Abstract:
BACKGROUND:Obesity is a worldwide disease related to genetic, environmental, and behavioral factors, and it is associated with high rates of morbidity and mortality. Recently, obesity has been characterized by a low-grade inflammatory state known as inflammome indicated by chronic increases in circulating concentrations of inflammatory markers. The purpose of this study was to evaluate the effect of weight loss induced by surgery for obesity and weight-related diseases on pro-inflammatory cytokine (TNF-α) and anti-inflammatory adipokine (adiponectin) levels, and on an adipose-derived hormone (leptin) in severely obese subjects. METHODS:This randomized, controlled trial involved 55 severe obese patients (50 women, age 18-63 years, and body mass index of 35.7-63 kg/m2) who underwent bariatric surgery (BS). Patients with a BMI > 65 kg/m2 and clinical and mental instability, or significant and unrealistic expectations of surgery were excluded. Blood samples were collected during the fasting period to analyze tumor necrosis factor alpha (TNF-α), adiponectin, and leptin levels by enzyme-linked immunosorbent assay. RESULTS:At baseline, no significant difference was observed in the anthropometric, demographic, clinical characteristics and biochemistry and inflammatory markers between the control group (CG) and bariatric surgery group (BSG). The same finding was also observed when we compared the baseline variables to those at the 6-month follow-up in the CG. However, the same variables in the BSG group were significantly different between baseline and the 6-month follow-up after BS. CONCLUSIONS:Weight loss induced by surgery for obesity and weight-related diseases reduced the inflammome state in severely obese patients.
journal_name
Obes Surgjournal_title
Obesity surgeryauthors
Freitas WR Jr,Oliveira LVF,Perez EA,Ilias EJ,Lottenberg CP,Silva AS,Urbano JJ,Oliveira MC Jr,Vieira RP,Ribeiro-Alves M,Alves VLS,Kassab P,Thuler FR,Malheiros CAdoi
10.1007/s11695-017-3104-9subject
Has Abstractpub_date
2018-07-01 00:00:00pages
1931-1942issue
7eissn
0960-8923issn
1708-0428pii
10.1007/s11695-017-3104-9journal_volume
28pub_type
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