Abstract:
:The nematode Caenorhabditis elegans has served as a fruitful setting for cell death research for over three decades. A conserved pathway of four genes, egl-1/BH3-only, ced-9/Bcl-2, ced-4/Apaf-1, and ced-3/caspase, coordinates most developmental cell deaths in C. elegans. However, other cell death forms, programmed and pathological, have also been described in this animal. Some of these share morphological and/or molecular similarities with the canonical apoptotic pathway, while others do not. Indeed, recent studies suggest the existence of an entirely novel mode of programmed developmental cell destruction that may also be conserved beyond nematodes. Here, we review evidence for these noncanonical pathways. We propose that different cell death modalities can function as backup mechanisms for apoptosis, or as tailor-made programs that allow specific dying cells to be efficiently cleared from the animal.
journal_name
Methods Enzymoljournal_title
Methods in enzymologyauthors
Kinet MJ,Shaham Sdoi
10.1016/B978-0-12-801430-1.00007-Xsubject
Has Abstractpub_date
2014-01-01 00:00:00pages
157-80eissn
0076-6879issn
1557-7988pii
B978-0-12-801430-1.00007-Xjournal_volume
545pub_type
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