Abstract:
OBJECTIVES:To analyse the learning curve for the management of tyrosine kinase inhibitors as the first line of treatment for patients with metastatic renal cancer. MATERIAL AND METHODS:We evaluated 32 consecutive patients treated in our department for metastatic renal cancer with tyrosine kinase inhibitors (pazopanib or sunitinib) as first-line treatment between September 2012 and November 2015. We retrospectively analysed this sample. We measured the time to the withdrawal of the first-line treatment, the time to progression and overall survival using Kaplan-Meier curves. The learning curve was analysed with the cumulative sum (CUSUM) methodology. RESULTS:In our series, the median time to the withdrawal of the first-line treatment was 11 months (95% CI 4.9-17.1). The mean time to progression was 30.4 months (95% CI 22.7-38.1), and the mean overall survival was 34.9 months (95% CI 27.8-42). By applying the CUSUM methodology, we obtained a graph for the CUSUM value of the time to withdrawal of the first-line treatment (CUSUM TW), observing 3 well-differentiated phases: phase 1 or initial learning phase (1-15), phase 2 (16-26) in which the management of the drug progressively improved and phase 3 (27-32) of maximum experience or mastery of the management of these drugs. The number of treated patients needed to achieve the proper management of these patients was estimated at 15. CONCLUSIONS:Despite the limitations of the sample size and follow-up time, we estimated (in 15 patients) the number needed to reach the necessary experience in the management of these patients with tyrosine kinase inhibitors. We observed no relationship between the time to the withdrawal of the first-line treatment for any cause and progression.
journal_name
Actas Urol Espjournal_title
Actas urologicas espanolasauthors
Lendínez-Cano G,Osman García I,Congregado Ruiz CB,Conde Sánchez JM,Medina López RAdoi
10.1016/j.acuro.2018.01.004subject
Has Abstractpub_date
2018-03-07 00:00:00eissn
0210-4806issn
1699-7980pii
S0210-4806(18)30026-3pub_type
杂志文章abstract:PURPOSE:Pulsed dye laser lithotripsy has shown to be an effective and safe procedure for treatment of ureteral calculi. We report our experience. MATERIAL AND METHODS:A total of 1000 patients were treated with pulsed dye laser between January 1990 and February 1996. In 450 patients the procedure was performed under ge...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:
更新日期:1999-01-01 00:00:00
abstract::We describe a case of urothelial carcinoma of renal pelvis in a 48 years old woman affected of autosomal dominant polycystic kidney disease (ADPKD). We discuss the difficulty of the radiological diagnostic and we revise the incidence of renal tumors in this entity. Association between urothelial carcinoma and ADPKD is...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
doi:10.1016/s0210-4806(07)73784-1
更新日期:2007-11-01 00:00:00
abstract::Contribution of one left renal adenocarcinoma in a 54-year old women, where the initial data was the finding of erythrocytosis discovered during routine laboratory tests performed by her gynaecologist. Review of the diagnostic and therapeutic procedures followed in this case, establishing a differentiation between ery...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:
更新日期:1992-05-01 00:00:00
abstract::Treatment of infiltrant vesical cancer has traditionally been the grounds for intense controversy. Transurethral resection (TUR) followed by high voltage radiotherapy (RT) in selected cases of locally advanced vesical urothelial tumours can be a valid alternative for the treatment of this condition. This paper disclos...
journal_title:Actas urologicas espanolas
pub_type: 临床试验,杂志文章
doi:
更新日期:1996-03-01 00:00:00
abstract:INTRODUCTION:The prognosis of patients diagnosed with metastatic prostate cancer seems to be modulated by factors such as the number and site of metastases. Our objective is to evaluate survival outcomes according to the number and site of metastases in our series of metastatic patients over the last 15 years. MATERIA...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/j.acuro.2016.09.004
更新日期:2017-05-01 00:00:00
abstract::Contribution of two cases of congenital adrenal hyperplasia by blockade in the 21-hydroxylase enzyme synthesis. Diagnosis was reached from the clinical signs and symptoms (virilization syndrome), and was confirmed by radiological and laboratory tests. Hormone treatment was done with hydrocortisone and fludrocortisone,...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:
更新日期:1995-02-01 00:00:00
abstract:INTRODUCTION:Open adenomectomy (OA) is the surgery of choice for large volume benign prostatic hyperplasia, and laparoscopic adenomectomy (LA) represents a minimally invasive alternative. We present a long-term, prospective study comparing both techniques. PATIENTS AND METHODS:The study consecutively included 199 pati...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/j.acuro.2016.04.008
更新日期:2017-01-01 00:00:00
abstract::There is an increasement on the incidence of tumours within the population of renal transplanted, from three to five times over general population. Related to urological tumours, it emphasizes an increase in the incidence of the renal carcinoma, around 4,7% against 3% on general population. In this case, we present a ...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/s0210-4806(09)74007-0
更新日期:2009-01-01 00:00:00
abstract:CONTEXT:Cervical cancer is the second most common tumor in women worldwide and due to diagnostic and therapeutic advances, the overall survival rates at 5 years is approaching 70%. Disorders in micturition, defecation, sexuality and quality of life have been described, frequently caused by different treatments. Address...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
doi:10.1016/j.acuro.2012.03.008
更新日期:2013-01-01 00:00:00
abstract:OBJECTIVES:The authors present a clinical report of an imperforate syringocele diagnosed on a male patient and treated by laparoscopic surgery. MATERIAL AND METHODS:A forty-four year old patient attends the emergency room with acute urinary retention. With a former history of mild obstructive voiding symptoms, he pres...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/s0210-4806(04)73125-3
更新日期:2004-07-01 00:00:00
abstract:OBJECTIVE:To analyse the differences in the postoperative period between bipolar and monopolar resection of the prostate in the endoscopic surgery of the benign prostatic hyperplasia. METHODS:45 patients were prospectively randomized. Twenty-one underwent monopolar resection (Storz Ch 26, 30 degrees) and 24 underwent ...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,随机对照试验
doi:10.1016/s0210-4806(06)73515-x
更新日期:2006-07-01 00:00:00
abstract::Presentation of one case of malignant fibrohistiocytoma derived from the renal capsule. While conducting a bibliographic review the low incidence of this tumoration of renal origin was noted. The difficulties in differentiating this entity from a secondary renal invasion by a malignant fibrohistiocytoma derived from o...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
doi:
更新日期:1996-09-01 00:00:00
abstract::Report case of a Wunderlich syndrome due to spontaneous rupture of a simple renal cyst. The patient is a 77-year old, hypertensive female who was on routine treatment with Aspirin. The rarity of retroperitoneal haemorrhage with this origin is documented; also the influence of aspirin as predisposing factor for this co...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:
更新日期:1998-04-01 00:00:00
abstract::We report on new case of a rare vesical tumour. We result the importance of immunohistochemistry and ultrastructural study to support the diagnosis of malignant fibrous histiocytoma of the urinary bladder. There has been described another 16 cases of this tumour in the literature, however, only four of them -five with...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/s0210-4806(00)72507-1
更新日期:2000-07-01 00:00:00
abstract::Sarcomatoid bladder carcinoma is a high-grade neoplasm and accounts for approximately 0,3% of all bladder malignancies. Sarcomatoid carcinoma originates from transitional cells of the bladder. Sarcomatoid carcinoma is charactericed by a epithelial component and a sarcomatoid component, consisting of spindle cells, tha...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/s0210-4806(09)74175-0
更新日期:2009-04-01 00:00:00
abstract::We report a case of a carcinoid tumor originated in testicle associated with mature teratoma in a 31 years old male. Primary gonadal location of this tumor is unusual, moreover when associated with teratoma. Early diagnosis and treatment determine the prognostic of the patients affected of this neoplasm since the only...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/s0210-4806(08)73863-4
更新日期:2008-04-01 00:00:00
abstract::Presentation of three cases of haemodialysis patients with acquired cystic renal disease (ACRD) who, over the course of their illness, developed clear cells renal carcinoma. The paper emphasizes the common association of these two entities and the need to consider ACRD cases as patients at high risk of developing rena...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:
更新日期:1992-07-01 00:00:00
abstract::We report the case of a 26 years old female who presented, as a casual finding, a right complete ureteral triplicity (probably Campbell's tipe I) with no other associated abnormalities. Despite ureteral duplication is a frequent urological anomaly, the presence of three ureters occurring in the same side, in a complet...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
doi:10.1016/s0210-4806(04)73179-4
更新日期:2004-11-01 00:00:00
abstract:INTRODUCTION:Gleason score biopsy undergrading (GSBU) can have an impact on the management and prognosis of patients with prostate cancer. We analyze the possible impact of time and other clinical and analytical factors in the appearance of GSBU in our series. PATIENTS AND METHOD:Ambispective, multicenter study of 195...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/j.acuro.2019.08.004
更新日期:2020-04-01 00:00:00
abstract:OBJECTIVES:Evaluation of a new mesh for incontinence (TVA/TOA) which enables the degree of tension applied during surgery to be readjusted at the post-operative stage. PATIENTS AND METHOD:62 patients treated with the TVA mesh and monitored over a 14-month period (SD 7.8, range 6-38). In 33 patients (53%) some other pe...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/s0210-4806(06)73422-2
更新日期:2006-02-01 00:00:00
abstract:OBJECTIVE:Analysis of the results of patients who had been operated of renal cell carcinoma with vascular invasion in our institution, evaluation of prognostic factors and complications. METHODS:Retrospective observational study of 37 patients diagnosed of renal cell carcinoma with vascular invasion operated between M...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/j.acuro.2016.06.007
更新日期:2017-03-01 00:00:00
abstract::Introduction of a new approach for uretero-ileal implantation when only one kidney is available. The technique follows the same approach as the Wallace-type re-implantation but in this case the uretero-ileal anastomosis plate is formed with the far en 2-3 cm of ureter. All cases performed with this technique have been...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/s0210-4806(00)72409-0
更新日期:2000-01-01 00:00:00
abstract::Contribution of one case of epidermoid carcinoma of the urethra in a 47-year old male with a several years old urethral stenosis. The significance of urethroscopy and the obtention of biopsies for diagnosis is emphasised. Also a review is made of the existing literature on the different therapeutical alternatives. ...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
doi:
更新日期:1998-09-01 00:00:00
abstract::Sling procedures have been around for decades in the management female stress urinary incontinence (SUI), but only in the past decade they have become the preferred technique. Minimally invasive procedures are the procedure of choice in many centers for your efficacy and low morbidity. The tendinous urethral support (...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/s0210-4806(07)73718-x
更新日期:2007-07-01 00:00:00
abstract:PURPOSE:To analyse the success of transvaginal urethrolysis in resolving voiding dysfunction in patients following an anti-incontinence procedure. MATERIALS AND METHODS:A retrospective chart review was performed on 20 patients who had undergone transvaginal urethrolysis for urethral obstruction following an anti-incon...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/s0210-4806(05)73224-1
更新日期:2005-02-01 00:00:00
abstract:AIMS:To describe the 3-year progression-free survival (PFS), overall survival (OS) and disease-specific mortality in the prospective prostate cancer GESCAP cohort, as well as the progression to castration resistance in patients on hormone therapy. MATERIAL AND METHODS:Prospective, observational, epidemiological, multi...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,多中心研究
doi:10.1016/j.acuro.2018.03.004
更新日期:2019-01-01 00:00:00
abstract:OBJECTIVE:To analyze the indications, results and complications of embolisation of a non-tolerated, non-functioning renal graft with regards to surgical transplantectomy. MATERIAL AND METHODS:Between 1990 and 1998, 55 patients with failed renal graft were studied. Patients had undergone either subcapsular transplantec...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/s0210-4806(00)72455-7
更新日期:2000-04-01 00:00:00
abstract:OBJECTIVE:To analyze the incidence of urological complications, like fistula and stenosis in our series of 282 renal transplants and their management. MATERIALS AND METHODS:Between December 1995 and October 2005, 282 adult recipients underwent renal transplant. The most common urological complication was urinary fistu...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:10.1016/s0210-4806(06)73503-3
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:To describe the surgical technique of AMS MiniArc swing system for the treatment of female urinary incontinence, evaluate its results and complications. METHOD:We performed a retrospective study of surgery with AMS Miniarc swing system. From august 2007 to march 2009, 135 patients with urinary incontinence (...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章
doi:
更新日期:2010-04-01 00:00:00
abstract::Pseudoaneurism in renal grafts is a well known complication of the percutaneous biopsy. Colour Doppler has been shown to be the choice technique for their diagnosis and subsequent control, the most effective treatment being embolization. This paper presents an unusual form of pseudoaneurism in terms of its size (up to...
journal_title:Actas urologicas espanolas
pub_type: 杂志文章,评审
doi:
更新日期:1998-03-01 00:00:00