Examining the relationship between face processing and social interaction behavior in children with and without autism spectrum disorder.

Abstract:

BACKGROUND:Children with autism spectrum disorder (ASD) show impairment in reciprocal social communication, which includes deficits in social cognition and behavior. Since social cognition and social behavior are considered to be interdependent, it is valuable to examine social processes on multiple levels of analysis. Neuropsychological measures of face processing often reveal deficits in social cognition in ASD including the ability to identify and remember facial information. However, the extent to which neuropsychological measures are associated with or predictive of real-world social behavior is unclear. METHODS:The study investigated 66 children (ASD 34, typically developing (TD) 32) using neuropsychological measures of face processing (identity, affect, and memory). Children also participated in a peer interaction paradigm, which allowed observation and coding of natural social interaction behaviors during play with peers (e.g., Self-Play, Cooperative Play, Verbal Bout). ANCOVA, regression, and correlation models analyzed between-group differences, the ability of neuropsychological measures to predict social behavior, and the strength of the associations. RESULTS:Between-group differences were shown on Memory for Faces Delayed and the peer interaction variables Self-Play and Verbal Bout. Regression models indicated that Memory for Faces Delayed predicted the amount of Self-Play, Equipment use alone, and Cooperative Play with peers on the playground. Autism symptomology only predicted verbal exchange with peers. CONCLUSIONS:Face memory strongly predicts relevant social engagement patterns in both children with and without ASD. Impairment in facial memory is associated with reduced 'real-world' social interaction and more self-play, whereas higher performance in face memory predicts more cooperative play. Results highlight the strong connection between face memory and reciprocal social interaction, suggesting that improvement in one may benefit the other.

journal_name

J Neurodev Disord

authors

Corbett BA,Newsom C,Key AP,Qualls LR,Edmiston EK

doi

10.1186/1866-1955-6-35

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

35

issue

1

eissn

1866-1947

issn

1866-1955

pii

1866-1955-6-35

journal_volume

6

pub_type

杂志文章
  • Maternal immune response and air pollution exposure during pregnancy: insights from the Early Markers for Autism (EMA) study.

    abstract:BACKGROUND:Perinatal exposure to air pollution and immune system dysregulation are two factors consistently associated with autism spectrum disorders (ASD) and other neurodevelopmental outcomes. However, little is known about how air pollution may influence maternal immune function during pregnancy. OBJECTIVES:To asse...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1186/s11689-020-09343-0

    authors: Volk HE,Park B,Hollingue C,Jones KL,Ashwood P,Windham GC,Lurman F,Alexeeff SE,Kharrazi M,Pearl M,Van de Water J,Croen LA

    更新日期:2020-12-16 00:00:00

  • Phelan-McDermid syndrome: a review of the literature and practice parameters for medical assessment and monitoring.

    abstract::Autism spectrum disorder (ASD) and intellectual disability (ID) can be caused by mutations in a large number of genes. One example is SHANK3 on the terminal end of chromosome 22q. Loss of one functional copy of SHANK3 results in 22q13 deletion syndrome or Phelan-McDermid syndrome (PMS) and causes a monogenic form of A...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章,评审

    doi:10.1186/1866-1955-6-39

    authors: Kolevzon A,Angarita B,Bush L,Wang AT,Frank Y,Yang A,Rapaport R,Saland J,Srivastava S,Farrell C,Edelmann LJ,Buxbaum JD

    更新日期:2014-01-01 00:00:00

  • Comparison of spatial working memory in children with prenatal alcohol exposure and those diagnosed with ADHD; A functional magnetic resonance imaging study.

    abstract:BACKGROUND:Alcohol related neurodevelopmental disorder (ARND) falls under the umbrella of fetal alcohol spectrum disorder (FASD), but individuals do not demonstrate the facial characteristics associated with fetal alcohol syndrome (FAS), making diagnosis difficult. While attentional problems in ARND are similar to thos...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1186/1866-1955-4-12

    authors: Malisza KL,Buss JL,Bolster RB,de Gervai PD,Woods-Frohlich L,Summers R,Clancy CA,Chudley AE,Longstaffe S

    更新日期:2012-05-18 00:00:00

  • The NIH Toolbox Cognitive Battery for intellectual disabilities: three preliminary studies and future directions.

    abstract:BACKGROUND:Recent advances in understanding molecular and synaptic mechanisms of intellectual disabilities (ID) in fragile X syndrome (FXS) and Down syndrome (DS) through animal models have led to targeted controlled trials with pharmacological agents designed to normalize these underlying mechanisms and improve clinic...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1186/s11689-016-9167-4

    authors: Hessl D,Sansone SM,Berry-Kravis E,Riley K,Widaman KF,Abbeduto L,Schneider A,Coleman J,Oaklander D,Rhodes KC,Gershon RC

    更新日期:2016-09-06 00:00:00

  • Phenotypic characterization of individuals with SYNGAP1 pathogenic variants reveals a potential correlation between posterior dominant rhythm and developmental progression.

    abstract:BACKGROUND:The SYNGAP1 gene encodes for a small GTPase-regulating protein critical to dendritic spine maturation and synaptic plasticity. Mutations have recently been identified to cause a breadth of neurodevelopmental disorders including autism, intellectual disability, and epilepsy. The purpose of this work is to def...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1186/s11689-019-9276-y

    authors: Jimenez-Gomez A,Niu S,Andujar-Perez F,McQuade EA,Balasa A,Huss D,Coorg R,Quach M,Vinson S,Risen S,Holder JL Jr

    更新日期:2019-08-08 00:00:00

  • FMR1 premutation and full mutation molecular mechanisms related to autism.

    abstract::Fragile X syndrome (FXS) is caused by an expanded CGG repeat (>200 repeats) in the 5' un-translated portion of the fragile X mental retardation 1 gene (FMR1) leading to a deficiency or absence of the FMR1 protein (FMRP). FMRP is an RNA-binding protein that regulates the translation of a number of other genes that are ...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1007/s11689-011-9084-5

    authors: Hagerman R,Au J,Hagerman P

    更新日期:2011-09-01 00:00:00

  • Erratum to: A developmental, longitudinal investigation of autism phenotypic profiles in fragile X syndrome.

    abstract::[This corrects the article DOI: 10.1186/s11689-016-9179-0.]. ...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 已发布勘误

    doi:10.1186/s11689-017-9192-y

    authors: Lee M,Martin GE,Berry-Kravis E,Losh M

    更新日期:2017-03-06 00:00:00

  • Reduced vagal tone in women with the FMR1 premutation is associated with FMR1 mRNA but not depression or anxiety.

    abstract:BACKGROUND:Autonomic dysfunction is implicated in a range of psychological conditions, including depression and anxiety. The fragile X mental retardation-1 (FMR1) premutation is a common genetic mutation that affects ~1:150 women and is associated with psychological vulnerability. This study examined cardiac indicators...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1186/s11689-017-9197-6

    authors: Klusek J,LaFauci G,Adayev T,Brown WT,Tassone F,Roberts JE

    更新日期:2017-05-02 00:00:00

  • Social attention: a possible early indicator of efficacy in autism clinical trials.

    abstract:: For decades, researchers have sought to clarify the nature of the social communication impairments in autism, highlighting impaired or atypical 'social attention' as a key measurable construct that helps to define the core impairment of social communication. In this paper, we provide an overview of research on social...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1186/1866-1955-4-11

    authors: Dawson G,Bernier R,Ring RH

    更新日期:2012-05-17 00:00:00

  • Teasing apart the heterogeneity of autism: Same behavior, different brains in toddlers with fragile X syndrome and autism.

    abstract::To examine brain volumes in substructures associated with the behavioral features of children with FXS compared to children with idiopathic autism and controls. A cross-sectional study of brain substructures was conducted at the first time-point as part of an ongoing longitudinal MRI study of brain development in FXS....

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1007/s11689-009-9009-8

    authors: Hazlett HC,Poe MD,Lightbody AA,Gerig G,Macfall JR,Ross AK,Provenzale J,Martin A,Reiss AL,Piven J

    更新日期:2009-03-01 00:00:00

  • Genetics and language: a neurobiological perspective on the missing link (-ing hypotheses).

    abstract::The paper argues that both evolutionary and genetic approaches to studying the biological foundations of speech and language could benefit from fractionating the problem at a finer grain, aiming not to map genetics to "language"-or even subdomains of language such as "phonology" or "syntax"-but rather to link genetic ...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1007/s11689-011-9097-0

    authors: Poeppel D

    更新日期:2011-12-01 00:00:00

  • Correction to: Expressive language sampling as a source of outcome measures for treatment studies in fragile X syndrome: feasibility, practice effects, test-retest reliability, and construct validity.

    abstract::In the original publication of this article [1], the author name Leonard Abbeduto was misspelled as Leonardkk Abbeduto. The original article has been corrected. ...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章,已发布勘误

    doi:10.1186/s11689-020-09314-5

    authors: Abbeduto L,Berry-Kravis E,Sterling A,Sherman S,Edgin JO,McDuffie A,Hoffmann A,Hamilton D,Nelson M,Aschkenasy J,Thurman AJ

    更新日期:2020-04-02 00:00:00

  • Medical conditions in autism spectrum disorders.

    abstract::Autism spectrum disorder (ASD) is a behaviourally defined syndrome where the etiology and pathophysiology is only partially understood. In a small proportion of children with the condition, a specific medical disorder is identified, but the causal significance in many instances is unclear. Currently, the medical condi...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1007/s11689-009-9021-z

    authors: Bolton PF

    更新日期:2009-06-01 00:00:00

  • Deficient maternal care resulting from immunological stress during pregnancy is associated with a sex-dependent enhancement of conditioned fear in the offspring.

    abstract::Activation of maternal stress response systems during pregnancy has been associated with altered postpartum maternal care and subsequent abnormalities in the offspring's brain and behavioral development. It remains unknown, however, whether similar effects may be induced by exposure to immunological stress during preg...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1007/s11689-008-9000-9

    authors: Schwendener S,Meyer U,Feldon J

    更新日期:2009-03-01 00:00:00

  • Abnormal social reward processing in autism as indexed by pupillary responses to happy faces.

    abstract:BACKGROUND:Individuals with Autism Spectrum Disorders (ASD) typically show impaired eye contact during social interactions. From a young age, they look less at faces than typically developing (TD) children and tend to avoid direct gaze. However, the reason for this behavior remains controversial; ASD children might avo...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1186/1866-1955-4-17

    authors: Sepeta L,Tsuchiya N,Davies MS,Sigman M,Bookheimer SY,Dapretto M

    更新日期:2012-06-07 00:00:00

  • A 13-year follow-up of Finnish patients with Salla disease.

    abstract:BACKGROUND:Salla disease (SD) is a rare lysosomal storage disorder leading to severe intellectual disability. SD belongs to the Finnish disease heritage, and it is caused by mutations in the SLC17A5 gene. The aim of the study was to investigate the course of neurocognitive features of SD patients in a long-term follow-...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1186/s11689-015-9116-7

    authors: Paavola LE,Remes AM,Harila MJ,Varho TT,Korhonen TT,Majamaa K

    更新日期:2015-01-01 00:00:00

  • Autistic behavior in boys with fragile X syndrome: social approach and HPA-axis dysfunction.

    abstract::The primary goal of this study was to examine environmental and neuroendocrine factors that convey increased risk for elevated autistic behavior in boys with Fragile X syndrome (FXS). This study involves three related analyses: (1) examination of multiple dimensions of social approach behaviors and how they vary over ...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1007/s11689-009-9028-5

    authors: Roberts JE,Clarke MA,Alcorn K,Carter JC,Long AC,Kaufmann WE

    更新日期:2009-12-01 00:00:00

  • Array-based molecular karyotyping in fetuses with isolated brain malformations identifies disease-causing CNVs.

    abstract:BACKGROUND:The overall birth prevalence for congenital malformations of the central nervous system (CNS) among Europeans may be as high as 1 in 100 live births. The etiological factors remain largely unknown. The aim of this study was to detect causative copy number variations (CNVs) in fetuses of terminated pregnancie...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1186/s11689-016-9144-y

    authors: Schumann M,Hofmann A,Krutzke SK,Hilger AC,Marsch F,Stienen D,Gembruch U,Ludwig M,Merz WM,Reutter H

    更新日期:2016-04-15 00:00:00

  • Toward epigenetic and gene regulation models of specific language impairment: looking for links among growth, genes, and impairments.

    abstract:: Children with specific language impairment (SLI) are thought to have an inherited form of language impairment that spares other developmental domains. SLI shows strong heritability and recent linkage and association studies have replicated results for candidate genes. Regulatory regions of the genes may be involved. ...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1186/1866-1955-4-27

    authors: Rice ML

    更新日期:2012-11-24 00:00:00

  • Early negative affect in males and females with fragile X syndrome: implications for anxiety and autism.

    abstract:BACKGROUND:Fragile X syndrome (FXS) is a genetic disorder that is highly comorbid with anxiety and autism spectrum disorder (ASD). Elevated negative affect in young children has been associated with increased risk for both anxiety and ASD; however, these relations remain poorly understood in FXS. METHODS:The present p...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1186/s11689-019-9284-y

    authors: Wall CA,Hogan AL,Will EA,McQuillin S,Kelleher BL,Roberts JE

    更新日期:2019-09-13 00:00:00

  • Mitochondrial aminoacyl-tRNA synthetase disorders: an emerging group of developmental disorders of myelination.

    abstract:BACKGROUND:The mitochondrial aminoacyl-tRNA synthetase proteins (mt-aaRSs) are a group of nuclear-encoded enzymes that facilitate conjugation of each of the 20 amino acids to its cognate tRNA molecule. Mitochondrial diseases are a large, clinically heterogeneous group of disorders with diverse etiologies, ages of onset...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章,评审

    doi:10.1186/s11689-019-9292-y

    authors: Fine AS,Nemeth CL,Kaufman ML,Fatemi A

    更新日期:2019-12-16 00:00:00

  • Identification of a distinct developmental and behavioral profile in children with Dup15q syndrome.

    abstract:BACKGROUND:One of the most common genetic variants associated with autism spectrum disorder (ASD) are duplications of chromosome 15q11.2-q13.1 (Dup15q syndrome). To identify distinctive developmental and behavioral features in Dup15q syndrome, we examined the social communication, adaptive, and cognitive skills in clin...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1186/s11689-016-9152-y

    authors: DiStefano C,Gulsrud A,Huberty S,Kasari C,Cook E,Reiter LT,Thibert R,Jeste SS

    更新日期:2016-05-06 00:00:00

  • Magnetoencephalographic (MEG) brain activity during a mental flexibility task suggests some shared neurobiology in children with neurodevelopmental disorders.

    abstract:BACKGROUND:Children with neurodevelopmental disorders (NDDs) exhibit a shared phenotype that involves executive dysfunctions including impairments in mental flexibility (MF). It is of interest to understand if this phenotype stems from some shared neurobiology. METHODS:To investigate this possibility, we used magnetoe...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1186/s11689-019-9280-2

    authors: Mogadam A,Keller AE,Arnold PD,Schachar R,Lerch JP,Anagnostou E,Pang EW

    更新日期:2019-08-19 00:00:00

  • Young adult male carriers of the fragile X premutation exhibit genetically modulated impairments in visuospatial tasks controlled for psychomotor speed.

    abstract:UNLABELLED: BACKGROUND:A previous study reported enhanced psychomotor speed, and subtle but significant cognitive impairments, modulated by age and by mutations in the fragile X mental retardation 1 (FMR1) gene in adult female fragile X premutation carriers (fXPCs). Because male carriers, unlike females, do not have a...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1186/1866-1955-4-26

    authors: Wong LM,Goodrich-Hunsaker NJ,McLennan Y,Tassone F,Harvey D,Rivera SM,Simon TJ

    更新日期:2012-11-13 00:00:00

  • Aberrant basal ganglia metabolism in fragile X syndrome: a magnetic resonance spectroscopy study.

    abstract:BACKGROUND:The profile of cognitive and behavioral variation observed in individuals with fragile X syndrome (FXS), the most common known cause of inherited intellectual impairment, suggests aberrant functioning of specific brain systems. Research investigating animal models of FXS, characterized by limited or lack of ...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1186/1866-1955-5-20

    authors: Bruno JL,Shelly EW,Quintin EM,Rostami M,Patnaik S,Spielman D,Mayer D,Gu M,Lightbody AA,Reiss AL

    更新日期:2013-08-28 00:00:00

  • Atypical sound discrimination in children with ASD as indicated by cortical ERPs.

    abstract:BACKGROUND:Individuals with autism spectrum disorder (ASD) show a relative indifference to the human voice. Accordingly, and contrarily to their typically developed peers, adults with autism do not show a preferential response to voices in the superior temporal sulcus; this lack of voice-specific response was previousl...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1186/s11689-017-9194-9

    authors: Bidet-Caulet A,Latinus M,Roux S,Malvy J,Bonnet-Brilhault F,Bruneau N

    更新日期:2017-04-05 00:00:00

  • Children with facial paralysis due to Moebius syndrome exhibit reduced autonomic modulation during emotion processing.

    abstract:BACKGROUND:Facial mimicry is crucial in the recognition of others' emotional state. Thus, the observation of others' facial expressions activates the same neural representation of that affective state in the observer, along with related autonomic and somatic responses. What happens, therefore, when someone cannot mimic...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1186/s11689-019-9272-2

    authors: De Stefani E,Ardizzi M,Nicolini Y,Belluardo M,Barbot A,Bertolini C,Garofalo G,Bianchi B,Coudé G,Murray L,Ferrari PF

    更新日期:2019-07-10 00:00:00

  • Genomic sequencing of a dyslexia susceptibility haplotype encompassing ROBO1.

    abstract:BACKGROUND:The DYX5 locus for developmental dyslexia was mapped to chromosome 3 by linkage study of a large Finnish family, and later, roundabout guidance receptor 1 (ROBO1) was implicated as a candidate gene at DYX5 with suppressed expression from the segregating rare haplotype. A functional magnetoencephalographic st...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1186/s11689-016-9136-y

    authors: Massinen S,Wang J,Laivuori K,Bieder A,Tapia Paez I,Jiao H,Kere J

    更新日期:2016-01-27 00:00:00

  • Vocabulary comprehension in adults with fragile X syndrome (FXS).

    abstract:BACKGROUND:Receptive and expressive vocabulary in adult and adolescent males with fragile X syndrome (FXS) have been shown as significantly lower than their chronological age; however, receptive vocabulary has been considered a strength relative to mental age. This has not been formally examined, however, and data are ...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1186/s11689-019-9285-x

    authors: Hoffmann A,Krause SE,Wuu J,Leurgans S,Guter SJ Jr,Block SS,Salt J,Cook E Jr,Maino DM,Berry-Kravis E

    更新日期:2019-10-16 00:00:00

  • Altered modulation of gamma oscillation frequency by speed of visual motion in children with autism spectrum disorders.

    abstract:BACKGROUND:Recent studies link autism spectrum disorders (ASD) with an altered balance between excitation and inhibition (E/I balance) in cortical networks. The brain oscillations in high gamma-band (50-120 Hz) are sensitive to the E/I balance and may appear useful biomarkers of certain ASD subtypes. The frequency of g...

    journal_title:Journal of neurodevelopmental disorders

    pub_type: 杂志文章

    doi:10.1186/s11689-015-9121-x

    authors: Stroganova TA,Butorina AV,Sysoeva OV,Prokofyev AO,Nikolaeva AY,Tsetlin MM,Orekhova EV

    更新日期:2015-01-01 00:00:00