Interventions for treating oral mucositis for patients with cancer receiving treatment.

Abstract:

BACKGROUND:Treatment of cancer is increasingly effective but associated with short and long term side effects. Oral side effects, including oral mucositis (mouth ulceration), remain a major source of illness despite the use of a variety of agents to treat them. OBJECTIVES:To assess the effectiveness of interventions for treating oral mucositis or its associated pain in patients with cancer receiving chemotherapy or radiotherapy or both. SEARCH STRATEGY:Electronic searches of Cochrane Oral Health Group and PaPaS Trials Registers (to 1 June 2010), CENTRAL via The Cochrane Library (to Issue 2, 2010), MEDLINE via OVID (1950 to 1 June 2010), EMBASE via OVID (1980 to 1 June 2010), CINAHL via EBSCO (1980 to 1 June 2010), CANCERLIT via PubMed (1950 to 1 June 2010), OpenSIGLE (1980 to 1 June 2010) and LILACS via the Virtual Health Library (1980 to 1 June 2010) were undertaken. Reference lists from relevant articles were searched and the authors of eligible trials were contacted to identify trials and obtain additional information. SELECTION CRITERIA:All randomised controlled trials comparing agents prescribed to treat oral mucositis in people receiving chemotherapy or radiotherapy or both. Outcomes were oral mucositis, time to heal mucositis, oral pain, duration of pain control, dysphagia, systemic infection, amount of analgesia, length of hospitalisation, cost and quality of life. DATA COLLECTION AND ANALYSIS:Data were independently extracted, in duplicate, by two review authors. Authors were contacted for details of randomisation, blindness and withdrawals. Risk of bias assessment was carried out on six domains. The Cochrane Collaboration statistical guidelines were followed and risk ratio (RR) values calculated using fixed-effect models (less than 3 trials in each meta-analysis). MAIN RESULTS:Thirty-two trials involving 1505 patients satisfied the inclusion criteria. Three comparisons for mucositis treatment including two or more trials were: benzydamine HCl versus placebo, sucralfate versus placebo and low level laser versus sham procedure. Only the low level laser showed a reduction in severe mucositis when compared with the sham procedure, RR 5.28 (95% confidence interval (CI) 2.30 to 12.13).Only 3 comparisons included more than one trial for pain control: patient controlled analgesia (PCA) compared to the continuous infusion method, therapist versus control, cognitive behaviour therapy versus control. There was no evidence of a difference in mean pain score between PCA and continuous infusion, however, less opiate was used per hour for PCA, mean difference 0.65 mg/hour (95% CI 0.09 to 1.20), and the duration of pain was less 1.9 days (95% CI 0.3 to 3.5). AUTHORS' CONCLUSIONS:There is weak and unreliable evidence that low level laser treatment reduces the severity of the mucositis. Less opiate is used for PCA versus continuous infusion. Further, well designed, placebo or no treatment controlled trials assessing the effectiveness of interventions investigated in this review and new interventions for treating mucositis are needed.

authors

Clarkson JE,Worthington HV,Furness S,McCabe M,Khalid T,Meyer S

doi

10.1002/14651858.CD001973.pub4

subject

Has Abstract

pub_date

2010-08-04 00:00:00

pages

CD001973

issue

8

issn

1469-493X

pub_type

杂志文章,meta分析,评审
  • Chinese medicinal herbs to treat the side-effects of chemotherapy in breast cancer patients.

    abstract:BACKGROUND:Short term side-effects of chemotherapy include fatigue, nausea, vomiting, mucositis and myelosuppression or neutropenia. These occur during the course of treatment and generally resolve within months of completion of chemotherapy. A variety of Chinese medicinal herbs have been used for managing these side e...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD004921.pub2

    authors: Zhang M,Liu X,Li J,He L,Tripathy D

    更新日期:2007-04-18 00:00:00

  • Glucocorticosteroid-free versus glucocorticosteroid-containing immunosuppression for liver transplanted patients.

    abstract:BACKGROUND:Liver transplantation is an established treatment option for end-stage liver failure. Now that newer, more potent immunosuppressants have been developed, glucocorticosteroids may no longer be needed and their removal may prevent adverse effects. OBJECTIVES:To assess the benefits and harms of glucocorticoste...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD007606.pub4

    authors: Fairfield C,Penninga L,Powell J,Harrison EM,Wigmore SJ

    更新日期:2018-04-09 00:00:00

  • Urgent-start peritoneal dialysis versus haemodialysis for people with chronic kidney disease.

    abstract:BACKGROUND:Patients with chronic kidney disease (CKD) who require urgent initiation of dialysis but without having a permanent dialysis access have traditionally commenced haemodialysis (HD) using a central venous catheter (CVC). However, several studies have reported that urgent initiation of peritoneal dialysis (PD) ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD012899.pub2

    authors: Htay H,Johnson DW,Craig JC,Teixeira-Pinto A,Hawley CM,Cho Y

    更新日期:2021-01-27 00:00:00

  • Hyperfractionated or accelerated radiotherapy for head and neck cancer.

    abstract:BACKGROUND:Several trials have studied the role of altered fractionation radiotherapy in head and neck squamous cell carcinoma, but the effect of such treatment on survival is not clear. OBJECTIVES:The aim of this individual patient data (IPD) meta-analysis was to assess whether this type of radiotherapy could improve...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD002026

    authors: Baujat B,Bourhis J,Blanchard P,Overgaard J,Ang KK,Saunders M,Le Maître A,Bernier J,Horiot JC,Maillard E,Pajak TF,Poulsen MG,Bourredjem A,O'Sullivan B,Dobrowsky W,Andrzej H,Skladowski K,Hay JH,Pinto LH,Fu KK,Fallai

    更新日期:2010-12-08 00:00:00

  • Olanzapine alone or in combination for acute mania.

    abstract:BACKGROUND:Olanzapine, an atypical antipsychotic, is used in the treatment of mania both as monotherapy and combined with other medicines. OBJECTIVES:To review the efficacy and tolerability of olanzapine in the treatment of mania SEARCH STRATEGY:The Cochrane Collaboration Depression, Anxiety and Neurosis Controlled T...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD004040

    authors: Rendell JM,Gijsman HJ,Keck P,Goodwin GM,Geddes JR

    更新日期:2003-01-01 00:00:00

  • Fetal electrocardiogram (ECG) for fetal monitoring during labour.

    abstract:BACKGROUND:Hypoxaemia during labour can alter the shape of the fetal electrocardiogram (ECG) waveform, notably the relation of the PR to RR intervals, and elevation or depression of the ST segment. Technical systems have therefore been developed to monitor the fetal ECG during labour as an adjunct to continuous electro...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD000116.pub2

    authors: Neilson JP

    更新日期:2006-07-19 00:00:00

  • Topical negative pressure for treating chronic wounds.

    abstract:BACKGROUND:Chronic wounds mainly affect the elderly and those with multiple health problems. Despite the use of modern dressings, some of these wounds take a long time to heal, fail to heal, or recur, causing significant pain and discomfort to the person and cost to health services. Topical negative pressure (TNP) is u...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD001898.pub2

    authors: Ubbink DT,Westerbos SJ,Evans D,Land L,Vermeulen H

    更新日期:2008-07-16 00:00:00

  • Treatments for breast engorgement during lactation.

    abstract:BACKGROUND:Engorgement is the overfilling of breasts with milk, often occurring in the early days postpartum. It results in swollen, hard, painful breasts and may lead to premature cessation of breastfeeding, decreased milk production, cracked nipples and mastitis. Various treatments have been studied but little consis...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章

    doi:10.1002/14651858.CD006946.pub4

    authors: Zakarija-Grkovic I,Stewart F

    更新日期:2020-09-18 00:00:00

  • Topical antibiotic prophylaxis to reduce respiratory tract infections and mortality in adults receiving mechanical ventilation.

    abstract:BACKGROUND:Patients treated with mechanical ventilation in intensive care units (ICUs) have a high risk of developing respiratory tract infections (RTIs). Ventilator-associated pneumonia (VAP) has been estimated to affect 5% to 40% of patients treated with mechanical ventilation for at least 48 hours. The attributable ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000022.pub4

    authors: Minozzi S,Pifferi S,Brazzi L,Pecoraro V,Montrucchio G,D'Amico R

    更新日期:2021-01-22 00:00:00

  • Surgical versus non-surgical interventions for treating humeral shaft fractures in adults.

    abstract:BACKGROUND:Fractures of the shaft of the humerus account for 1% to 3% of all fractures in adults. The management of these fractures, including surgical intervention, varies widely. OBJECTIVES:To assess and compare the effects of surgical versus non-surgical intervention for non-pathological fractures of the humeral sh...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD008832.pub2

    authors: Gosler MW,Testroote M,Morrenhof JW,Janzing HM

    更新日期:2012-01-18 00:00:00

  • Vedolizumab for induction and maintenance of remission in ulcerative colitis.

    abstract:BACKGROUND:Cellular adhesion molecules play an important role in the pathogenesis of ulcerative colitis, making selective blockade of these molecules a promising therapeutic strategy. Vedolizumab, a recombinant humanized IgG1 monoclonal antibody, inhibits adhesion and migration of leukocytes into the gastrointestinal t...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD007571.pub2

    authors: Bickston SJ,Behm BW,Tsoulis DJ,Cheng J,MacDonald JK,Khanna R,Feagan BG

    更新日期:2014-08-08 00:00:00

  • Interventions for asymptomatic retinal breaks and lattice degeneration for preventing retinal detachment.

    abstract:BACKGROUND:Asymptomatic retinal breaks and lattice degeneration are visible lesions that are risk factors for later retinal detachment. Retinal detachments occur when fluid in the vitreous cavity passes through tears or holes in the retina and separates the retina from the underlying retinal pigment epithelium. Creatio...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003170.pub4

    authors: Wilkinson CP

    更新日期:2014-09-05 00:00:00

  • Fresh versus frozen embryo transfers in assisted reproduction.

    abstract:BACKGROUND:In general, in vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) implies a single fresh and one or more frozen-thawed embryo transfers. Alternatively, the 'freeze-all' strategy implies transfer of frozen-thawed embryos only, with no fresh embryo transfers. In practice, both strategies can ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD011184.pub2

    authors: Wong KM,van Wely M,Mol F,Repping S,Mastenbroek S

    更新日期:2017-03-28 00:00:00

  • Fetal assessment methods for improving neonatal and maternal outcomes in preterm prelabour rupture of membranes.

    abstract:BACKGROUND:Fetal assessment following preterm prelabour rupture of membranes (PPROM) may result in earlier delivery due to earlier detection of fetal compromise. However, early delivery may not always be in the fetal or maternal interest, and the effectiveness of different fetal assessment methods in improving neonatal...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD010209.pub2

    authors: Sharp GC,Stock SJ,Norman JE

    更新日期:2014-10-03 00:00:00

  • Selenium for preventing cancer.

    abstract:BACKGROUND:This review is an update of the first Cochrane publication on selenium for preventing cancer (Dennert 2011).Selenium is a metalloid with both nutritional and toxicological properties. Higher selenium exposure and selenium supplements have been suggested to protect against several types of cancers. OBJECTIVE...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD005195.pub3

    authors: Vinceti M,Dennert G,Crespi CM,Zwahlen M,Brinkman M,Zeegers MP,Horneber M,D'Amico R,Del Giovane C

    更新日期:2014-03-30 00:00:00

  • Multi-professional simulation-based team training in obstetric emergencies for improving patient outcomes and trainees' performance.

    abstract:BACKGROUND:Simulation-based obstetric team training focuses on building a system that will anticipate errors, improve patient outcomes and the performance of clinical care teams. Simulation-based obstetric team training has been proposed as a tool to improve the overall outcome of obstetric health care. OBJECTIVES:To ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD011545.pub2

    authors: Fransen AF,van de Ven J,Banga FR,Mol BWJ,Oei SG

    更新日期:2020-12-16 00:00:00

  • Prescription of prosthetic ankle-foot mechanisms after lower limb amputation.

    abstract:BACKGROUND:A correct prosthetic prescription can be derived from adapting the functional benefits of a prosthesis to the functional needs of the prosthetic user. For adequate matching, the functional abilities of the amputees are of value, as well as the technical and functional aspects of the various prosthetic ankle-...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003978.pub2

    authors: Hofstad C,Linde H,Limbeek J,Postema K

    更新日期:2004-01-01 00:00:00

  • Potentiators (specific therapies for class III and IV mutations) for cystic fibrosis.

    abstract:BACKGROUND:Cystic fibrosis (CF) is the commonest inherited life-shortening illness in white populations, caused by a mutation in the gene that codes for the cystic fibrosis transmembrane regulator protein (CFTR), which functions as a salt transporter. This mutation mainly affects the airways where excess salt absorptio...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD009841.pub3

    authors: Skilton M,Krishan A,Patel S,Sinha IP,Southern KW

    更新日期:2019-01-07 00:00:00

  • Erythromycin for feeding intolerance in preterm infants.

    abstract:BACKGROUND:Functional immaturity of gastrointestinal motility predisposes preterm infants to feeding intolerance. Motilin, a gastrointestinal peptide, stimulates propagative contractile activity during phase III of the migratory motor complex in the interdigestive state. Erythromycin (EM) is a motilin agonist with prok...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD001815

    authors: Ng E,Shah V

    更新日期:2001-01-01 00:00:00

  • Donepezil for dementia due to Alzheimer's disease.

    abstract:BACKGROUND:Alzheimer's disease is the most common cause of dementia in older people. One of the aims of therapy is to inhibit the breakdown of a chemical neurotransmitter, acetylcholine, by blocking the relevant enzyme. This can be done by a group of chemicals known as cholinesterase inhibitors. However, some (like tac...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD001190

    authors: Birks JS,Harvey R

    更新日期:2003-01-01 00:00:00

  • Psychological interventions for needle-related procedural pain and distress in children and adolescents.

    abstract:BACKGROUND:This is the second update of a Cochrane Review (Issue 4, 2006). Pain and distress from needle-related procedures are common during childhood and can be reduced through use of psychological interventions (cognitive or behavioral strategies, or both). Our first review update (Issue 10, 2013) showed efficacy of...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析

    doi:10.1002/14651858.CD005179.pub4

    authors: Birnie KA,Noel M,Chambers CT,Uman LS,Parker JA

    更新日期:2018-10-04 00:00:00

  • Inhaled steroids for acute asthma following emergency department discharge.

    abstract:BACKGROUND:Patients with acute asthma treated in the emergency department (ED) are frequently treated with inhaled beta(2)-agonists and systemic corticosteroids after discharge. The use of inhaled corticosteroids (ICS) following discharge may also be beneficial in improving patient outcomes after acute asthma. OBJECTI...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD002316.pub2

    authors: Edmonds ML,Milan SJ,Brenner BE,Camargo CA Jr,Rowe BH

    更新日期:2012-12-12 00:00:00

  • Endometriosis: an overview of Cochrane Reviews.

    abstract:BACKGROUND:This overview reports on interventions for pain relief and for subfertility in pre-menopausal women with clinically diagnosed endometriosis. OBJECTIVES:The objective of this overview was to summarise the evidence from Cochrane systematic reviews on treatment options for women with pain or subfertility assoc...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD009590.pub2

    authors: Brown J,Farquhar C

    更新日期:2014-03-10 00:00:00

  • Vinpocetine for acute ischaemic stroke.

    abstract:BACKGROUND:Vasoactive and neuroprotective drugs such as vinpocetine are used to treat stroke in some countries. OBJECTIVES:To assess the effect of vinpocetine in acute ischaemic stroke. SEARCH STRATEGY:We searched the Cochrane Stroke Group Trials Register (last searched February 2007), MEDLINE (1966 to February 2007)...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000480.pub2

    authors: Bereczki D,Fekete I

    更新日期:2008-01-23 00:00:00

  • Medical methods for first trimester abortion.

    abstract:BACKGROUND:Surgical abortion up to 63 days by vacuum aspiration or dilatation and curettage has been the method of choice since the 1960s. Medical abortion became an alternative method of first trimester pregnancy termination with the availability of prostaglandins in the early 1970s and anti-progesterones in the 1980s...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD002855.pub3

    authors: Kulier R,Gülmezoglu AM,Hofmeyr GJ,Cheng LN,Campana A

    更新日期:2004-01-01 00:00:00

  • Treatment for Lambert-Eaton myasthenic syndrome.

    abstract:BACKGROUND:Lambert-Eaton myasthenic syndrome (LEMS) is an autoimmune disorder of neuromuscular transmission. Treatments attempt to overcome the harmful autoimmune process, or improve residual neuromuscular transmission OBJECTIVES:The objective was to examine the efficacy of treatment in Lambert-Eaton myasthenic syndro...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003279.pub3

    authors: Keogh M,Sedehizadeh S,Maddison P

    更新日期:2011-02-16 00:00:00

  • Oral betamimetics for maintenance therapy after threatened preterm labour.

    abstract:BACKGROUND:Some women who have threatened to give birth prematurely, subsequently settle. They may then take oral tocolytic maintenance therapy to prevent preterm birth and to prolong gestation. OBJECTIVES:To assess the effects of oral betamimetic maintenance therapy after threatened preterm labour for preventing pret...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD003927.pub3

    authors: Dodd JM,Crowther CA,Middleton P

    更新日期:2012-12-12 00:00:00

  • Interventions for chronic suppurative otitis media.

    abstract:BACKGROUND:Chronic suppurative otitis media (CSOM) is a serious bacterial infection of the middle ear that can follow untreated acute otitis media. OBJECTIVES:To assess the effects of different treatments for CSOM. SEARCH STRATEGY:We searched Medline from 1966 to 1996 and a bibliographic collection of the Hearing Imp...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD000473

    authors: Acuin J,Smith A,Mackenzie I

    更新日期:2000-01-01 00:00:00

  • Urodynamic investigations for management of urinary incontinence in adults.

    abstract:BACKGROUND:Urodynamic tests are used to investigate people who have urinary incontinence or other urinary symptoms in order to make a definitive objective diagnosis. The aim is to help to select the treatment most likely to be successful. The investigations are invasive and time consuming. OBJECTIVES:The objective of ...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,评审

    doi:10.1002/14651858.CD003195

    authors: Glazener CM,Lapitan MC

    更新日期:2002-01-01 00:00:00

  • Intra-aortic balloon pump counterpulsation (IABP) for myocardial infarction complicated by cardiogenic shock.

    abstract:BACKGROUND:Intra-aortic balloon pump counterpulsation (IABP) is currently the most commonly used mechanical assist device for patients with cardiogenic shock due to acute myocardial infarction.Although there is only limited evidence by randomised controlled trials, the current guidelines of the American Heart Associati...

    journal_title:The Cochrane database of systematic reviews

    pub_type: 杂志文章,meta分析,评审

    doi:10.1002/14651858.CD007398.pub2

    authors: Unverzagt S,Machemer MT,Solms A,Thiele H,Burkhoff D,Seyfarth M,de Waha A,Ohman EM,Buerke M,Haerting J,Werdan K,Prondzinsky R

    更新日期:2011-07-06 00:00:00