Exploring Nitrous Oxide as Treatment of Mood Disorders: Basic Concepts.

abstract：:Individual daily dosages of nortriptyline (NT) can be predicted from administration of a 50-mg or 100-mg single test dose, with a determination of the plasma level 24 hours later. Because the 50-mg or 100-mg test dose used in previous studies may cause unmanageable acute side effects in elderly patients, a 25-mg NT te...

journal_title：Journal of clinical psychopharmacology

authors： Schneider LS,Cooper TB,Staples FR,Sloane RB

更新日期：1987-10-01 00:00:00

abstract：:In a double-blind, parallel groups study, 60 healthy student volunteers (29 men and 31 women, aged 19-22 years) were randomly allocated to receive placebo, 100 or 200 mg modafinil. Two hours later, in the early evening, they completed an extensive cognitive battery. The 3 groups did not differ in self-ratings of sleep...

journal_title：Journal of clinical psychopharmacology

authors： Randall DC,Viswanath A,Bharania P,Elsabagh SM,Hartley DE,Shneerson JM,File SE

更新日期：2005-04-01 00:00:00

abstract：AIMS:To study whether listed putative corrected QT (QTc)-prolonging psychotropic drugs indeed prolong the QTc interval under everyday circumstances and to evaluate whether this is a class effect or an individual drug effect, we conducted a prospective population-based cohort study. METHODS:This study was conducted as ...

journal_title：Journal of clinical psychopharmacology

authors： van Noord C,Straus SM,Sturkenboom MC,Hofman A,Aarnoudse AJ,Bagnardi V,Kors JA,Newton-Cheh C,Witteman JC,Stricker BH

更新日期：2009-02-01 00:00:00

abstract：:The therapeutic spectrum of nemonapride, a new substituted benzamide, and its relationship with plasma concentrations of the drug and prolactin were investigated by a fixed-dose study (18 mg/day for 3 weeks) in 31 patients with acutely exacerbated schizophrenia. Of 31 patients, 25 (80.6%) were responders who showed a ...

journal_title：Journal of clinical psychopharmacology

authors： Kondo T,Mihara K,Yasui N,Nagashima U,Ono S,Kaneko S,Ohkubo T,Osanai T,Sugawara K,Otani K

更新日期：2000-08-01 00:00:00

abstract：:Transient amnesias, fugues, twilight states, automatisms, depersonalization, and furors or explosive disorders can occur in association with, or be caused by, various medications or substance-induced organic brain states. Agents capable of precipitating dissociative-like states include alcohol, barbiturates and simila...

journal_title：Journal of clinical psychopharmacology

authors： Good MI

更新日期：1989-04-01 00:00:00

abstract：:The clinical features and pharmacokinetics of 22 lithium overdoses are described. Effectiveness of different treatment regimens regarding elimination of lithium is discussed. Origin of overdose was due to deliberate poisoning or precipitated by concomitant diseases, coadministration of drugs, or combination of both. T...

journal_title：Journal of clinical psychopharmacology

authors： Eyer F,Pfab R,Felgenhauer N,Lutz J,Heemann U,Steimer W,Zondler S,Fichtl B,Zilker T

更新日期：2006-06-01 00:00:00

abstract：PURPOSE/BACKGROUND:The study objective was to compare the impact of being treated by paliperidone palmitate (PP) or risperidone long-acting injection (RLAI) on the length of stay on initial hospitalization, rehospitalization risk, and treatment duration in schizophrenic patients. METHODS:We conducted an observational ...

journal_title：Journal of clinical psychopharmacology

authors： Limosin F,Belhadi D,Comet D,Pacou M,Bouju S,Van Impe K,Guillon P

更新日期：2018-02-01 00:00:00

abstract：:A role for serotonin in season affective disorder (SAD) has been explored with a variety of serotonergic pharmacologic agents. The authors initially hypothesized that metergoline, a nonspecific serotonin antagonist, would exacerbate depressive symptoms. In a small, open-label pilot study, the authors observed the oppo...

journal_title：Journal of clinical psychopharmacology

authors： Turner EH,Schwartz PJ,Lowe CH,Nawab SS,Feldman-Naim S,Drake CL,Myers FS,Barnett RL,Rosenthal NE

更新日期：2002-04-01 00:00:00

abstract：:Unlike many other areas of medicine, psychiatric clinical trials have no gold standard laboratory tests with which to measure drug effects. Although reliable and valid psychometric measures are available, the standard analysis of such measures obscures the clinical relevance of drug effects. In this study, the authors...

journal_title：Journal of clinical psychopharmacology

authors： Faraone SV,Biederman J,Spencer TJ,Wilens TE

更新日期：2000-12-01 00:00:00

abstract：:This study investigated the effects of antidepressant treatment on platelet activation in depressed patients with ischemic heart disease (IHD). Plasma levels of platelet alpha-granule release products beta-thromboglobulin (BTG) and platelet factor 4 (PF4) were measured in 17 depressed patients with IHD who were treate...

journal_title：Journal of clinical psychopharmacology

authors： Pollock BG,Laghrissi-Thode F,Wagner WR

更新日期：2000-04-01 00:00:00

abstract：:The Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition borderline personality disorder (BPD) seems to constitute a very heterogeneous category. Therefore, pharmacological therapy is symptom-oriented or targets comorbid conditions. A high comorbidity exists between BPD and posttraumatic stress disord...

journal_title：Journal of clinical psychopharmacology

authors： Ziegenhorn AA,Roepke S,Schommer NC,Merkl A,Danker-Hopfe H,Perschel FH,Heuser I,Anghelescu IG,Lammers CH

更新日期：2009-04-01 00:00:00

abstract：:Medication nonadherence in severe mental disorders is an important clinical issue, but estimates vary between studies. There is a need for valid self-reports for both research and clinical practice. This study examined the level of adherence to prescribed medication in outpatients with severe mental disorders and eval...

journal_title：Journal of clinical psychopharmacology

authors： Jónsdóttir H,Opjordsmoen S,Birkenaes AB,Engh JA,Ringen PA,Vaskinn A,Aamo TO,Friis S,Andreassen OA

更新日期：2010-04-01 00:00:00

abstract：:The aim of the study was to investigate the use of antidepressant drugs among elderly people in nursing homes. Elderly residents who where found to have been prescribed at least one antidepressant drug according to the specific medication dispensing system were identified in 8 nursing homes in the county of Ostergötla...

journal_title：Journal of clinical psychopharmacology

authors： Chermá MD,Löfgren UB,Almkvist G,Hallert C,Bengtsson F

更新日期：2008-08-01 00:00:00

abstract：:Fifty-five patients completed a 5-week double-blind study comparing alprazolam, propranolol, and placebo in the treatment of panic disorder and agoraphobia with panic attacks. There was no concomitant behavioral treatment. Patient and therapist rating scales included Sheehan's Panic and Anxiety Attack Scales, the Mark...

journal_title：Journal of clinical psychopharmacology

authors： Munjack DJ,Crocker B,Cabe D,Brown R,Usigli R,Zulueta A,McManus M,McDowell D,Palmer R,Leonard M

更新日期：1989-02-01 00:00:00

abstract：BACKGROUND:Bipolar disorder (BPD) is a chronic and recurrent mood disorder characterized by episodes of mania, hypomania, and major depression. Based on available evidence, mitochondrial dysfunction, oxidative stress, and inflammation have important roles in the pathophysiology of bipolar depression. More specifically,...

journal_title：Journal of clinical psychopharmacology

authors： Mehrpooya M,Yasrebifar F,Haghighi M,Mohammadi Y,Jahangard L

更新日期：2018-10-01 00:00:00

abstract：:Drug-associated extrapyramidal symptoms (EPS) in people with intellectual disability (ID) may be difficult to recognize, and clinicians' assessments may be hampered by lack of patients' capacities to adequately cooperate and by lack of reliable instruments to measure EPS in this population. Therefore, we compared asse...

journal_title：Journal of clinical psychopharmacology

authors： de Kuijper GM,Hoekstra PJ

更新日期：2016-10-01 00:00:00

abstract：:Many drugs, including alcohol and stimulants, demonstrably increase sociability and verbal interaction and are recreationally consumed in social settings. One drug, 3,4-methylenedioxymethamphetamine (MDMA, ecstasy), seems to produce its prosocial effects by increasing plasma oxytocin levels, and the oxytocin system ha...

journal_title：Journal of clinical psychopharmacology

authors： Bershad AK,Kirkpatrick MG,Seiden JA,de Wit H

更新日期：2015-06-01 00:00:00

abstract：:Hyperprolactinemia mediated by antagonism of dopaminergic neurotransmission in the pituitary gland is a common adverse effect of antipsychotics. Recent studies have suggested that polymorphisms of dopamine receptors can affect the therapeutic response to antipsychotics. Thus, our aim was to evaluate whether 2 such pol...

journal_title：Journal of clinical psychopharmacology

authors： López-Rodríguez R,Román M,Novalbos J,Pelegrina ML,Ochoa D,Abad-Santos F

更新日期：2011-10-01 00:00:00

abstract：:Lithium augmentation, the most studied augmentation strategy for depression, has not been evaluated in patients with a history of non-response to multiple antidepressants. The objective of this study was to assess the efficacy of lithium augmentation for patients with a history of treatment resistant depression who al...

journal_title：Journal of clinical psychopharmacology

authors： Nierenberg AA,Papakostas GI,Petersen T,Montoya HD,Worthington JJ,Tedlow J,Alpert JE,Fava M

更新日期：2003-02-01 00:00:00

abstract：:Over the past 10 years, knowledge gained about the pharmacokinetic profiles of valproate and carbamazepine has increased the clinical effectiveness of their use. Much of the information has been gained through their use as successful antiepileptic medications. As these agents begin to play an increasing role as mood-s...

journal_title：Journal of clinical psychopharmacology

authors： Wilder BJ

更新日期：1992-02-01 00:00:00

abstract：OBJECTIVE:Researchers, by studying first-generation antipsychotics, have established an early prediction model, which had a favorable specificity but a low sensitivity. This study aims to optimize early prediction of treatment response for schizophrenia using a novel statistic method that can be done even under the Mic...

journal_title：Journal of clinical psychopharmacology

authors： Chang YC,Lane HY,Yang KH,Huang CL

更新日期：2006-12-01 00:00:00

abstract：:Olanzapine is an atypical antipsychotic effective in the treatment of schizophrenic patients. After a 2- to 9-day placebo lead-in, 79 inpatients with schizophrenia according to DSM-III-R criteria were placed on an olanzapine dosage of 10 mg/day or 1 mg/day for up to 6 weeks. Blood samples were obtained weekly during t...

journal_title：Journal of clinical psychopharmacology

authors： Perry PJ,Sanger T,Beasley C

更新日期：1997-12-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to use a visual analog scale (VAS) longitudinally measuring somnolence severity in patients with bipolar disorder. METHODS:A data set of patients with bipolar spectrum disorders who were randomized to lithium or quetiapine-IR for 16 weeks was used. The somnolence severity was measur...

journal_title：Journal of clinical psychopharmacology

authors： Gao K,Su M,Ganocy SJ,Goto T,Yuan C,Fang F,Conroy C,Brownrigg B,Serrano MB,Calabrese JR

更新日期：2019-05-01 00:00:00

abstract：OBJECTIVE:The associations between prenatal exposure to antidepressants and preterm delivery and fetal growth restriction are controversial and poorly understood. We studied the relation between antidepressant use and these outcomes. METHODS:Analysis included women with nonmalformed infants interviewed in the Slone Ep...

journal_title：Journal of clinical psychopharmacology

authors： Toh S,Mitchell AA,Louik C,Werler MM,Chambers CD,Hernández-Díaz S

更新日期：2009-12-01 00:00:00

abstract：:A study of medication compliance, side effects, and clinical change with the use of antidepressants in 32 Southeast Asian refugee patients seen at an urban mental health center is reported. Patients met criteria for either major depressive episode, posttraumatic stress disorder, or both. Only five of the 32 patients w...

journal_title：Journal of clinical psychopharmacology

authors： Kroll J,Linde P,Habenicht M,Chan S,Yang M,Vang T,Souvannasoth L,Nguyen T,Ly M,Nguyen H

更新日期：1990-08-01 00:00:00

abstract：:Olanzapine therapeutic drug monitoring (TDM) is the measurement of plasma olanzapine to assess adherence and guide dosage. We have audited data from an olanzapine TDM service, 1999-2009. Multiple linear regression analysis was conducted to investigate the contribution of dose, age, sex, body weight, and smoking status...

journal_title：Journal of clinical psychopharmacology

authors： Patel MX,Bowskill S,Couchman L,Lay V,Taylor D,Spencer EP,Flanagan RJ

更新日期：2011-08-01 00:00:00

abstract：BACKGROUND:The combination of olanzapine and valproic acid (VPA) is regularly prescribed in the treatment of bipolar or schizoaffective disorders. The VPA has been shown to reduce olanzapine concentration, but the mechanism behind this interaction remains unknown. We aimed to investigate the effect of VPA on olanzapine...

journal_title：Journal of clinical psychopharmacology

authors： Tveito M,Smith RL,Høiseth G,Molden E

更新日期：2019-11-01 00:00:00

abstract：INTRODUCTION:Zonisamide is an anticonvulsant medication with GABAergic, glutamatergic, and monoaminergic effects. Zonisamide has also been shown to reduce alcohol intake in rodents and in risky drinkers in the context of a laboratory study. This pilot clinical trial evaluated the safety, tolerability, and efficacy of z...

journal_title：Journal of clinical psychopharmacology

authors： Arias AJ,Feinn R,Oncken C,Covault J,Kranzler HR

更新日期：2010-06-01 00:00:00

abstract：:Adult attention deficit/hyperactivity disorder (ADHD) is an increasingly recognized disorder with associated psychiatric comorbidity and impairment. Although pharmacotherapy serves an important role in treating ADHD and other concurrent psychiatric disorders in children and adolescents, the use of pharmacotherapeutics...

journal_title：Journal of clinical psychopharmacology

authors： Wilens TE,Biederman J,Spencer TJ,Prince J

更新日期：1995-08-01 00:00:00

abstract：:Therapeutic drug monitoring studies of selective serotonin reuptake inhibitor (SSRI) antidepressants thus far failed to identify a clear concentration-response relationship in major depression. Majority of the previous studies defined clinical response as 50% or greater reduction from baseline in depression rating sca...

journal_title：Journal of clinical psychopharmacology

authors： Suzuki Y,Fukui N,Sawamura K,Sugai T,Watanabe J,Ono S,Inoue Y,Ozdemir V,Someya T

更新日期：2008-06-01 00:00:00