Abstract:
:A new consensus-based classification of congenital melanocytic nevi (CMN) has recently been proposed. It includes categories for projected adult size (PAS) and location, satellite nevi counts, and morphologic characteristics (color heterogeneity, rugosity, nodularity, and hypertrichosis). The objective of the current study was to test the applicability of the new categorization scheme and to correlate classification outcome with the patient's history of melanoma and neurocutaneous melanocytosis (NCM). Children and adults with CMN attending a patient conference in Dallas, Texas, in 2012 were invited to participate in the study. Anamnestical data were collected using a standardized questionnaire. Two dermatologists performed clinical examinations. Of 45 patients enrolled, 33 had a giant CMN (G1 [>40 cm PAS], n = 13; G2 [>60 cm PAS], n = 20), 12 had an NCM (5 symptomatic, 7 asymptomatic), and 1 had a history of melanoma. CMN size was positively correlated with NCM (p < 0.05). The classification system allowed an easy and detailed phenotypic characterization of each individual CMN. CMN size and morphology were difficult to assess in patients after surgical removal, and the number of satellite nevi at birth or during infancy was not always known. Our report provides practical aids for the application of the newly proposed CMN classification. Prospective evaluation of accurately classified patients in CMN registries will reveal the predictive value of the scheme. The small study sample limits meaningful conclusions regarding the correlation between CMN parameters and the risk of NCM and melanoma.
journal_name
Pediatr Dermatoljournal_title
Pediatric dermatologyauthors
Price HN,O'Haver J,Marghoob A,Badger K,Etchevers H,Krengel Sdoi
10.1111/pde.12428subject
Has Abstractpub_date
2015-01-01 00:00:00pages
23-7issue
1eissn
0736-8046issn
1525-1470journal_volume
32pub_type
指南,杂志文章abstract::An increased number of melanocytic nevi and lentigines have been reported in patients with two types of autosomal recessive congenital ichthyosis (ARCI): lamellar ichthyosis and nonbullous congenital ichthyosiform erythroderma. These melanocytic lesions may have clinical and dermoscopic features of atypia, necessitati...
journal_title:Pediatric dermatology
pub_type:
doi:10.1111/pde.14066
更新日期:2020-01-01 00:00:00
abstract::An 8-year-old boy developed a sudden mahogany discoloration of his skin after exposure to defensive secretions of a millipede. The mechanisms and the composition of the secretion and other clinical features are briefly reviewed. ...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.1991.tb00834.x
更新日期:1991-03-01 00:00:00
abstract::Pyoderma gangrenosum (PG) is an inflammatory neutrophilic dermatosis that may present with limited to severe disease, posing a therapeutic challenge. A 7-year-old African female who presented with extensive PG showed a remarkable response to corticosteroid wrap monotherapy. ...
journal_title:Pediatric dermatology
pub_type:
doi:10.1111/pde.14348
更新日期:2020-09-06 00:00:00
abstract::Accessory tragus is a fairly common congenital malformation of the external ear. In the vast majority of cases it is an isolated developmental defect not associated with other abnormalities. However, the remote possibility exists that it could be associated with other abnormalities of the first and second branchial ar...
journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
doi:10.1046/j.1525-1470.2000.017005391.x
更新日期:2000-09-01 00:00:00
abstract::We describe a bullous-hemorrhagic reaction of the ear lobes in a child with nephrosis after levamisole intake. This drug is used in children as an alternative treatment of corticosteroid-responsive nephrotic syndrome. Histologic evaluation of a lesion revealed necrotizing vasculitis involving mainly the large vessels ...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.1997.tb00695.x
更新日期:1997-11-01 00:00:00
abstract::Sixty novice Buddhist monks with tinea capitis confirmed according to clinical presentation and mycological laboratory finding were included in this study. Mixed-type clinical presentation was observed in approximately half of all cases, together with scarring alopecia (95%) and superficial fungal skin infection at lo...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/pde.13102
更新日期:2017-05-01 00:00:00
abstract::Clinical aspects of sequestrated meningocele can be varied, causing difficulties in histopathological diagnosis. The meningeal tissue is scanty and appears as nonspecific connective tissue, therefore it may be overlooked. One classical and two unusual clinical presentations of sequestrated meningocele are described: o...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.1994.tb00095.x
更新日期:1994-12-01 00:00:00
abstract::Although acne vulgaris is common in preadolescents (<13 yrs), few acne treatments are currently approved for children. This study assessed the safety and efficacy of tretinoin microsphere gel (TMG) 0.04% pump in children aged 9-11 with acne vulgaris. In this multicenter, randomized, double-blind, vehicle-controlled pi...
journal_title:Pediatric dermatology
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1111/j.1525-1470.2012.01811.x
更新日期:2012-09-01 00:00:00
abstract::Papular epidermal nevus with "skyline" basal cell layer (PENS), a variant of epidermal nevus, was recently described in otherwise normal children. We describe herein a patient with multiple, typical PENS lesions associated with peculiar facies, bilateral Achilles tendon shortening, and mild psychomotor delay. The asso...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2012.01830.x
更新日期:2013-07-01 00:00:00
abstract::Case of an 18-month-old child with congenital lymphedema subsequently diagnosed with tuberous sclerosis and Hirschsprung disease. ...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2010.01231.x
更新日期:2011-03-01 00:00:00
abstract::A 4-month-old female infant presented with widespread pyoderma gangrenosum associated with stridor, presumed secondary to tracheal involvement. No underlying cause was revealed despite extensive investigation. Treatment with immunosuppressive agents only partially suppressed disease activity. Complete resolution follo...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2008.00825.x
更新日期:2009-01-01 00:00:00
abstract::A 3 year-old boy presented to our clinic with a 3-day history of itchy rash involving the face and limbs and recent contact with a caterpillar. A diagnosis of caterpillar dermatitis was suspected. This condition has rarely been reported and may be underestimated in the pediatric population who may suffer more systemic...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/pde.14126
更新日期:2020-05-01 00:00:00
abstract::Alopecia areata (AA) involves the immune-related destruction of hair follicles, resulting in patches of complete hair loss, most often on the scalp. The topical sensitizer squaric acid dibutylester (SADBE) is a popular treatment option given its low side-effect profile, hair regrowth potential, and lack of cross-react...
journal_title:Pediatric dermatology
pub_type:
doi:10.1111/pde.12993
更新日期:2017-01-01 00:00:00
abstract::Lindane (gamma benzene hexachloride) is a widely prescribed topical scabicide because of its efficacy and cost-effectiveness. Although toxicity from a single proper application of lindane is generally not observed, the hazards of repeated applications, industrial exposure, and accidental ingestion have been well docum...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.0736-8046.2004.21515.x
更新日期:2004-09-01 00:00:00
abstract::A 17-year-old woman with Cornelia de Lange syndrome had asymptomatic skin lesions since the age of 4 years. These were multiple, follicular, horny papules, present on both cheeks, and surrounded by erythematous skin. Similar lesions were present on the external aspect of the arms, but amidst skin of normal coloration....
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1046/j.1525-1470.2002.00003.x
更新日期:2002-01-01 00:00:00
abstract::Childhood granulomatous periorificial dermatitis (CGPD) is a condition included in the spectrum of rosacea and perioral dermatitis that affects prepubescent children. It is characterized by papular eruptions located around the mouth, nose, and eyes that histopathologically show a granulomatous pattern. We report a 9-y...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/pde.12110
更新日期:2013-09-01 00:00:00
abstract::Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a type of skin lymphoma. Pleomorphic T-cells infiltrate the subcutaneous tissue and mimic lobular panniculitis. We report a case occurring in a 12-year-old Chinese boy who presented with multiple indolent erythematous subcutaneous nodules on both extremities wi...
journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
doi:10.1111/pde.12452
更新日期:2015-07-01 00:00:00
abstract::Generalized chronic cutaneous lupus including lupus panniculitis in childhood is rare and usually occurs in the setting of genetic complement deficiencies. The association with antiphospholipid syndrome is even more rare. We report a 13-year-old girl with extensive lupus panniculitis since the age of 8 months and no e...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1046/j.1525-1470.1999.00060.x
更新日期:1999-07-01 00:00:00
abstract::Dyskeratosis congenita (DC) is an unusual inherited disease characterized by the triad of mucosal leukoplakia, nail dystrophy, and skin pigmentation. Hyperkeratosis of the palms and soles is another reported skin finding. This hyperkeratosis can lead to fissures, chronic erosion, and deep ulcerations. These atypical w...
journal_title:Pediatric dermatology
pub_type:
doi:10.1111/pde.14316
更新日期:2020-11-01 00:00:00
abstract::Mutations in the keratinocyte lipid transporter adenosine triphosphate-binding cassette A12 (ABCA12) are known to cause harlequin ichthyosis. More recently, mutations in this gene have been demonstrated to cause other phenotypes within the spectrum of recessive congenital ichthyosis. We report the case of an infant wi...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2011.01695.x
更新日期:2013-11-01 00:00:00
abstract::We treated a 5-year-old boy with clear-cell hidradenoma of the forearm. Our literature search found only one previous report of this disease occurring during the first decade of life, and the present patient is the first with involvement of the limbs. This presentation demonstrates that clear-cell hidradenoma needs to...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2005.00115.x
更新日期:2005-09-01 00:00:00
abstract::Molluscum contagiosum is a common viral infection of the skin that frequently affects children. Lesions take between 6 and 18 months to resolve spontaneously and are a source of great embarrassment to both caretakers and children, often affecting attendance at school and limiting social activity. Treatment options to ...
journal_title:Pediatric dermatology
pub_type: 杂志文章,随机对照试验
doi:10.1111/j.1525-1470.2006.00235.x
更新日期:2006-05-01 00:00:00
abstract::Discoid lupus erythematosus (DLE) is the most common variant of cutaneous chronic lupus erythematosus (CLE). Sun protection, topical corticosteroids, and antimalarials constitute the first-line options for treatment. In refractory cases, alternative antimalarials, methotrexate, retinoids, and thalidomide have been uti...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/pde.14067
更新日期:2020-01-01 00:00:00
abstract::Demodex mites are commensal inhabitants of the pilosebaceous unit that are typically absent or at low numbers in childhood. When they are present, they can cause a primary eruption or exacerbate an underlying facial dermatosis. Here we report five cases of demodicosis occurring in childhood, the clinical presentations...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/pde.13852
更新日期:2019-09-01 00:00:00
abstract::We describe the case of a 7-year-old boy with urticaria, fever, and arthritis that appeared 10 days after starting cefditoren therapy for acute tonsillopharyngitis, which was diagnosed as a serum sickness-like reaction due to this medication. ...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2011.01539.x
更新日期:2012-05-01 00:00:00
abstract::Circumscribed juvenile pityriasis rubra pilaris (PRP) is an uncommon dermatosis. We describe the unusual clustering of circumscribed juvenile PRP cases in our pediatric dermatology clinic in 2011. A retrospective chart review was done of patients presenting during the summer of 2011 with classic findings of circumscri...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/pde.12260
更新日期:2014-03-01 00:00:00
abstract:BACKGROUND/OBJECTIVES:Port-wine stains, also known as capillary malformations, are due to dermal vascular ectasia and dilation and are most commonly congenital; however, acquired port-wine stains (APWS) developing later in life have been noted in the literature, most commonly in the context of trauma. METHODS/RESULTS:...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/pde.14019
更新日期:2020-01-01 00:00:00
abstract::Two hundred and sixty-eight children with pediculosis capitis took part in a comparative study to test the efficacy of five different pediculocides commonly used in Israel. The preparations used were pyrethrin shampoo, pyrethroid spray, malathion solution, carbaryl shampoo and carbaryl lotion. Carbaryl lotion and mala...
journal_title:Pediatric dermatology
pub_type: 临床试验,杂志文章
doi:10.1111/j.1525-1470.1988.tb00903.x
更新日期:1988-11-01 00:00:00
abstract::The present study aimed to investigate the prevalence of atopic dermatitis in primary schoolchildren in Denizli, Turkey, and to determine the possible risk factors for atopic dermatitis in home environment. A self-administered questionnaire was handled to the parents of 2,100 children aged 7 to 15 years, from three ra...
journal_title:Pediatric dermatology
pub_type: 杂志文章
doi:10.1111/j.1525-1470.2008.00697.x
更新日期:2008-05-01 00:00:00
abstract::Many supplements and products containing botanical extracts are marketed to patients for the treatment of acne vulgaris. Additionally, increasing attention has been paid to the role of diet in acne vulgaris. Studies on this topic including pediatric patients are limited, with variable efficacy data. Despite these limi...
journal_title:Pediatric dermatology
pub_type: 杂志文章,评审
doi:10.1111/pde.13904
更新日期:2019-09-01 00:00:00