Abstract:
Aims:It has previously been demonstrated that the ratio of early mitral inflow velocity to global diastolic strain rate (E/e'sr) is a significant predictor of cardiac events in specific patient populations. The utility of this measurement to predict cardiovascular events in a general population has not been evaluated. Methods and results:A total of 1238 participants in a general population study underwent a health examination including echocardiography where global longitudinal strain (GLS) and E/e'sr were determined. The primary endpoint was the composite of incident heart failure (HF), acute myocardial infarction (AMI) or cardiovascular death (CVD). During follow-up (median 11 years), 140 (11.3%) participants reached the composite endpoint. E/e'sr was associated with adverse outcome [HR 1.17 95% CI (1.13-1.21); P < 0.001, per 10 cm increase]. After multivariable adjustment for echocardiographic and clinical parameters, E/e'sr remained an independent predictor of the composite endpoint [HR 1.08, 95% CI (1.02-1.13); P = 0.003] as opposed to E/e' [HR 1.03, 95% CI (0.99-1.06); P = 0.11 per 1 unit increase]. Global longitudinal strain modified the relationship between E/e'sr and outcome (P for interaction = 0.015). E/e'sr was a stronger predictor in participants with good systolic function as determined by GLS (GLS > 18%) after multivariable adjustment, when compared to participants with reduced systolic function (GLS < 18%) [HR 1.28 95% CI (1.06-1.54); P = 0.011, and HR 1.08 95% CI (1.02-1.14); P = 0.012, respectively). E/e'sr provided incremental information [Harrell's C-index: 0.839 (0.81-0.87) vs. 0.844 (0.82-0.87); P = 0.045] beyond the SCORE risk chart. Conclusion:In the general population, E/e'sr provides independent and incremental prognostic information regarding cardiovascular morbidity and mortality. Additionally, E/e'sr is a stronger predictor of cardiac events than E/e'.
journal_name
Eur Heart Jjournal_title
European heart journalauthors
Lassen MCH,Biering-Sørensen SR,Olsen FJ,Skaarup KG,Tolstrup K,Qasim AN,Møgelvang R,Jensen JS,Biering-Sørensen Tdoi
10.1093/eurheartj/ehy164subject
Has Abstractpub_date
2019-02-07 00:00:00pages
518-525issue
6eissn
0195-668Xissn
1522-9645pii
4962595journal_volume
40pub_type
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journal_title:European heart journal
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abstract::Hypokalaemia commonly occurs in acute myocardial infarction (AMI) and may be caused by elevated serum levels of adrenaline, allegedly by beta 2-adrenergic mediated influx of potassium (K) into cells. We investigated the effect on serum K of intravenous acebutolol (a relatively beta 1-selective agent) in 50 patients wi...
journal_title:European heart journal
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更新日期:2007-09-01 00:00:00
abstract::During a 3-year period 2500 asymptomatic male aviators were screened routinely for coronary artery disease by maximal bicycle exercise testing. In 55 cases (2.1%) the exercise ECG was abnormal (40 subjects exhibited ST depression, 14 ventricular ectopic activity and in one subject both abnormalities were observed). Fu...
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doi:10.1093/eurheartj/12.7.766
更新日期:1991-07-01 00:00:00
abstract:AIMS:Adverse left ventricular (LV) remodelling after myocardial infarction (MI) frequently leads to congestive heart failure (CHF). We have previously shown that myocardial beta-adrenoceptor density (beta-ARD) is reduced soon after acute MI and correlates with LV dilatation in the short term. The aim of the present stu...
journal_title:European heart journal
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doi:10.1093/eurheartj/ehq138
更新日期:2010-07-01 00:00:00
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journal_title:European heart journal
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doi:10.1053/euhj.2001.3034
更新日期:2002-06-01 00:00:00
abstract::Hereditary factors may have a part to play in the development of bicuspid aortic valve. This report concerns a pair of identical twins, probably monozygotic, who required aortic valve replacement as a result of aortic stenosis occurring in bicuspid aortic valves. This supports the contention that there may be a geneti...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a062276
更新日期:1987-03-01 00:00:00
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journal_title:European heart journal
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doi:10.1093/oxfordjournals.eurheartj.a015345
更新日期:1997-05-01 00:00:00
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journal_title:European heart journal
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更新日期:1993-07-01 00:00:00
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journal_title:European heart journal
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doi:10.1093/oxfordjournals.eurheartj.a060769
更新日期:1995-11-01 00:00:00
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doi:10.1093/oxfordjournals.eurheartj.a014998
更新日期:1996-07-01 00:00:00
abstract::The left atrial appendage (LAA) is the main source of thromboembolism in patients with non-valvular atrial fibrillation (AF). As such, the LAA can be the target of specific occluding device therapies. Optimal management of patients with AF includes a comprehensive knowledge of the many aspects related to LAA structure...
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journal_title:European heart journal
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更新日期:2012-04-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a060386
更新日期:1994-01-01 00:00:00
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更新日期:2013-03-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a059513
更新日期:1989-05-01 00:00:00
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更新日期:2016-05-14 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a060259
更新日期:1992-06-01 00:00:00
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pub_type: 杂志文章,多中心研究,随机对照试验
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更新日期:2017-07-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
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更新日期:2001-01-01 00:00:00
abstract::The understanding of atrial fibrillation (AF) evolved from a sole rhythm disturbance towards the complex concept of a cardiomyopathy based on arrhythmia substrates. There is evidence that atrial fibrosis can be visualized using late gadolinium enhancement cardiac magnetic resonance imaging and that it is a powerful pr...
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/eurheartj/14.3.391
更新日期:1993-03-01 00:00:00
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更新日期:2017-05-07 00:00:00
abstract::In seven patients with re-entry tachycardias and the implanted antitachycardia device Tachylog (Siemens Elema, Sweden) the variation in the termination window related to posture and exertion was investigated. The investigations were performed on an outpatient basis utilizing the interactive pacing mode of the implante...
journal_title:European heart journal
pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a062605
更新日期:1988-09-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
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更新日期:1993-06-01 00:00:00
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更新日期:2010-10-01 00:00:00
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journal_title:European heart journal
pub_type: 杂志文章
doi:10.1016/j.ehj.2004.05.029
更新日期:2004-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1093/oxfordjournals.eurheartj.a060780
更新日期:1995-11-01 00:00:00