The role of easter, an apparent serine protease, in organizing the dorsal-ventral pattern of the Drosophila embryo.

abstract：:We have identified two major and approximately ten minor poly(A)-containing RNA species in S. cerevisiae which arise from in vivo transcription of the yeast plasmid, known as 2mu circle. The two major species, which are 1325 and 1275 bases in length, are transcribed from the two unique halves of the plasmid and extend...

journal_title：Cell

authors： Broach JR,Atkins JF,McGill C,Chow L

更新日期：1979-04-01 00:00:00

abstract：:It was previously demonstrated that the 60,000 dalton (p60) precursor-like polyprotein containing murine p30 was a constituent of the feline leukemia virus pseudotype of Moloney sarcoma virus [m1MSV(FeLV)]. It is now shown that p60 is detected in cells of five mammalian species transformed by m1MSV, indicating that p...

journal_title：Cell

authors： Robey WG,Oskarsson MK,Vande Woude GF,Naso RB,Arlinghaus RB,Haapala DK,Fischinger PJ

更新日期：1977-01-01 00:00:00

abstract：:We have developed an in vitro system utilizing yeast cell-free extracts to catalyze recombination events between homologous plasmids containing different mutant alleles of the Tet or ARG4 genes. The reaction increased the frequency of Tcr or Arg+ transformants (recombinants) from 2 X 10(-6) to 1-3 X 10(-3). Linearizin...

journal_title：Cell

authors： Symington LS,Fogarty LM,Kolodner R

更新日期：1983-12-01 00:00:00

abstract：:Genetic alterations in signaling pathways that control cell-cycle progression, apoptosis, and cell growth are common hallmarks of cancer, but the extent, mechanisms, and co-occurrence of alterations in these pathways differ between individual tumors and tumor types. Using mutations, copy-number changes, mRNA expressio...

journal_title：Cell

authors： Sanchez-Vega F,Mina M,Armenia J,Chatila WK,Luna A,La KC,Dimitriadoy S,Liu DL,Kantheti HS,Saghafinia S,Chakravarty D,Daian F,Gao Q,Bailey MH,Liang WW,Foltz SM,Shmulevich I,Ding L,Heins Z,Ochoa A,Gross B,Gao J,Z

更新日期：2018-04-05 00:00:00

abstract：:The archetypal human tumor suppressor p53 is considered to have unique transactivation properties. The assumption is based on the fact that additionally identified human p53 isoforms lack transcriptional activity. However, we provide evidence for the existence of an alternatively spliced p53 isoform (Deltap53) that ex...

journal_title：Cell

authors： Rohaly G,Chemnitz J,Dehde S,Nunez AM,Heukeshoven J,Deppert W,Dornreiter I

更新日期：2005-07-15 00:00:00

abstract：:The alpha-amylase mRNAs which accumulate in two different tissues of the mouse, the salivary gland and the liver, are identical except for their 5' non-translated sequences: the 5' terminal 158 nucleotides of the major liver alpha-amylase mRNA are unrelated to the 5' terminal 47 nucleotides found in its salivary gland...

journal_title：Cell

authors： Young RA,Hagenbüchle O,Schibler U

更新日期：1981-02-01 00:00:00

abstract：:c-Myc (Myc) and Max proteins dimerize and bind DNA through basic-helix-loop-helix-leucine zipper motifs (b-HLH-LZ). Using a genetic approach, we demonstrate that binding to Max is essential for Myc transforming activity and that Myc homodimers are inactive. Mutants of Myc and Max that bind efficiently to each other bu...

journal_title：Cell

authors： Amati B,Brooks MW,Levy N,Littlewood TD,Evan GI,Land H

更新日期：1993-01-29 00:00:00

abstract：:Fast-spiking interneurons (FSIs) are a prominent class of forebrain GABAergic cells implicated in two seemingly independent network functions: gain control and network plasticity. Little is known, however, about how these roles interact. Here, we use a combination of cell-type-specific ablation, optogenetics, electrop...

journal_title：Cell

authors： Owen SF,Berke JD,Kreitzer AC

更新日期：2018-02-08 00:00:00

abstract：:Most secreted growth factors and cytokines are functionally pleiotropic because their receptors are expressed on diverse cell types. While important for normal mammalian physiology, pleiotropy limits the efficacy of cytokines and growth factors as therapeutics. Stem cell factor (SCF) is a growth factor that acts throu...

journal_title：Cell

authors： Ho CCM,Chhabra A,Starkl P,Schnorr PJ,Wilmes S,Moraga I,Kwon HS,Gaudenzio N,Sibilano R,Wehrman TS,Gakovic M,Sockolosky JT,Tiffany MR,Ring AM,Piehler J,Weissman IL,Galli SJ,Shizuru JA,Garcia KC

更新日期：2017-03-09 00:00:00

abstract：:The X-linked Foxp3 is a member of the forkhead/winged helix transcription factor family. Germline mutations cause lethal autoimmune diseases in males. Serendipitously, we observed that female mice heterozygous for the "scurfin" mutation of the Foxp3 gene (Foxp3(sf/+)) developed cancer at a high rate. The majority of t...

journal_title：Cell

authors： Zuo T,Wang L,Morrison C,Chang X,Zhang H,Li W,Liu Y,Wang Y,Liu X,Chan MW,Liu JQ,Love R,Liu CG,Godfrey V,Shen R,Huang TH,Yang T,Park BK,Wang CY,Zheng P,Liu Y

更新日期：2007-06-29 00:00:00

abstract：:The integration of mass spectrometry-based proteomics with next-generation DNA and RNA sequencing profiles tumors more comprehensively. Here this "proteogenomics" approach was applied to 122 treatment-naive primary breast cancers accrued to preserve post-translational modifications, including protein phosphorylation a...

journal_title：Cell

authors： Krug K,Jaehnig EJ,Satpathy S,Blumenberg L,Karpova A,Anurag M,Miles G,Mertins P,Geffen Y,Tang LC,Heiman DI,Cao S,Maruvka YE,Lei JT,Huang C,Kothadia RB,Colaprico A,Birger C,Wang J,Dou Y,Wen B,Shi Z,Liao Y,Wizn

更新日期：2020-11-25 00:00:00

abstract：:Abiotic stress, such as salinity, drought, and cold, causes detrimental yield losses for all major plant crop species. Understanding mechanisms that improve plants' ability to produce biomass, which largely is constituted by the plant cell wall, is therefore of upmost importance for agricultural activities. Cellulose ...

journal_title：Cell

authors： Endler A,Kesten C,Schneider R,Zhang Y,Ivakov A,Froehlich A,Funke N,Persson S

更新日期：2015-09-10 00:00:00

abstract：:Kit/SCF signaling and Mitf-dependent transcription are both essential for melanocyte development and pigmentation. To identify Mitf-dependent Kit transcriptional targets in primary melanocytes, microarray studies were undertaken. Among identified targets was BCL2, whose germline deletion produces melanocyte loss and w...

journal_title：Cell

authors： McGill GG,Horstmann M,Widlund HR,Du J,Motyckova G,Nishimura EK,Lin YL,Ramaswamy S,Avery W,Ding HF,Jordan SA,Jackson IJ,Korsmeyer SJ,Golub TR,Fisher DE

更新日期：2002-06-14 00:00:00

abstract：:The tumor suppressor PTEN, a critical regulator for multiple cellular processes, is mutated or deleted frequently in various human cancers. Subtle reductions in PTEN expression levels have profound impacts on carcinogenesis. Here we show that PTEN level is regulated by ubiquitin-mediated proteasomal degradation, and p...

journal_title：Cell

authors： Wang X,Trotman LC,Koppie T,Alimonti A,Chen Z,Gao Z,Wang J,Erdjument-Bromage H,Tempst P,Cordon-Cardo C,Pandolfi PP,Jiang X

更新日期：2007-01-12 00:00:00

abstract：:We have tested a model for global ribosome biosynthesis by examining the effects of increased gene dosage on the synthesis of rRNA. Increasing gene dosage does not lead to a significant increase in total rRNA transcription; i.e., rRNA synthesis from individual rRNA operons is reduced to keep total rRNA production unch...

journal_title：Cell

authors： Jinks-Robertson S,Gourse RL,Nomura M

更新日期：1983-07-01 00:00:00

abstract：:In the mouse, the zona pellucida (ZP) glycoprotein ZP3 both binds intact sperm and induces acrosomal exocytosis. The subsequent signaling pathway(s) is still uncertain, but Gi-like proteins have been implicated. By analogy with other signal transduction mechanisms, we examined anti-phosphotyrosine antibody reactivity ...

journal_title：Cell

authors： Leyton L,Saling P

更新日期：1989-06-30 00:00:00

abstract：:Null mutant mice for retinoic acid receptor gamma 2 (RAR gamma 2) or all RAR gamma isoforms were generated. RAR gamma 2 mutants appeared normal, whereas RAR gamma mutants exhibited growth deficiency, early lethality, and male sterility due to squamous metaplasia of the seminal vesicles and prostate. These defects were...

journal_title：Cell

authors： Lohnes D,Kastner P,Dierich A,Mark M,LeMeur M,Chambon P

更新日期：1993-05-21 00:00:00

abstract：:Mouse macrophages and lymphocytes express two distinct isoforms of a single class of Fc receptor for IgG. The macrophage isoform (FcRII-B2) is identical to the lymphocyte isoform (FcRII-B1) except for an inframe insertion in the cytoplasmic tail of FcRII-B1 that increases its length from 47 to 94 amino acids. To deter...

journal_title：Cell

authors： Miettinen HM,Rose JK,Mellman I

更新日期：1989-07-28 00:00:00

abstract：:Steroid hormones induce transcription from the mouse mammary tumor virus (MMTV) promoter by complex mechanisms requiring binding of the hormone receptors to the hormone responsive element (HRE) of the long terminal repeat region. Here we show that the MMTV promoter contains two degenerated octamer motifs immediately u...

journal_title：Cell

authors： Brüggemeier U,Kalff M,Franke S,Scheidereit C,Beato M

更新日期：1991-02-08 00:00:00

abstract：:The HVEM (TNFRSF14) receptor gene is among the most frequently mutated genes in germinal center lymphomas. We report that loss of HVEM leads to cell-autonomous activation of B cell proliferation and drives the development of GC lymphomas in vivo. HVEM-deficient lymphoma B cells also induce a tumor-supportive microenvi...

journal_title：Cell

authors： Boice M,Salloum D,Mourcin F,Sanghvi V,Amin R,Oricchio E,Jiang M,Mottok A,Denis-Lagache N,Ciriello G,Tam W,Teruya-Feldstein J,de Stanchina E,Chan WC,Malek SN,Ennishi D,Brentjens RJ,Gascoyne RD,Cogné M,Tarte K,Wende

更新日期：2016-10-06 00:00:00

abstract：:Electrophoretic and autoradiographic analyses of the incorporation of 35S--methionine into newly synthesized proteins during myogenesis reveal that presumptive chicken myoblasts synthesize primarily one intermediate filament protein: vimentin. Desmin synthesis is initiated at the onset of fusion. Synthesis rates of bo...

journal_title：Cell

authors： Gard DL,Lazarides E

更新日期：1980-01-01 00:00:00

abstract：:Cholera toxin inhibition of progesterone-induced meiosis of Xenopus laevis oocytes in vitro has been correlated with increased cAMP levels. Inhibition of germinal vesicle breakdown (Gvbd) and cAMP increase occurred after a lag period of 2 hr, when cholera toxin was injected, or 4--5 hr, when applied externally. The ab...

journal_title：Cell

authors： Schorderet-Slatkine S,Schorderet M,Boquet P,Godeau F,Baulieu EE

更新日期：1978-12-01 00:00:00

abstract：:Developing systems exhibit robust and tolerant properties in the form of compensation and competition within cell groups. Fundamentally, these behaviors are governed by mechanisms that elicit proliferation and apoptosis. Recent insights from the Drosophila system implicate new determinants that specify "winners" and "...

journal_title：Cell

authors： Abrams JM

更新日期：2002-08-23 00:00:00

abstract：:After translational termination, mRNA and P site deacylated tRNA remain associated with ribosomes in posttermination complexes (post-TCs), which must therefore be recycled by releasing mRNA and deacylated tRNA and by dissociating ribosomes into subunits. Recycling of bacterial post-TCs requires elongation factor EF-G ...

journal_title：Cell

authors： Pisarev AV,Hellen CU,Pestova TV

更新日期：2007-10-19 00:00:00

abstract：:Living organisms sense their physical environment through cellular mechanotransduction, which converts mechanical forces into electrical and biochemical signals. In turn, signal transduction serves a wide variety of functions, from basic cellular processes as diverse as proliferation, differentiation, migration, and a...

journal_title：Cell

authors： Delmas P,Coste B

更新日期：2013-10-10 00:00:00

abstract：:Poorly immunogenic tumor cells evade host immunity and grow even in the presence of an intact immune system, but the complex mechanisms regulating tumor immunogenicity have not been elucidated. Here, we discovered an unexpected role of the Hippo pathway in suppressing anti-tumor immunity. We demonstrate that, in three...

journal_title：Cell

authors： Moroishi T,Hayashi T,Pan WW,Fujita Y,Holt MV,Qin J,Carson DA,Guan KL

更新日期：2016-12-01 00:00:00

abstract：:Recent studies are beginning to shed light on the mechanism of ribosome-catalyzed peptide bond formation. ...

journal_title：Cell

authors： Green R,Lorsch JR

更新日期：2002-09-20 00:00:00

abstract：:Eukaryotic cells sterilize the cytosol by using autophagy to route invading bacterial pathogens to the lysosome. During macrophage infection with Mycobacterium tuberculosis, a vacuolar pathogen, exogenous induction of autophagy can limit replication, but the mechanism of autophagy targeting and its role in natural inf...

journal_title：Cell

authors： Watson RO,Manzanillo PS,Cox JS

更新日期：2012-08-17 00:00:00

abstract：:In addition to xeroderma pigmentosum, mutations in the human XPG gene cause early onset Cockayne syndrome (CS). Here, we provide evidence for the involvement of RAD2, the S. cerevisiae counterpart of XPG, in promoting efficient RNA polymerase II transcription. Inactivation of RAD26, the S. cerevisiae counterpart of th...

journal_title：Cell

authors： Lee SK,Yu SL,Prakash L,Prakash S

更新日期：2002-06-28 00:00:00

abstract：:A cDNA library has been constructed from an RNA preparation highly enriched in silkmoth chorion mRNAs. Many distinct clones have been identified from this library using a stepwise procedure: scoring for infrequent hexanucleotide restriction enzyme recognition sequences; detailed characterization with restriction enzym...

journal_title：Cell

authors： Sim GK,Kafatos FC,Jones CW,Koehler MD,Efstratiadis A,Maniatis T

更新日期：1979-12-01 00:00:00