Abstract:
:Tropaeolum majus L., popularly known as nasturtium, is a species widely used in the form of infusions and salads. In the last years, the antihypertensive, diuretic, and calcium and potassium sparing activities of T. majus preparations were shown. Moreover, no preclinical 90-day oral toxicity studies were conducted. Thus, this study evaluated the toxicity of the hydroethanolic extract obtained from T. majus (HETM) leaves in female and male mice, rats, and rabbits. Swiss mice and Wistar rats were treated with HETM (75, 375, and 750 mg/kg). The doses of rabbits (30, 150, and 300 mg/kg) were calculated by allometric extrapolation. The control groups received vehicle. The animals were orally treated, daily, for 90 days. At the end, the animals were anesthetized, and body weight gain, relative weight of liver, kidney, and spleen, and histopathological changes were evaluated. Serum hematological and biochemical parameters were also analyzed. No alterations were found in body and organ weights or in histopathological and biochemical evaluation. Hematological analyses revealed small changes in lymphocytes and neutrophil counts in rats after administration of 750 mg/kg of HETM. These results showed that 90-day use of T. majus is safe in rodents and lagomorphs.
journal_name
J Med Foodjournal_title
Journal of medicinal foodauthors
Araújo VO,Andreotti CEL,Reis MP,de Lima DA,Pauli KB,Nunes BC,Gomes C,Germano RM,Cardozo Junior EL,Gasparotto Junior A,Lourenço ELBdoi
10.1089/jmf.2017.0128subject
Has Abstractpub_date
2018-08-01 00:00:00pages
823-831issue
8eissn
1096-620Xissn
1557-7600journal_volume
21pub_type
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