Abstract:
INTRODUCTION AND HYPOTHESIS:We sought to determine whether baseline characteristics predict which overactive bladder (OAB) patients benefit from fesoterodine 8 mg versus 4 mg. METHODS:In double-blind, placebo-controlled, flexible-dose trials, baseline characteristics of OAB patients with ≥ 1 urgency urinary incontinence (UUI) episodes/24 h who escalated from fesoterodine 4 mg to 8 mg were evaluated. Possible dose-escalation predictors (age; sex; previous antimuscarinic use; UUI, micturitions, and urgency episodes/24 h; race; body mass index; time to dose escalation; OAB duration) were compared in escalators versus non-escalators. Patients from fixed-dose trials with dose-escalator characteristics were identified (matched dose-escalator sample) to assess changes from baseline with fesoterodine 4 mg, 8 mg, and placebo. RESULTS:In flexible-dose trials, significant predictors of fesoterodine dose escalation were younger age (≤ 65.8 years), greater number of baseline micturitions (≥ 13.1) and urgency episodes/24 h (≥ 10.9), greater OAB duration (≥ 9.1 years), and more frequent previous antimuscarinic use (58.3%), but not baseline UUI episodes/24 h. In the matched dose-escalator sample (fesoterodine 4 mg: n = 215; 8 mg: n = 198; placebo: n = 217), change from baseline in UUI episodes significantly improved with fesoterodine 8 mg versus 4 mg (P = 0.043) and with both doses versus placebo (P < 0.001). Dry mouth and constipation rates were higher with fesoterodine 8 mg. CONCLUSIONS:Dose-escalator patients had a significantly greater UUI response with fesoterodine 8 mg versus 4 mg. Given the potential for adverse events, fesoterodine 4 mg is recommended to start; however, patients with UUI and identified predictors may benefit from initial treatment with fesoterodine 8 mg or rapid dose escalation.
journal_name
Int Urogynecol Jjournal_title
International urogynecology journalauthors
Goldman HB,Oelke M,Kaplan SA,Kitta T,Russell D,Carlsson M,Arumi D,Mangan E,Ntanios Fdoi
10.1007/s00192-018-3640-4subject
Has Abstractpub_date
2019-02-01 00:00:00pages
239-244issue
2eissn
0937-3462issn
1433-3023pii
10.1007/s00192-018-3640-4journal_volume
30pub_type
杂志文章,随机对照试验abstract:INTRODUCTION AND HYPOTHESIS:Lower tract urinary symptoms are underestimated by women as well as health professionals. The objective of this study was to evaluate the behavior of adult women with urinary incontinence and overactive bladder symptoms in seeking medical treatment. METHODS:Two hundred ninety-two women betw...
journal_title:International urogynecology journal
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abstract:INTRODUCTION AND HYPOTHESIS:The aim was to determine factors associated with performing concurrent apical support procedures in hysterectomies carried out for uterovaginal prolapse. METHODS:Hysterectomies performed for uterovaginal prolapse from 2000 to 2010 were identified by ICD-9 codes. Uterovaginal prolapse was a ...
journal_title:International urogynecology journal
pub_type: 杂志文章
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journal_title:International urogynecology journal
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journal_title:International urogynecology journal
pub_type: 杂志文章,评审
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abstract::Recurrent pelvic organ prolapse occurs rarely after obliterative procedures. The optimal surgical approach for therapy is unknown. We describe a case of recurrent prolapse after LeFort colpocleisis. The patient presented with stage III prolapse through the lateral vaginal channel. At surgery, the prolapse was repaired...
journal_title:International urogynecology journal
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abstract::Oxybutynin chloride is primarily indicated for the treatment of overactive bladder syndrome (OAB). It remains the most widely prescribed compound for OAB in the world. OAB is defined as the presence of urinary urgency, usually accompanied by daytime urinary frequency and nocturia, with or without urgency urinary incon...
journal_title:International urogynecology journal
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journal_title:International urogynecology journal
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journal_title:International urogynecology journal
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journal_title:International urogynecology journal
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更新日期:2013-09-01 00:00:00
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journal_title:International urogynecology journal
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更新日期:2011-05-01 00:00:00
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更新日期:2017-08-01 00:00:00
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pub_type: 杂志文章,多中心研究
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journal_title:International urogynecology journal
pub_type: 杂志文章
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更新日期:2012-05-01 00:00:00
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journal_title:International urogynecology journal
pub_type: 杂志文章
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更新日期:2014-08-01 00:00:00
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journal_title:International urogynecology journal
pub_type: 杂志文章
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更新日期:2018-11-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:The aim of this study was to compare pelvic floor muscle strength (PFMS) and the prevalence of urinary incontinence (UI) and pelvic organ prolapse(POP) in women with and without diastasis recti abdominis (DRA) at 6-8 weeks postpartum. METHODS:Three hundred and ten women underwent routine ex...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-019-04005-9
更新日期:2020-02-01 00:00:00
abstract::Bladder dysfunction is a very prevalent disorder and often refractory to behavioral and pharmacologic therapies. Sacral nerve stimulation is an approved method of managing urinary urgency, frequency, urge incontinence, and urinary retention. Alternative approaches to neuromodulation are being developed. The purpose of...
journal_title:International urogynecology journal
pub_type: 杂志文章,评审
doi:10.1007/s00192-010-1282-2
更新日期:2010-12-01 00:00:00
abstract::Reports have shown that high-energy pelvic trauma might be associated with advanced pelvic organ prolapse in conjunction with other causes. We report the case of a 21-year-old nulliparous, premenopausal, non-overweight woman with no predisposing factors for prolapse who developed stage IV massive pelvic organ prolapse...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-010-1320-0
更新日期:2011-06-01 00:00:00
abstract:INTRODUCTION AND HYPOTHESIS:To evaluate the efficacy and safety of the intravesical injection of Chinese botulinum toxin A (BTX-A) in patients with interstitial cystitis/bladder pain syndrome (IC/BPS). METHODS:Between January 2003 and June 2013, 124 women with IC/BPS were studied. Of these 124 patients, 66 were treate...
journal_title:International urogynecology journal
pub_type: 杂志文章
doi:10.1007/s00192-015-2631-y
更新日期:2015-07-01 00:00:00
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journal_title:International urogynecology journal
pub_type: 杂志文章,评审
doi:10.1007/s00192-015-2886-3
更新日期:2016-08-01 00:00:00