Abstract：
:Recent observations connected DNA cytosine deaminase APOBEC3B to the genetic evolution of breast cancer. We addressed whether APOBEC3B is associated with breast cancer clinical outcomes. APOBEC3B messenger RNA (mRNA) levels were related in 1,491 primary breast cancers to disease-free (DFS), metastasis-free (MFS), and overall survival (OS). For independent validation, APOBEC3B mRNA expression was associated with patient outcome data in five additional cohorts (over 3,500 breast cancer cases). In univariate Cox regression analysis, increasing APOBEC3B expression as a continuous variable was associated with worse DFS, MFS, and OS (hazard ratio [HR] = 1.20, 1.21, and 1.24, respectively; all P < .001). Also, in untreated ER-positive (ER+), but not in ER-, lymph-node-negative patients, high APOBEC3B levels were associated with a poor DFS (continuous variable: HR = 1.29, P = .001; dichotomized at the median level, HR = 1.66, P = .0002). This implies that APOBEC3B is a marker of pure prognosis in ER + disease. These findings were confirmed in the analyses of five independent patient sets. In these analyses, APOBEC3B expression dichotomized at the median level was associated with adverse outcomes (METABRIC discovery and validation, 788 and 706 ER + cases, disease-specific survival (DSS), HR = 1.77 and HR = 1.77, respectively, both P < .001; Affymetrix dataset, 754 ER + cases, DFS, HR = 1.57, P = 2.46E-04; NKI295, 181 ER + cases, DFS, HR = 1.72, P = .054; and BIG 1-98, 1,219 ER + cases, breast-cancer-free interval (BCFI), HR = 1.42, P = 0.0079). APOBEC3B is a marker of pure prognosis and poor outcomes for ER + breast cancer, which strongly suggests that genetic aberrations induced by APOBEC3B contribute to breast cancer progression.
journal_name
Horm Cancerjournal_title
Hormones & cancerauthors
Sieuwerts AM,Willis S,Burns MB,Look MP,Meijer-Van Gelder ME,Schlicker A,Heideman MR,Jacobs H,Wessels L,Leyland-Jones B,Gray KP,Foekens JA,Harris RS,Martens JWdoi
10.1007/s12672-014-0196-8subject
Has Abstractpub_date
2014-12-01 00:00:00pages
405-13issue
6eissn
1868-8497issn
1868-8500journal_volume
5pub_type
杂志文章abstract：:The pathological diagnosis of adrenocortical carcinoma (ACC) is still challenging for its rarity and the presence of special variants (pediatric, oncocytic, myxoid, and sarcomatoid). It is based on the recognition at light microscopy of at least three among nine morphological parameters, according to the Weiss scoring...
journal_title：Hormones & cancer
pub_type： 杂志文章,评审
doi：10.1007/s12672-011-0088-0
更新日期：2011-12-01 00:00:00
abstract：:Castration-resistant prostate cancer (CRPC) is an androgen receptor (AR)-dependent disease expected to cause the death of more than 27,000 Americans in 2015. There are only a few available treatments for CRPC, making the discovery of new drugs an urgent need. We report that CUDC-101 (an inhibitor od HER2/NEU, EGFR and...
journal_title：Hormones & cancer
pub_type： 杂志文章
doi：10.1007/s12672-016-0257-2
更新日期：2016-06-01 00:00:00
abstract：:Consumption of methylxanthine alkaloids appears to induce activities by antagonizing adenosine receptors, implicated in breast cancer behavior in vitro. Our goal was to evaluate expression of genes for methylxanthine receptors and metabolizing enzymes to assess risk of breast carcinoma recurrence. Clinical outcomes, e...
journal_title：Hormones & cancer
pub_type： 杂志文章
doi：10.1007/s12672-017-0309-2
更新日期：2017-12-01 00:00:00
abstract：:Thyroid hormone status has long been implicated in cancer development. Here we investigated the role of thyroxine (T4) in colorectal cancer cell lines HCT 116 (APC wild type) and HT-29 (APC mutant), as well as the primary cultures of cancer cells derived from patients. Cell proliferation was evaluated with standard as...
journal_title：Hormones & cancer
pub_type： 杂志文章
doi：10.1007/s12672-018-0324-y
更新日期：2018-06-01 00:00:00
abstract：:The authors conducted a cross-sectional study to investigate the associations of fat, fiber, and carbohydrate intake with endogenous estrogen, androgen, and insulin-like growth factor (IGF) levels among 595 premenopausal women. Overall, no significant associations were found between dietary intake of these macronutrie...
journal_title：Hormones & cancer
pub_type： 杂志文章
doi：10.1007/s12672-010-0050-6
更新日期：2010-10-01 00:00:00
abstract：:We previously reported that an accelerated decline in circulating testosterone level is associated with a higher risk of prostate cancer (PCa). This study is to examine whether testosterone change rate is related to serum prostate-specific antigen (PSA) concentration among PCa-free men. Longitudinal data were derived ...
journal_title：Hormones & cancer
pub_type： 杂志文章
doi：10.1007/s12672-019-00369-y
更新日期：2019-12-01 00:00:00
abstract：:Endometrial cancer is the most common gynecological cancer in the developed world, and it is one of the few cancer types that is becoming more prevalent and leading to more deaths in the USA each year. The majority of endometrial tumors are considered to be hormonally driven, where estrogen signaling through estrogen ...
journal_title：Hormones & cancer
pub_type： 杂志文章,评审
doi：10.1007/s12672-019-0358-9
更新日期：2019-06-01 00:00:00
abstract：:Mitotic checkpoint is a fundamental mechanism involved in fidelity mitotic chromosome segregation, and its alteration results in progression of human malignancies. In this study, we examined expression profiles of seven mitotic checkpoint genes in 20 breast carcinomas using microarray analysis. Results demonstrated th...
journal_title：Hormones & cancer
pub_type： 杂志文章
doi：10.1007/s12672-012-0130-x
更新日期：2013-04-01 00:00:00
abstract：:Silent corticotrophins adenomas (SCAs) are clinically silent and non-secreting but immunostain positively for ACTH. We hypothesize that SCAs comprise both corticotroph and gonadotroph characteristics. Cohort analysis from 1994-2008 with follow-up time ranging from 1-15 years in a tertiary referral center. We compared ...
journal_title：Hormones & cancer
pub_type： 杂志文章
doi：10.1007/s12672-010-0014-x
更新日期：2010-04-01 00:00:00
abstract：:Von Hippel-Lindau (VHL) syndrome is an inherited cancer syndrome in which 8-17 % of germline mutation carriers develop pancreatic neuroendocrine tumors (PNETs). There is limited data on prognostic markers for PNETs other than Ki-67, which is included in the World Health Organization classification system. Recently, sp...
journal_title：Hormones & cancer
pub_type： 杂志文章
doi：10.1007/s12672-013-0134-1
更新日期：2013-06-01 00:00:00
abstract：:Oestrogen receptor alpha (ERα) is a ligand-dependent transcription factor that mediates oestrogen effects in hormone-responsive cells. Following oestrogenic activation, ERα directly regulates the transcription of target genes via DNA binding. MicroRNAs (miRNAs) represent a class of small noncoding RNAs that function a...
journal_title：Hormones & cancer
pub_type： 杂志文章
doi：10.1007/s12672-012-0102-1
更新日期：2012-06-01 00:00:00
abstract：:Adjuvant glucocorticoid treatment is routinely used in the treatment of ovarian cancer to mitigate the undesirable side effects of chemotherapy, thereby enhancing tolerability to higher cytotoxic drug doses and frequency of treatment cycles. However, in vitro and preclinical in vivo and ex vivo studies indicate that g...
journal_title：Hormones & cancer
pub_type： 杂志文章,评审
doi：10.1007/s12672-017-0319-0
更新日期：2018-04-01 00:00:00
abstract：:The US Food and Drug Administration-approved BRAF inhibitors, vemurafenib and dabrafenib, have demonstrated superior efficacy in patients with BRAF-mutant melanomas but have limited efficacy in BRAF-mutant colorectal cancer. Little is known at this time regarding BRAF inhibitors in thyroid cancer. Initial reports in p...
journal_title：Hormones & cancer
pub_type： 杂志文章,评审
doi：10.1007/s12672-014-0207-9
更新日期：2015-02-01 00:00:00
abstract：:In hepatocellular carcinoma (HCC), the hypoxic tumor microenvironment can drive enhance tumor malignancy and recurrence. The microRNA (miRNA) miR-196-5p has been shown to modulate the progression of several cancer types, but its roles in HCC remain uncertain. In the present report we observed significant miR-196-5p do...
journal_title：Hormones & cancer
pub_type： 杂志文章
doi：10.1007/s12672-019-00370-5
更新日期：2019-12-01 00:00:00
abstract：:Residential characteristics in urban neighborhoods impact health and might be important factors contributing to health disparities, especially in the African American population. The purpose of this systematic review is to understand the relationship between urban neighborhood and residential factors and breast cancer...
journal_title：Hormones & cancer
pub_type： 杂志文章
doi：10.1007/s12672-018-0325-x
更新日期：2018-04-01 00:00:00
abstract：:Lymphangioleiomyomatosis (LAM) is a female-predominant lung disease that can lead to respiratory failure. LAM cells typically have inactivating tuberous sclerosis 2 (TSC2) mutations, leading to mTORC1 hyperactivation. The gender specificity of LAM suggests that female hormones contribute to disease progression. Clinic...
journal_title：Hormones & cancer
pub_type： 杂志文章
doi：10.1007/s12672-014-0192-z
更新日期：2014-10-01 00:00:00
abstract：:The molecular pathogenesis of sporadic parathyroid adenomas is incompletely understood. The possible role of cyclin-dependent kinase inhibitor (CDKI) genes was raised by recognition of cyclin D1 as a parathyroid oncogene, identification of rare germline mutations in CDKI genes in patients with multiple endocrine neopl...
journal_title：Hormones & cancer
pub_type： 杂志文章
doi：10.1007/s12672-013-0147-9
更新日期：2013-10-01 00:00:00
abstract：:Differential utilization of cancer screening between populations could lead to changes in cancer disparities. Evaluating incidence rates trends is one means of monitoring these disparities. Using Surveillance, Epidemiology, and End Results data, we compared annual percent changes (APC) in age-adjusted incidence rates ...
journal_title：Hormones & cancer
pub_type： 杂志文章
doi：10.1007/s12672-009-0002-1
更新日期：2010-02-01 00:00:00
abstract：:The anti-diabetic drug metformin (1,1-dimethylbiguanide hydrochloride) reduces both the incidence and mortality of several types of cancer. Metformin has been shown to selectively kill cancer stem cells, and triple-negative breast cancer (TNBC) cell lines are more sensitive to the effects of metformin as compared to l...
journal_title：Hormones & cancer
pub_type： 杂志文章
doi：10.1007/s12672-014-0188-8
更新日期：2014-12-01 00:00:00
abstract：:Evidence has not been established to support that combination chemotherapy with cyclophosphamide, vincristine, and dacarbazine (CVD) improves survival in patients with malignant pheochromocytoma and paraganglioma (M-PPGL). To investigate the efficacy of CVD for this disease, we retrospectively analyzed data of 23 pati...
journal_title：Hormones & cancer
pub_type： 杂志文章
doi：10.1007/s12672-017-0284-7
更新日期：2017-04-01 00:00:00
abstract：:Genetic variants in CYP19A1, the gene encoding aromatase, have been reported to be associated with circulating estrogen concentrations, a key risk factor for breast cancer. The mechanism underlying this association is still unclear; it has been suggested that some of these variants may alter the expression and/or acti...
journal_title：Hormones & cancer
pub_type： 杂志文章
doi：10.1007/s12672-017-0317-2
更新日期：2018-04-01 00:00:00
abstract：:Small glutamine-rich tetratricopeptide repeat-containing protein α (SGTA) is a steroid receptor molecular co-chaperone that may substantially influence hormone action and, consequently, hormone-mediated carcinogenesis. To date, published studies describe SGTA as a protein that is potentially critical in a range of bio...
journal_title：Hormones & cancer
pub_type： 杂志文章,评审
doi：10.1007/s12672-013-0151-0
更新日期：2013-12-01 00:00:00
abstract：:Ovarian cancer is the leading cause of death among gynecological malignancies. Chemotherapy alone is not sufficient to achieve long-term survival of the patient with advanced stage ovarian cancer. Although cancer immune therapy has long been expected as a new modality for ovarian cancer, very few trials have been clin...
journal_title：Hormones & cancer
pub_type： 杂志文章
doi：10.1007/s12672-010-0046-2
更新日期：2010-12-01 00:00:00
abstract：:Breast cancer survivors are at an increased risk of second primary cancers, and the risk factors for the latter may have clinical significance. The aims of our study were to evaluate the incidences and risk factors of second primary female genital cancers (corpus uteri, cervix uteri plus ovary) in a large cohort of br...
journal_title：Hormones & cancer
pub_type： 杂志文章
doi：10.1007/s12672-018-0330-0
更新日期：2018-06-01 00:00:00
abstract：:Breast and prostate cancers are malignancies in which steroid hormones drive cellular proliferation. Over the past century, this understanding has led to successful treatment strategies aimed to inhibit hormone-mediated tumor growth. Nonetheless, disease relapse and progression still pose significant clinical problems...
journal_title：Hormones & cancer
pub_type： 杂志文章,评审
doi：10.1007/s12672-016-0259-0
更新日期：2016-06-01 00:00:00
abstract：:The androgen receptor (AR) has context-dependent roles in breast cancer growth and progression. Overall, high tumor AR levels predict a favorable patient outcome, but several studies have established a tumor promotional role for AR, particularly in supporting the growth of estrogen receptor positive (ER-positive) brea...
journal_title：Hormones & cancer
pub_type： 杂志文章
doi：10.1007/s12672-017-0302-9
更新日期：2017-12-01 00:00:00
abstract：:Cancer progression is driven by genome instability incurred rearrangements such as transmembrane protease, serine 2 (TMPRSS2)/v-ets erythroblastosis virus E26 oncogene (ERG) that could possibly turn some of the tumor suppressor micro-RNAs into pro-oncogenic ones. Previously, we found dualistic miR-204 effects, acting ...
journal_title：Hormones & cancer
pub_type： 杂志文章
doi：10.1007/s12672-016-0279-9
更新日期：2017-02-01 00:00:00
abstract：:The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor best known for its ability to mediate the effects of environmental toxins such as 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin), polycyclic aromatic hydrocarbons (PAHs), benzene, and polychlorinated biphenyls (PCBs) through the initi...
journal_title：Hormones & cancer
pub_type： 杂志文章,评审
doi：10.1007/s12672-017-0300-y
更新日期：2017-08-01 00:00:00
abstract：:Oral contraceptive use is a well-established risk factor for breast cancer and is common among reproductive-aged women in the USA. Its relationship with less common, more aggressive, molecular subtypes is less clear. A population-based case-case analysis was conducted comparing three less common molecular subtypes to ...
journal_title：Hormones & cancer
pub_type： 杂志文章
doi：10.1007/s12672-019-00362-5
更新日期：2019-06-01 00:00:00
abstract：:The prostate is a luminal secretory tissue whose function is regulated by male sex hormones. Castration produces involution of the prostate to a reversible basal state, and as the majority of prostate cancers also have a luminal phenotype, drug-induced castration is a front line therapy. It has therefore been assumed ...
journal_title：Hormones & cancer
pub_type： 杂志文章
doi：10.1007/s12672-010-0058-y
更新日期：2011-02-01 00:00:00
