Vascular dysfunction as a target for adjuvant therapy in cerebral malaria.

Abstract:

:Cerebral malaria (CM) is a life-threatening complication of Plasmodium falciparum malaria that continues to be a major global health problem. Brain vascular dysfunction is a main factor underlying the pathogenesis of CM and can be a target for the development of adjuvant therapies for the disease. Vascular occlusion by parasitised red blood cells and vasoconstriction/vascular dysfunction results in impaired cerebral blood flow, ischaemia, hypoxia, acidosis and death. In this review, we discuss the mechanisms of vascular dysfunction in CM and the roles of low nitric oxide bioavailability, high levels of endothelin-1 and dysfunction of the angiopoietin-Tie2 axis. We also discuss the usefulness and relevance of the murine experimental model of CM by Plasmodium berghei ANKA to identify mechanisms of disease and to screen potential therapeutic interventions.

journal_name

Mem Inst Oswaldo Cruz

authors

Carvalho LJ,Moreira Ada S,Daniel-Ribeiro CT,Martins YC

doi

10.1590/0074-0276140061

subject

Has Abstract

pub_date

2014-08-01 00:00:00

pages

577-88

issue

5

eissn

0074-0276

issn

1678-8060

pii

S0074-02762014000500577

journal_volume

109

pub_type

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