Abstract:
:Titanium dioxide (TiO2) is a common additive in many foods, pigments, personal care products, and other consumer products used in daily life. Despite the widespread use of nanoscale TiO2 and composites of nanoscale TiO2 in the food industry, there is a serious lack of awareness of the toxicity of TiO2 nanoparticles (NPs) among consumers and manufacturers. There is an urgent need for toxicological studies of TiO2 NPs. TiO2 food additives separated from marketed foods were characterized by transmission electron microscopy. In addition, the effects of TiO2 NPs on metabolic stress in WI-38 cells were analyzed. Cell viability, total ROS, mitochondrial transmembrane potential (ΔψM), cell cycle, and metabolism-related gene expression were analyzed. The results indicate that TiO2 NPs have a significant concentration-dependent toxic effect in lung cells. The ΔψM, the intracellular ROS level, and the stages of the WI-38 cell cycle were altered by increasing TiO2 concentrations after exposure for 24 and 48 h relative to the control. Cytochrome P450 1A, GSTM3, and glutathione S-transferase A4 upregulation in response to the TiO2 NPs was observed. These findings suggest that the toxicity of TiO2 from confectionery products in WI-38 cells may be mediated through an increase in oxidative stress. The results of this study clearly demonstrate the nanotoxicological effects of TiO2 on WI-38 cells and will be useful for nanotoxicological indexing.
journal_name
Arch Environ Contam Toxicoljournal_title
Archives of environmental contamination and toxicologyauthors
Periasamy VS,Athinarayanan J,Al-Hadi AM,Juhaimi FA,Alshatwi AAdoi
10.1007/s00244-014-0109-4subject
Has Abstractpub_date
2015-04-01 00:00:00pages
521-33issue
3eissn
0090-4341issn
1432-0703journal_volume
68pub_type
杂志文章abstract::Pilot whales strand periodically along the U.S. coast, and these strandings offer an opportunity for the collection of tissues for biomonitoring of contaminant exposure in cetaceans, as well as for specimen archiving. Concentrations of organochlorine (OC) contaminants (e.g., PCB congeners, pesticides, DDTs) were measu...
journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
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doi:10.1007/BF02097772
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journal_title:Archives of environmental contamination and toxicology
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doi:10.1007/s00244-016-0353-x
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journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
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doi:10.1007/s00244-002-0109-7
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journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
pub_type: 杂志文章
doi:10.1007/BF01056203
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journal_title:Archives of environmental contamination and toxicology
pub_type: 杂志文章
doi:10.1007/s002449900234
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journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
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doi:10.1007/BF01055620
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journal_title:Archives of environmental contamination and toxicology
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更新日期:2013-01-01 00:00:00
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journal_title:Archives of environmental contamination and toxicology
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journal_title:Archives of environmental contamination and toxicology
pub_type: 杂志文章
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abstract::Di-n-butyl phthalate (DBP) is one of the most ubiquitous plasticizers used worldwide. However, it has negatives effects on the soil, water, atmosphere, and other environmental media and can cause serious pollution. According to the artificial soil test and previous studies, this study was conducted to evaluate the tox...
journal_title:Archives of environmental contamination and toxicology
pub_type: 杂志文章
doi:10.1007/s00244-017-0451-4
更新日期:2018-05-01 00:00:00
abstract::Six prairie grain farmers were monitored for pesticide exposure and related adverse effects while they mixed and/or sprayed carbofuran (Furadan 480F) with ground rig application equipment to control grasshoppers in southern Alberta, Canada. Dermal exposure was estimated with Tegaderm patches placed at seventeen locati...
journal_title:Archives of environmental contamination and toxicology
pub_type: 杂志文章
doi:10.1007/BF01056087
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abstract::A series of eleven nitrogen-containing heterocyclic compounds, which may be potentially associated with aqueous effluents from coal conversion technologies, were examined to determine the relationships between their n-octanol/H2O partition coefficients, molecular weights, boiling points, and their toxicity monitored a...
journal_title:Archives of environmental contamination and toxicology
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doi:10.1007/BF01056938
更新日期:1980-01-01 00:00:00