Molecular analysis of human papillomavirus in never-smokers with non-small cell lung cancer.

Abstract:

:The causes of lung cancer in never-smokers remain unclear. The potential contribution of human papillomavirus (HPV) to the carcinogenesis of non-small cell lung cancer (NSCLC) has been reported. In 2008, a prospective registry of never-smokers with NSCLC was established at the Kinki-Chuo Chest Medical Center, Sakai, Osaka, Japan. Never-smokers with NSCLC were consecutively enrolled onto the registry. Of these patients, 114 with large tumor specimens, the majority of which were surgical tissues, were selected. In total, 23 of the most clinically relevant HPV types were assayed using polymerase chain reaction amplification of the viral genome. Following exclusion of samples with suboptimal quality, DNA was extracted from 96 formalin-fixed paraffin-embedded samples. These 96 cases consisted of 82 females (85.4%) and 14 males (14.6%), with a median age of 67 years (range, 29-83). Almost all cases (93.8%) were of the adenocarcinoma histological subtype. Despite confirmation of the quality and amount of DNA, HPV type 6 was detected in only one case (1.1%). Furthermore, no other samples examined were positive for any other HPV types. The results therefore suggest that HPV does not play a major role as the driving oncogenic event in never-smokers with NSCLC.

journal_name

Oncol Lett

journal_title

Oncology letters

authors

Isa SI,Kurahara Y,Yamamoto S,Tamiya A,Omachi N,Asami K,Okishio K,Utsumi T,Ito N,Yoon HE,Matsumura A,Atagi S,Kawaguchi T

doi

10.3892/ol.2014.2713

subject

Has Abstract

pub_date

2015-02-01 00:00:00

pages

927-929

issue

2

eissn

1792-1074

issn

1792-1082

pii

ol-09-02-0927

journal_volume

9

pub_type

杂志文章
  • Interferon-α suppresses invasion and enhances cisplatin-mediated apoptosis and autophagy in human osteosarcoma cells.

    abstract::Interferon (IFN)-α is generated in response to viral infections and is used clinically in the therapy of a variety of viral infections and cancers. The present study investigated whether IFN-α could inhibit the invasive ability of osteosarcoma cells using a Matrigel invasion assay. In addition, the osteosarcoma cells ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2013.1762

    authors: Zhao J,Wang M,Li Z,Chen J,Yin Z,Chang J,Gao D,Wang S

    更新日期:2014-03-01 00:00:00

  • High expression of AGBL2 is a novel prognostic factor of adverse outcome in patients with ovarian carcinoma.

    abstract::The putative oncogenic role of ATP/GTP binding protein like 2 (AGBL2) in catalyzing α-tubulin detyrosination has recently been characterized in cancer. However, the status of AGBL2 expression in ovarian cancer and its potential clinical and prognostic significance remain unclear. In the present study, immunohistochemi...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2019.10829

    authors: He WP,Wang LL

    更新日期:2019-11-01 00:00:00

  • Foot sarcomas: Factors affecting oncological and functional outcomes.

    abstract::Oncological and functional prognostic factors for patients with foot sarcomas have yet to be clarified. This study was undertaken to identify the prognostic factors for oncological and functional outcomes and the significance of adjuvant radiotherapy in achieving local control in patients with foot sarcomas. We review...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2011.427

    authors: Kozawa E,Nishida Y,Nakashima H,Tsukushi S,Toriyama K,Kamei Y,Ishiguro N

    更新日期:2012-01-01 00:00:00

  • Activation of the TLR4/MyD88 signaling pathway contributes to the development of human hepatocellular carcinoma via upregulation of IL-23 and IL-17A.

    abstract::Toll-like receptor 4 (TLR4) and the interleukin (IL)-23/IL-17A axis serve an important role in tumor immunology. In the present study, the activation of the TLR4/myeloid differentiation primary response 88 (MyD88)-mediated signal transduction pathway in human hepatocellular carcinoma (HCC) cells was examined using imm...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8586

    authors: Kang Y,Su G,Sun J,Zhang Y

    更新日期:2018-06-01 00:00:00

  • MMP-2 silencing reduces the osteogenic transformation of fibroblasts by inhibiting the activation of the BMP/Smad pathway in ankylosing spondylitis.

    abstract::Ankylosing spondylitis (AS) is a common type of rheumatoid disease, which has recently been demonstrated to be associated with the expression of matrix metalloproteinase (MMP)-2. The aim of the present study was to investigate whether MMP-2 interference reduced the osteogenic differentiation of fibroblasts and to expl...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.7714

    authors: Yuan B,Wu Z

    更新日期:2018-03-01 00:00:00

  • Prognosis and treatment differences between initial and second primary chondrosarcoma.

    abstract::Prognosis and treatment differences between initial and second primary chondrosarcoma (pCS) remain unknown. In the present study, patients with chondrosarcoma diagnosed between January 2004 and December 2015 were identified using the Surveillance Epidemiology and End Results database. Kaplan-Meier curves and log-rank ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2019.10329

    authors: Mao W,Kong M,Yu H,Wang D,Huang X,Yao X,Fan J,Geng J

    更新日期:2019-07-01 00:00:00

  • Stromal fibroblast activation and their potential association with uterine fibroids (Review).

    abstract::Uterine fibroids are the most common type of benign, gynecologic neoplasm and are the primary indication for performance of a hysterectomy, accounting for >200,000 hysterectomies annually in the USA. At present, females are younger and exhibit larger leiomyomas at the time of diagnosis. Cancer-associated fibroblasts i...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.2225

    authors: Zheng LH,Cai FF,Ge I,Biskup E,Cheng ZP

    更新日期:2014-08-01 00:00:00

  • Interaction between regulatory T cells and mast cells via IL-9 and TGF-β production.

    abstract::Research on the immunosuppression of cancer cells has attracted much attention in recent years. The present study sought to provide a new strategy for tumor immunotherapy targeting mast cells by studying the mechanisms underlying mast cell function in cancer immunosuppression. Between January 2015 and December 2017, t...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.12224

    authors: Zhao YB,Yang SH,Shen J,Deng K,Li Q,Wang Y,Cui W,Ye H

    更新日期:2020-12-01 00:00:00

  • Oncogenic role of microRNA-532-5p in human colorectal cancer via targeting of the 5'UTR of RUNX3.

    abstract::Previous studies have demonstrated that microRNAs (miRs) are involved in the carcinogenesis of colorectal cancer (CRC). To the best of our knowledge, the function and regulatory role of miR-532-5p in human CRC remains unknown. The aim of the present study was to determine the role and regulation of miR-532-5p in CRC. ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8217

    authors: Zhang J,Zhou W,Liu Y,Liu T,Li C,Wang L

    更新日期:2018-05-01 00:00:00

  • Telomerase reverse transcriptase promotes the proliferation of human laryngeal carcinoma cells through activation of the activator protein 1.

    abstract::TERT is the main functional unit of telomerase, which maintains telomere length and chromosome structure stability. TERT has been shown to act as a key factor in various biological processes, such as cell proliferation, via uncharacterized mechanisms. We transfected HEp-2 laryngeal carcinoma cells with a TERT overexpr...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2013.1344

    authors: Jiang Y,Chen C,Chen SM,Wang YQ,Xu Y,Wang Y,Chen Z,Xiao BK,Tao ZZ

    更新日期:2013-07-01 00:00:00

  • TSG101 and PEG10 are prognostic markers in squamous cell/adenosquamous carcinomas and adenocarcinoma of the gallbladder.

    abstract::The clinicopathological characteristics of squamous cell/adenosquamous carcinoma (SC/ASC) are currently not well documented, and as the prevalence of SC/ASC is uncommon in gallbladder cancers, a prognostic marker has not yet been found. In the present study, the expression of tumor susceptibility gene (TSG) 101 and pa...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.1886

    authors: Liu Z,Yang Z,Liu D,Li D,Zou Q,Yuan Y,Li J,Liang L,Chen M,Chen S

    更新日期:2014-04-01 00:00:00

  • Inflammatory cytokines, appetite-regulating hormones, and energy metabolism in patients with gastrointestinal cancer.

    abstract::This study investigated energy metabolism and its association with inflammatory cytokines and appetite- regulating hormones in patients with gastrointestinal cancer. Subjects were inpatients scheduled to undergo therapeutic intervention for diagnosed gastrointestinal cancer. Nutritional status on admission was assesse...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11662

    authors: Shinsyu A,Bamba S,Kurihara M,Matsumoto H,Sonoda A,Inatomi O,Andoh A,Takebayashi K,Kojima M,Iida H,Tani M,Sasaki M

    更新日期:2020-08-01 00:00:00

  • Non-invasive detection of nasopharyngeal carcinoma using saliva surface-enhanced Raman spectroscopy.

    abstract::The present study evaluated the use of saliva surface-enhanced Raman spectroscopy (SERS) for the detection of non-invasive nasopharyngeal carcinoma (NPC). SERS measurements were taken from 62 saliva samples, of which 32 were from NPC patients and 30 from healthy volunteers. Notable biochemical Raman bands in the SERS ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2015.3969

    authors: Qiu S,Xu Y,Huang L,Zheng W,Huang C,Huang S,Lin J,Lin D,Feng S,Chen R,Pan J

    更新日期:2016-01-01 00:00:00

  • Melanoma leptomeningeal dissemination following frontoparietal metastasis surgery: Case report and review of the literature.

    abstract::We present the case of a patient with a solitary left frontoparietal brain metastasis of melanoma previously treated with surgery. Three months later, the patient was admitted to the emergency room in a confusional state with meningeal signs. A cerebrospinal fluid (CSF) test and magnetic resonance imaging findings sug...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2010.194

    authors: Moyano MS,Gutiérrez-Gutiérrez G,Rodríguez-Esteban I,Crespo GS,Casado E

    更新日期:2010-11-01 00:00:00

  • Safety of bevacizumab in clinical practice for recurrent ovarian cancer: A retrospective cohort study.

    abstract::The poor outcome of patients with recurrent ovarian cancer constitutes a continuous challenge for decision-making in clinical practice. In this setting, molecular targets have recently been identified, and novel compounds are now available. Bevacizumab has been introduced for the treatment of patients with ovarian can...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.4146

    authors: Selle F,Emile G,Pautier P,Asmane I,Soares DG,Khalil A,Alexandre J,Lhommé C,Ray-Coquard I,Lotz JP,Goldwasser F,Tazi Y,Heudel P,Pujade-Lauraine E,Gouy S,Tredan O,Barbaza MO,Ady-Vago N,Dubot C

    更新日期:2016-03-01 00:00:00

  • Value of shear wave elastography in the diagnosis and evaluation of cervical cancer.

    abstract::The aim of the present study was to explore the value of shear wave elastography (SWE) in the differential diagnosis of cervical disease and to evaluate the infiltration of cervical cancer. A total of 40 inpatients with cervical cancer, 40 inpatients with cervical benign lesion and 40 healthy volunteers encountered be...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11759

    authors: Fu B,Zhang H,Song ZW,Lu JX,Wu SH,Li J

    更新日期:2020-09-01 00:00:00

  • Oligodendroglioma metastasis to the bone marrow mimicking multiple myeloma: A case report.

    abstract::The present study reports a case of a 59-year-old male suffering from oligodendroglioma that metastasized to the bone marrow (BM). The metastasis was detected 5 years after craniotomy was performed for the resection of the primary tumor; however, it manifested as multiple myeloma (MM)-like bone lesions, a small M comp...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.4568

    authors: Jian Y,Gao W,Wu Y,Li Y,Zhang Y,Yang G,Chen W

    更新日期:2016-07-01 00:00:00

  • Accumulation of stabilin-1 positive macrophages in the early stage of gastric cancer is associated with short cumulative survival.

    abstract::The scavenger receptor stabilin-1 has been reported to be expressed by tumor-associated macrophages (TAMs) and to facilitate tumor growth and metastasis in mouse models of breast carcinoma and melanoma. However, to the best of our knowledge, its expression and association with prognosis in human gastric cancer has not...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11310

    authors: Yin SP,Gao Y,Xie XS,Xu DD,Riabov V,Du WD

    更新日期:2020-03-01 00:00:00

  • Gambogic acid reverses oxaliplatin resistance in colorectal cancer by increasing intracellular platinum levels.

    abstract::Resistance to oxaliplatin (L-OHP) is a major obstacle to successful chemotherapy in colorectal cancer (CRC). In the present study, the ability of gambogic acid (GA) to reverse L-OHP resistance in CRC LoVo cells was investigated. L-OHP-resistant LoVo/L-OHP cells were established by exposing them to increasing concentra...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.8916

    authors: Wang Q,Wei J,Wang C,Zhang T,Huang D,Wei F,He F,Cai W,Yang P,Zeng S,Li W,Cao J

    更新日期:2018-08-01 00:00:00

  • Biological intensity-modulated radiotherapy plus neoadjuvant chemotherapy for multiple peritoneal metastases of ovarian cancer: A case report.

    abstract::The current study presents the case of a 68-year-old female patient who received biological intensity-modulated radiotherapy (BIMRT) and neoadjuvant chemotherapy for multiple peritoneal metastases of ovarian cancer. The International Federation of Gynecology and Obstetrics disease stage was IIIc. In addition, the pati...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2014.2820

    authors: Huang S,Dang Y,Li F,Wei W,Ma Y,Qiao S,Wang Q

    更新日期:2015-03-01 00:00:00

  • Expression of c-Met and hepatocyte growth factor in various gastric pathologies and its association with Helicobacter pylori infection.

    abstract::Activation of the hepatocyte growth factor (HGF)/c-Met signaling pathway was identified to be associated with malignant tumors. The present study aimed at determining the expression of HGF and c-Met in gastric carcinogenesis and its association with Helicobacter pylori infection. Gastric biopsies were obtained from 16...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2017.6983

    authors: Xie C,Yang Z,Hu Y,Cao X,Chen J,Zhu Y,Lu N

    更新日期:2017-11-01 00:00:00

  • Decreased copy number of mitochondrial DNA: A potential diagnostic criterion for gastric cancer.

    abstract::An alteration in the mitochondrial DNA (mtDNA) copy number has been detected in numerous human cancers. However, certain changes in the mtDNA copy number that occur during the initiation and progression of gastric cancer remain undetected. In the present study, using quantitative PCR analysis, the quantitative changes...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2013.1492

    authors: Wen SL,Zhang F,Feng S

    更新日期:2013-10-01 00:00:00

  • Increased serum levels of miR-214 in patients with PCa with bone metastasis may serve as a potential biomarker by targeting PTEN.

    abstract::MicroRNAs (miRNAs/miRs) are identified to serve key functions in the progression of various tumors. miR-214 is aberrantly expressed in various types of cancer. In the present study, the function of miR-214 and its feasibility as a potential non-invasive biomarker for patients with prostate cancer (PCa) in a hyperplasi...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.9522

    authors: Fang Y,Qiu J,Jiang ZB,Xu SR,Zhou ZH,He RL

    更新日期:2019-01-01 00:00:00

  • Tumor suppression by Tegafur combined with Barbadian in S-180 tumor-bearing mice.

    abstract::The aim of this study was to discuss the antitumor effect of Tegafur combined with Barbadian on S-180 tumor-bearing mice. A murine tumor model was prepared by subcutaneous injection of S-180 sarcoma cells to the armpit of the right limb of healthy female SPF KM mice. The 24 tumor-bearing mice were randomly divided int...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.9373

    authors: Zhang E,Fu A,Chen W,Wang X

    更新日期:2018-11-01 00:00:00

  • Identification of potential pathogenic candidates or diagnostic biomarkers in papillary thyroid carcinoma using expression and methylation profiles.

    abstract::The mechanisms underlying the pathogenesis of papillary thyroid carcinoma (PTC) have not yet been elucidated. The aim of the current study was to identify potential pathogenic biomarkers in PTC by comprehensively analyzing gene expression and methylation profiles, and to increase the understanding of PTC pathogenesis....

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2019.11059

    authors: Wei S,Yun X,Ruan X,Wei X,Zheng X,Gao M

    更新日期:2019-12-01 00:00:00

  • Effect of marital status on duodenal adenocarcinoma survival: A Surveillance Epidemiology and End Results population analysis.

    abstract::Numerous studies have shown that marital status may be a prognostic factor in various malignancies, but little is known about its effect on duodenal adenocarcinoma. The aim of the present study was to determine the association between marital status and survival in patients with duodenal adenocarcinoma. The Surveillan...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2019.10475

    authors: Wang N,Bu Q,Liu Q,Yang J,He H,Liu J,Ren X,Lyu J

    更新日期:2019-08-01 00:00:00

  • Classical intracranial chondrosarcoma: A case report.

    abstract::Intracranial chondrosarcoma is a rare malignant cartilage-forming tumor, with only a small number of cases in the posterior cranial fossa reported previously. The present study reports the case of a 40-year-old male patient who was admitted to Tianjin Huanhu Hospital with a progressive headache and dizziness that had ...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2016.5154

    authors: Chi J,Zhang M,Kang J

    更新日期:2016-11-01 00:00:00

  • miR-494 promotes progression of retinoblastoma via PTEN through PI3K/AKT signaling pathway.

    abstract::Increasing evidence has indicated that the dysregulation of microRNA (miRNA) occur in the pathogenesis of retinoblastoma (RB). Aim of the present study was to investigate the possible role of miR-494 (miR-494-3p) in RB. It was demonstrated that miR-494 expression was increased in RB tissue samples and cell lines. Also...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2020.11749

    authors: Xu F,Liu G,Wang L,Wang X,Jin X,Bo W

    更新日期:2020-08-01 00:00:00

  • Dosimetric comparison between IMRT and VMAT in irradiation for peripheral and central lung cancer.

    abstract::The aim of the present study was to compare intensity-modulated radiation therapy (IMRT) and volumetric modulated arc therapy (VMAT) in irradiation of lung cancer. Plans of 14 patients were compared. The results demonstrated that in peripheral lung cancer, V5 (%) of the lung in partial-arc (PA)-VMAT was decreased comp...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2018.7732

    authors: Li Y,Wang J,Tan L,Hui B,Ma X,Yan Y,Xue C,Shi X,Drokow EK,Ren J

    更新日期:2018-03-01 00:00:00

  • Clear cell myoepithelial carcinoma in the base of the tongue: Case report and review of the literature.

    abstract::Clear cell myoepithelial carcinoma is a very rare disease which develops primarily in the parotid gland. To date, only 17 cases of clear cell myoepithelial carcinoma have been reported worldwide. Among them, only three cases developed in the minor salivary gland in the oral cavity. No cases developed in the base of th...

    journal_title:Oncology letters

    pub_type: 杂志文章

    doi:10.3892/ol.2012.900

    authors: Park JH,Choi JY,Hong R,DO NY

    更新日期:2012-12-01 00:00:00