGF-AA, PDGF-BB), basic fibroblast growth factor (bFGF...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210001000203
更新日期:2000-04-01 00:00:00
abstract:PURPOSE:To evaluate the risk factors for posterior capsule rupture with or without vitreous loss (PCR +/- VL) in extracapsular cataract extraction (ECCE). METHODS:The charts of 2794 consecutive patients who had ECCE with or without intraocular lens implantation between January 1992 and December 1997 were reviewed retr...
journal_title:European journal of ophthalmology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1177/112067210001000306
更新日期:2000-07-01 00:00:00
abstract:PURPOSE:To evaluate the efficacy, safety, and tolerability of Timogel® preservative-free once daily compared to timolol 0.5% ophthalmic solution bid in patients with ocular hypertension (OHT) and patients with primary open-angle glaucoma (POAG). METHODS:A total of 75 patients with OHT and patients with POAG treated wi...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000006
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:To delineate and discuss a not yet described possible ocular complication of selective intra-arterial chemotherapy (SIAC) for treatment of retinoblastoma. METHODS:A 23-month-old girl with a large unilateral retinoblastoma was treated with repeated SIAC using 5 mg melphalan between July 2010 and January 2012. C...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000393
更新日期:2014-05-01 00:00:00
abstract:PURPOSE:Malignant melanoma associated with a blue nevus is a rare diagnosis. Additionally, only a handful of cases of malignant melanoma associated with blue nevi involving the ocular structures have been reported. We report a probable case of malignant melanoma associated with a blue nevus with metastasis to multiple ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/EJO.2011.6375
更新日期:2011-09-01 00:00:00
abstract:PURPOSE:The aim of the present study was to evaluate the efficacy of diode laser cyclophotocoagulation (DCPC) and cyclocryotherapy (CCT) in the treatment of refractory glaucoma and compare the postoperative complications and discomfort rates. METHODS:In a prospective, randomized, controlled clinical study, 40 eyes of ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章,随机对照试验
doi:10.5301/EJO.2011.6326
更新日期:2011-09-01 00:00:00
abstract:PURPOSE:To assess corneal tissue modifications after riboflavin-UVA-induced cross-linking of corneal collagen in patients with progressive keratoconus as well as regeneration of epithelium and subepithelial nerve plexus by in vivo HRT II system confocal microscopy in humans. METHODS:Ten patients with progressive kerat...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.1177/112067210601600405
更新日期:2006-07-01 00:00:00
abstract:PURPOSE:To compare 4 limbal-conjunctival autograft fixation techniques-conventional suture, commercial fibrin glue, autologous fibrin glue, and cautery-in primary nasal pterygium surgery. METHODS:This is a retrospective and descriptive study. The postoperative patient discomfort, graft edema, ocular inflammation, and ...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/ejo.5000924
更新日期:2017-06-26 00:00:00
abstract:PURPOSE:To evaluate the diagnostic ability of a new perimetric procedure in glaucoma. METHODS:Pulsar perimeter shows white circular sinusoidal grating patterns with decreasing amplitude, 5 in diameter, 500 msec in duration in 66 locations. The stimuli scale combines spatial resolution and contrast. The stimuli were sh...
journal_title:European journal of ophthalmology
pub_type: 杂志文章
doi:10.5301/EJO.2008.2727
更新日期:2004-01-01 00:00:00