Novel strategy for biofilm inhibition by using small molecules targeting molecular chaperone DnaK.

abstract：:Nine carbapenem-resistant Enterobacteriaceae isolates collected from eight patients in five German hospitals were investigated. Six isolates produced the OXA-48 carbapenemase, and three isolates produced OXA-162, which is a point mutant form of OXA-48. Both carbapenemase genes were located on IncL/M-type conjugative p...

journal_title：Antimicrobial agents and chemotherapy

authors： Pfeifer Y,Schlatterer K,Engelmann E,Schiller RA,Frangenberg HR,Stiewe D,Holfelder M,Witte W,Nordmann P,Poirel L

更新日期：2012-04-01 00:00:00

abstract：:Streptonigrin, a quinone antitumor antibiotic, has been reported to be effective in human trials. A sensitive and precise microbiological assay for the determination of distribution and concentrations of streptonigrin in the body fluids and tissues of treated mice has been developed in an attempt to supplement success...

journal_title：Antimicrobial agents and chemotherapy

authors： Pittillo RF,Woolley C

更新日期：1974-01-01 00:00:00

abstract：:A case of Mycobacterium leprae rifampin resistance after irregular antileprosy treatments since 1971 is reported. Whole-genome sequencing from four longitudinal samples indicated relapse due to acquired rifampin resistance and not to reinfection with another strain. A putative compensatory mutation in rpoC was also de...

journal_title：Antimicrobial agents and chemotherapy

authors： Avanzi C,Maia RC,Benjak A,Nery JA,Sales AM,Miranda A,Duppre NC,Nogueira Brum Fontes A,Pereira da Silva T,Olmo Pinheiro R,Neves-Manta F,Moreira SJM,Busso P,Sarno EN,Suffys PN,Cole ST,Moraes MO

更新日期：2020-06-23 00:00:00

abstract：:Induction of the cloned ampC Citrobacter freundii beta-lactamase in Escherichia coli by 6-aminopenicillanic acid was prevented by periplasmic TEM beta-lactamase in the same cell. In contrast, cytoplasmic TEM beta-lactamase did not prevent induction. This result implies that entry of the beta-lactam into the cytoplasm ...

journal_title：Antimicrobial agents and chemotherapy

authors： Everett MJ,Chopra I,Bennett PM

更新日期：1990-12-01 00:00:00

abstract：:UK-18892 is a new aminoglycoside antibiotic, a derivative of kanamycin A structurally related to amikacin. It was found to be active against a wide range of pathogenic bacteria, including many gentamicin-resistant strains. The spectrum and degree of activity of UK-18892 were similar to those of amikacin, and differenc...

journal_title：Antimicrobial agents and chemotherapy

authors： Wise R,Andrews JM

更新日期：1978-08-01 00:00:00

abstract：:Lipopolysaccharide (LPS) samples isolated from a parent and two antibiotic-hypersusceptible mutant strains of Escherichia coli were analyzed for polycation affinity and level of binding. Purified salts of the LPSs from the parent strain, UB1005, and from one of the mutant strains, DC1, bound similar amounts of sodium ...

journal_title：Antimicrobial agents and chemotherapy

authors： Rocque WJ,Fesik SW,Haug A,McGroarty EJ

更新日期：1988-03-01 00:00:00

abstract：:Kill-kinetic methods were used to provide data on the bactericidal activity of subinhibitory (0.5x MIC), inhibitory (1x MIC), and suprainhibitory (4x MIC) concentrations of LY146032 against methicillin-susceptible and -resistant Staphylococcus aureus and Staphylococcus epidermidis. These bactericidal activities were c...

journal_title：Antimicrobial agents and chemotherapy

authors： Stratton CW,Liu C,Weeks LS

更新日期：1987-08-01 00:00:00

abstract：:The aims of the study were to investigate the prevalence of azole resistance among Aspergillus fumigatus clinical isolates. A total of 533 clinical isolates that had been collected between 1995 and 2006, from 441 patients, were screened. No resistance was detected in isolates collected between 1995 and 1997. Starting ...

journal_title：Antimicrobial agents and chemotherapy

authors： Lazzarini C,Esposto MC,Prigitano A,Cogliati M,De Lorenzis G,Tortorano AM

更新日期：2015-11-09 00:00:00

abstract：:The in vitro and in vivo activities of a mixture of six oleane triterpene saponins, recovered from the methanolic extract of the leaves of the Vietnamese plant Maesa balansae (PX-6518), were evaluated against drug-sensitive visceral Leishmania strains. The in vitro 50% inhibitory concentration (IC(50)) against intrace...

journal_title：Antimicrobial agents and chemotherapy

authors： Maes L,Vanden Berghe D,Germonprez N,Quirijnen L,Cos P,De Kimpe N,Van Puyvelde L

更新日期：2004-01-01 00:00:00

abstract：:Platelet microbicidal proteins (PMPs), small cationic peptides released at sites of endovascular damage, kill common bloodstream pathogens in vitro. Our group previously showed that in vitro resistance of clinical staphylococcal and viridans group streptococcal bacteremic strains to PMPs correlated with the diagnosis ...

journal_title：Antimicrobial agents and chemotherapy

authors： Bayer AS,Cheng D,Yeaman MR,Corey GR,McClelland RS,Harrel LJ,Fowler VG Jr

更新日期：1998-12-01 00:00:00

abstract：:We recently reported that in lung tissue, thioridazine accumulates at high concentrations relative to serum levels, displaying modest synergy with isoniazid and reducing the emergence of isoniazid-resistant mutants in mouse lungs. In this study, we sought to investigate the sterilizing activity of human-equivalent dos...

journal_title：Antimicrobial agents and chemotherapy

authors： Dutta NK,Pinn ML,Karakousis PC

更新日期：2014-09-01 00:00:00

abstract：:The accumulation of OPC-17116 by human polymorphonuclear leukocytes was studied by comparison with three other new quinolones, ofloxacin, levofloxacin, and DR-3354. The intracellular/extracellular concentration ratio was the highest for OPC-17116, being 66.2, followed by 9.8 for levofloxacin, 7.6 for ofloxacin, and 5....

journal_title：Antimicrobial agents and chemotherapy

authors： Taira K,Koga H,Kohno S

更新日期：1993-09-01 00:00:00

abstract：:Omadacycline is a first-in-class aminomethylcycline antibiotic with microbiological activity against Gram-positive and Gram-negative aerobes and anaerobes and atypical bacteria that is being developed for the treatment of acute bacterial skin and skin structure infections (ABSSSI) and community-acquired bacterial pneu...

journal_title：Antimicrobial agents and chemotherapy

authors： Sun H,Ting L,Machineni S,Praestgaard J,Kuemmell A,Stein DS,Sunkara G,Kovacs SJ,Villano S,Tanaka SK

更新日期：2016-11-21 00:00:00

abstract：:Ethambutol (EMB) is a major component of the first-line therapy of tuberculosis. Mutations in codon 306 of embB (embB306) were suggested as a major resistance mechanism in clinical isolates. To directly analyze the impact of individual embB306 mutations on EMB resistance, we used allelic exchange experiments to genera...

journal_title：Antimicrobial agents and chemotherapy

authors： Plinke C,Walter K,Aly S,Ehlers S,Niemann S

更新日期：2011-06-01 00:00:00

abstract：:Enzymes in the ergosterol-biosynthetic pathway are the targets of a number of antifungal agents including azoles, allylamines, and morpholines. In order to understand the response of Saccharomyces cerevisiae to perturbations in the ergosterol pathway, genome-wide transcript profiles following exposure to a number of a...

journal_title：Antimicrobial agents and chemotherapy

authors： Bammert GF,Fostel JM

更新日期：2000-05-01 00:00:00

abstract：:Yersinia enterocolitica has emerged as an enteropathogen associated with several types of human infections that often require antimicrobial therapy, but little is known about the antimicrobial susceptibilities of pathogenic strains isolated from humans in Canada. To determine the present patterns of antimicrobial susc...

journal_title：Antimicrobial agents and chemotherapy

authors： Preston MA,Brown S,Borczyk AA,Riley G,Krishnan C

更新日期：1994-09-01 00:00:00

abstract：:We studied the influence of the lipid/amphotericin B (AMB) ratio and the phospholipid type on the in vitro renal cell toxicity and antifungal efficacy of lipid-associated AMB (L-AMB). L-AMB was prepared at one of two different lipid/AMB ratios (1 and 40) by incubating AMB with empty small unilamellar vesicles, made fr...

journal_title：Antimicrobial agents and chemotherapy

authors： Joly V,Bolard J,Saint-Julien L,Carbon C,Yeni P

更新日期：1992-02-01 00:00:00

abstract：:Macrolide-resistant Mycoplasma pneumoniae (MR M. pneumoniae) has been isolated from clinical specimens in Japan since 2000. A comparative study was carried out to determine whether or not macrolides are effective in treating patients infected with MR M. pneumoniae. The clinical courses of 11 patients with MR M. pneumo...

journal_title：Antimicrobial agents and chemotherapy

authors： Suzuki S,Yamazaki T,Narita M,Okazaki N,Suzuki I,Andoh T,Matsuoka M,Kenri T,Arakawa Y,Sasaki T

更新日期：2006-02-01 00:00:00

abstract：:Lactation studies are necessary evaluations of medications for reproductive-age women. We evaluated pharmacokinetics (PK), pharmacodynamics, safety, and adherence profiles associated with 7 days of 1% tenofovir (TFV) vaginal gel use during lactation. Tenofovir levels (maternal/infant serum, milk) and anti-HIV activity...

journal_title：Antimicrobial agents and chemotherapy

authors： Noguchi LM,Montgomery ET,Biggio JR,Hendrix CW,Bogen DL,Hillier SL,Dai JY,Piper JM,Marzinke MA,Dezzutti CS,Isaacs SK,Schwartz JL,Watts DH,Beigi RH

更新日期：2016-08-22 00:00:00

abstract：:The activity of cefotaxime, either alone or combined with an aminoglycoside, was determined against 50 isolates of Pseudomonas aeruginosa, of which 50, 33, and 10 were resistant to gentamicin, tobramycin, and amikacin, respectively. Cefotaxime inhibited 34 isolates at a concentration of 16 microgram/ml and all isolate...

journal_title：Antimicrobial agents and chemotherapy

authors： Murray PR

更新日期：1980-03-01 00:00:00

abstract：:Granulocytopenia is a complication of human immunodeficiency virus disease, as well as a toxic manifestation of zidovudine therapy. To evaluate pharmacokinetic and pharmacodynamic relationships, 11 AIDS-AIDS-related complex patients who had developed zidovudine-associated granulocytopenia (mean absolute neutrophil cou...

journal_title：Antimicrobial agents and chemotherapy

authors： Hewitt RG,Morse GD,Lawrence WD,Maliszewski ML,Santora J,Bartos L,Bonnem E,Poiesz B

更新日期：1993-03-01 00:00:00

abstract：:Recent years have seen the rapid advancement of new therapeutic agents against hepatitis C virus (HCV) in response to the need for treatment that is unmet by interferon (IFN)-based therapies. Most antiviral drugs discovered to date are small molecules that modulate viral enzyme activities. In the search for highly sel...

journal_title：Antimicrobial agents and chemotherapy

authors： Cheng Y,Tsou LK,Cai J,Aya T,Dutschman GE,Gullen EA,Grill SP,Chen AP,Lindenbach BD,Hamilton AD,Cheng YC

更新日期：2010-01-01 00:00:00

abstract：:Selection of resistance to cefamandole has been observed, and the drug has failed to protect animals lethally infected with certain Enterobacteriaceae that appeared to be highly susceptible in vitro. Using spectrophotometric assays, some of these organisms were found to produce beta-lactamases highly active against ce...

journal_title：Antimicrobial agents and chemotherapy

authors： Sanders CC,Sanders WE Jr

更新日期：1979-06-01 00:00:00

abstract：:We evaluated the potency of garenoxacin in selecting resistant Streptococcus pneumoniae mutants by determining its mutant prevention concentration, using strains with and without topoisomerase gene mutations, and compared its potency to that of other quinolones. Garenoxacin had a significantly greater potency against ...

journal_title：Antimicrobial agents and chemotherapy

authors： Yamamoto K,Yanagihara K,Sugahara K,Imamura Y,Seki M,Izumikawa K,Kakeya H,Yamamoto Y,Hirakata Y,Kamihira S,Kohno S

更新日期：2009-08-01 00:00:00

abstract：:The structure-activity relations of myxinidin, a peptide derived from epidermal mucus of hagfish, Myxine glutinosa L., were investigated. Analysis of key residues allowed us to design new peptides with increased efficiency. Antimicrobial activity of native and modified peptides demonstrated the key role of uncharged r...

journal_title：Antimicrobial agents and chemotherapy

authors： Cantisani M,Leone M,Mignogna E,Kampanaraki K,Falanga A,Morelli G,Galdiero M,Galdiero S

更新日期：2013-11-01 00:00:00

abstract：:In response to the need for rapid, inexpensive, high-throughput assays for antimycobacterial drug screening, a microplate-based assay which uses Alamar blue reagent for determination of growth was evaluated. MICs of 30 antimicrobial agents against Mycobacterium tuberculosis H37Rv, M. tuberculosis H37Ra, and Mycobacter...

journal_title：Antimicrobial agents and chemotherapy

authors： Collins L,Franzblau SG

更新日期：1997-05-01 00:00:00

abstract：:The mode of action of a new type of UDP-glucose analog against herpes simplex virus type 1 (HSV-1) replication was examined. The analog showed good selectivity and potent activity. At 10 micrograms/ml, P-536 inhibited the formation of infectious HSV-1 by more than 90%, whereas at 100 micrograms/ml it had no cytotoxic ...

journal_title：Antimicrobial agents and chemotherapy

authors： Alarcón B,González ME,Carrasco L,Méndez-Castrillón PP,García-López MT,de las Heras FG

更新日期：1988-08-01 00:00:00

abstract：:The kinetics of the lethal action of metronidazole and the formation of acetamide have been studied in a strain of Bacteroides fragilis which is relatively resistant to metronidazole. As with a susceptible strain of B. fragilis, the data are consistent with a model in which a labile intermediate in metronidazole metab...

journal_title：Antimicrobial agents and chemotherapy

authors： McLafferty MA,Koch RL,Goldman P

更新日期：1982-01-01 00:00:00

abstract：:Thirty-five strains of Pasteurella multocida from humans and animals were tested for susceptibility to five cephalosporins by a broth dilution method. Cefcanel showed high activity against all isolates (MIC and MBC, less than or equal to 0.64 micrograms/ml). The corresponding figure for cefaclor and cefuroxime was 2.5...

journal_title：Antimicrobial agents and chemotherapy

authors： Holst E,Rollof J,Miörner H

更新日期：1989-12-01 00:00:00

abstract：:Infection with multiple ganciclovir-resistant human cytomegalovirus mutants, containing different substitutions and deletions in the UL97 gene, was found in a patient with severe combined immunodeficiency (SCID) within 3 weeks of ganciclovir therapy. A novel 11-codon deletion at positions 590 to 600 was identified. Th...

journal_title：Antimicrobial agents and chemotherapy

authors： Wolf DG,Yaniv I,Ashkenazi S,Honigman A

更新日期：2001-02-01 00:00:00