Abstract:
:Congenital heart defect (CHD) represents the most prevalent birth defect, and accounts for substantial morbidity and mortality in humans. Aggregating evidence demonstrates the genetic basis for CHD. However, CHD is a heterogeneous disease, and the genetic determinants underlying CHD in most patients remain unknown. In the present study, a cohort of 186 unrelated cases with CHD and 300 unrelated control individuals were recruited. The coding exons and flanking introns of the MEF2C gene, which encodes a transcription factor crucial for proper cardiovascular development, were sequenced in all study participants. The functional effect of an identified MEF2C mutation was characterized using a dual-luciferase reporter assay system. As a result, a novel heterozygous MEF2C mutation, p.R15C, was detected in an index patient with congenital double outlet right ventricle (DORV) as well as ventricular septal defect. Analysis of the proband's pedigree showed that the mutation co-segregated with CHD with complete penetrance. The missense mutation, which changed the evolutionarily conserved amino acid, was absent in 300 control individuals. Functional deciphers revealed that the mutant MEF2C protein had a significantly decreased transcriptional activity. Furthermore, the mutation significantly reduced the synergistic activation between MEF2C and GATA4, another transcription factor linked to CHD. This study firstly associates MEF2C loss-of-function mutation with DORV in humans, which provides novel insight into the molecular pathogenesis of CHD, suggesting potential implications for genetic counseling and personalized treatment of CHD patients.
journal_name
Pediatr Cardioljournal_title
Pediatric cardiologyauthors
Lu CX,Wang W,Wang Q,Liu XY,Yang YQdoi
10.1007/s00246-018-1822-ysubject
Has Abstractpub_date
2018-04-01 00:00:00pages
794-804issue
4eissn
0172-0643issn
1432-1971pii
10.1007/s00246-018-1822-yjournal_volume
39pub_type
杂志文章abstract::It is unclear if neonatal tetralogy of Fallot repair offers better outcomes compared to repair later in infancy. We therefore conducted a meta-analysis comparing outcomes of neonatal and non-neonatal repair. Manuscripts were identified and reviewed for quality and bias with favorably scored manuscripts being included ...
journal_title:Pediatric cardiology
pub_type: 杂志文章,meta分析,评审
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更新日期:2017-06-01 00:00:00
abstract::We herein describe, for the first time, the fetal presentation of a case of ventricular inversion, restrictive ventricular septal defect, pulmonary stenosis, hypertensive left ventricle and double outlet right ventricle at 34 weeks of gestational age. Postnatal echocardiography confirmed the prenatal diagnosis. The pa...
journal_title:Pediatric cardiology
pub_type: 杂志文章,评审
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journal_title:Pediatric cardiology
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journal_title:Pediatric cardiology
pub_type: 杂志文章
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更新日期:1982-01-01 00:00:00
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journal_title:Pediatric cardiology
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journal_title:Pediatric cardiology
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Pediatric cardiology
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doi:10.1007/s00246-019-02224-x
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journal_title:Pediatric cardiology
pub_type: 杂志文章
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journal_title:Pediatric cardiology
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journal_title:Pediatric cardiology
pub_type: 杂志文章
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更新日期:2001-09-01 00:00:00
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journal_title:Pediatric cardiology
pub_type: 杂志文章
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journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-012-0526-y
更新日期:2013-03-01 00:00:00
abstract::Congenital heart defects (CHDs) are the most prevalent of all birth defects and the leading cause of death in the first year of life. The molecular causes of most CHDs remain largely unknown. The LIM homeodomain transcriptor factor ISL1 is a marker for undifferentiated cardiac progenitor cells that give rise to both t...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-012-0578-z
更新日期:2013-04-01 00:00:00
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journal_title:Pediatric cardiology
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doi:10.1007/s00246-009-9626-8
更新日期:2010-05-01 00:00:00
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journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-009-9595-y
更新日期:2010-02-01 00:00:00
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journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-012-0606-z
更新日期:2013-06-01 00:00:00
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journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s002460010264
更新日期:2001-09-01 00:00:00
abstract::At the University of California Davis Medical Center, a screening fetal ultrasound examination (level I or II) incorporates a comprehensive segmental evaluation of the fetal heart. This study evaluated the reliability of the fetal ultrasound exam in the detection of abnormal heart anatomy. Our retrospective study revi...
journal_title:Pediatric cardiology
pub_type: 杂志文章
doi:10.1007/s00246-001-0073-4
更新日期:2002-11-01 00:00:00
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journal_title:Pediatric cardiology
pub_type: 杂志文章
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journal_title:Pediatric cardiology
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journal_title:Pediatric cardiology
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journal_title:Pediatric cardiology
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journal_title:Pediatric cardiology
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journal_title:Pediatric cardiology
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doi:10.1007/s00246-005-1150-x
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journal_title:Pediatric cardiology
pub_type: 杂志文章,评审
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journal_title:Pediatric cardiology
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更新日期:2002-01-01 00:00:00
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journal_title:Pediatric cardiology
pub_type: 杂志文章
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