Abstract:
:Bacterial meningitis is a disease of pronounced clinical significance, especially in the developing world. Immediate treatment with antibiotics is essential, and no single test can provide a conclusive diagnosis. It is well established that elevated total protein in cerebrospinal fluid (CSF) is associated with bacterial meningitis. Brillouin spectroscopy is a widely used optical technique for noninvasive determination of the elastic moduli of materials. We found that elevated protein levels in CSF alter the fluid elasticity sufficiently to be measurable by Brillouin spectroscopy, with model healthy and diseased fluids distinguishable to marked significance (P = 0.014), which increases with sample concentration by dialysis. Typical raw output of a 2-stage VIPA Brillouin spectrometer: inelastically scattered Brillouin peaks (arrows) and elastically scattered incident radiation (center cross).
journal_name
J Biophotonicsjournal_title
Journal of biophotonicsauthors
Steelman Z,Meng Z,Traverso AJ,Yakovlev VVdoi
10.1002/jbio.201400047subject
Has Abstractpub_date
2015-05-01 00:00:00pages
408-14issue
5eissn
1864-063Xissn
1864-0648journal_volume
8pub_type
杂志文章abstract::Myelin is a key component of the peripheral nervous system, whose structure anomaly in the digital skin is implicated in neuropathy. Here we demonstrate an in vivo labeling and imaging technique, capable of visualizing myelin sheaths deep in the mouse digital skin. Through material characterization, we verify that 3-p...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.202000321
更新日期:2020-12-01 00:00:00
abstract::We describe a novel, minimally invasive laser technology for skin rejuvenation by creating isolated microscopic lesions within tissue below the epidermis using laser induced optical breakdown. Using an in-house built prototype device, tightly focused near-infrared laser pulses are used to create optical breakdown in t...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201100083
更新日期:2012-02-01 00:00:00
abstract::Spahr et al. recently commented on our latest paper "Retinal pulse wave velocity measurement using spectral-domain optical coherence tomography" with a conclusion that the measured retinal pulse wave velocity (rPWV) in our paper was contradictory to theoretical predictions and previously published results. However, th...
journal_title:Journal of biophotonics
pub_type: 评论,杂志文章
doi:10.1002/jbio.201700379
更新日期:2018-02-01 00:00:00
abstract::The capabilities of cross-polarization optical coherence tomography (CP OCT) for early bladder-cancer detection are assessed in statistical study and compared with the traditional OCT. Unlike the traditional OCT that demonstrates images only in copolarization, CP OCT acquires images in cross-polarization and copolariz...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201000088
更新日期:2011-08-01 00:00:00
abstract::The photodetachment of Br(-), I(-) and OH(-) in aqueous solution is studied by 2- and 3-pulse femtosecond spectroscopy. The UV excitation leads to fast electron separation followed by formation of a donor-electron pairs. An additional repump pulse is used for secondary excitation of the intermediates. The 3-pulse tech...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201000099
更新日期:2011-03-01 00:00:00
abstract::There has been increasing use of in vitro cell culture models that more realistically replicate the three-dimensional (3D) environment found in vivo. Multicellular tumor spheroids (MTS) using cell lines or patient-derived organoids have become an important in vitro drug development tool, where cells are grown in a 3D ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800201
更新日期:2019-05-01 00:00:00
abstract::Since stimulated emission depletion (STED) nanoscopy was invented in 1994, this technique has been widely used in the fields of biomedicine and materials science. According to the imaging principle of STED technology, increasing the power of the depletion laser within a certain threshold can improve the resolution. Ho...
journal_title:Journal of biophotonics
pub_type: 信件
doi:10.1002/jbio.202000402
更新日期:2020-12-13 00:00:00
abstract::The processes associated with pollen germination were studied in vitro for two tree species, Salix caprea and Fraxinus excelsior under different nutrient conditions. The results provide evidence of changes in chemical composition of the pollen grains during germination. From the comparison of spectra of the pollen gra...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201000031
更新日期:2010-08-01 00:00:00
abstract::In vivo imaging of cerebral vasculature is highly vital for clinicians and medical researchers alike. For a number of years non-invasive optical-based imaging of brain vascular network by using standard fluorescence probes has been considered as impossible. In the current paper controverting this paradigm, we present ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201400140
更新日期:2015-11-01 00:00:00
abstract::For the screening purposes urine is an especially attractive biofluid, since it offers easy and noninvasive sample collection and provides a snapshot of the whole metabolic status of the organism, which may change under different pathological conditions. Raman spectroscopy (RS) has the potential to monitor these chang...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201900143
更新日期:2020-01-01 00:00:00
abstract::Monitoring living cells in real-time is important in order to unravel complex dynamic processes in life sciences. In particular the dynamics of initiation and progression of degenerative diseases is intensely studied. In atherosclerosis the thickening of arterial walls is related to high lipid levels in the blood stre...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600279
更新日期:2017-09-01 00:00:00
abstract::We suggest to use a combination of optical tweezers and single-image quantitative differential interference contrast (DIC) emulated by a spatial light modulator (SLM) to study physiological shape changes in thrombocytes after activation and demonstrate the effectiveness of this system for the given task. A specially d...
journal_title:Journal of biophotonics
pub_type: 社论
doi:10.1002/jbio.201100010
更新日期:2011-09-01 00:00:00
abstract::Previous studies for melanin visualization in the retinal pigment epithelium (RPE) have exploited either its absorption properties (using photoacoustic tomography or photothermal optical coherence tomography [OCT]) or its depolarization properties (using polarization sensitive OCT). However, these methods are only sui...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201900153
更新日期:2019-12-01 00:00:00
abstract::We report a compact, cost-effective tuned amplifier for frequency-selective amplification of the modulated signal in heterodyne detected nonlinear optical microscopy. Our method improved the signal to noise ratio by an order of magnitude compared to conventional lock-in detection, as demonstrated through stimulated Ra...
journal_title:Journal of biophotonics
pub_type: 社论
doi:10.1002/jbio.201200005
更新日期:2012-10-01 00:00:00
abstract::Highly emissive europium complexes with specific endoplasmic reticulum localization potential includes several advantages such as fast uptake, long resident lifetime, low dosage requirement, low cytotoxicity and highly emissive two-photon induced f-f emission imaging. ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.200910052
更新日期:2009-12-01 00:00:00
abstract::Atherosclerosis is a process of thickening and stiffening of the arterial walls through the accumulation of lipids and fibrotic material, as a consequence of aging and unhealthy life style. However, not all arterial plaques lead to complications, which can lead to life-threatening events such as stroke and myocardial ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800013
更新日期:2018-12-01 00:00:00
abstract::Fluctuations in brain water content has attracted increasing interest, particularly as regards studies of the glymphatic system, which is connected with the complex organization of dural lymphatic vessels, responsible for cleaning tissue. Disturbances of glymphatic circulation are associated with several brain disorde...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700123
更新日期:2018-08-01 00:00:00
abstract::223 Radium (223 Ra) is widely used in nuclear medicine to treat patients with osseous metastatic prostate cancer. In clinical practice 223 Ra cannot be imaged directly; however, gamma photons produced by its short-lived daughter nuclides can be captured by conventional gamma cameras. In this work, we show that 223 Ra ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700209
更新日期:2018-04-01 00:00:00
abstract::Despite an ever increasing demand for reliable and cheap methods in the detection and quantification of microbes, surprisingly few investigations have explored or utilized the luminescence of rare earths in the microbial context, neither in conventional, that is, plating and microscopic imaging techniques, nor in adva...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.202000068
更新日期:2020-09-01 00:00:00
abstract::Photoacoustic microscopy (PAM) is a noninvasive imaging technique and is excellent to study structural and functional changes in the microcirculation. In this work, a lipopolysaccharide (LPS)-induced inflammation model in mice is noninvasively evaluated by PAM. PAM is used to image the microvascular structural changes...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800251
更新日期:2019-03-01 00:00:00
abstract::The sun protection factor (SPF) values are currently determined using an invasive procedure, in which the volunteers are irradiated with ultraviolet (UV) light. Non-invasive approaches based on hybrid diffuse reflectance spectroscopy (HDRS) have shown a good correlation with conventional SPF testing. Here, we present ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.202000348
更新日期:2020-10-06 00:00:00
abstract::We fabricated composite nanoparticles consisting of a plasmonic core (gold nanorods or gold-silver nanocages) and a hematoporphyrin-doped silica shell. The dual photodynamic and photothermal activities of such nanoparticles against Staphylococcus aureus 209 P were studied and compared with the activities of reference ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201200079
更新日期:2013-04-01 00:00:00
abstract::Photobiomodulation (PBM) therapy has been noted to promote cell proliferation and growth in many different cell types shown both in vitro and in vivo. Currently, treatment regimens are used in the clinic for a variety of ailments, including wound healing. However, most protocols treat an anatomical site without consid...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600025
更新日期:2016-12-01 00:00:00
abstract::Skin optical clearing has shown tremendous potential in improving various optical imaging performances, but there is some certain blindness in screening out high-efficiency in vivo optical clearing methods. In this work, three optical clearing agents: sucrose (Suc), fructose (Fruc) and PEG-400 (PEG), and two chemical ...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201600221
更新日期:2017-06-01 00:00:00
abstract::Photodynamic inactivation (PDI) is a promising alternative for combating infections caused by antimicrobial resistant bacteria. Pneumonias are among the most worrisome infections because of their high-mortality rate. Previous studies have demonstrated the feasibility of using PDI with extracorporeal light to treat pne...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.202000176
更新日期:2020-10-01 00:00:00
abstract::Lasers are used in dentistry for a variety of indications. One of these is the disinfection of root canals or the sterilization of residual caries. Many studies have demonstrated the capacity to kill bacteria for lasers but the fundamental mechanism of the laser effect remains quite unclear. With our experiments we wa...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201000007
更新日期:2010-06-01 00:00:00
abstract::Skin fibrosis is a chronic debilitating feature of several skin diseases that lead to characteristic increases in dermal fibroblast proliferation and collagen deposition through upregulation in components of the transforming growth factor beta (TGF-B)/SMAD pathway. In contrast to ultraviolet phototherapy, high-fluence...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201800207
更新日期:2019-05-01 00:00:00
abstract::Perfusion and oxygenation are critical parameters of muscle metabolism in health and disease. They have been both the target of many studies, in particular using near-infrared spectroscopy (NIRS). However, difficulties with quantifying NIRS signals have limited a wide dissemination of the method to the clinics. Our ai...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201960169
更新日期:2020-06-01 00:00:00
abstract::Laser treatment on a large size of prostate gland often encounters significant bleeding that can prolong the entire procedure and cause urinary complications. The current study investigates the feasibility of dual-wavelength (532 and 980 nm) application to achieve rapid hemostasis for 532-nm laser prostatectomy. Porci...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700192
更新日期:2018-04-01 00:00:00
abstract::Nanosecond pulsed laser irradiation can trigger a release of nucleic acids from gold nanoparticles, but the involved nanoeffects are not fully understood yet. Here we investigate the release of coumarin labeled siRNA from 15 to 30 nm gold particles after nanosecond pulsed laser irradiation. Temperatures in the particl...
journal_title:Journal of biophotonics
pub_type: 杂志文章
doi:10.1002/jbio.201700329
更新日期:2018-09-01 00:00:00