[Metabolic syndrome and cognitive dysfunction in the old age].

Abstract:

BACKGROUND:We analyzed metabolic profile of patients with cognitive dysfunctions by means of levels of lipoproteins, glycaemia and hypertension. RESEARCH DESIGN AND METHODS:In naturalistic, open manner, we studied 100 persons--44 without cognitive dysfunctions, 17 with MCI and 39 with dementia. Patients were grouped according to ICD-10, NIA/AA, McKhann's criteria of cognitive impairment and STMS cutoff levels. RESULTS:We found correlations between HDL cholesterol (p = 0.036, OR = 1.061, <0.99; 1.13>), hyperglycaemia (p = 0.008, OR = 0.97, <0.95; 0.99>), metabolic syndrome (p = 0.03; OR = 0.34; <0.12; 0.91>) with age (p = 0.001; OR = 0.9; <0.84; 0.95>) and dementia. We confirmed also correlations of glucose levels with CT changes (p = 0.01, OR = 0.97, <0.95; 0.99>), and age (r = -0.47, p = 0.000001), fasting glucose (r =-0.33, p = 0.0024), HDL levels (r = 0.32; p = 0.05) with STMS results. CONCLUSIONS:Metabolic-cognitive syndrome seems to be a part of pathogenesis of dementia.

journal_name

Psychiatr Pol

journal_title

Psychiatria polska

authors

Parnowski T,Kałuza B

subject

Has Abstract

pub_date

2013-11-01 00:00:00

pages

1087-99

issue

6

eissn

0033-2674

issn

2391-5854

journal_volume

47

pub_type

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