Defects in dendrite and spine maturation and synaptogenesis associated with an anxious-depressive-like phenotype of GABAA receptor-deficient mice.

abstract：:The secreted glycoprotein Dickkopf-1 (Dkk1), an antagonist of the Wnt/β-catenin pathway, has been implicated in many neurodegenerative diseases. However, it is unknown whether Dkk1 is involved in the pathogenesis of Parkinson's disease (PD). In this study, we discovered that Dkk1 was induced in MPP(+)-treated PC12 cel...

journal_title：Neuropharmacology

authors： Dun Y,Yang Y,Xiong Z,Feng M,Zhang Y,Wang M,Xiang J,Li G,Ma R

更新日期：2013-04-01 00:00:00

abstract：:A large body of evidence indicates that ligand-gated channels may open spontaneously, exhibiting a basal activity in the absence of the neurotransmitter. In the present work, we were interested in studying the Ca(2+)-induced modulation of the basal channel activity of unliganded human L248Talpha7 receptors expressed i...

journal_title：Neuropharmacology

authors： Tonini R,Renzi M,Eusebi F

更新日期：2004-04-01 00:00:00

abstract：:The kynurenine pathway of tryptophan metabolism has been implicated in brain function, immunoregulation, anti-microbial mechanisms and pregnancy. Some of these actions are due to depletion of tryptophan and others to the formation of biologically active metabolites. This review focuses on the roles of the kynurenine p...

journal_title：Neuropharmacology

authors： Hunt NH,Too LK,Khaw LT,Guo J,Hee L,Mitchell AJ,Grau GE,Ball HJ

更新日期：2017-01-01 00:00:00

abstract：:We investigated the role of nitric oxide (NO) in learning and memory formation in a radial maze test, by using the NO synthase (NOS) inhibitors, NG-nitro-L-arginine methyl ester (L-NAME) and 7-nitroindazole (7-NI), and an NO precursor, L-arginine. Rats were trained on a working and reference memory task in an eight ar...

journal_title：Neuropharmacology

authors： Zou LB,Yamada K,Tanaka T,Kameyama T,Nabeshima T

更新日期：1998-01-01 00:00:00

abstract：:Nicotine stimulates the secretion of catecholamines from sympathetic nerve endings and adrenal medulla by acting on peripheral nicotinic cholinergic receptors. Nicotine is also a potent stimulant in the central nervous system but the significance of nicotinic receptors in brain in mediating cardiovascular and sympatho...

journal_title：Neuropharmacology

authors： Kiritsy-Roy JA,Mousa SA,Appel NM,Van Loon GR

更新日期：1990-06-01 00:00:00

abstract：:One proposed factor contributing to the increased frequency of opioid overdose deaths is the emergence of novel synthetic opioids, including illicit fentanyl and fentanyl analogues. A treatment strategy currently under development to address the ongoing opioid crisis is immunopharmacotherapies or opioid-targeted vacci...

journal_title：Neuropharmacology

authors： Tenney RD,Blake S,Bremer PT,Zhou B,Hwang CS,Poklis JL,Janda KD,Banks ML

更新日期：2019-11-01 00:00:00

abstract：:The posterior hypothalamic receptors involved in the cardiovascular responses to electrical stimulation of the rostral ventrolateral medulla were investigated in urethane-anaesthetized rats. Electrical stimulation of the rostral ventrolateral medulla produced a significant increase in systolic blood pressure. This res...

journal_title：Neuropharmacology

authors： Bachelard H,Rivest R,Marsden CA

更新日期：1991-07-01 00:00:00

abstract：:Neurotensin (NTS) is a neuropeptide neurotransmitter expressed in the central and peripheral nervous systems. Many studies over the years have revealed a number of roles for this neuropeptide in body temperature regulation, feeding, analgesia, ethanol sensitivity, psychosis, substance use, and pain. This review provid...

journal_title：Neuropharmacology

authors： Torruella-Suárez ML,McElligott ZA

更新日期：2020-05-01 00:00:00

abstract：:The potential contributions of dysregulation of the brain's histaminergic modulatory system to neuropsychiatric disease, and the potential of histamine-targeting medications as therapeutic agents, are gradually coming into focus. The H3R receptor, which is expressed primarily in the central nervous system, is a promis...

journal_title：Neuropharmacology

authors： Rapanelli M,Pittenger C

更新日期：2016-07-01 00:00:00

abstract：:GABAA receptor is the primary mediator of inhibition in the adult mammalian brain. Our recent studies revealed that a classic gating scheme for GABAAR needed to be updated with an intermediate step (flipping) and that the α1Phe64 mutation at the GABA binding site affects this transition. However, description of flippi...

journal_title：Neuropharmacology

authors： Kisiel M,Jatczak M,Brodzki M,Mozrzymas JW

更新日期：2018-03-15 00:00:00

abstract：:Glutamatergic neurotransmission in the central nucleus of the amygdala (CeA) plays an important role in many behaviors including anxiety, memory consolidation and cardiovascular responses. While these behaviors can be modulated by corticotropin releasing factor (CRF) and catecholamine signaling, the mechanism(s) by wh...

journal_title：Neuropharmacology

authors： Silberman Y,Winder DG

更新日期：2013-07-01 00:00:00

abstract：:Despite evidence of local glycinergic circuits in the mature cerebellar nuclei the result of their activation remains unknown. Here, using whole cell recordings in rat cerebellar slices we demonstrated that after postnatal day 17 (>P17) glycinergic IPSCs can be readily evoked in large deep cerebellar nuclear neurons (...

journal_title：Neuropharmacology

authors： Pedroarena CM,Kamphausen S

更新日期：2008-04-01 00:00:00

abstract：:The excitatory amino acid antagonist, D-alpha-aminoadipate, was found to be a potent antagonist of responses to N-methyl-D-aspartate and L-aspartate, but less potent against L-glutamate responses of neurones in the rat caudal trigeminal nucleus. The responses to quisqualate and kainate were relatively unaffected by D-...

journal_title：Neuropharmacology

authors： Salt TE,Hill RG

更新日期：1982-05-01 00:00:00

abstract：:Two peptide fragments of native Protein Kinase A inhibitor (PKI), PKI-(6-22)-amide and PKI-(Myr-14-22)-amide, significantly reversed low-level morphine antinociceptive tolerance in mice. The inhibition of Protein Kinase A (PKA) activity by both peptide fragments was then measured in specific brain regions (thalamus, p...

journal_title：Neuropharmacology

authors： Dalton GD,Smith FL,Smith PA,Dewey WL

更新日期：2005-04-01 00:00:00

abstract：:The effect of 5-(2-cyclohexylideneethyl)-5-ethyl barbituric acid (CHEB) on the isolated spinal cord of the immature rat was examined using extracellular recording. At concentrations less than 20 microM CHEB increased the monosynaptic reflex (MSR) but depressed the reflex at greater concentrations (30-100 microM). At c...

journal_title：Neuropharmacology

authors： Nicholson GM,Spence I,Johnston GA

更新日期：1985-06-01 00:00:00

abstract：:Postsynaptic Density Protein-95 (PSD-95) is a major scaffolding protein in the excitatory synapses in the brain and a critical regulator of synaptic maturation for NMDA and AMPA receptors. PSD-95 deficiency has been linked to cognitive and learning deficits implicated in neurodevelopmental disorders such as autism and...

journal_title：Neuropharmacology

authors： McEachern EP,Coley AA,Yang SS,Gao WJ

更新日期：2020-11-15 00:00:00

abstract：:Similar to patients with ventromedial prefrontal cortex (VMPC) lesions, substance abusers show altered decision-making, characterized by a tendency to choose the immediate reward, at the expense of negative future consequences. The somatic marker model proposes that decision-making depends on neural substrates that re...

journal_title：Neuropharmacology

authors： Verdejo-García A,Bechara A

更新日期：2009-01-01 00:00:00

abstract：:The present study was designed to determine whether abnormalities in serotonin receptor binding co-exist with the presynaptic serotonergic deficits that have previously been identified in the genetically epilepsy-prone rat (GEPR) brain. In vitro binding of [3H]8-OH-DPAT (0.16-10.3 nM) to 5-HT1A receptor sites was foun...

journal_title：Neuropharmacology

authors： Statnick MA,Dailey JW,Jobe PC,Browning RA

更新日期：1996-01-01 00:00:00

abstract：:gamma-Aminobutyric acid type A (GABA(A)) receptors are an important target for general anesthetics in the central nervous system. Site-directed mutagenesis techniques have identified amino acid residues that are important for the positive modulation of GABA(A) receptors by general anesthetics. In the present study, we...

journal_title：Neuropharmacology

authors： Krasowski MD,Nishikawa K,Nikolaeva N,Lin A,Harrison NL

更新日期：2001-12-01 00:00:00

abstract：:NMDA receptors have been known to play a central role in long-term potentiation at glutamatergic synapses in principal cells for thirty years. In contrast, their roles in the development and activity-dependent plasticity of synapses in inhibitory circuits have only recently begun to be understood. Progress has, to a g...

journal_title：Neuropharmacology

authors： Moreau AW,Kullmann DM

更新日期：2013-11-01 00:00:00

abstract：:Basal ganglia, an ensemble of interconnected subcortical nuclei, are involved in adaptive motor planning and procedural learning. Striatum, the primary input nucleus of basal ganglia, extracts the pertinent cortical and thalamic information from background noise in relation with the environmental stimuli and motivatio...

journal_title：Neuropharmacology

authors： Fino E,Venance L

更新日期：2011-04-01 00:00:00

abstract：:Female rats were treated daily with electroconvulsive shocks (ECS) or imipramine (10 mg/kg) for 10 days. Both types of treatment enhanced behavioural responses mediated by 5-hydroxytryptamine (5-HT) and noradrenaline (NA). A behavioural response mediated by dopamine (DA) was enhanced by electroconvulsive shock-treatme...

journal_title：Neuropharmacology

authors： Bhavsar VH,Dhumal VR,Kelkar VV

更新日期：1983-06-01 00:00:00

abstract：:Bilateral injection of gamma-aminobutyric acid (GABA, 10-300 micrograms) into the substantia nigra (pars reticulata) of rats produced stereotyped sniffing and had an analgesic-like effect on the hot-plate but not on the tail-flick test. These effects of GABA (30 micrograms) were suppressed by simultaneous administrati...

journal_title：Neuropharmacology

authors： Baumeister AA,Hawkins MF,Anderson-Moore LL,Anticich TG,Higgins TD,Griffin P

更新日期：1988-08-01 00:00:00

abstract：:Drugs that alter the function of gamma-aminobutyric acid (GABA) neurotransmission seem to reduce cocaine reinforcement, and as such may be useful in pharmacologically treating cocaine addiction. In the present experiment, the anti-cocaine effects of CGP 44532, a phosphinic acid analogue of GABA, and a highly selective...

journal_title：Neuropharmacology

authors： Dobrovitsky V,Pimentel P,Duarte A,Froestl W,Stellar JR,Trzcińska M

更新日期：2002-04-01 00:00:00

abstract：:Alpha2-adrenergic drugs modulate cortical arousal and EEG. However, the role of individual alpha2-adrenoceptor (alpha(2)-AR) subtypes in these functions is not clear. We investigated the role of alpha(2C)-ARs in the modulation of baseline cortical EEG activity and EEG responses to the alpha(2)-AR selective agonist, de...

journal_title：Neuropharmacology

authors： Puoliväli J,Björklund M,Holmberg M,Ihalainen JA,Scheinin M,Tanila H

更新日期：2002-12-01 00:00:00

abstract：:Tityustoxin (TsTx) inhibited high affinity choline uptake (HAChU) in cortical slices of the rat brain. The effect was dependent on the concentration of tityustoxin, energy source, incubation time, temperature, and the pH of the incubation medium. The inhibitory effect was dependent upon the presence of sodium and calc...

journal_title：Neuropharmacology

authors： Macedo TM,Gomez MV

更新日期：1983-02-01 00:00:00

abstract：:Agonists and positive allosteric modulators (PAMs) of α7 nicotinic acetylcholine receptors (nAChRs) are currently being considered as novel therapeutic approaches for managing cognitive deficits in schizophrenia and Alzheimer's disease. Though α7 agonists were recently found to possess antinociceptive and anti-inflamm...

journal_title：Neuropharmacology

authors： Freitas K,Ghosh S,Ivy Carroll F,Lichtman AH,Imad Damaj M

更新日期：2013-02-01 00:00:00

abstract：:Some phytochemical-derived synthetic compounds have been shown to improve neurological disorders, especially in ischemic stroke. In this study, we identified a novel biscoumarin compound, known as COM 3, which had substantial antioxidant effects in neurons. Next, we found that COM 3 occupies a critical binding site be...

journal_title：Neuropharmacology

authors： Wang J,Zhang W,Lv C,Wang Y,Ma B,Zhang H,Fan Z,Li M,Li X

更新日期：2020-05-01 00:00:00

abstract：:A cDNA encoding the human metabotropic glutamate receptor type 4 (hmGluR4) was isolated from human brain cDNA libraries by cross-hybridization with rat mGluR4 probes. The deduced amino acid sequence of human mGluR4 consists of 912 residues and shows a sequence identity of 96% to the amino acid sequence of rat mGluR4. ...

journal_title：Neuropharmacology

authors： Flor PJ,Lukic S,Rüegg D,Leonhardt T,Knöpfel T,Kuhn R

更新日期：1995-02-01 00:00:00

abstract：:In Major Depressive Disorder, a growing data base suggests that the onset of antidepressants' action can be detected by improvement of depressive symptoms in the first 10-14 days of treatment. Previous studies showed that the mean concentration of the brain-derived neurotrophic factor (BDNF) in blood increases during ...

journal_title：Neuropharmacology

authors： Dreimüller N,Schlicht KF,Wagner S,Peetz D,Borysenko L,Hiemke C,Lieb K,Tadić A

更新日期：2012-01-01 00:00:00