Regulation of TWIK-related potassium channel-1 (Trek1) restitutes intestinal epithelial barrier function.

abstract：:MicroRNAs (miRNAs) are a class of small non-coding regulatory RNAs, and changes in miRNAs are involved in tumor origin and progression. Studies have shown that miR-20a is overexpressed in human ovarian cancer tissues and that this miRNA enhances long-term cellular proliferation and invasion capabilities. In this study...

journal_title：Cellular & molecular immunology

authors： Xie J,Liu M,Li Y,Nie Y,Mi Q,Zhao S

更新日期：2014-09-01 00:00:00

abstract：:Psoriasis is a chronic inflammatory skin disease with a strong genetic background and is triggered by environmental factors. Available evidence supports CD6, a lymphocyte surface receptor mostly expressed by T cells, as a putative target in autoimmunity. Accordingly, a humanized anti-CD6 antibody has been assayed for ...

journal_title：Cellular & molecular immunology

authors： Consuegra-Fernández M,Julià M,Martínez-Florensa M,Aranda F,Català C,Armiger-Borràs N,Arias MT,Santiago F,Guilabert A,Esteve A,Muñoz C,Ferrándiz C,Carrascosa JM,Pedrosa E,Romaní J,Alsina M,Mascaró-Galy JM,Lozano F

更新日期：2018-10-01 00:00:00

abstract：:Circulating monocyte subsets with distinct functions play important roles in hepatitis C virus (HCV) infection. However, the mechanisms have not been well studied. In this study, we analyzed the distributions and phenotypic characteristics of three circulating monocyte subsets-CD14(++)CD16(-), CD14(++)CD16(+) and CD14...

journal_title：Cellular & molecular immunology

authors： Zheng J,Liang H,Xu C,Xu Q,Zhang T,Shen T,Lu F

更新日期：2014-05-01 00:00:00

abstract：:Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been redetected after discharge in some coronavirus disease 2019 (COVID-19) patients. The reason for the recurrent positivity of the test and the potential public health concern due to this occurrence are still unknown. Here, we analyzed the viral data a...

journal_title：Cellular & molecular immunology

authors： Hu F,Chen F,Ou Z,Fan Q,Tan X,Wang Y,Pan Y,Ke B,Li L,Guan Y,Mo X,Wang J,Wang J,Luo C,Wen X,Li M,Ren P,Ke C,Li J,Lei C,Tang X,Li F

更新日期：2020-11-01 00:00:00

abstract：:To construct cDNA library of nasopharyngeal carcinoma (NPC) and obtain the NPC associated or specific antigens from it, we used a powerful new method to identify the antigens eliciting humoral immune response, which is SEREX (serological identification of antigen by recombinant cDNA expression library). Autologous ser...

journal_title：Cellular & molecular immunology

authors： Shu J,He XJ,Li GC

更新日期：2006-02-01 00:00:00

abstract：:The complement system plays an important role in mediating both acquired and innate responses to defend against microbial infection, and in disposing immunoglobins and apoptotic cells. The liver (mainly hepatocytes) is responsible for biosynthesis of about 80-90% of plasma complement components and expresses a variety...

journal_title：Cellular & molecular immunology

authors： Qin X,Gao B

更新日期：2006-10-01 00:00:00

abstract：:To evaluate the balance status of interleukin 18 (IL-18) and interleukin 18 binding protein (IL-18BP) in circulation in patients with lupus nephritis (LN) and primary nephrotic syndrome (PNS), plasma levels as well as mRNA expression in peripheral blood mononuclear cells (PBMCs) of IL-18 and IL-18BP were measured by E...

journal_title：Cellular & molecular immunology

authors： Liang D,Ma W,Yao C,Liu H,Chen X

更新日期：2006-08-01 00:00:00

abstract：:Regulatory B cells (Bregs) are a functionally defined B cell subset, and IL-10 is crucial for the suppressive functions of Bregs. However, little is known regarding how IL-10 production is regulated in B cells. To explore the mechanisms by which IL-10 is regulated in B cells, we used mRNA microarrays to screen for mol...

journal_title：Cellular & molecular immunology

authors： Wei Y,Zhang F,Zhang Y,Wang X,Xing C,Guo J,Zhang H,Suo Z,Li Y,Wang J,Wang R,Cai Z

更新日期：2019-06-01 00:00:00

abstract：:The combination of immunotherapy and chemotherapy is regarded as a promising approach for the treatment of certain types of cancer. However, the underlying mechanisms need to be fully investigated to guide the design of more efficient protocols for cancer chemoimmunotherapy. It is well known that danger-associated mol...

journal_title：Cellular & molecular immunology

authors： Fang H,Ang B,Xu X,Huang X,Wu Y,Sun Y,Wang W,Li N,Cao X,Wan T

更新日期：2014-03-01 00:00:00

abstract：:Transplantation of mesenchymal stem cells (MSCs) has been recently studied in animal models, and in clinical trials of patients with fulminant hepatic failure, end-stage liver diseases and inherited metabolic disorders. Modulatory cytokines produced by MSCs can inhibit immunocyte proliferation and migration to the liv...

journal_title：Cellular & molecular immunology

authors： Lin H,Xu R,Zhang Z,Chen L,Shi M,Wang FS

更新日期：2011-01-01 00:00:00

abstract：:pR(ST98) is a large and conjugative resistant plasmid (R plasmid) of 98.6 mega-dalton from multi-drug resistant Salmonella typhi (S. typhi), which was classified to incompatibility group C (Inc C). It has been found that pRST98 made its host bacteria not only antibiotic resistant but also more virulent. In this study ...

journal_title：Cellular & molecular immunology

authors： Huang R,Wu S,Zhang X,Zhang Y

更新日期：2005-04-01 00:00:00

abstract：:Exercise at regular intervals is assumed to have a positive effect on immune functions. Conversely, after spaceflight and under simulated weightlessness (e.g., bed rest), immune functions can be suppressed. We aimed to assess the effects of simulated weightlessness (Second Berlin BedRest Study; BBR2-2) on immunologica...

journal_title：Cellular & molecular immunology

authors： Hoff P,Belavý DL,Huscher D,Lang A,Hahne M,Kuhlmey AK,Maschmeyer P,Armbrecht G,Fitzner R,Perschel FH,Gaber T,Burmester GR,Straub RH,Felsenberg D,Buttgereit F

更新日期：2015-07-01 00:00:00

abstract：:Previously, we demonstrated that macrophages from thrombospondin 1 (TSP1)-deficient mice have a reduced inflammatory phenotype, suggesting that TSP1 plays a role in macrophage activation. In this study, we determined how TSP1 regulates macrophage function. We found that recombinant or purified platelet human TSP1 trea...

journal_title：Cellular & molecular immunology

authors： Li Y,Qi X,Tong X,Wang S

更新日期：2013-11-01 00:00:00

abstract：:Bispecific antibodies (bsAbs) refer to a large family of molecules that recognize two different epitopes or antigens. Although a series of challenges, especially immunogenicity and chain mispairing issues, once hindered the development of bsAbs, they have been gradually overcome with the help of rapidly developing tec...

journal_title：Cellular & molecular immunology

authors： Li H,Er Saw P,Song E

更新日期：2020-05-01 00:00:00

abstract：:Dendritic cells (DCs) are the most potent professional antigen-presenting cells, and capable of stimulating naïve T cells and driving primary immune responses. DCs are poised to capture antigen, migrate to draining lymphoid organs, and after a process of maturation, select antigen-specific lymphocytes to which they pr...

journal_title：Cellular & molecular immunology

authors： Sun K,Wang L,Zhang Y

更新日期：2006-06-01 00:00:00

abstract：:Mesenchymal stem/stromal cells (MSCs) possess some characteristics of immune cells, including a pro-inflammatory phenotype, an immunosuppressive phenotype, antibacterial properties and the expression of Toll-like receptor proteins. Here we show that, similar to immune cells, MSCs retain information from danger signals...

journal_title：Cellular & molecular immunology

authors： Liu GY,Liu Y,Lu Y,Qin YR,Di GH,Lei YH,Liu HX,Li YQ,Wu C,Hu XW,Duan HF

更新日期：2016-05-01 00:00:00

abstract：:In human adipose tissue and obesity, miR-99a expression is negatively correlated with inflammation. Therefore, the present study investigated the role of miR-99a in macrophage phenotype activation and adipose tissue inflammation. M2 BMDMs showed a significant increase in miR-99a expression when compared to the M0 and ...

journal_title：Cellular & molecular immunology

authors： Jaiswal A,Reddy SS,Maurya M,Maurya P,Barthwal MK

更新日期：2019-05-01 00:00:00

abstract：:Metagenomic approaches are currently being used to decipher the genome of the microbiota (microbiome), and, in parallel, functional studies are being performed to analyze the effects of the microbiota on the host. Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization...

journal_title：Cellular & molecular immunology

authors： Tlaskalová-Hogenová H,Stěpánková R,Kozáková H,Hudcovic T,Vannucci L,Tučková L,Rossmann P,Hrnčíř T,Kverka M,Zákostelská Z,Klimešová K,Přibylová J,Bártová J,Sanchez D,Fundová P,Borovská D,Srůtková D,Zídek Z,Schwarzer M

更新日期：2011-03-01 00:00:00

abstract：:B cells play an important role in the clearance of hepatitis B virus (HBV) and protection against reinfection. However, the functional characteristics of these cells that are associated with the outcome of chronic HBV infection remain unknown. We comprehensively investigated the frequency, phenotype, and function of p...

journal_title：Cellular & molecular immunology

authors： Xu X,Shang Q,Chen X,Nie W,Zou Z,Huang A,Meng M,Jin L,Xu R,Zhang JY,Fu J,Wang L,Tang Z,Xie Y,Yang X,Zhang Z,Wang FS

更新日期：2015-05-01 00:00:00

abstract：:The capacity of pluri-potent stem cells to repair the tissues in which stem cells reside holds great promise in development of novel cell replacement therapeutics for treating chronic and degenerative diseases. However, numerous reports show that stem cell therapy, even in an autologous setting, triggers lymphocyte in...

journal_title：Cellular & molecular immunology

authors： Yang XF

更新日期：2007-06-01 00:00:00

abstract：:Among various immunoregulatory molecules, the B7 family of immune-checkpoint receptors consists of highly valuable targets for cancer immunotherapy. Antibodies targeting two B7 family co-inhibitory receptors, CTLA-4 and PD-1, have elicited long-term clinical outcomes in previously refractory cancer types and are consi...

journal_title：Cellular & molecular immunology

authors： Xu W,Hiếu T,Malarkannan S,Wang L

更新日期：2018-05-01 00:00:00

abstract：:The major limitation for the maturation of dendritic cells (DCs) using Toll-like receptor (TLR) agonists is their decreased ability to migrate into lymph nodes compared with conventional DCs. CD38 can be used as a multifunctional marker to modulate migration, survival and Th1 responses of DCs. CD74 has been shown to n...

journal_title：Cellular & molecular immunology

authors： Nguyen-Pham TN,Lim MS,Nguyen TA,Lee YK,Jin CJ,Lee HJ,Hong CY,Ahn JS,Yang DH,Kim YK,Chung IJ,Park BC,Kim HJ,Lee JJ

更新日期：2011-07-01 00:00:00

abstract：:Experimental autoimmune encephalomyelitis (EAE) is a good model for human multiple sclerosis (MS) research. However, there are some defects in the traditional models. Here, we improved the model by using the human myelin basic protein (MBP) as antigen. EAE was induced by immunization of female Wistar rats with human M...

journal_title：Cellular & molecular immunology

authors： Guo L,Li Y,Lin H,Ji X,Li J,Que L,Zhang Y,Rong Y,Wang J

更新日期：2004-10-01 00:00:00

abstract：:Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by B-cell hyperreactivity. The Toll-like receptor 7 (TLR7) signaling pathway is abnormally activated in SLE B cells. CyclinD3 (CCND3) plays an important role in B-cell proliferation, development, and differentiation. Although previous studies fo...

journal_title：Cellular & molecular immunology

authors： Ren D,Liu F,Dong G,You M,Ji J,Huang Y,Hou Y,Fan H

更新日期：2016-11-01 00:00:00

abstract：:Infection with human immunodeficiency virus (HIV) disrupts the balance among γδ T cell subsets, with increasing Vδ1+ cells and substantial depletion of circulating Vδ2+ cells. Depletion is an indirect effect of HIV in CD4-negative Vδ2 cells, but is specific for phosphoantigen-responsive subpopulations identified by th...

journal_title：Cellular & molecular immunology

authors： Li H,Chaudhry S,Poonia B,Shao Y,Pauza CD

更新日期：2013-01-01 00:00:00

abstract：OBJECTIVE:Plasma phospholipid transfer protein (PLTP) is a key determinant of lipoprotein metabolism, and both animal and human studies converge to indicate that PLTP promotes atherogenesis and its thromboembolic complications. Moreover, it has recently been reported that PLTP modulates inflammation and immune response...

journal_title：Cellular & molecular immunology

authors： Desrumaux C,Lemaire-Ewing S,Ogier N,Yessoufou A,Hammann A,Sequeira-Le Grand A,Deckert V,Pais de Barros JP,Le Guern N,Guy J,Khan NA,Lagrost L

更新日期：2016-11-01 00:00:00

abstract：:Complications arising from abnormal immune responses are the major causes of mortality and morbidity in diabetic patients. CD4+CD25+T regulatory cells (Tregs) play pivotal roles in controlling immune homeostasis, immunity and tolerance. The effect of hyperglycemia on CD4+CD25+Tregs has not yet been addressed. Here we ...

journal_title：Cellular & molecular immunology

authors： Zhen Y,Sun L,Liu H,Duan K,Zeng C,Zhang L,Jin D,Peng J,Ding W,Zhao Y

更新日期：2012-01-01 00:00:00

abstract：:The aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor initially identified as the receptor for dioxin. Almost half a century after its discovery, AHR is now recognized as a receptor for multiple physiological ligands, with important roles in health and disease. In this review, we discuss the r...

journal_title：Cellular & molecular immunology

authors： Barroso A,Mahler JV,Fonseca-Castro PH,Quintana FJ

更新日期：2021-02-01 00:00:00

abstract：:The uterus in early pregnancy is a non-lymphoid organ that is enriched in natural killer (NK) cells. Studies to address the role of these abundant human NK cells at the maternal/fetal interface have focused on their response to the major histocompatibility complex (MHC) molecules on fetal trophoblast cells that they c...

journal_title：Cellular & molecular immunology

authors： Rajagopalan S

更新日期：2014-09-01 00:00:00

abstract：:The T-cell-mediated immune response is implicated in many clinical hepatic injuries, such as autoimmune hepatitis and acute virus hepatitis. CD24 is widely expressed by different immune cells and plays an important role in the pathogenesis of many autoimmune diseases. However, the role of CD24 in T-cell-mediated liver...

journal_title：Cellular & molecular immunology

authors： Zheng C,Yin S,Yang Y,Yu Y,Xie X

更新日期：2018-03-01 00:00:00