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Coronary artery manifestations of fibromuscular dysplasia.

Abstract：

:Fibromuscular dysplasia (FMD) involving the coronary arteries is an uncommon but important condition that can present as acute coronary syndrome, left ventricular dysfunction, or potentially sudden cardiac death. Although the classic angiographic "string of beads" that may be observed in renal artery FMD does not occur in coronary arteries, potential manifestations include spontaneous coronary artery dissection, distal tapering or long, smooth narrowing that may represent dissection, intramural hematoma, spasm, or tortuosity. Importantly, FMD must be identified in at least one other noncoronary arterial territory to attribute any coronary findings to FMD. Although there is limited evidence to guide treatment, many lesions heal spontaneously; thus, a conservative approach is generally preferred. The etiology is poorly understood, but there are ongoing efforts to better characterize FMD and define its genetic and molecular basis. This report reviews the clinical course of FMD involving the coronary arteries and provides guidance for diagnosis and treatment strategies.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Michelis KC,Olin JW,Kadian-Dodov D,d'Escamard V,Kovacic JC

doi

10.1016/j.jacc.2014.07.014

subject

Has Abstract

pub_date

2014-09-09 00:00:00

pages

1033-46

issue

10

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(14)04464-7

journal_volume

64

pub_type

杂志文章,评审

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