[Thrombosis of the sinus durae matris as a complication of therapy in patients with Hodgkin lymphoma].

Abstract:

AIM:To describe thrombosis of the sinus durae matris (TSDM) in lymphomas. SUBJECTS AND METHODS:402 patients with Hodgkin lymphoma were treated using the BEACOPP-14 protocol in 2006 to 2013. Thrombotic events occurred in 6% of the patients, including 3 (0.8%) who developed brain magnetic resonance imaging-verified TSDM. RESULTS:TSDM developed in 3 women aged 17, 18, and 25 years during 3-6 chemotherapy cycles involving glucocorticosteroids in a dose of 80 mg/m2 on days 1-7 and an oral contraceptive used continuously for 1.5-3 months. The symptoms of thrombosis were severe headache; 2 patients had convulsive syndrome with short-term loss of consciousness. Anticoagulant therapy with intravenous heparin 20,000--24,000 U/day led to thrombus recanalization within 4-10 days. No rethromoboses were observed during a subsequent follow-up. CONCLUSION:The BEACOPP-14 treatment in young women with Hodgkin lymphoma who continuously take oral contraceptives should be combined with anticoagulant therapy, by monitoring their coagulogram.

journal_name

Ter Arkh

journal_title

Terapevticheskii arkhiv

authors

Shitareva IV,Moiseeva TN,Al'-Radi LS,Margolin OV,Khlavno AB,Iatsyk GA,Kravchenko SK

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

68-72

issue

7

eissn

0040-3660

issn

2309-5342

journal_volume

86

pub_type

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