The Role of Inflammation in Epicardial Adipose Tissue in Heart Diseases.

Abstract:

:Epicardial adipose tissue is not only a specific adipose tissue depot but also an active endocrine organ producing numerous substances with an important role in the development of obesity-related heart diseases. It is located between myocardium and visceral pericardium and consists predominantly of adipocytes, immunocompetent cells, ganglia and interconnecting nerve branches. Several studies documented a positive correlation between pericardial and epicardial fat and left ventricular hypertrophy and septal thickening, leading to diastolic dysfunction, electrocardiographic abnormalities and facilitating cardiac failure. The cellular cross-talks between epicardial fat and myocardium may include both the vasocrine and the paracrine mechanisms. Adipokines secreted from epicardial adipose tissue, vascular and stromal cells diffuse into interstitial fluid crossing the adventitia, media and intima and modulate cardiac function and cardiomyocyte phenotype and survival. In this article, we review the significance of epicardial adipose tissue and its association with cardiovascular diseases, cellular interactions between epicardial fat and myocardium, secretions of adipokines and inflammatory mediators and a potential of epicardial fat as a therapeutic target for the prevention of obesity-related heart diseases.

journal_name

Curr Pharm Des

authors

Matloch Z,Cinkajzlova A,Mraz M,Haluzik M

doi

10.2174/1381612824666180110102125

subject

Has Abstract

pub_date

2018-01-01 00:00:00

pages

297-309

issue

3

eissn

1381-6128

issn

1873-4286

pii

CPD-EPUB-87799

journal_volume

24

pub_type

杂志文章,评审
  • Proteomic validation of protease drug targets: pharmacoproteomics of matrix metalloproteinase inhibitor drugs using isotope-coded affinity tag labelling and tandem mass spectrometry.

    abstract::We illustrate the use of quantitative proteomics, namely isotope-coded affinity tag labelling and tandem mass spectrometry, to assess the targets and effects of the blockade of matrix metalloproteinases by an inhibitor drug in a breast cancer cell culture system. Treatment of MT1-MMP-transfected MDA-MB-231 cells with ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161207779313524

    authors: Butler GS,Overall CM

    更新日期:2007-01-01 00:00:00

  • Molecular mechanics.

    abstract::Molecular Mechanics (MM) force fields are the methods of choice for protein simulations, which are essential in the study of conformational flexibility. Given the importance of protein flexibility in drug binding, MM is involved in most if not all Computational Structure-Based Drug Discovery (CSBDD) projects. This pap...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/13816128113199990600

    authors: Vanommeslaeghe K,Guvench O,MacKerell AD Jr

    更新日期:2014-01-01 00:00:00

  • Circular micro-proteins and mechanisms of cyclization.

    abstract::Transpeptidation reactions result in the formation of new peptide bonds and this can occur between two separate peptides or within the one peptide. These reactions are catalyzed by enzymes and when the N- and C-terminus of the one peptide are joined it results in the formation of cyclic proteins. Cyclization via head-...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161211798999410

    authors: Conlan BF,Anderson MA

    更新日期:2011-12-01 00:00:00

  • Novel aβ isoforms in Alzheimer's disease - their role in diagnosis and treatment.

    abstract::The last decades have witnessed an explosion in studies of the role of amyloid-β (Aβ) in the progress of the neurodegenerative disorder Alzheimer's disease (AD) and it is now widely accepted that Aβ is related to the pathogenesis of AD. For example, studies have shown that Aβ is neurotoxic and that the neurotoxicity o...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161211797416039

    authors: Portelius E,Mattsson N,Andreasson U,Blennow K,Zetterberg H

    更新日期:2011-01-01 00:00:00

  • Understanding the physical and chemical nature of the warfarin drug binding site in human serum albumin: experimental and theoretical studies.

    abstract::Human serum albumin (HSA) is one of the major carrier proteins in the body and constitutes approximately half of the protein found in blood plasma. It plays an important role in lipid metabolism, and its ability to reversibly bind a large variety of pharmaceutical compounds makes it a crucial determinant of drug pharm...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612821666150304163447

    authors: Abou-Zied OK

    更新日期:2015-01-01 00:00:00

  • Particle design of membrane emulsification for protein drug and vaccine delivery.

    abstract::Biodegradable particles have important applications in Drug Delivery Systems (DDS) of protein/peptide drugs. And recently, particle systems have also showed to be powerful for vaccine delivery (adjuvant) in order to solve the difficulties when conventional Alum adjuvant was used. However, in above applications, the pr...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612821666150416100031

    authors: Wang L,Yang T,Ma G

    更新日期:2015-01-01 00:00:00

  • Efficacy of Ropinirole-Loaded PLGA Microspheres for the Reversion of Rotenone- Induced Parkinsonism.

    abstract::A new controlled delivery system has been developed for ropinirole (RP) for the treatment of Parkinson´s Disease (PD) consisting in PLGA microparticles (MPs) which exhibited in vitro constant release of RP (78.23 µg/day/10 mg MPs) for 19 days. The neuroprotective effects of RP released from MPs were evaluated in SKN-A...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612822666160928145346

    authors: Negro S,Boeva L,Slowing K,Fernandez-Carballido A,Garcia-García L,Barcia E

    更新日期:2017-01-01 00:00:00

  • Antibiotics Associated Disorders and Post-biotics Induced Rescue in Gut Health.

    abstract::The gut microbiota plays significant roles in the human body during all spheres' of life and influences innate immunity, promotes granulocyte signaling and provides resistance during pathogenic colonization of the gut; crucial for a healthy life. Antibiotics directly affect the gut microbiota that consequently alters ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612824666171227221731

    authors: Paul D,Manna S,Mandal SM

    更新日期:2018-01-01 00:00:00

  • Tissue engineering techniques in cardiac repair and disease modelling.

    abstract::Cell therapy has been proposed to treat patients with end-stage heart failure. However, it has been suggested that the significant mechanical forces in an often ischaemic, inflamed, biochemically hostile environment may cause poor cell survival and retention. It is hypothesised that tissue engineering techniques could...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/13816128113199990442

    authors: Rao C,Barratt H,Prodromakis T,Terracciano CM

    更新日期:2014-01-01 00:00:00

  • A redox pathway leading to the alkylation of nucleic acids by doxorubicin and related anthracyclines: application to the design of antitumor drugs for resistant cancer.

    abstract::Doxorubicin has been a constituent of antitumor drug protocols for a broad spectrum of cancers for more than two decades. Side effects and resistance continue to be important limitations. Drug targets responsible for both side effects and anti-tumor activity are cell membrane receptors, cell membrane lipids, nucleic a...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:

    authors: Taatjes DJ,Fenick DJ,Gaudiano G,Koch TH

    更新日期:1998-06-01 00:00:00

  • HPV pathway profiling: HPV related cervical dysplasia and carcinoma studies.

    abstract::Cervical cancer is the second most common malignancy among women worldwide. While more than 90% of cervical cancers carry one or more high risk HPV types, the exact relationship between HPV oncoproteins and signaling pathways alterations in cervical cancer remains to be clarified. Vaccines and targeted therapies are t...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161213804805577

    authors: Scholl SM,Kamal M,De Koning L,Kereszt A,Jordanova ES,Ungureanu S,Berns E,Sastre X

    更新日期:2013-01-01 00:00:00

  • A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation.

    abstract::Δ(9)-tetrahydrocannabinol (Δ(9)-THC) is the main compound of the Cannabis Sativa responsible for most of the effects of the plant. Another major constituent is cannabidiol (CBD), formerly regarded to be devoid of pharmacological activity. However, laboratory rodents and human studies have shown that this cannabinoid i...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161212802884681

    authors: Zuardi AW,Crippa JA,Hallak JE,Bhattacharyya S,Atakan Z,Martin-Santos R,McGuire PK,Guimarães FS

    更新日期:2012-01-01 00:00:00

  • Promotion of remyelination by immunoglobulins: implications for the treatment of multiple sclerosis.

    abstract::During the last decade immunomodulatory treatments have been shown to influence the natural course of multiple sclerosis (MS). However, demyelination in the central nervous system (CNS) still occurs and repair mechanisms are incomplete leading to neurological deficits. Currently, there is no therapy available to promo...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161206775193118

    authors: Trebst C,Stangel M

    更新日期:2006-01-01 00:00:00

  • Effects of an Integrative Mind-body-medicine Group Program for Breast Cancer Patients during Chemotherapy: An Observational Study.

    abstract:BACKGROUND:Breast cancer is one of the leading cancers in women in the Western world. Cancer treatment, especially chemotherapy, is often associated with physical and psychosocial side effects. OBJECTIVE:To improve the quality of life and manage side effects, a new integrative mind-body-medicine group concept for brea...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612826666201211111122

    authors: Haller H,Choi KE,Lange S,Kümmel S,Paul A,Cramer H,Dobos G,Voiss P

    更新日期:2020-12-10 00:00:00

  • The STAT3 inhibitor stattic impairs cardiomyocyte mitochondrial function through increased reactive oxygen species formation.

    abstract::The signal transducer and activator of transcription 3 (STAT3) transduces stress signals from the plasma membrane to the nucleus but has recently also been identified in mitochondria. Inhibition of cardiomyocyte mitochondrial STAT3 with the STAT3-specific inhibitor Stattic decreases ADP-stimulated respiration and enha...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/138161281939131127115940

    authors: Boengler K,Ungefug E,Heusch G,Schulz R

    更新日期:2013-01-01 00:00:00

  • Ghrelin as a potential anti-obesity target.

    abstract::In order to develop an effective pharmacological treatment for obesity, an endogenous factor that promotes a positive energy balance by increasing appetite and decreasing fat oxidation could represent the drug target scientists have been looking for. The recently discovered gastric endocrine agent ghrelin, which appea...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612033454748

    authors: Horvath TL,Castañeda T,Tang-Christensen M,Pagotto U,Tschöp MH

    更新日期:2003-01-01 00:00:00

  • Rheumatoid arthritis: genetic variants as biomarkers of cardiovascular disease.

    abstract::Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with premature mortality, severe morbidity, and functional impairment leading to considerable financial burden for both patients and society. Since disease progression and complications can differ from one patient to another, genetic markers are of...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612820666140825123407

    authors: Rodriguez-Rodriguez L,López-Mejias R,Fernández-Gutiérrez B,Balsa A,González-Gay MA,Martín J

    更新日期:2015-01-01 00:00:00

  • Dietary Approaches and Supplements in the Prevention of Cognitive Decline and Alzheimer's Disease.

    abstract::Age-associated cognitive decline and dementia are conditions in which there is deterioration in memory, thinking, and behavior, with profound effects on the ability to perform everyday activities and well-being. Even if dementia mainly affects older persons, it is not a normal part of aging. Alzheimer's disease accoun...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612822666151204000733

    authors: Dominguez LJ,Barbagallo M

    更新日期:2016-01-01 00:00:00

  • Beneficial effects of the Mediterranean diet on metabolic syndrome.

    abstract::The metabolic syndrome (MetS) represents a cluster of medical disorders, such as hyperglycemia, dyslipidemia, hypertension, and abdominal obesity that, when occurring together, increase the risk of developing cardiovascular disease. The role of food and nutrients in the aetiology of chronic diseases has become clearer...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612819666131206112144

    authors: Grosso G,Mistretta A,Marventano S,Purrello A,Vitaglione P,Calabrese G,Drago F,Galvano F

    更新日期:2014-01-01 00:00:00

  • Role of nitric oxide in the central interferon-alpha-induced inhibition of gastric acid secretion in rats.

    abstract::Cytokines are known to play a key role in regulation of gastric functions. Interferon-alpha (IFN-α) has been published to impair gastric motility. Aims of this study were to clarify effect of IFN-α on gastric acid secretion (GAS) and determine role of nitric oxide (NO) in the process. Both subcutaneous (1000, 10000, 1...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/13816128130104

    authors: Czimmer J,Király Á,Szabó IL,Mózsik G,Sütő G

    更新日期:2013-01-01 00:00:00

  • Green Enabling Technologies for Competitive Synthesis of Pharmaceutical Lead Compounds.

    abstract::Combinations of different technologies are at the heart of the development and implementation of new, innovative processes and approaches for Industry 4.0 in the field of medicinal chemistry and drug discovery. Process intensification and advances in high-throughput synthetic techniques can dramatically improve reacti...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612826999201116163951

    authors: Tagliapietra S,Binello A,Bucciol F,Trukhan V,Colia M,Cravotto G

    更新日期:2020-01-01 00:00:00

  • Antimicrobial peptides and peptaibols, substitutes for conventional antibiotics.

    abstract::In this review, the antimicrobial properties of a number of peptides are described. We first deal with helical linear peptides such as the well-known gramicidin, magainins, melittin, and other less well-known or more recently discovered peptides. Then, beta-sheet peptides (defensins isolated from insects and also from...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161210793292500

    authors: Duclohier H

    更新日期:2010-01-01 00:00:00

  • Cytokine and anti-cytokine therapies for inflammatory bowel disease.

    abstract::Although the pathogenesis of inflammatory bowel disease (IBD) remains elusive, it appears that there is chronic activation of the immune and inflammatory cascade in genetically susceptible individuals. Current disease management guidelines have therefore focused on the use of anti-inflammatory agents, aminosalicylates...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612033455035

    authors: Ogata H,Hibi T

    更新日期:2003-01-01 00:00:00

  • Acamprosate: how, where, and for whom does it work? Mechanism of action, treatment targets, and individualized therapy.

    abstract::By updating John Littleton's work published 15 years ago this review summarizes recent work on pharmacodynamic aspects of acamprosate and the perspective for future developments. In addition to insights into the role of glutamatergic receptor systems, craving and relapse inspired by acamprosate, clinical research poin...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161210791516341

    authors: Kiefer F,Mann K

    更新日期:2010-01-01 00:00:00

  • Developing antiangiogenic peptide drugs for angiogenesis-related diseases.

    abstract::Angiogenesis is regulated by stimulators and inhibitors and involve multiple biological processes including endothelial cell proliferation, migration, cell-cell and cell-matrix adhesion, assembly into tube structures as well as apoptosis. Designing and developing peptides for therapeutic application to inhibit angioge...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/138161207781039715

    authors: Sulochana KN,Ge R

    更新日期:2007-01-01 00:00:00

  • Natural Carriers for siRNA Delivery.

    abstract::This review is based on carriers of natural origin such as polysaccharides, proteins, and cell derived entities which have been used for delivery of siRNA. To realize the therapeutic potential of a delivery system, the role of the carrier is of utmost importance. Historical aspects of viral vectors, the first carriers...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161282131151013185528

    authors: Karunaratne DN,Jafari M,Ranatunga RJ,Siriwardhana A

    更新日期:2015-01-01 00:00:00

  • Potential cardio-protective agents: A Resveratrol review (2000-2019).

    abstract::With a 2030 projection of 23.6 million deaths per year the prevalence and severity of cardiovascular disease is at an astounding high. Thus, a definitive need for the identification of novel compounds with potential to prevent or treat the disease and associated states. Moreover, there is also an ever-increasing need ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章

    doi:10.2174/1381612826666200909125354

    authors: Houacine C,Khan I,Yousaf SS

    更新日期:2020-09-09 00:00:00

  • Novel approaches in the treatment of angiogenic eye disease.

    abstract::Angiogenic eye disease is among the most common causes of blindness worldwide. Current treatment approaches are insufficiently effective and partially associated with significant adverse effects. From an investigational view, the eye provides an ideal setting to observe real-time and serial observations of angiogenesi...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/1381612054367292

    authors: Wegewitz U,Göhring I,Spranger J

    更新日期:2005-01-01 00:00:00

  • The role of mast cells in the structural alterations of the airways as a potential mechanism in the pathogenesis of severe asthma.

    abstract::Mast cells, traditionally regarded as effector cells of the immune system, have more recently been demonstrated to be key figures in initiating, developing and sustaining complex pathophysiological processes underlying asthma and other allergic diseases. Asthma is characterised by airway inflammation alongside a distu...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161211795428975

    authors: Carter RJ,Bradding P

    更新日期:2011-01-01 00:00:00

  • The cell type-specific signal proteins (pheromones) of protozoan ciliates.

    abstract::In association with their mechanisms of self/non-self recognition (known as mating type systems), ciliates synthesize and constitutively secrete cell type-specific proteins into their extracellular medium. These proteins, designated as pheromones, have been isolated from species of Euplotes and shown to be members of ...

    journal_title:Current pharmaceutical design

    pub_type: 杂志文章,评审

    doi:10.2174/138161206777947452

    authors: Luporini P,Vallesi A,Alimenti C,Ortenzi C

    更新日期:2006-01-01 00:00:00