The safety of quinolones in pregnancy.

Abstract:

:Quinolones and fluoroquinolones are highly efficient antibiotics. However, concerns regarding possible harmful effects have limited their use during pregnancy. Nevertheless, accumulating clinical data suggest that they may be safe during pregnancy. This review aimed to explore the mechanisms of action of the quinolones and fluoroquinolones, which set the stage for concerns regarding possible teratogenic and mutagenic effects; to clarify the clinical dilemmas that brought forth the necessity in reevaluating the use of those medications during pregnancy; and to review the accumulated data regarding their safety during pregnancy in animal models and humans.

journal_name

Obstet Gynecol Surv

authors

Yefet E,Salim R,Chazan B,Akel H,Romano S,Nachum Z

doi

10.1097/OGX.0000000000000122

subject

Has Abstract

pub_date

2014-11-01 00:00:00

pages

681-94

issue

11

eissn

0029-7828

issn

1533-9866

journal_volume

69

pub_type

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