Methamphetamine-associated dysregulation of the hypothalamic-pituitary-thyroid axis.

Abstract:

:Methamphetamine and HIV impair thyroid function, but few studies have investigated their combined effects on thyroid dysregulation. This study examined the associations of methamphetamine use alone and in combination with HIV on thyroid function among men in South Florida. Measures of thyroid function in methamphetamine-using, HIV-infected (METH+HIV+; n = 127) and HIV-negative (METH+HIV-; n = 46) men who have sex with men (MSM) were compared to non-methamphetamine-using, HIV-negative men (METH-HIV-; n = 136). Thyroid function was dysregulated in methamphetamine-using MSM, irrespective of HIV status. Both meth-using groups had greater odds of abnormal thyroid stimulating hormone levels and significantly higher mean free triiodothyronine (T3) levels. Elevated free T3 was associated with greater depressive symptoms. Overall, outcomes have important implications for assessment of thyroid function in methamphetamine users, particularly among those presenting with depression.

journal_name

J Behav Med

authors

Jones DL,Carrico AW,Babayigit S,Rodriguez VJ,Aguila C,Kumar M

doi

10.1007/s10865-018-9935-6

subject

Has Abstract

pub_date

2018-12-01 00:00:00

pages

792-797

issue

6

eissn

0160-7715

issn

1573-3521

pii

10.1007/s10865-018-9935-6

journal_volume

41

pub_type

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