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Brain death is associated with endoplasmic reticulum stress and apoptosis in rat liver.

Abstract：

:Cell death pathways initiated by stress on the endoplasmic reticulum (ER) have been implicated in a variety of common diseases, such as ischemia/reperfusion injury, diabetes, heart disease, and neurodegenerative disorders. However, the contribution of ER stress to apoptosis and liver injury after brain death is not known. In the present study, we found that brain death induces a variety of signature ER stress markers, including ER stress-specific X box-binding protein 1 and up-regulation of glucose-regulated protein 78. Furthermore, brain death causes up-regulation of C/EBP homologous protein and caspase-12. Consistent with this, terminal deoxynucleotidyl transferase-mediated 2'-deoxyuridine 5'-triphosphate nick-end labeling assay and transmission electron microscopy confirmed apoptosis in the liver after brain death. Taken together, the present study provides strong evidence supporting the presence and importance of ER stress and response in mediating brain death-induced apoptosis and liver injury.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Cao S,Wang T,Yan B,Lu Y,Zhao Y,Zhang S

doi

10.1016/j.transproceed.2014.04.016

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

3297-302

issue

10

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(14)00933-6

journal_volume

46

pub_type

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