Abstract：
BACKGROUND/OBJECTIVES:Cold exposure increases thermogenesis and could improve insulin sensitivity. We hypothesized a blunted response in the metabolic syndrome (MetS). SUBJECTS/METHODS:Twenty older adults 59 ± 10.4 years (with MetS, MetS+, n = 9; without MetS, MetS-, n = 11) completed a randomized crossover design of 3.5 h exposures to 20, 25 and 27 °C on three visits. After an hour's rest at the desired temperature, resting metabolic rate (RMR), respiratory quotient (RQ), forearm to fingertip gradients (FFG), and in the ear temperature (IET) were measured over 30 min. An oral glucose tolerance test followed, and serial measurements were continued for 2 h. Venous blood was sampled for clinical chemistry, irisin, and fibroblast growth factor 21(FGF21). A mixed model ANCOVA adjusted data for age, gender, fat mass, fat-free mass and seasonality. RESULTS:There was a significant MetS×temperature interaction where adjusted RMR was significantly higher in MetS+ compared to MetS- by 12% at 20 °C and by 6% at 25 °C, but similar at 27 °C. FFG increased and IET decreased with decreasing temperature to the same extent in both groups. Fasting irisin and FGF21 did not vary with temperature but the former was significantly higher in MetS-. Adjusted postprandial RQ and insulin to glucose ratios were significantly higher at 20 °C relative to 25 °C. Partial correlation analysis of differences between 27 and 20 °C indicated significant positive relationships between fasting as well as postprandial RQ and the respective changes in irisin and FGF21. CONCLUSIONS:There could be an upward shift of the TNZ in MetS+, but this needs reevaluation.
journal_name
Eur J Clin Nutrjournal_title
European journal of clinical nutritionauthors
Pathak K,Woodman RJ,James AP,Soares MJdoi
10.1038/s41430-017-0058-xsubject
Has Abstractpub_date
2018-10-01 00:00:00pages
1421-1430issue
10eissn
0954-3007issn
1476-5640pii
10.1038/s41430-017-0058-xjournal_volume
72pub_type
杂志文章,随机对照试验abstract：BACKGROUND/OBJECTIVES:The fatty acid pattern of membrane phospholipids is suggested to affect membrane fluidity and epithelial barrier function as a result of membrane fatty acid unsaturation. The incorporation of n-3 polyunsaturated fatty acids (PUFAs) into membrane phospholipids may diminish inflammatory potential in...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/ejcn.2009.151
更新日期：2010-04-01 00:00:00
abstract：BACKGROUND/OBJECTIVE:To study whether a free supply of vitamin D(2) drops to 6-week-old infants together with tailor-made information handouts improves the vitamin D status after 7 weeks in the intervention group compared to a control group. SUBJECTS/METHODS:In this cluster randomized controlled trial in eight child h...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602982
更新日期：2009-04-01 00:00:00
abstract：OBJECTIVE:To assess the carotenoid status in young type I diabetic patients and its relationship to the glycaemic control of the disease. DESIGN:A follow-up study. SETTING:Hospital Universitario Puerta de Hierro, Health Area VI of Madrid (Spain). SUBJECTS:Forty-seven type I diabetic patients, followed for 2.5 years....
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602411
更新日期：2006-08-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Consumption of n-3 polyunsaturated fatty acids (PUFA) has a favourable impact on inflammation and cardiovascular disease. However, the Western diet is characterized by a low n-3 PUFA intake and an imbalance in the n-6/n-3 PUFA ratio. Study the effect 10-week of diet modification to decrease the n-...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602857
更新日期：2008-11-01 00:00:00
abstract：OBJECTIVE:To assess the effect of zinc supplementation on respiratory tract disease, immunity and growth in malnourished children. DESIGN:A randomized double-blind placebo-controlled trial. SETTING:A day-care center in Quito, Ecuador. SUBJECTS:Fifty children (12-59 months old) recruited by height-for-age and weight-...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1996-01-01 00:00:00
abstract：:The growth literature from developing countries is reviewed to assess the extent to which stunting, a phenomenon of early childhood, can be reversed in later childhood and adolescence. The potential for catch-up growth increases as maturation is delayed and the growth period is prolonged. However, maturational delays ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：
更新日期：1994-02-01 00:00:00
abstract：OBJECTIVE:Exclusive breastfeeding is recommended till 6 months age. Factors regulating the breastmilk iron and lactoferrin levels are incompletely known. Considering high prevalence of nutritional anemia in lactating mothers, we studied the iron status of lactating mothers, their breastmilk iron and lactoferrin levels ...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602398
更新日期：2006-07-01 00:00:00
abstract：OBJECTIVE:To assess total daily energy expenditure (TDEE) and patterns of physical activity among Swedish male and female adolescents and to relate the amount and intensity of physical activity to existing recommendations (energy expenditure equal to or above 12.4 kJ/kg/day or accumulation of 30 min/day in moderate phy...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1600918
更新日期：2000-03-01 00:00:00
abstract：OBJECTIVE:To investigate the iron status of 6-y-old children and its association with growth and earlier iron status. DESIGN:In a cross-sectional study, children's body size measurements were recorded and blood samples taken near their sixth birthday. SUBJECTS:A sample of 188 children, randomly selected in two previo...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1602137
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:To assess dietary patterns (DPs) in European adolescents and to examine their relationship with several indicators of sedentary behaviour. SUBJECTS/METHODS:A multinational cross-sectional study was carried out in 2202 adolescents (45.4% boys) aged 12.5-17.5 years. A self-reported questionnaire wi...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2013.170
更新日期：2014-03-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Young Indian adults are at greater risk of overweight/obesity due to their high energy intake and sedentary lifestyle. Their energy requirement (ER) is based on their total energy expenditure (TEE) estimated from factorial method, which possibly overestimates their basal metabolic rate (BMR) and p...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-020-00790-5
更新日期：2020-10-24 00:00:00
abstract：BACKGROUND/OBJECTIVE:To assess the relationship between maternal stress and distress in pregnancy and 5-8 years postpartum and child nutritional status. SUBJECTS/METHODS:Longitudinal cohort study carried out in Jundiai city, Southeast Brazil, involving 409 women followed throughout pregnancy to 5-8 years postpartum, a...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2013.28
更新日期：2013-04-01 00:00:00
abstract：BACKGROUND:Previous studies suggest that eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), and alpha-linolenic acid (ALA), may decrease the risk of preeclampsia, but many suffer from important methodological limitations. METHODS:We prospectively examined the association between fat intake during pregnancy and p...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-018-0290-z
更新日期：2019-07-01 00:00:00
abstract：OBJECTIVE:The effect of a diet rich in monounsaturated fatty acids (MUFA) on blood pressure, glycemic control, lipids and insulin sensitivity was evaluated in women with gestational diabetes mellitus. DESIGN AND METHODS:A randomized, unpaired diet intervention was performed in 27 women with gestational diabetes mellit...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1601193
更新日期：2001-06-01 00:00:00
abstract：OBJECTIVE:The aim of this study was to assess the effects of fish oil supplementation in pregnancy on maternal erythrocyte fatty acid composition at different stages of pregnancy and in the post-partum period, and on neonatal erythrocyte fatty acid composition. DESIGN:A double-blind, randomised, placebo-controlled stu...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1601825
更新日期：2004-03-01 00:00:00
abstract：:It has been hypothesized that the increased risk of obesity among African Americans may be partially explained by low energy expenditure (EE) and impaired fat oxidation. Twelve White adults without obesity were pair-matched by age, sex and body mass index (BMI) to a sample of 12 African Americans. Resting EE (REE), 24...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/s41430-018-0202-2
更新日期：2018-06-01 00:00:00
abstract：OBJECTIVE:To investigate the association between total alcohol intake and intake of different types of alcoholic beverages in relation to the risk of basal cell (BCC) and squamous cell (SCC) carcinoma of the skin. DESIGN:Prospective cohort study. SETTING:Follow-up data from a community-based skin cancer study in Aust...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602717
更新日期：2008-02-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:The aim of this study was to evaluate the association of serum 25-hydroxyvitamin D (25(OH)D) with disability and frequency of relapses in relapsing-remitting multiple sclerosis (MS) patients. SUBJECTS/METHODS:The study included 184 patients with relapsing-remitting MS who were receiving immune-mo...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2016.51
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVE:To assess the relationship of energy stress during pregnancy and lactation to maternal body stores in marginally nourished rural Bangladeshi women. SUBJECTS AND METHODS:Two-hundred and fifty-two women were followed from 5-7 months of pregnancy until 6 months postpartum. Energy intake was estimated during pre...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/sj.ejcn.1601514
更新日期：2003-01-01 00:00:00
abstract：:Prospective studies have suggested that hypovitaminosis D can predict the onset of obesity, but they relied mainly on body mass index, which could be scarcely reliable in older people. We investigated whether baseline hypovitaminosis D could predict higher fat mass (FM) levels using dual-energy X-ray absorptiometry in...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2016.95
更新日期：2016-09-01 00:00:00
abstract：OBJECTIVE:To study the effect of infection on iron status in children suffering from acute, mild or severe respiratory infections and to determine the nature of anemia in infection using serum transferrin receptor (sTfR) levels. DESIGN:Forty-three children aged between 3 and 5 y with no evidence of infection and recei...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1601496
更新日期：2003-01-01 00:00:00
abstract：:Food fortification can deliver essential micronutrients to large population segments without modifications in consumption pattern, suggesting that fortified foods may be formulated for populations at risk for fragility fractures. This scoping review determined the extent to which randomized controlled studies have bee...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/ejcn.2016.42
更新日期：2016-10-01 00:00:00
abstract：:Traditional methods for estimating total body fat rely on the assumption that body fat distribution and bone mineral content are constant. However, in patients undergoing renal transplantation rapid changes in body composition occur, with variations in fat distribution and bone mineral content. In order to determine t...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：
更新日期：1993-05-01 00:00:00
abstract：:Bioelectrical impedance analysis is an extremely popular method for assessment of body composition. Despite its wide-spread use over the past thirty years, its accuracy and clinical value is still questioned. Most frequently, criticisms focus on its purported poor absolute accuracy and that different impedance analyse...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：10.1038/s41430-018-0335-3
更新日期：2019-02-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:We evaluated the agreement of air displacement plethysmography (ADP) and bioelectrical impedance analysis (BIA) with dual-energy X-ray absorptiometry (DXA) for the assessment of percent fat mass (%FM) in morbidly obese women. SUBJECTS/METHODS:Fifty-seven women aged 19-55 years and with a body mas...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2013.159
更新日期：2013-11-01 00:00:00
abstract：BACKGROUND:There is evidence linking oral propionate to a reduction in food intake, which could confer functional food properties in the fight against obesity. However, propionate is typically volatile with a pungent smell and taste and so incorporating into foods naturally, at levels acceptable to the consumer is a no...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,随机对照试验
doi：10.1038/ejcn.2012.1
更新日期：2012-07-01 00:00:00
abstract：OBJECTIVE:To assess the differential response of plasma, lymphocyte and neutrophil vitamin E levels to high-intensity physical activity and to vitamin C and E supplementation. SUBJECTS:In all, 14 male trained amateur runners (32-36 y old) were randomly divided in two groups (supplemented and placebo), and participated...
journal_title：European journal of clinical nutrition
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1038/sj.ejcn.1602143
更新日期：2005-06-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:To understand determinants of overweight, several studies addressed the association between neighbourhood characteristics and adult obesity. However, little is known about the association of such characteristics with adolescents' overweight. This study aims at the influence of neighbourhood charac...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2011.21
更新日期：2011-06-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:The aim of this study is to determine whether vitamin D status is associated with incident urinary incontinence (UI) among community-dwelling older adults. SUBJECTS/METHODS:The University of Alabama at Birmingham Study of Aging is a prospective cohort study of community-dwelling Medicare enrollee...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章
doi：10.1038/ejcn.2016.20
更新日期：2016-09-01 00:00:00
abstract：:The article deals with the generation of a prediction equation for basal metabolic rate (BMR) of well-nourished Indian males, from prospective measurements on 121 males, using a single validated technique. The equation related BMR to simple measures such as weight (WT) and age, and was given by: BMR (kJ/d) = 48.7 * WT...
journal_title：European journal of clinical nutrition
pub_type： 杂志文章,评审
doi：
更新日期：1993-06-01 00:00:00
