Abstract：
:Hepatitis C virus (HCV) infection is a significant health problem worldwide, and is the leading cause of cirrhosis, hepatocellular carcinoma, and liver transplantation in the United States. The management of HCV has changed significantly over the last 5 years, as treatments have become simpler and more efficacious. Medication efficacy is now greater than 90%, with a high barrier to resistance and few side effects. This review is a collaboration between primary care and hepatology providers to explore all aspects of HCV management: acute versus chronic HCV infection, transmission and testing, and diagnosis and treatment. Specific medications for the treatment of HCV infection are considered, and patient and medication factors including genotype, liver disease status, and comorbidities affecting medication choice are discussed. This is a new era for the management of HCV infection, and interested primary care physicians, family doctors, and general internists can be at the forefront of diagnosis, management, and treatment of HCV.
journal_name
J Gen Intern Medjournal_title
Journal of general internal medicineauthors
Guss D,Sherigar J,Rosen P,Mohanty SRdoi
10.1007/s11606-017-4280-ysubject
Has Abstractpub_date
2018-04-01 00:00:00pages
551-557issue
4eissn
0884-8734issn
1525-1497pii
10.1007/s11606-017-4280-yjournal_volume
33pub_type
杂志文章,评审abstract：BACKGROUND:Entry into general internal medicine (GIM) has declined. The effect of the inpatient general medicine rotation on medical student career choices is uncertain. OBJECTIVE:To assess the effect of student satisfaction with the inpatient general medicine rotation on pursuit of a career in GIM. DESIGN:Multicente...
journal_title：Journal of general internal medicine
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1525-1497.2006.00429.x
更新日期：2006-05-01 00:00:00
abstract：:In the HTML version of this paper, Ms. Goddu was incorrectly listed. The correct citation should be AP Goddu. Exposure to the stigmatizing language note was associated with more negative attitudes towards the patient (20.3 stigmatizing vs. 25.1 neutral, p < 0.001). Reading the stigmatizing language note was associated...
journal_title：Journal of general internal medicine
pub_type： 已发布勘误
doi：10.1007/s11606-018-4583-7
更新日期：2019-01-01 00:00:00
abstract：:The purpose of the study was to develop a comprehensive program evaluation instrument. Following pilot work with residents, a 69-item instrument consisting of statements with 5-point strongly agree to strongly disagree response options was distributed to 107 residents; 104 responded. Psychometric analyses revealed no ...
journal_title：Journal of general internal medicine
pub_type： 杂志文章
doi：10.1046/j.1525-1497.1997.07139.x
更新日期：1997-11-01 00:00:00
abstract：:Nicotine meets all critical criteria for an addictive drug. Furthermore, there is no evidence that there would be widespread compulsive use of tobacco without nicotine. These findings have led to consideration of the cigarette as a contaminated vehicle for an addictive drug (nicotine). Nevertheless, nicotine itself ma...
journal_title：Journal of general internal medicine
pub_type： 杂志文章,评审
doi：10.1007/BF02600847
更新日期：1990-09-01 00:00:00
abstract：OBJECTIVE:To review the current information on medical complications, psychological implications, and legislative issues related to body piercing, a largely unregulated industry in the United States. METHODS:We conducted a MEDLINE search of English language articles from 1966 until May 1998 using the search terms "bod...
journal_title：Journal of general internal medicine
pub_type： 杂志文章,评审
doi：10.1046/j.1525-1497.1999.00357.x
更新日期：1999-06-01 00:00:00
abstract：BACKGROUND:Extension for Community Healthcare Outcomes (ECHO) and related models of medical tele-education are rapidly expanding; however, their effectiveness remains unclear. This systematic review examines the effectiveness of ECHO and ECHO-like medical tele-education models of healthcare delivery in terms of improve...
journal_title：Journal of general internal medicine
pub_type： 杂志文章
doi：10.1007/s11606-019-05291-1
更新日期：2019-12-01 00:00:00
abstract：MAIN RESULTS:Compared with younger patients, patients aged 50 years or older were less likely to have acquired HIV via intravenous drug use or homosexual contact (p = .0001). Older patients were more likely to have comorbid diseases (12% vs 4%; p = .0001), had more frequent neurologic findings on admission (19% vs 9%; ...
journal_title：Journal of general internal medicine
pub_type： 杂志文章
doi：10.1007/BF02599026
更新日期：1996-10-01 00:00:00
abstract：OBJECTIVE:Our goal was to establish whether psychosocial risk factors for nonadherence, previously identified as negative predictors of warfarin prescribing, are predictors of adverse events for patients with nonvalvular atrial fibrillation receiving warfarin. DESIGN:Retrospective cohort analysis. SETTING:Ohio Medica...
journal_title：Journal of general internal medicine
pub_type： 杂志文章
doi：10.1111/j.1525-1497.2005.0242.x
更新日期：2005-12-01 00:00:00
abstract：:Hospitalists provide a significant amount of direct clinical care in both academic and community hospitals. Peer feedback is a potentially underutilized and low resource method for improving clinical performance, which lends itself well to the frequent patient care handoffs that occur in the practice of hospital medic...
journal_title：Journal of general internal medicine
pub_type： 杂志文章,评审
doi：10.1007/s11606-020-06235-w
更新日期：2020-12-01 00:00:00
abstract：BACKGROUND:Use of electronic health records (EHRs) is associated with physician stress and burnout. While emergency departments and subspecialists have used scribes to address this issue, little is known about the impact of scribes in academic primary care. OBJECTIVE:Assess the impact of a scribe on physician and pati...
journal_title：Journal of general internal medicine
pub_type： 杂志文章
doi：10.1007/s11606-018-4434-6
更新日期：2018-07-01 00:00:00
abstract：:African Americans and Latinos use services that require a doctor's order at lower rates than do whites. Racial bias and patient preferences contribute to disparities, but their effects appear small. Communication during the medical interaction plays a central role in decision making about subsequent interventions and ...
journal_title：Journal of general internal medicine
pub_type： 杂志文章
doi：10.1046/j.1525-1497.2003.20532.x
更新日期：2003-02-01 00:00:00
abstract：BACKGROUND:The risk of adverse events among alcohol-interactive medication users can occur with one standard alcoholic drink. Research on the extent to which this occurs is scant. OBJECTIVE:To examine the prevalence and correlates of concurrent alcohol and alcohol-interactive (AI) medication use across different level...
journal_title：Journal of general internal medicine
pub_type： 杂志文章
doi：10.1007/s11606-008-0639-4
更新日期：2008-09-01 00:00:00
abstract：BACKGROUND:Depression is common among older patients yet is often inadequately treated. Patient beliefs about antidepressants are known to affect treatment initiation and adherence, but are often not expressed in clinical settings. OBJECTIVE:To explore attitudes toward antidepressants in a sample of depressed, communi...
journal_title：Journal of general internal medicine
pub_type： 杂志文章
doi：10.1111/j.1525-1497.2005.00296.x
更新日期：2006-02-01 00:00:00
abstract：:The quality of diabetes care delivered to patients falls below the expectations of practice guidelines and clinical trial evidence. Studies in many jurisdictions with varying health care systems have shown that recommended processes of care occur less often than they should; hence, outcomes of care are inadequate. Man...
journal_title：Journal of general internal medicine
pub_type： 杂志文章,评审
doi：10.1007/s11606-006-0027-x
更新日期：2007-02-01 00:00:00
abstract：BACKGROUND:Multiple payment reform efforts are under way to improve the value of care delivered to Medicare beneficiaries, yet few directly address the interface between primary and specialty care. OBJECTIVE:To describe regional variation in outpatient visits for individual specialties and the association between spec...
journal_title：Journal of general internal medicine
pub_type： 杂志文章
doi：10.1007/s11606-016-3745-8
更新日期：2016-11-01 00:00:00
abstract：:The call for value-based medicine has augmented the role of primary care physicians, potentially exacerbating the already-acknowledged shortage of primary care physicians in the current delivery landscape. Lifetime earnings for primary care physicians are millions lower than those for other specialties, and the burden...
journal_title：Journal of general internal medicine
pub_type： 杂志文章
doi：10.1007/s11606-020-05759-5
更新日期：2020-05-01 00:00:00
abstract：:The management of patients who have HIV disease, particularly those in early, asymptomatic disease stages, has recently improved. Clinical trials with zidovudine have demonstrated efficacy and greatly reduced toxicity when the drug is used for asymptomatic HIV-infected persons who have fewer than 500 CD4+ cells/mm3. A...
journal_title：Journal of general internal medicine
pub_type： 杂志文章,评审
doi：10.1007/BF02599251
更新日期：1991-01-01 00:00:00
abstract：BACKGROUND:Differences among hospitals in the use of inpatient consultation may contribute to variation in outcomes and costs for hospitalized patients, but basic epidemiologic data on consultations nationally are lacking. OBJECTIVE:The purpose of the study was to identify physician, hospital, and geographic factors t...
journal_title：Journal of general internal medicine
pub_type： 杂志文章
doi：10.1007/s11606-015-3216-7
更新日期：2015-07-01 00:00:00
abstract：:Comprehensiveness of primary care (the extent to which the clinician, as part of the primary care team, recognizes and meets the majority of each patient's physical and mental health care needs) is an important element of primary care, but seems to be declining in the U.S. This is concerning, because more comprehensiv...
journal_title：Journal of general internal medicine
pub_type： 杂志文章,评审
doi：10.1007/s11606-015-3300-z
更新日期：2015-08-01 00:00:00
abstract：BACKGROUND:Enhancing the cultural competency of students is emerging as a key issue in medical education; however, students may perceive that they are more able to function within cross-cultural situations than their teachers, reducing the effectiveness of cultural competency educational efforts. OBJECTIVE:The purpose...
journal_title：Journal of general internal medicine
pub_type： 杂志文章
doi：10.1007/s11606-009-1245-9
更新日期：2010-05-01 00:00:00
abstract：:A number of new biological markers are being studied as predictors of disease or adverse medical events among those who already have a disease. Systematic reviews of this growing literature can help determine whether the available evidence supports use of a new biomarker as a prognostic test that can more accurately p...
journal_title：Journal of general internal medicine
pub_type： 杂志文章,评审
doi：10.1007/s11606-011-1899-y
更新日期：2012-06-01 00:00:00
abstract：OBJECTIVE:African-American (black) and white individuals have been shown to differ in their desire for life-sustaining treatments and their use of living wills for end-of-life care, but the reasons for these differences are unclear. This study was designed to test the hypothesis that these ethnic differences exist beca...
journal_title：Journal of general internal medicine
pub_type： 杂志文章
doi：10.1007/BF02600155
更新日期：1996-11-01 00:00:00
abstract：BACKGROUND:The transition from pediatric to adult care is a critical period for young adults with childhood-onset conditions. General internists are tasked with participating in the care of this vulnerable population. Existing guidelines regarding transition do not fully address structural or organizational characteris...
journal_title：Journal of general internal medicine
pub_type： 杂志文章,多中心研究
doi：10.1007/s11606-019-05226-w
更新日期：2019-10-01 00:00:00
abstract：BACKGROUND:Thirty-day readmission penalties implemented with the Hospital Readmission Reduction Program (HRRP) place a larger burden on safety-net hospitals which treat a disproportionate share of racial minorities, leading to concerns that already large racial disparities in readmissions could widen. OBJECTIVE:To exa...
journal_title：Journal of general internal medicine
pub_type： 杂志文章
doi：10.1007/s11606-019-04841-x
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:Global health measures represent an attractive option for researchers and clinicians seeking a brief snapshot of a patient's overall perspective on his or her health. Because scores on different global health measures are not comparable, comparative effectiveness research (CER) is challenging. OBJECTIVE:To ...
journal_title：Journal of general internal medicine
pub_type： 杂志文章
doi：10.1007/s11606-015-3453-9
更新日期：2015-10-01 00:00:00
abstract：BACKGROUND:Food insecurity refers to limited or uncertain access to food resulting from inadequate financial resources. There is a clear association between food insecurity and obesity among women, but little is known about the relationship between food insecurity and type 2 diabetes. OBJECTIVE:To evaluate whether the...
journal_title：Journal of general internal medicine
pub_type： 杂志文章
doi：10.1007/s11606-007-0192-6
更新日期：2007-07-01 00:00:00
abstract：:The fourth-year medicine clerkship was restructured at one of four sites. Teams consisting of one attending physician and three students cared for eight new patients per week. The overall experience of the restructured clerkship was rated significantly more positively than the experiences at all other sites and the te...
journal_title：Journal of general internal medicine
pub_type： 杂志文章
doi：10.1007/BF02600292
更新日期：1993-01-01 00:00:00
abstract：OBJECTIVE:To decrease unnecessary antibiotic use for acute respiratory tract infections in adults in a point-of-service health care setting. DESIGN:Prospective, nonrandomized controlled trial. SETTING:An urban urgent care clinic associated with the major indigent care hospital in Denver, Colorado between October 2000...
journal_title：Journal of general internal medicine
pub_type： 临床试验,杂志文章
doi：10.1046/j.1525-1497.2003.20410.x
更新日期：2003-05-01 00:00:00
abstract：BACKGROUND:Decisions to limit use of life-sustaining treatment occur frequently during hospitalizations, and portable medical orders (also known as Portable Orders for Life-Sustaining Treatment (POLST)) can ensure that patient preferences regarding resuscitation are followed after discharge. OBJECTIVE:To determine the...
journal_title：Journal of general internal medicine
pub_type： 杂志文章
doi：10.1007/s11606-020-05698-1
更新日期：2020-07-01 00:00:00
abstract：OBJECTIVE:To identify differences in the incidences of myocardial infarction in women and men with chest pain. DESIGN:Prospective multicenter cohort study. SETTING:Emergency rooms of three university and four community hospitals. PATIENTS:7,734 emergency room patients with acute chest pain. MEASUREMENTS AND MAIN RE...
journal_title：Journal of general internal medicine
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1007/BF02599688
更新日期：1989-09-01 00:00:00
