[Disseminated tuberculosis following infliximab therapy for Crohn disease: a case report].

Abstract:

UNLABELLED:Anti-tumor necrosis factor (TNF) therapy has been the major advance in the treatment of inflammatory bowel disease, especially Crohn's disease. But there is a higher risk of infections, especially tuberculosis (TB), in patients treated with anti-TNFα. The authors report a case of disseminated tuberculosis with the following features: pulmonary tuberculosis, left supra clavicular cervical and meditational lymphadenopathy, bilateral pleural effusion, peritoneal and splenic involvement. This disseminated tuberculosis was observed in a 39-year-old woman who was treated by infliximab for refractory Crohn's disease. The evolution with antituberculosis drugs was fatal, the death of the patient was due to hepatic encephalitis. CONCLUSION:The physicians should always be aware in the use of TNF-alpha blockers according to guidelines. Its recommended to realize a complete pretherapeutic assessment and it is necessary to follow-up the patients to detect possible reactivation of latent tuberculosis.

journal_name

Rev Pneumol Clin

authors

Bouchentouf R,Yasser Z,Aitbenasser MA

doi

10.1016/j.pneumo.2014.07.002

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

366-9

issue

6

eissn

0761-8417

issn

1776-2561

pii

S0761-8417(14)00079-0

journal_volume

70

pub_type

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