Efficacy of nanofibrous conduits in repair of long-segment sciatic nerve defects.

Abstract:

:Our previous studies have histomorphologically confirmed that nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) conduit can be used to repair 30-mm-long sciatic nerve defects. However, the repair effects on rat behaviors remain poorly understood. In this study, we used nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) conduit and autologous sciatic nerve to bridge 30-mm-long rat sciatic nerve gaps. Within 4 months after surgery, rat sciatic nerve functional recovery was evaluated per month by behavioral analyses, including toe out angle, toe spread analysis, walking track analysis, extensor postural thrust, swimming test, open-field analysis and nociceptive function. Results showed that rat sciatic nerve functional recovery was similar after nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) conduit and autologous nerve grafting. These findings suggest that nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) conduit is suitable in use for repair of long-segment sciatic nerve defects.

journal_name

Neural Regen Res

authors

Biazar E,Keshel SH,Pouya M

doi

10.3969/j.issn.1673-5374.2013.27.001

subject

Has Abstract

pub_date

2013-09-25 00:00:00

pages

2501-9

issue

27

eissn

1673-5374

issn

1876-7958

pii

NRR-8-2501

journal_volume

8

pub_type

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