Abstract:
OBJECTIVES:To compare the association between a restrictive transfusion strategy and cardiovascular complications during hospitalization for hip fracture with the association between a liberal transfusion strategy and cardiovascular complications, accounting for all transfusions from the emergency department to postacute rehabilitation settings. DESIGN:Retrospective study. SETTING:Perioperative geriatric care unit. PARTICIPANTS:All individuals aged 70 and older admitted to the emergency department for hip fracture and hospitalized in our perioperative geriatric care unit (N=667; n=193 in the liberal transfusion group, n=474 in the restrictive transfusion group) from July 2009 to April 2016. INTERVENTION:A restrictive transfusion strategy (hemoglobin level threshold ≥8 g/dL or symptoms) used from January 2012 to April 2016 was compared with the liberal transfusion strategy (hemoglobin level threshold ≥10 g/dL) used from July 2009 to December 2011. MEASUREMENTS:Primary endpoint was in-hospital acute cardiovascular complications (heart failure, myocardial infarction, atrial fibrillation or stroke). RESULTS:The change to a restrictive transfusion strategy was associated with fewer acute cardiovascular complications (odds ratio=0.45, 95% confidence interval (CI)=0.31-0.67, p<.001), without any noticeable difference in in-hospital or 6-month mortality. The change also led to a reduction in packed red blood cell units used per participant (median 1, interquartile range (IQR) 0-2 in restrictive vs median 2, IQR 0-3 in liberal transfusion strategy, P<.001). In rehabilitation settings, the frequency of transfusion was greater with the restrictive transfusion strategy than the liberal transfusion strategy (18% vs 9%, P<.001). CONCLUSION:A restrictive transfusion strategy in older adults with hip fracture was found to be safe and was associated with fewer cardiovascular complications but more transfusions in rehabilitation settings. Prospective studies are needed to confirm these findings.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Zerah L,Dourthe L,Cohen-Bittan J,Verny M,Raux M,Mézière A,Khiami F,Tourette C,Neri C,Le Manach Y,Riou B,Vallet H,Boddaert Jdoi
10.1111/jgs.15371subject
Has Abstractpub_date
2018-07-01 00:00:00pages
1151-1157issue
6eissn
0002-8614issn
1532-5415journal_volume
66pub_type
杂志文章abstract:OBJECTIVES:Use of objectively measured physical activity (PA) in older adults to assess relationship between PA and risk of all-causes mortality is scarce. This study evaluated the associations of PA based on accelerometry and a questionnaire with the risk of mortality among older adults from a city in Southern Brazil....
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.16180
更新日期:2020-01-01 00:00:00
abstract:OBJECTIVES:To assess the incidence of chronic illness and its effect on veteran centenarians. DESIGN:Retrospective longitudinal cohort study. SETTING:United States Veterans Affairs Corporate Data Warehouse (CDW). PARTICIPANTS:Community-dwelling veterans born between 1910 and 1915 who survived to at least age 80 (N =...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.14900
更新日期:2017-09-01 00:00:00
abstract::Older women are often sexually active, but physicians caring for older women rarely address sexual concerns. Although women's desire for sex declines with age, a majority of older women rate sex as having importance in their lives. Women identify emotional intimacy as an important reason for engaging in sexual relatio...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.15198
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:To determine whether classic muscle function tests and jumping mechanography (JM) are related to tongue strength. DESIGN:Cross-sectional. SETTING:Community. PARTICIPANTS:Ninety-seven community-dwelling individuals aged 70 and older (49 female, 48 male, mean age 80.7, range 70-95) with and without identifi...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.12124
更新日期:2013-03-01 00:00:00
abstract:OBJECTIVE:To examine the antiplatelet effect of a novel pyrazolopyridine derivative (KC-764) in geriatric patients with ischemic stroke. DESIGN:Randomized clinical trial of three graded dose levels. SETTING:A geriatric clinic attached to a nursing home. PATIENTS:Fifteen patients with a history of cerebral infarction...
journal_title:Journal of the American Geriatrics Society
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1532-5415.1994.tb06863.x
更新日期:1994-06-01 00:00:00
abstract:OBJECTIVES:Knowledge of male sexual function is somewhat limited because of a lack of current population-based data. This study provides information on sexual function and satisfaction in a population-based sample of men. METHODS:Men aged 40 to 79 years (n = 2115) were selected randomly from the Olmsted County populat...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1995.tb07009.x
更新日期:1995-10-01 00:00:00
abstract::Caregiving can have a profound effect on the health of the caregiver, yet research on caregiving among American Indians is limited. The purpose of this study was to examine the influence of caregiving on the health-related quality of life (HRQoL) of American Indians enrolled in the Education And Research Towards Healt...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.12409
更新日期:2013-09-01 00:00:00
abstract:OBJECTIVES:To examine concerns that vulnerable populations, such as depressed or cognitively impaired beneficiaries would have challenges accessing Part D coverage. DESIGN:Logistic regression analysis was used to assess whether elderly Medicare beneficiaries with depression or cognitive impairment differentially plann...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2009.02348.x
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Nursing facility (NF) residents are commonly hospitalized, and many of these hospitalizations may be avoidable. A Centers for Medicare & Medicaid Services (CMS) initiative enables participating NFs to bill Medicare for providing on-site acute care to long-stay residents diagnosed with one of six a...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.16901
更新日期:2020-11-12 00:00:00
abstract:OBJECTIVES:To examine the extent to which elderly individuals use various skilled care facilities after coronary artery bypass grafting (CABG). DESIGN:Retrospective cohort study. SETTING:State of Michigan from 1997 to 1998. PARTICIPANTS:Residents aged 65 and older enrolled in Medicare who underwent CABG. MEASUREMEN...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2005.53356.x
更新日期:2005-07-01 00:00:00
abstract:OBJECTIVES:To establish the prevalence and correlates of disability during the 2 years before hip fracture. DESIGN:Data from participants who experienced hip fracture in the Health and Retirement Study (HRS) with hip fracture identified using linked Medicare claims. Each participant was interviewed at varying time poi...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.13658
更新日期:2015-10-01 00:00:00
abstract:OBJECTIVES:To evaluate the safety and efficacy of donepezil in the management of patients with Alzheimer's disease (AD) residing in nursing home facilities. DESIGN:Twenty-four-week, randomized, multicenter, parallel-group, double-blind, placebo-controlled trial. SETTING:Twenty-seven nursing homes across the United St...
journal_title:Journal of the American Geriatrics Society
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:
更新日期:2001-12-01 00:00:00
abstract:OBJECTIVES:To determine whether resting heart rate is associated with several types of osteoporotic fractures, mortality, and cause-specific mortality in older women. DESIGN:A prospective cohort study. SETTING:Four communities across the United States. PARTICIPANTS:We prospectively assessed resting pulse rate in 9,7...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1046/j.1532-5415.2002.50110.x
更新日期:2002-03-01 00:00:00
abstract::Prescription drugs are not always taken as directed. When there is a discrepancy between the use of a drug and the prescription directions, the drug-taking behavior is considered "nonadherent." To determine the extent of prescription non adherence by old persons and the reasons for nonadherence, an in-home survey was ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1982.tb05623.x
更新日期:1982-05-01 00:00:00
abstract:OBJECTIVES:To determine whether the ability to walk 400 m could be predicted from self-reported walking habits and abilities in older adults and to develop an accurate self-report measure appropriate for observational trials of mobility when functional measures are impractical to collect. DESIGN:Cross-sectional. SETT...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2004.52571.x
更新日期:2004-12-01 00:00:00
abstract:OBJECTIVES:To describe the prevalence of self reported sleep disturbances in older men and women and to describe their relationships with health status and cardiovascular disease (CVD). DESIGN:Cross-sectional study of sleep disturbance, CVD, general health, psychosocial factors, physical function, and use of psychotro...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1997.tb00970.x
更新日期:1997-01-01 00:00:00
abstract:OBJECTIVES:To describe the prevalence of visual and auditory impairment in frail older persons and to evaluate the association between sensory impairment and overall functional status. DESIGN:Prospective patient evaluation and retrospective analysis of data. SETTING:The outpatient geriatric assessment clinic of a uni...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1999.tb07432.x
更新日期:1999-11-01 00:00:00
abstract:OBJECTIVES:To investigate whether higher circulating levels of C-reactive protein (CRP), interleukin-6 (IL-6), and alpha1-antichymotrypsin (ACT) are associated with worse cognitive function and decline in old age. DESIGN:Two independent population-based cohort studies. SETTING:The Rotterdam Study (mean follow-up 4.6 ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2007.01159.x
更新日期:2007-05-01 00:00:00
abstract::In 13 elderly patients, 12 of whom had Parkinson's disease, visual hallucinations and delirium developed as a side effect of amantadine hydrochloride (Symmetrel) therapy. The symptoms promptly disappearred when amantadine was discontinued. Thereafter, each parkinsonian patient was treated satisfactorily with levo-dopa...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1975.tb00187.x
更新日期:1975-05-01 00:00:00
abstract:OBJECTIVES:To examine differences in a proxy measure of muscle quality across the adult life span and explore potential mechanisms of muscle quality change through identification of cross-sectional correlates of muscle quality. DESIGN:Cross-sectional study. SETTING:Baltimore Longitudinal Study of Aging. PARTICIPANTS...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.12653
更新日期:2014-02-01 00:00:00
abstract::The case report presented is clinically compatible with late onset HD. The diagnosis was initially obscured by a lack of family history due to the early death of both parents and siblings. The presence of symptoms at the age of 59 in one offspring is consistent with the intrafamilial transmission of late onset HD dise...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,评审
doi:10.1111/j.1532-5415.1988.tb01807.x
更新日期:1988-03-01 00:00:00
abstract:OBJECTIVES:To determine the effect of home-based primary care (HBPC) on Medicare costs and mortality in frail elders. DESIGN:Case-control concurrent study using Medicare administrative data. SETTING:HBPC practice in Washington, District of Columbia. PARTICIPANTS:HBPC cases (n = 722) and controls (n = 2,161) matched ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.12974
更新日期:2014-10-01 00:00:00
abstract:OBJECTIVE:To investigate the relationship between bone mineral density (in the axial and appendicular skeleton) and calcification of the aorta. DESIGN:Cross-sectional study. SETTING:Community-based study. PARTICIPANTS:A total of 2051 women aged 65 years and older enrolled in the Study of Osteoporotic Fractures. MEA...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1997.tb04498.x
更新日期:1997-02-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Behavioral problems in individuals with Alzheimer's disease (AD) impose major management challenges. Current prevention strategies are anchored to cognitive outcomes, but behavioral outcomes may provide another, clinically relevant opportunity for preemptive therapy. We sought to determine whether...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.15182
更新日期:2018-04-01 00:00:00
abstract:OBJECTIVES:To determine whether the increasing fall death rate among people aged 65 and older is due in part to temporal changes in recording the underlying cause of death. DESIGN:Analyses of multiple cause of death data using the online Centers for Disease Control and Prevention Wide-ranging ON-line Data for Epidemio...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/jgs.12702
更新日期:2014-03-01 00:00:00
abstract::Familial achalasia most often has been recorded in siblings, and only rarely (twice previously) in a parent and offspring. This report concerns a third case of achalasia in a parent and offspring (mother and son). Clinical and radiographic features of the esophageal achalasia are presented. The possibility that geneti...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.1979.tb01741.x
更新日期:1979-11-01 00:00:00
abstract:OBJECTIVES:To improve screening for Alzheimer's disease (AD) with the Memory Impairment Screen (MIS), a 4-minute, four-item delayed free and cued recall memory test with controlled learning and high discriminative validity. To assess the discriminative validity of the MIS for AD and to compare it with the conventional ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1046/j.1532-5415.2002.50265.x
更新日期:2002-06-01 00:00:00
abstract:OBJECTIVES:To study the effects of comprehensive geriatric assessment (CGA) and multidisciplinary intervention on elderly patients sent home from the emergency department (ED). DESIGN:Prospective, randomized, controlled trial with 18 months of follow-up. SETTING:Large medical school-affiliated public hospital in an u...
journal_title:Journal of the American Geriatrics Society
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1111/j.1532-5415.2004.52401.x
更新日期:2004-09-01 00:00:00
abstract:OBJECTIVE:To measure behaviors indicative of quality of life (QOL) in patients with Alzheimer's disease and to examine correlates of patient QOL. DESIGN:Cross-sectional investigation. SETTING:Multi-center study. PARTICIPANTS:Sample of 130 diagnosed patients. PRINCIPAL OUTCOME MEASURES: Proxy ratings of (1) the frequ...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章,多中心研究
doi:10.1111/j.1532-5415.1996.tb01405.x
更新日期:1996-11-01 00:00:00
abstract:OBJECTIVES:To identify differences in cognitive function between elderly adults with sleep apnea syndrome (SAS) and healthy controls. DESIGN:Cross-sectional. SETTING:Sleep laboratory at Seoul National University Bundang Hospital. PARTICIPANTS:Sixty-three elderly adults (26 female; mean age 68.2 ± 4.8) without cognit...
journal_title:Journal of the American Geriatrics Society
pub_type: 杂志文章
doi:10.1111/j.1532-5415.2012.03961.x
更新日期:2012-06-01 00:00:00