Abstract:
:Alterations in brain structure are viewed as neurobiological indicators which are closely tied to cognitive changes in healthy human aging. The current study used diffusion tensor imaging (DTI) tractography to investigate the relationship between age, brain variation in white matter (WM) integrity, and cognitive function. Sixteen younger adults (aged 20-28 years) and 18 healthy older adults (aged 60-75 years) underwent DTI scanning and a standardized battery of neuropsychological measures. Behaviorally, older adults exhibited poorer performance on multiple cognitive measures compared to younger adults. At the neural level, the effects of aging on theWM integrity were evident within interhemispheric (the anterior portion of corpus callosum) and transverse (the right uncinate fasciculus) fibers of the frontal regions, and the cingulum-angular fibers. Our correlation results showed that age-related WM differentially influenced cognitive function, with increased fractional anisotropy values in both the anterior corpus callosum and the right cingulum/angular fibers positively correlated with performance on the visuospatial task in older adults. Moreover, mediation analysis further revealed that the WM tract integrity of the frontal interhemspheric fibers was a significant mediator of age-visuospatial performance relation in older adults, but not in younger adults. These findings support the vulnerability of the frontal WM fibers to normal aging and push forward our understanding of cognitive aging by providing a more integrative view of the neural basis of linkages among aging, cognition, and brain.
journal_name
Aging Ment Healthjournal_title
Aging & mental healthauthors
Fan YT,Fang YW,Chen YP,Leshikar ED,Lin CP,Tzeng OJL,Huang HW,Huang CMdoi
10.1080/13607863.2018.1455804subject
Has Abstractpub_date
2019-07-01 00:00:00pages
831-839issue
7eissn
1360-7863issn
1364-6915journal_volume
23pub_type
杂志文章abstract::Objectives: Survivors of the Holocaust have reached an age during which it is common for them to look back on their lives. Previous research has shown that reminiscence can take on either adaptive ('self-positive') or detrimental ('self-negative') forms, which in turn are differently linked to psychological well-being...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2018.1525608
更新日期:2020-04-01 00:00:00
abstract:UNLABELLED:Hoarding disorder (HD) in late life is associated with increased risk for fire, falling, poor sanitary conditions, disability, and health risks. However, research on the health status of individuals with HD is limited. Hoarding symptoms and the resulting clutter may exacerbate health conditions and lead to i...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2013.814105
更新日期:2014-03-01 00:00:00
abstract::Objectives: The study used data from the Canadian Longitudinal Study on Aging to investigate the relationships among social support (measured as affectionate support, emotional/informational support, positive social interaction, tangible support), social participation and depression in caregivers and non-caregivers.Me...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2018.1544223
更新日期:2020-05-01 00:00:00
abstract:OBJECTIVES:To investigate associations between dementia-attitudes and help-seeking intentions. METHOD:An online survey of 611 Australian adults (45-60 years) assessed dementia-related attitudes and help-seeking intentions in response to two scenarios of an experience of early dementia: for themselves (Scenario 1); and...
journal_title:Aging & mental health
pub_type: 杂志文章,已发布勘误
doi:10.1080/13607863.2014.995588
更新日期:2015-01-01 00:00:00
abstract::Objectives: Studies of adults with autism spectrum disorder (ASD) have demonstrated poor outcomes related to independence and everyday living skills compared to the general population. In a sample of 74 adults with ASD who require a high level of support we sought to identify correlates of daily functioning.Methods: W...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2019.1647138
更新日期:2020-10-01 00:00:00
abstract:OBJECTIVES:Using two waves of panel data from the China Health and Retirement Longitudinal Study, this study prospectively assessed whether four distinct patterns of productive activity engagement would predict depressive symptoms among older adults in urban China two years later. METHODS:A sample of urban residents a...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2016.1204983
更新日期:2017-11-01 00:00:00
abstract:OBJECTIVES:Effects of two mentally stimulating art interventions on processing speed and visuo-spatial cognition were compared in three samples. METHOD:In a randomized 10-week art intervention study with a pre-post follow-up design, 113 adults (27 healthy older adults with subjective memory complaints, 50 healthy olde...
journal_title:Aging & mental health
pub_type: 杂志文章,随机对照试验
doi:10.1080/13607863.2015.1114587
更新日期:2017-04-01 00:00:00
abstract:BACKGROUND:Few studies have measured the impact of dementia-related fear on daily functioning, despite its clinical relevance. Our aim was to determine the relationship between fear-avoidance of memory loss, perceived memory failures and self-reported quality of life in a community based sample of older adults using a ...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2020.1856780
更新日期:2020-12-09 00:00:00
abstract:OBJECTIVES:Stressors are critical to the caregiver stress process, yet little work has examined resources that contribute to longitudinal changes in subjective stressors. The present study examines a variety of factors that contribute to changes in subjective stressors across time. METHOD:Dementia caregivers (N = 153)...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2017.1402292
更新日期:2019-02-01 00:00:00
abstract::This study examines the effectiveness of a peer counselling program in Hong Kong for the elderly with depression living in the community, and its impact on the peer counsellors. Thirty depressed elderly subjects participated in the program, which was found to have improved their perceived health status and level of de...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607860600735861
更新日期:2007-01-01 00:00:00
abstract::Objectives: Little research examines trajectories of carer resilience or the factors that facilitate or hinder resilience over time. We use qualitative longitudinal methods to examine trajectories of resilience and which assets and resources are associated with resilience and care status transitions in spousal dementi...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2018.1503998
更新日期:2019-11-01 00:00:00
abstract:OBJECTIVES:This qualitative study aimed to illuminate former family caregivers' experiences of aspects that facilitate and hinder the process of relinquishing the care of a person with dementia to a nursing home. METHOD:Ten narrative interviews with former family caregivers were performed and subjected to qualitative ...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2014.908456
更新日期:2014-01-01 00:00:00
abstract::During World War Two 1.9 million people were evacuated from British cities where the risk of bombing was perceived to be highest. 1.5 million of these were children who, often unaccompanied, were sent to live with strangers. Two hundred and forty-five people who were evacuated as children were compared with 96 of simi...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607860600844473
更新日期:2007-03-01 00:00:00
abstract::Objectives: There is an association between depression and diminished social support; indeed, interpersonal dysfunction is often a central feature of depression. The purpose of this study is to examine the role that an emotion regulation (ER) strategy, cognitive reappraisal, plays in influencing the association betwee...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2019.1698516
更新日期:2019-12-26 00:00:00
abstract:OBJECTIVE:This study examined the relationship between the use of the Internet and the mental health status of older care-givers in Australia. METHODS:It utilized data obtained from a national health survey of a stratified random sample from the total population of people with disability, aged 60 years or older and ca...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607860802607306
更新日期:2009-07-01 00:00:00
abstract:OBJECTIVES:This study investigated the mental health of a cohort of 262 female and 168 male grandparents across the first two years of their transition to grandparenthood, with particular focus on the impact of providing childcare for the grandchild. METHOD:Baseline assessments were made during the pregnancy with the ...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2016.1248897
更新日期:2018-03-01 00:00:00
abstract:OBJECTIVES:Spousal dementia carers have unique support needs; they are likely to disengage from their existing social networks as they need to devote more time to caring as the disease progresses. Previously we showed that support resources can facilitate resilience in carers, but the relationship is complex and varies...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2016.1209734
更新日期:2017-11-01 00:00:00
abstract::Objectives: To provide prevalence estimates of needs of people with dementia living at home, and to determine sources of variation associated with needs for this population.Method: A systematic review and meta-analysis was performed searching CINAHL, MEDLINE, PsycINFO and ASSIA databases. Following quality checks, ran...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2019.1695741
更新日期:2019-12-03 00:00:00
abstract::Objectives: Although numerous studies have documented that negative age stereotypes and perceived age discrimination are related to older adults' lower well-being, few studies have investigated the mechanisms underlying these relationships. In this study, we tested whether self-perceptions of aging and subjective age ...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2018.1514487
更新日期:2019-12-01 00:00:00
abstract:OBJECTIVES:To investigate what empirical studies report on the perceptions of community-dwelling LGBT adults regarding sexuality and sexual expression in residential aged care (RAC), and how their sexuality should be addressed in RAC. METHODS:Relevant papers were identified through electronic searches in databases; an...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2018.1428938
更新日期:2019-05-01 00:00:00
abstract:OBJECTIVES:This study examines: (1) the effect of widowed persons' frequency of contact with friends and relatives on their depressive and grief symptoms six months following spousal loss and (2) the extent to which the effects of social contact are contingent upon the degree of emotional support received from these re...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2010.519325
更新日期:2011-04-01 00:00:00
abstract::I examine: whether specific emotion-focused coping and help-seeking strategies adopted by older widow(er)s 6 months postloss affect depressive, anger, and yearning symptoms 1 year later; whether these effects are accounted for by psychosocial factors which guide the selection of coping strategies; and the extent to wh...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2018.1531381
更新日期:2020-02-01 00:00:00
abstract::Objectives: Home dwelling people with dementia and their informal carers often do not receive the formal care services they need. This study examined and mapped the research regarding interventions to improve access and use of formal community care services.Method: This is a scoping review with searches in PubMed, CIN...
journal_title:Aging & mental health
pub_type: 杂志文章,评审
doi:10.1080/13607863.2018.1523876
更新日期:2020-02-01 00:00:00
abstract:OBJECTIVES:The aim of this study was to investigate physical decline over 1-year in a cohort of older people across the cognitive spectrum. METHODS:Physical function was assessed using the Physiological Profile Assessment (PPA) in 593 participants (cognitively normal [CN]: n = 342, mild cognitive impairment [MCI]: n =...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2018.1474446
更新日期:2019-07-01 00:00:00
abstract:INTRODUCTION:While several studies have found a link between impaired cognition and social isolation, few have examined the relationship between cognition and loneliness. Loneliness has been thought to increase the risk of development of Alzheimer's dementia. AIM:The aims of this study were to explore the relationship...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2011.628977
更新日期:2012-01-01 00:00:00
abstract::Objectives: Impaired cognition and pre-frailty are associated with poor health outcomes. However, research has not examined the combined impact of cognitive impairment and pre-frailty on future frailty and mortality among older Mexican Americans. Methods: Data for this analysis came from the 2006-2007 and 2010-2011 wa...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2018.1493719
更新日期:2019-10-01 00:00:00
abstract:OBJECTIVES:Frailty affects an estimated 15% of community dwelling older adults. Few studies look at psychosocial variables like self-efficacy (confidence to perform well at a particular task or life domain) in relation to frailty. The purpose of this study was to evaluate associations between pre-frailty/frailty and se...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2019.1639136
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND AND OBJECTIVE:Psychological well-being as one of the most important indicators of successful aging has received substantial attention in the gerontological literature. Prior studies show that sociodemographic factors influencing elderly's psychological well-being are multiple and differ across cultures. The ...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607863.2010.536141
更新日期:2011-05-01 00:00:00
abstract:BACKGROUND:Older people with dementia living in care homes often lack appropriate activities. Although homes are expected to offer a range of activities to meet residents' needs, little is known about what makes activities meaningful for people with dementia. This study explores concepts of meaningful activity, as defi...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/13607860802343019
更新日期:2008-09-01 00:00:00
abstract::Policy research into the service needs of persons with dementia had its origin looking at challenges confronting caregivers-extended hours of instrumental task assistance, social isolation, fatigue, depression-and how public policy might support informal care-giving while saving public expenditures from nursing home c...
journal_title:Aging & mental health
pub_type: 杂志文章
doi:10.1080/713649997
更新日期:2001-05-01 00:00:00