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Presence of Myocardial Damage Predicts Future Development of Hypertension in a Normotensive Japanese General Population: The Yamagata (Takahata) Study.

Abstract：

BACKGROUND:A modest rise in blood pressure (BP) reportedly increases cardiovascular mortality despite not reaching obvious hypertension, suggesting that target organ damages are latently induced by slight BP rising. The goal of this study was to determine whether presence of subclinical myocardial damage can predict the future development of hypertension in the normotensive general population. METHODS AND RESULTS:The cohort study was conducted with subjects who participated in a community-based annual health check. Normotensive subjects without prior cardiovascular diseases at baseline were eligible for analyses (n = 524, mean age 58 ± 9 years; 53% women). We measured heart-type fatty acid binding protein (H-FABP) at baseline as a biomarker of ongoing myocardial damage. Longitudinal changes in BP were examined during median follow-up period of 6.2 years, and we investigated the association between the baseline H-FABP level and longitudinal BP changes. RESULTS:During the follow-up, 177 subjects (34%) developed hypertension. In multivariate Cox proportional hazard analysis adjusted for potential confounders including age and baseline BP, presence of myocardial damage was significantly associated with the development of hypertension (hazard ratio 1.80, 95% confidence interval, 1.26-2.54; P = 0.0014). Furthermore, relative risk of myocardial damage for incident hypertension was higher in younger subjects and lower BP category. CONCLUSIONS:Presence of subclinical myocardial damage was independently associated with the future development of hypertension in the normotensive general population.

journal_name

Am J Hypertens

journal_title

American journal of hypertension

authors

Honda Y,Watanabe T,Tamura H,Nishiyama S,Takahashi H,Arimoto T,Shishido T,Miyamoto T,Shibata Y,Konta T,Kayama T,Kubota I

doi

10.1093/ajh/hpy008

subject

Has Abstract

pub_date

2018-04-13 00:00:00

pages

549-556

issue

5

eissn

0895-7061

issn

1941-7225

pii

4802343

journal_volume

31

pub_type

杂志文章

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