Impact of hemophilia B on quality of life in affected men, women, and caregivers-Assessment of patient-reported outcomes in the B-HERO-S study.

abstract：PURPOSE:To estimate the clinical significance of low serum concentrations of mannose-binding lectin (MBL) in patients with acute myeloid leukaemia (AML) during initial cancer chemotherapy. PATIENTS AND METHODS:80 consecutive, newly diagnosed, and unselected AML patients (age 18-77 yr) undergoing remission induction ch...

journal_title：European journal of haematology

authors： Bergmann OJ,Christiansen M,Laursen I,Bang P,Hansen NE,Ellegaard J,Koch C,Andersen V

更新日期：2003-02-01 00:00:00

abstract：OBJECTIVES:To compare the gene expression pattern in children and adults with acute lymphoblastic leukaemia (ALL) in order to improve our understanding of the difference in disease biology and prognosis. METHODS:The gene expression profiles in diagnostic samples from 29 children and 15 adults with ALL were analysed us...

journal_title：European journal of haematology

authors： Kuchinskaya E,Heyman M,Grandér D,Linderholm M,Söderhäll S,Zaritskey A,Nordgren A,Porwit-Macdonald A,Zueva E,Pawitan Y,Corcoran M,Nordenskjöld M,Blennow E

更新日期：2005-06-01 00:00:00

abstract：:Propagation of the vaso-occlusive process in sickle cell anaemia (SCA) is a complex process involving the adhesion of steady-state SCA patients red cells and reticulocytes to the vascular endothelium. The effect of hydroxyurea therapy (HUT) on the adhesive properties of sickle cells and the expression of adhesion mole...

journal_title：European journal of haematology

authors： Gambero S,Canalli AA,Traina F,Albuquerque DM,Saad ST,Costa FF,Conran N

更新日期：2007-02-01 00:00:00

abstract：:Cobalamin levels are frequently low in patients with dementia, but it is unclear if they represent definable deficiency and what the mechanisms are. Therefore, patients being evaluated for dementia who had low cobalamin levels but no obvious evidence of deficiency were studied hematologically, neurologically and with ...

journal_title：European journal of haematology

authors： Carmel R,Gott PS,Waters CH,Cairo K,Green R,Bondareff W,DeGiorgio CM,Cummings JL,Jacobsen DW,Buckwalter G

更新日期：1995-04-01 00:00:00

abstract：OBJECTIVES:Imatinib (Glivec, STI571) has been successfully used in patients with chronic myelogenous leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome (Ph). We used imatinib interim therapy for four consecutive patients with newly diagnosed Ph+ acute myeloid leukemia (AML). We monitored the pat...

journal_title：European journal of haematology

authors： Cho BS,Kim HJ,Lee S,Eom KS,Min WS,Lee JW,Kim CC

更新日期：2007-08-01 00:00:00

abstract：:Mononuclear phagocytes play an important role in the regulation of hematopoiesis, not only by producing regulatory monokines such as prostaglandins, tumor necrosis factor and interleukin-1 (IL-1), but also by the production of colony-stimulating activity (CSA). Previously, we have demonstrated that granulocyte-macroph...

journal_title：European journal of haematology

authors： Fibbe WE,Kluck PM,Duinkerken N,Voogt PJ,Willemze R,Falkenburg JH

更新日期：1988-10-01 00:00:00

abstract：:Twenty-nine consecutive cases with a t(8;21)(q22;q22) in the bone marrow (BM) karyotype were retrospectively studied concerning clinical, morphological and cytogenetic data. All had been diagnosed as acute myeloid leukaemia (AML), 27 FAB subtype M2 and two M1, comprising 5% of all cytogenetically analysed AML during 1...

journal_title：European journal of haematology

authors： Billström R,Johansson B,Fioretos T,Garwicz S,Malm C,Zettervall O,Mitelman F

更新日期：1997-07-01 00:00:00

abstract：OBJECTIVES:Some patients with myelodysplastic syndrome (MDS) show a marked increase in the percentage of immature platelet fraction (IPF%) despite the absence of severe thrombocytopenia. To determine the significance of such an unbalanced increase in the IPF%, we investigated the IPF% and other laboratory findings of 5...

journal_title：European journal of haematology

authors： Sugimori N,Kondo Y,Shibayama M,Omote M,Takami A,Sugimori C,Ishiyama K,Yamazaki H,Nakao S

更新日期：2009-01-01 00:00:00

abstract：:The oncogenes c-myc and c-ras are known to elicit a cooperative tumorigenicity. In this study we investigated their role in the pathogenesis of Hodgkin's disease. The expression of these oncogenes was determined in Hodgkin's disease patients by avidin-biotin peroxidase complex immunohistochemical staining and was comp...

journal_title：European journal of haematology

authors： Benharroch D,Yermiahu T,Geffen DB,Prinsloo I,Gopas J,Segal S,Aboud M

更新日期：1995-09-01 00:00:00

abstract：OBJECTIVE:A new interleukin-6 (IL-6)-dependent plasma cell leukemia cell line UHKT-944 was established from bone marrow cells derived from a 55-yr-old man with plasma cell leukemia. RESULTS:The cell line possesses phenotypic characteristics of plasma cells including the production of a monoclonal immunoglobulin IgA1-k...

journal_title：European journal of haematology

authors： Vyhlídalová I,Uherková L,Pleschnerová M,Špička I,Březinová J,Michalová K,Čermáková K,Polanská V,Jedelský PL,Hamšíková E,Kuželová K,Stöckbauer P

更新日期：2015-10-01 00:00:00

abstract：:Tissue factor (TF) production is under strict control in mature monocytic cells. However, constitutive expression of TF can be found in myelomonocytic cells and in haematopoietic cells arrested at an early stage of differentiation. In this paper we show that TF expression is down-regulated during the monocyte/granuloc...

journal_title：European journal of haematology

authors： Tenno T,Oberg F,Nilsson K,Siegbahn A

更新日期：1999-08-01 00:00:00

abstract：:Despite a wide spectrum of treatment options, mantle cell lymphoma (MCL) remains a challenging hematologic malignancy to manage. Advances in front-line therapy, including the monoclonal antibody rituximab and increasing use of cytarabine, have improved remission rates. Autologous hematopoietic cell transplantation (HC...

journal_title：European journal of haematology

authors： Cohen JB,Burns LJ,Bachanova V

更新日期：2015-04-01 00:00:00

abstract：BACKGROUND:Most viral infections are known to exert adverse effects on bone marrow function. However, certain viruses have recently been found to be therapeutically beneficial in the treatment of some malignant disorders. METHODS AND MATERIALS:A retrospective study was conducted at the Armed Forces Hospital, Riyadh, S...

journal_title：European journal of haematology

authors： Al-Anazi KA,Al-Jasser AM,Evans DA

更新日期：2005-09-01 00:00:00

abstract：:Multiple myeloma (MM) is considered to be an essentially incurable haematological malignant disease, probably because of the existence of resistant clonal precursor cell with self-renewal capacity. Recent data have indicated that the myeloma cell hierarchy includes circulating clonal memory B cells, which differ consi...

journal_title：European journal of haematology

authors： Björkstrand B,Rasmussen T,Remes K,Gruber A,Pelliniemi TT,Johnsen HE

更新日期：2003-06-01 00:00:00

abstract：OBJECTIVES:An excessive intramedullar progenitor cell apoptosis, to which elevated expression of tumor necrosis factor-alpha (TNF-alpha) might contribute, is considered the main cause of inefficient hematopoiesis in myelodysplastic syndromes (MDS). Enhanced bone marrow (BM) angiogenesis is regarded as an essential cofa...

journal_title：European journal of haematology

authors： Stifter G,Heiss S,Gastl G,Tzankov A,Stauder R

更新日期：2005-12-01 00:00:00

abstract：:Implantation of Yoshida ascites sarcoma in rats was found to lead to a reduction in the hemoglobin content, the erythrocyte count and the packed cell volume of blood to 30% of normal in 4 d; however, there was no decrease in the mean cell hemoglobin, the mean cell volume and the mean corpuscular hemoglobin concentrati...

journal_title：European journal of haematology

authors： Bhanushali AA,Raghunathan R,Kalraiya RD,Mehta NG

更新日期：2002-01-01 00:00:00

abstract：:Cardiac disease is the primary cause of mortality in beta-thalassemia patients. Except for ventricular dysfunction and pulmonary hypertension that represent the main forms of heart disease in these patients, valvular abnormalities including valvular regurgitation, endocardial thickening and calcification and mitral va...

journal_title：European journal of haematology

authors： Farmakis D,Deftereos S,Giakoumis A,Polymeropoulos E,Aessopos A

更新日期：2004-04-01 00:00:00

abstract：:Immunoglobulin gene rearrangements in B-cell lymphoma subtypes may not always be detected by PCR if only one primer set is applied. We therefore analysed a range of low and high grade B-cell lymphoma subtypes for monoclonality using PCR, to determine appropriate primer selection strategies for routine diagnostic use. ...

journal_title：European journal of haematology

authors： Essop MF,Blakolmer K,Close PM,Manuel YE,Cornelius S

更新日期：1997-09-01 00:00:00

abstract：:The European LeukemiaNet (ELN) is composed of several work packages, four of them being directly involved in the various aspects of diagnosis. On the occasion of the annual ELN meeting of 2015 in Mannheim, these four work packages collectively examined the current situation and future prospects of cytomorphology, flow...

journal_title：European journal of haematology

authors： Béné MC,Grimwade D,Haferlach C,Haferlach T,Zini G,European LeukemiaNet.

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:The objective of this study was to evaluate the kinetics of molecular response in chronic myeloid leukemia (CML) patients treated with imatinib and to compare between the fluorescent in situ hybridization (FISH), multiplex and real-time quantitative RT-PCR (RQ-PCR) methods with this respect. METHODS:Molecula...

journal_title：European journal of haematology

authors： Raanani P,Ben-Bassat I,Gan S,Trakhtenbrot L,Mark Z,Ashur-Fabian O,Itskovich S,Brok-Simoni F,Rechavi G,Amariglio N,Nagler A

更新日期：2004-10-01 00:00:00

abstract：:There are established guidelines for treatment and monitoring of chronic myeloid leukemia (CML) but little is known about routine care. Data on ICD-10 codes as well as prescribed medications were available for 10.5 million patients in the statutory health insurance system in Bavaria for the years 2010 to 2016. Also, d...

journal_title：European journal of haematology

authors： Lauseker M,Gerlach R,Worseg W,Haferlach T,Tauscher M,Hasford J,Hoffmann VS

更新日期：2019-10-01 00:00:00

abstract：:The fate of polymorphonuclear neutrophilic granulocytes (PMN) after their mobilization from the bone marrow of healthy individuals is not clearly understood. It has been suggested that there is a continuous utilization of these cells in widespread, subclinical inflammatory foci, where they are ultimately degraded. The...

journal_title：European journal of haematology

authors： Løvås K,Knudsen E,Iversen PO,Benestad HB

更新日期：1996-04-01 00:00:00

abstract：:Flow cytometry (FCM) has gained wide use in the determination of clonality in B-cell lymphoproliferative diseases and many methodological variations exist. We have compared the suitability of a) dual fluorochrome (FITC/PE)-labelled monoclonal antibodies, b) single fluorochrome (FITC)-labelled monoclonal antibodies and...

journal_title：European journal of haematology

authors： Agrawal YP,Hämäläinen E,Mahlamäki EK,Aho H,Nousianinen T,Lahtinen R,Penttilä IM

更新日期：1992-01-01 00:00:00

abstract：INTRODUCTION:Increased levels of Wilms' tumor (WT1) mRNA have been used to establish risk categories in patients with acute myeloid leukemia (AML). Raised values of WT1 have been associated with progression in myelodysplastic syndrome (MDS). METHODS:We retrospectively analyzed the available bone marrow (BM) samples fr...

journal_title：European journal of haematology

authors： Santaliestra M,Garrido A,Carricondo M,Bussaglia E,Pratcorona M,Blanco ML,Gich I,Hoyos M,Esquirol A,García-Cadenas I,Brunet S,Martino R,Sierra J,Nomdedéu JF

更新日期：2019-09-01 00:00:00

abstract：:A murine cultured cell line (MKM-O) was established from a tumor of a BALB/C (nu/nu) mouse that had been subcutaneously inoculated with human hepatoma tissue fragments in the same location. The MKM-O cell line was proven to be of endothelial origin by morphological examinations and positive staining with fluorescein-l...

journal_title：European journal of haematology

authors： Yoshimura T,Miyanomae T,Tanaka M,Iwai Y,Mayumi M,Mikawa H

更新日期：1987-08-01 00:00:00

abstract：:We previously reported an increased risk of monoclonal gammopathy of undetermined significance (MGUS) in first-degree relatives of MGUS and multiple myeloma patients. Here, we examine whether primary cytogenetic categories of myeloma differ between patients with and without a family history of MGUS or myeloma. We stud...

journal_title：European journal of haematology

authors： Greenberg AJ,Cousin M,Kumar S,Ketterling RP,Knudson RA,Larson D,Colby C,Scott C,Vachon CM,Rajkumar SV

更新日期：2013-09-01 00:00:00

abstract：AIM:This review summarises the importance, recent progress and issues in measuring patient-reported outcomes (PROs) in haemophilia research. METHODS:A critical review of recent advances and trends in measuring haemophilia-related PROs was conducted, using current regulatory guidelines and methodological recommendation...

journal_title：European journal of haematology

authors： Pocoski J,Benjamin K,Michaels LA,Flood E,Sasane R

更新日期：2014-06-01 00:00:00

abstract：:The β⁰-thalassemia/Hb-E causes a wide range of severe conditions. A high medical cost is incurred in severe cases. Thus, the prevention of new cases of β⁰-thalassemia/Hb-E is required. The aim of this study is to use the SYTO9 and SYBR GREEN1 high-resolution melting (HRM) analysis for prenatal diagnosis of β⁰-thalasse...

journal_title：European journal of haematology

authors： Pornprasert S,Sukunthamala K

更新日期：2010-11-01 00:00:00

abstract：:We tested the immunosuppressive effect of cord blood (CB) natural killer (NK) cells using highly purified CB NK cells in mixed lymphocyte cultures (MLC) containing autologous CB T cells as responders. Control cultures were done without NK cells. Our findings revealed that CB NK cells induced a dose-dependent inhibitio...

journal_title：European journal of haematology

authors： El Marsafy S,Dosquet C,Coudert MC,Bensussan A,Carosella E,Gluckman E

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:To correlate different polymorphisms of the beta-globin cluster with fetal hemoglobin (HbF) level in beta-thalassemia and E-beta thalassemia patients. METHODS:Fifteen thalassemia patients, seven with high HbF and not requiring transfusion, eight with lower HbF and requiring transfusion were studied for beta-...

journal_title：European journal of haematology

authors： Bandyopadhyay S,Mondal BC,Sarkar P,Chandra S,Das MK,Dasgupta UB

更新日期：2005-07-01 00:00:00