Abstract:
OBJECTIVE:The aim of this study was to perform a blood pressure (BP) safety evaluation in patients with an overactive bladder receiving solifenacin (an antimuscarinic agent), mirabegron (a β3-adrenoceptor agonist), or both compared with placebo in the SYNERGY trial. PATIENTS AND METHODS:Patients were randomized to receive solifenacin 5 mg+mirabegron 50 mg (combination 5+50 mg); solifenacin 5 mg+mirabegron 25 mg (combination 5+25 mg); solifenacin 5 mg; mirabegron 50 mg; mirabegron 25 mg; or placebo for a double-blind 12-week treatment period. Systolic BP, diastolic BP, and heart rate were measured by ambulatory BP monitoring, and in the clinic or home. RESULTS:A total of 715 patients were analyzed in an ambulatory BP monitoring substudy. At the end of treatment, ambulatory BP monitoring measurements showed no consistent increases from baseline in the mean 24-h systolic BP or diastolic BP for combination versus monotherapy groups or for monotherapy groups versus placebo. Analysis of 1-h BP averages during the 6 h range that included the Tmax values of both study drugs showed no significant BP effects. Shift analysis (switch between different normotension/hypertension stages) did not show differences among the active and placebo groups, nor did outlier analysis of major BP changes differ between placebo and active treatment. Similarly, there were no significant signals in the 24-h heart rate. Office and home measurements were consistent with ambulatory BP monitoring findings. CONCLUSIONS:A paradigm of ambulatory BP monitoring analysis designed to test BP safety of noncardiovascular drugs showed that solifenacin plus mirabegron combination therapy during 12 weeks produced no meaningful changes in BP or heart rate.
journal_name
Blood Press Monitjournal_title
Blood pressure monitoringauthors
Weber MA,Chapple CR,Gratzke C,Herschorn S,Robinson D,Frankel JM,Ridder AM,Stoelzel M,Paireddy A,van Maanen R,White WBdoi
10.1097/MBP.0000000000000320subject
Has Abstractpub_date
2018-06-01 00:00:00pages
153-163issue
3eissn
1359-5237issn
1473-5725journal_volume
23pub_type
杂志文章,多中心研究,随机对照试验abstract:OBJECTIVE:The validation of sphygmomanometer is important in accurate blood pressure measurement. This study presents the validation results by the Medipro MediCare 100f upper arm blood pressure monitor according to the European Society of Hypertension International Protocol (ESH-IP) revision 2010. METHODS:The ESH-IP ...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0b013e328346d715
更新日期:2011-08-01 00:00:00
abstract:OBJECTIVE:The aim of the present study was to evaluate the accuracy of the automated oscillometric wrist blood pressure monitor AVITA BPM17 for home blood pressure monitoring according to the International Protocol of the European Society of Hypertension revision 2010. PARTICIPANTS AND METHODS:Systolic and diastolic b...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0000000000000261
更新日期:2017-08-01 00:00:00
abstract::Hypertension is a highly common condition with well-established adverse consequences. Ambulatory blood pressure monitoring has repeatedly been shown to better predict cardiovascular outcomes and mortality, compared to single office visit blood pressure. Non-dipping of sleep-time blood pressure is an independent marker...
journal_title:Blood pressure monitoring
pub_type: 杂志文章,评审
doi:10.1097/MBP.0000000000000426
更新日期:2020-04-01 00:00:00
abstract:BACKGROUND:Patients and doctors often use home blood pressure monitoring (HBPM) to assess the control of hypertension. Despite its popularity there has always been some uncertainty with regard to its accuracy, reliability, reproducibility, and comparability. Although there are pre-market HBPM standards of accuracy, the...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/00126097-199904010-00007
更新日期:1999-02-01 00:00:00
abstract::Ambulatory blood pressure monitoring (ABPM) has become more widely used in the assessment of elevated blood pressure in children. The accurate diagnosis of white coat hypertension (WCH) is particularly important in children because detection of elevated blood pressure often results in expensive and invasive diagnostic...
journal_title:Blood pressure monitoring
pub_type: 杂志文章,评审
doi:10.1097/00126097-200008000-00001
更新日期:2000-08-01 00:00:00
abstract:OBJECTIVE:Vitamin D has beneficial effects on vascular endothelial function, blood pressure (BP) and arterial stiffness. Arterial stiffness increases in early-stage hypertensive patients and it is a strong predictor of cardiovascular morbidity and mortality. The purpose of this study was to assess the association betwe...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0000000000000497
更新日期:2020-11-23 00:00:00
abstract::We carried out this meta-analysis to assess the effects of renal denervation (RDN) on resistant hypertension patients. According to the collaborative review group search strategy, we searched MEDLINE (1996 to 2015.10); EBCO (1996 to 2015.10) and CNKI. A meta-analysis was carried out using RevMan 5.0. We identified 11 ...
journal_title:Blood pressure monitoring
pub_type: 杂志文章,meta分析,评审
doi:10.1097/MBP.0000000000000177
更新日期:2016-08-01 00:00:00
abstract:BACKGROUND:The Keito machine offers automatic measurements of blood pressure (BP), height and weight on insertion of coins and has been introduced in pharmacies. DESIGN:Cross-sectional study comparing automatic BP measurements by the Keito machine to office BP measurements by physicians. METHODS:Patients scheduled fo...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/01.mbp.0000130223.80658.3d
更新日期:2004-06-01 00:00:00
abstract:OBJECTIVE:We aimed to analyze the difference in 24-h blood pressure values during Ramadan of fasting and nonfasting individuals with no previous history of hypertension. PATIENTS AND METHODS:This study was planned as a multicenter research study in the cities of Izmit, Zonguldak, Sivas, and Adana. The percentage chang...
journal_title:Blood pressure monitoring
pub_type: 杂志文章,多中心研究
doi:10.1097/MBP.0000000000000244
更新日期:2017-10-01 00:00:00
abstract:OBJECTIVE:Psoriasis is a chronic inflammatory disorder, which is associated with high risk of metabolic comorbidities. Hypertension (HTN) is among the most common and serious associations. In this study, we aimed to evaluate HTN in psoriatic patients through office and ambulatory blood pressure monitoring (ABPM). MATE...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0000000000000489
更新日期:2020-12-01 00:00:00
abstract:BACKGROUND:How far should blood pressure (BP) be lowered to achieve the greatest reduction in the risk of cardiovascular disease? Although a few trials have tried to answer this question, they failed to convincingly establish an optimal target BP level, in part because of poor reproducibility and the wide variability o...
journal_title:Blood pressure monitoring
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1097/00126097-200202000-00016
更新日期:2002-02-01 00:00:00
abstract::The aim of this study was to determine the accuracy of the A&D BP UA-651 device coupled to a wide-range cuff for home blood pressure (BP) measurement according to the International Protocol of the European Society of Hypertension. The device was evaluated in 33 patients. The mean age of the patients was 56.5±15.1 year...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0000000000000100
更新日期:2015-06-01 00:00:00
abstract:BACKGROUND:Self-measurements of blood pressure may offer some advantage in diagnostic and therapeutic evaluation and in management of patients. However, the most important limitation of self-measurement is that there are limited data available about the prognostic value of this information. RESULTS:Authors of several ...
journal_title:Blood pressure monitoring
pub_type: 共识发展会议,杂志文章,评审
doi:
更新日期:2000-04-01 00:00:00
abstract:BACKGROUND:The accuracy of home blood pressure measurement (HBPM) depends on adherence to the measurement schedule. We investigated the number of deviations from the requested schedule using an HBPM device equipped with a diagnostic mode that only allows patients to take a fixed number of BP readings at preset times. ...
journal_title:Blood pressure monitoring
pub_type: 杂志文章,随机对照试验
doi:10.1097/MBP.0b013e328357352a
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVES:In young and middle age, women have higher orthostatic intolerance (OI) than men, and hemodynamic differences have been found supporting this finding. In older people, these sex differences are less studied. Our aim was to contribute evidence. METHODS:Two hundred and twenty-four community-dwelling older par...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0b013e3283353199
更新日期:2010-02-01 00:00:00
abstract:OBJECTIVE:Measurement of office blood pressure using a fully automated sphygmomanometer that takes multiple readings with the patient resting quietly alone has been called automated office blood pressure (AOBP). Almost all AOBP research has involved the patient resting alone in an examining room, which is often impract...
journal_title:Blood pressure monitoring
pub_type: 临床试验,杂志文章
doi:10.1097/MBP.0000000000000133
更新日期:2015-08-01 00:00:00
abstract:OBJECTIVE:To evaluate blood pressure (BP)-lowering effects of Umezu polyphenols, polyphenols contained in Japanese plums, in a community-based sample by double-masked and placebo-controlled design. METHODS:Seventy-two Japanese community-dwellers who were interested in prevention or control of their BP (preferably high...
journal_title:Blood pressure monitoring
pub_type: 杂志文章,随机对照试验
doi:10.1097/MBP.0000000000000476
更新日期:2020-12-01 00:00:00
abstract::Hypertension is a major risk factor for cardiovascular morbidity and mortality. Therefore, blood pressure self-measuring devices have emerged as valuable tools in patient care and the accuracy of these instruments is of fundamental importance. For this reason, several validation procedures for assessing the efficacy o...
journal_title:Blood pressure monitoring
pub_type: 杂志文章,评审
doi:10.1097/MBP.0000000000000150
更新日期:2016-02-01 00:00:00
abstract::The objectives of the analysis are to compare the blood pressure levels at different phases of the trial and to be sure that the effect will continue until the next dose. There are problems before the analysis for which consensus is necessary. If the overall 24 h study is the first generally recognized stage, it is di...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:
更新日期:1996-06-01 00:00:00
abstract:AIM:The association between a blunted decrease in day–night heart rate and subclinical organ damage has not been investigated earlier in human hypertension. Therefore, we assessed such an association in a cohort of 658 untreated essential hypertensive patients. METHODS:All patients underwent procedures including cardi...
journal_title:Blood pressure monitoring
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/mbp.0b013e32834331fe
更新日期:2011-02-01 00:00:00
abstract:BACKGROUND:In acute ischemic stroke, a transient elevation of blood pressure is common; its significance and its relationship with the neurological outcome are still unclear. METHODS:In 71 consecutive patients with acute ischemic stroke, aged 25-94 years, admitted to our unit, we investigated the relationships between...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/01.mbp.0000209077.23084.93
更新日期:2006-08-01 00:00:00
abstract:OBJECTIVE:The ankle-brachial index (ABI) is the most useful and efficient tool for assessing the presence of peripheral artery disease (PAD). The aim of this study was to evaluate the effect of multiple sequential blood pressure (BP) measurements on the estimation of the ABI and the consequent diagnosis of PAD in a hig...
journal_title:Blood pressure monitoring
pub_type: 杂志文章,随机对照试验
doi:10.1097/MBP.0b013e328351de79
更新日期:2012-04-01 00:00:00
abstract:OBJECTIVES:Monitoring of brachial blood pressure during exercise-electrocardiogram (ECG) testing is mandatory and changes in blood pressure (BP) can provide critical management evidence. Patient movement, mechanical vibration, artifactual sounds and observer variability make standard manual techniques problematic. This...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/00126097-200410000-00007
更新日期:2004-10-01 00:00:00
abstract:OBJECTIVE:The aim of the study was to determine the accuracy of the Microlife WatchBP O3 monitor for ambulatory blood pressure (BP) measurement according to the new ISO81060-2 2018 protocol. METHODS:The WatchBP O3 was first tested in 97 subjects from the general population (mean age, 71.3 years; 48 men) using four cuf...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0000000000000459
更新日期:2020-10-01 00:00:00
abstract:BACKGROUND:Ambulatory blood pressure monitoring allows characterization of the patient's average blood pressure load as well as various profiles of blood pressure. Results from clinical studies suggest that dippers (patients whose blood pressures decrease during night-time) have a lower risk of cardiovascular events th...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/00126097-200002000-00004
更新日期:2000-02-01 00:00:00
abstract:OBJECTIVE:The independent prognostic significance of ambulatory blood pressure variability in the elderly is incompletely clear. We investigated the prognostic value of average real variability of 24-hour blood pressure in elderly treated hypertensive patients. METHODS:The occurrence of a combined end-point including ...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0000000000000381
更新日期:2019-08-01 00:00:00
abstract:OBJECTIVE:This study was designed mainly to establish the rates of response to valsartan 80mg once daily (qd) and to valsartan 160mg qd given to non-responders to 80mg qd, as well as to determine the safety of valsartan and the blood pressure control achieved using valsartan over a period of 24 h or more, using ambulat...
journal_title:Blood pressure monitoring
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1097/00126097-200104000-00005
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:Fixed-ratio and slope-based algorithms are used to derive oscillometric blood pressure (BP). However, a paucity of published data exists assessing the accuracy of these methods. Our objective was to determine the accuracy of fixed-ratio and slope-based algorithms in healthy adults and in adults with cardiova...
journal_title:Blood pressure monitoring
pub_type: 临床试验,杂志文章
doi:10.1097/MBP.0000000000000356
更新日期:2019-02-01 00:00:00
abstract:OBJECTIVE:To compare the methods of office blood pressure (BP) measurement and ambulatory blood pressure monitoring (ABPM) to ensure optimal BP control in hypertensive anticoagulated patients. PATIENTS AND METHODS:Seventy-eight patients who were receiving antihypertensive drugs and warfarin in a dose-adjusted approach...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0000000000000084
更新日期:2015-02-01 00:00:00
abstract:OBJECTIVE:To evaluate the accuracy of the YuWell YE680B oscillometric upper-arm blood pressure monitor for clinic and home blood pressure measurements in adults according to the American National Standards Institute/the Association for the Advancement of Medical Instrumentation/International Organization for Standardiz...
journal_title:Blood pressure monitoring
pub_type: 杂志文章
doi:10.1097/MBP.0000000000000405
更新日期:2019-12-01 00:00:00