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Histopathological validation of optical coherence tomography findings of the coronary arteries.

Abstract：

:Optical coherence tomography (OCT), a catheter-based imaging modality for the visualization of coronary arteries, is widely used during percutaneous coronary intervention to improve the understanding of the anatomy of coronary artery stenosis and to elucidate the mechanisms of atherosclerosis. In this review, we provide a short description of the histopathological validations of OCT for visualizing atherosclerotic plaques and vascular healing response after drug-eluting stent (DES) implantation. Because OCT measures the intensity of light returning from within a tissue, tissue having a higher heterogeneity of optical index of refraction, such as microcalcification deposition and foam cell accumulation on the luminal surface, may exhibit stronger optical scattering that appears as a thin-cap fibroatheroma image. Furthermore, even if OCT shows exposed uncovered stent struts, some of the struts could be re-endothelialized. In our ex vivo histopathological experience, re-endothelialization at the surface of stent struts was confirmed by histopathological analysis, although OCT images showed exposed uncovered struts after DES implantation. Therefore, careful interpretation is required to assess tissue morphology and stent strut coverage by OCT.

journal_name

J Cardiol

journal_title

Journal of cardiology

authors

Fujii K,Kawakami R,Hirota S

doi

10.1016/j.jjcc.2018.03.003

subject

Has Abstract

pub_date

2018-09-01 00:00:00

pages

179-185

issue

3

eissn

0914-5087

issn

1876-4738

pii

S0914-5087(18)30079-0

journal_volume

72

pub_type

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