Abstract:
:Nanomedicine constitutes the emerging field of medical applications for nanotechnology such as nanomaterial-based drug delivery systems. This technology may hold exceptional potential for novel therapeutic approaches to liver diseases. The specific and unspecific targeting of macrophages, hepatic stellate cells (HSC), hepatocytes, and liver sinusoidal endothelial cells (LSEC) using nanomedicine has been developed and tested in preclinical settings. These four major cell types in the liver are crucially involved in the complex sequence of events that occurs during the initiation and maintenance of liver inflammation and fibrosis. Targeting different cell types can be based on their capacity to ingest surrounding material, endocytosis, and specificity for a single cell type can be achieved by targeting characteristic structures such as receptors, sugar moieties or peptide sequences. Macrophages and especially the liver-resident Kupffer cells are in the focus of nanomedicine due to their highly efficient and unspecific uptake of most nanomaterials as well as due to their critical pathogenic functions during inflammation and fibrogenesis. The mannose receptor enables targeting macrophages in liver disease, but macrophages can also become activated by certain nanomaterials, such as peptide-modified gold nanorods (AuNRs) that render them proinflammatory. HSC, the main collagen-producing cells during fibrosis, are currently targeted using nanoconstructs that recognize the mannose 6-phosphate and insulin-like growth factor II, peroxisome proliferator activated receptor 1, platelet-derived growth factor (PDGF) receptor β, or integrins. Targeting of the major liver parenchymal cell, the hepatocyte, has only recently been achieved with high specificity by mimicking apolipoproteins, naturally occurring nanoparticles of the body. LSEC were found to be targeted most efficiently using carboxy-modified micelles and their integrin receptors. This review will summarize important functions of these cell types in healthy and diseased livers and discuss current strategies of cell-specific targeting for liver diseases by nanomedicine.
journal_name
Hepatobiliary Surg Nutrjournal_title
Hepatobiliary surgery and nutritionauthors
Bartneck M,Warzecha KT,Tacke Fdoi
10.3978/j.issn.2304-3881.2014.11.02subject
Has Abstractpub_date
2014-12-01 00:00:00pages
364-76issue
6eissn
2304-3881issn
2304-389Xpii
hbsn-03-06-364journal_volume
3pub_type
杂志文章,评审abstract::Human fascioliasis is a rare zoonosis in Chile. Clinically it presents with a highly polymorphous group of symptoms that evolve in two periods. The first, acute or a result of hepatic invasion, lasts 2 weeks to 4 months and is characterized essentially by pain in the right hypochondrium and/or epigastrium, continuous ...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.3978/j.issn.2304-3881.2014.09.15
更新日期:2015-02-01 00:00:00
abstract:BACKGROUND:Adult living donor liver transplantation (LDLT) is one of the best treatments for hepatocellular carcinoma (HCC). However, when recurrence of HCC after LDLT occurs, the prognosis is poor because of rapid progression. Preoperative level of α-fetoprotein (AFP) and protein induced by vitamin K antagonist-II (PI...
journal_title:Hepatobiliary surgery and nutrition
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journal_title:Hepatobiliary surgery and nutrition
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doi:10.21037/hbsn.2018.09.03
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abstract::Mirizzi syndrome, known as extrinsic bile compression syndrome, is a rare complication of cholecystitis and chronic cholelithiasis, secondary to the obliteration of the infundibulum of the gallbladder or cystic duct caused by the impact of one or more calculations in these anatomical structures, which leads to compres...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章,评审
doi:10.21037/hbsn.2016.11.01
更新日期:2017-06-01 00:00:00
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journal_title:Hepatobiliary surgery and nutrition
pub_type:
doi:10.3978/j.issn.2304-3881.2014.05.03
更新日期:2014-08-01 00:00:00
abstract::Though laparoscopic cholecystectomy (LC) was highly criticized in its early stages, it quickly grew to become a new standard of care and has revolutionized the field of general surgery. Now emerging robotic technology is making its way into the minimally invasive arena. Robotic cholecystectomy (RC) is often disparaged...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章,评审
doi:10.21037/hbsn.2017.03.01
更新日期:2018-02-01 00:00:00
abstract::The 2(nd) International Consensus Conference on Laparoscopic Liver Resection (ICCLLR) was held 4(th)-6(th) October, 2014, in Morioka, Japan. The level of evidence appears to be low in the field of laparoscopic liver resection (LLR) to create strong recommendations. Therefore, an independent jury-based consensus model ...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.21037/hbsn.2016.03.03
更新日期:2016-08-01 00:00:00
abstract::Adrenocortical carcinoma (ACC) is an uncommon and aggressive cancer occurring more frequently in women; local or distant recurrences occur in 80% of cases, typically within 1 year after curative resection. Liver is the preferred metastatic site. Herein, we report the case of a unique liver metastasis from ACC occurrin...
journal_title:Hepatobiliary surgery and nutrition
pub_type:
doi:10.21037/hbsn.2016.03.05
更新日期:2016-06-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the sixth most common malignant tumor worldwide and the most common primary liver cancer. Liver resection or liver transplantation is the therapeutic gold standards in patient with HCC related with or without underline liver disease. We present a video case of a 68-year-old woman admi...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.3978/j.issn.2304-3881.2015.07.01
更新日期:2015-12-01 00:00:00
abstract:Background:Although laparoscopic liver resection (LLR) has been increasingly popular worldwide, there is lack of predictive model to evaluate the feasibility and safety of LLR. The aim of this study was to establish a scoring system for predicting the possibility of conversion and complication, which could facilitate t...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.21037/hbsn.2018.10.09
更新日期:2018-12-01 00:00:00
abstract::Chronic infection with hepatitis B virus (HBV) is the leading cause of liver cirrhosis and hepatocellular carcinoma worldwide. HBV life cycle begins with viral attachment to hepatocytes, mediated by the large HBV surface protein (LHBs). Identification of the sodium-taurocholate cotransporting polypeptide (NTCP) as a H...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章,评审
doi:10.3978/j.issn.2304-3881.2014.12.08
更新日期:2015-02-01 00:00:00
abstract:Background:While the long-term survival rate among patients with pancreatic and periampullary carcinomas remains low, it can be influenced by various factors. The purpose of this retrospective study was to investigate the effects of body mass index (BMI) on postoperative complications and patient survival after pancrea...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.21037/hbsn.2019.02.05
更新日期:2019-06-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related deaths worldwide. In the past few years, the mechanisms of hepato-carcinogenesis have been elucidated and the involvement of a number of pathways, including angiogenesis, aberrant signal transduction, and dysregulated cell cycle control ha...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.3978/j.issn.2304-3881.2014.06.04
更新日期:2014-08-01 00:00:00
abstract:BACKGROUND:Hepatic angiomyolipoma (HAML) is a rare liver tumor. This paper summarized the clinical, radiological and pathological features of HAML. METHODS:Seventeen cases of HAML were analyzed retrospectively. All patients were subjected to surgical resection of tumor, one of which was performed emergency surgery bec...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.3978/j.issn.2304-3881.2012.07.02
更新日期:2012-12-01 00:00:00
abstract::In addition to hepatocellular carcinoma, metastatic liver cancer (MLC) is another focus of hepatic surgeon. Good outcome of patients with liver metastasis (LM) from colorectal cancer or neuroendocrine tumor have been achieved. Ovarian cancer liver metastasis (OCLM) has its unique oncological characteristics and a vari...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章,评审
doi:10.21037/hbsn.2018.12.06
更新日期:2019-04-01 00:00:00
abstract:Background:Improving the health-related quality of life (HRQOL) of living liver donors post-donation is an important aspect of care quality. Analyzing the HRQOL of living liver donors prospectively could help improve our understanding of the recovery of HRQOL and help improve the quality of donor care. In this study, w...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.21037/hbsn.2018.11.10
更新日期:2019-02-01 00:00:00
abstract::The connection between pancreatic cancer and venous thrombosis has been discussed for almost 150 years. The exact pathophysiological mechanisms are still partly understood, but it is known that pancreatic cancer induces a prothrombotic and hypercoagulable state and genetic events involved in neoplastic transformation ...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章,评审
doi:10.3978/j.issn.2304-3881.2015.06.08
更新日期:2015-10-01 00:00:00
abstract::In order to induce liver hypertrophy to enable liver resection in patients with a small future liver remnant (FLR), various methods have been proposed in addition to portal vein embolisation (PVE). Most recently, the associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) technique has gain...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.21037/hbsn.2016.05.02
更新日期:2016-08-01 00:00:00
abstract:OBJECTIVE:To investigate the effects of EZH2 gene on the growth and migration of hepatocellular carcinoma HepG2 cell in vitro and in vivo. METHODS:EZH2 shRNA plasmid vectors were constructed and transfected into HepG2 cells. A model of EZH2 gene-silencing HepG2 cell lines was constructed, and the experimental cells we...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.3978/j.issn.2304-3881.2012.12.12
更新日期:2013-04-01 00:00:00
abstract::Cancer stem cell (CSC) marker CD133 was found to be upregulated in many cancers including hepatocellular carcinoma (HCC). However, the molecular mechanism of CD133 regulation in the liver tumor microenvironment has remained elusive. In this study Won and colleagues report that interleukin-6 (IL-6) mediated signal tran...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.21037/hbsn.2016.03.02
更新日期:2016-06-01 00:00:00
abstract::Intrahepatic gallbladder perforation (GBP) is a rare medical entity, which creates a cholecystohepatic communication. We describe the case of a 70-year-old patient who presented with abdominal pain and a Niemeier type II GBP. This case report illustrates the minimally invasive management of a rare and life-threatening...
journal_title:Hepatobiliary surgery and nutrition
pub_type:
doi:10.3978/j.issn.2304-3881.2015.08.02
更新日期:2016-02-01 00:00:00
abstract::In living donor liver transplantation (LDLT), an adequate hepatic venous outflow constitutes one of the basic principles of a technically successful procedure. The issue of whether the anterior sector (AS) of the right lobe (RL) graft should or should not be routinely drained has been controversial. The aim of this 10...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章,评审
doi:10.3978/j.issn.2304-3881.2015.08.01
更新日期:2016-04-01 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the fifth leading cause of cancer mortality worldwide. It is noted that metastasis is a fundamental biological behavior of HCC and the main cause of treatment failure. The identification of somatic alterations and their specific inhibitors may contribute to reduce side effects and pro...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.3978/j.issn.2304-3881.2014.02.06
更新日期:2014-04-01 00:00:00
abstract:Importance:There is accumulating evidence that intermittent fasting (IF) is connected to improved health condition and longevity time-restricted feeding (TRF) is the most recognized and extensively studied model of IF. Objective:To investigate the underlying mechanism of pleiotropic benefits of IF and hint the most ad...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章,评审
doi:10.21037/hbsn-20-317
更新日期:2020-10-01 00:00:00
abstract::Hepatocellular carcinoma (HCC), a disease with poor survival rates unless recognized and treated early, ranks as the fifth most common cancer worldwide. Previous researches has led some authors to choose radiofrequency ablation (RFA) as the primary treatment even the tumor is resectable. Dr. Roayaie's study retrospect...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.3978/j.issn.2304-3881.2014.06.01
更新日期:2014-06-01 00:00:00
abstract::Robotic surgery is an evolving technology that has been successfully applied to a number of surgical specialties, but its use in liver surgery has so far been limited. In this review article we discuss the challenges of minimally invasive liver surgery, the pros and cons of robotics, the evolution of medical robots, a...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章,评审
doi:10.3978/j.issn.2304-3881.2014.09.02
更新日期:2014-10-01 00:00:00
abstract::Intrahepatic cholangiocarcinoma (ICC) is the second most common primary hepatic malignancy. Although surgical resection has been a cornerstone in the management of ICC, the efficacies of several non-surgical management strategies have been actively investigated and somewhat preferable outcomes have been reported for a...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章,评审
doi:10.21037/hbsn.2016.09.07
更新日期:2017-02-01 00:00:00
abstract:OBJECTIVE:The rising of individualized therapy requires nutritional risk screening has become a major topic for each particular disease, yet most of the screenings were for malignancies, less for benign diseases. There is no report on the screening of patients with benign liver tumors postoperatively. We aim to evaluat...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.3978/j.issn.2304-3881.2012.11.04
更新日期:2013-02-01 00:00:00
abstract:Background:Total pancreatectomy (TP) is a complex surgical procedure with significant postoperative morbidity. Despite the narrowed range of indications for TP, the introduction of neoadjuvant chemotherapy and the increasing complexity of surgical resections performed in high-volume centers has increased the number of ...
journal_title:Hepatobiliary surgery and nutrition
pub_type: 杂志文章
doi:10.21037/hbsn.2020.03.19
更新日期:2020-12-01 00:00:00