Autologous graft-versus-host disease in a child with stage IV neuroblastoma.

Abstract:

:Graft-versus-host disease (GVHD) is an underappreciated complication of autologous hematopoietic stem cell transplantation (AHSCT) that can affect the skin, gastrointestinal tract, and liver. The development of this rare condition is probably due to an impairment of immunologic tolerance that can occur spontaneously through T-cell dysregulation, possibly from intensive conditioning chemotherapy regimens, or intentionally through administration of cyclosporine in the hopes of promoting an antitumor response. We present the case of a 2-year-old boy with metastatic neuroblastoma who spontaneously developed autologous GVHD after AHSCT. Severe pruritus and an inability to taper his oral steroids without a disease flare marked his disease. Eventually partial relief was achieved with initiation of cyclosporine and a strict soak and smear protocol using topical triamcinolone 0.1% ointment.

journal_name

Pediatr Dermatol

journal_title

Pediatric dermatology

authors

Kaffenberger J,Basak SA,Ioffreda M

doi

10.1111/pde.12407

subject

Has Abstract

pub_date

2015-03-01 00:00:00

pages

276-9

issue

2

eissn

0736-8046

issn

1525-1470

journal_volume

32

pub_type

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