当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > Stroke admission and case-fatality in an urban medical unit in sub-Saharan Africa: a fourteen year trend study from 1999 to 2012.

Stroke admission and case-fatality in an urban medical unit in sub-Saharan Africa: a fourteen year trend study from 1999 to 2012.

Abstract：

BACKGROUND:Data on recent stroke trends in the context of rapidly deteriorating risk profile of populations within Africa is very limited. We investigated the admission trend for stroke and related outcomes in a major referral hospital in Cameroon. METHODS:Admission and discharge registries, and patient files for the period 1999-2012 of the medical department of the Yaoundé Central Hospital were reviewed for evidence of admission for stroke, and outcomes during hospitalization. Trajectories of case-fatality and risk factors over time were assessed, with adjustment for confounders using logistic regression models. RESULTS:Of the 28,239 medical admissions registered during the study period, 1688 (6.0%) were due to stroke. This proportion ranged from 2.5% in 1999-2000 to 13.1% in 2011-2012 overall and similarly in men and women. Mean age, alcohol consumption and history of stroke varied across years (all p ≤ 0.006). Computed tomography confirmed that stroke increased from 34.4% in 1999-2000 to 84.2% in 2011-2012, while the length of stay decreased from 21 to 10 days (both p<0.0001 for linear trend). Case-fatality rate increased from 14.4% to 22.4%. The adjusted odd ratio (95% CI) 2011-2012 vs. 1999-2000 was 2.93 (1.40-6.13), p<0.0001 for the linear trend across years. The unadjusted relative risk of death from stroke patients vs. general admissions was 0.95 (0.87-1.05) overall, 0.82 (0.71-0.94) in men and 1.08 (0.95-1.23) in women. CONCLUSION:During the last decade and a half, stroke admissions and case-fatality have increased in the study setting, reflecting in part the inadequate coping capacity of the health care system.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Lekoubou A,Nkoke C,Dzudie A,Kengne AP

doi

10.1016/j.jns.2015.02.002

subject

Has Abstract

pub_date

2015-03-15 00:00:00

pages

24-32

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022-510X(15)00067-2

journal_volume

350

pub_type

杂志文章

相关文献

JOURNAL OF THE NEUROLOGICAL SCIENCES文献大全
  • Multiple sclerosis in Iraq: does it have the same features encountered in Western countries?

    abstract：OBJECTIVES:To characterize the clinical, demographic and epidemiological features of MS patients from the only specialised MS centre in Iraq. METHODS:Data for consecutive Iraqi MS patients attending the Baghdad Multidiscipline MS Clinic between 2000 and 2002 who fulfilled Poser et al. criteria for clinically definite ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2005.03.033

    authors： Al-Araji A,Mohammed AI

    更新日期：2005-07-15 00:00:00

  • Deletions of mitochondrial DNA in Kearns-Sayre syndrome and ocular myopathies: genetic, biochemical and morphological studies.

    abstract：:Genetic, biochemical and morphological investigations were conducted on skeletal muscle mitochondria from 6 cases of ocular myopathy: 4 cases with Kearns-Sayre syndrome (KSS) and 2 with chronic progressive external ophthalmoplegia. All of these 6 cases showed mitochondrial DNA (mtDNA) deletions in addition to normal s...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(91)90042-6

    authors： Degoul F,Nelson I,Lestienne P,Francois D,Romero N,Duboc D,Eymard B,Fardeau M,Ponsot G,Paturneau-Jouas M

    更新日期：1991-02-01 00:00:00

  • Corticosteroids treatment.

    abstract：:Corticosteroids (Cs) are widely used for treatment of multiple sclerosis (MS) acute relapses because of the potent immunosuppressive and anti-inflammatory properties. As for patients with relapsing-remitting (RR) MS, short-term administrations of Cs markedly less severity of symptoms and promote faster recovery of cli...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2004.04.019

    authors： Pozzilli C,Marinelli F,Romano S,Bagnato F

    更新日期：2004-08-15 00:00:00

  • Paraneoplastic neurological syndromes in lung cancer patients with or without onconeural antibodies.

    abstract：BACKGROUND:Paraneoplastic neurological syndromes (PNS) are poorly described in patients without onconeural antibodies and in patients with non-small cell lung cancer (NSCLC). We compared the clinical characteristics of PNS in lung cancer patients with and without onconeural antibodies. METHODS:Medical records from pat...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2014.10.040

    authors： Raspotnig M,Vedeler C,Storstein A

    更新日期：2015-01-15 00:00:00

  • Early tolerability and safety of fingolimod in clinical practice.

    abstract：BACKGROUND:Fingolimod is approved by the U.S. Food and Drug Administration to reduce relapses and disability progression in relapsing forms of MS. Several screening studies and a first-dose observation (FDO) period are recommended due to adverse effects observed in clinical trials. OBJECTIVE:The objective of this stud...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2012.09.009

    authors： Ontaneda D,Hara-Cleaver C,Rudick RA,Cohen JA,Bermel RA

    更新日期：2012-12-15 00:00:00

  • Motor unit firing intervals and other parameters of electrical activity in normal and pathological muscle.

    abstract：:The analysis of the firing intervals of motor units has been suggested as a diagnostic tool in patients with neuromuscular disorders. Part of the increase in number of turns seen in patients with myopathy could be secondary to the decrease in motor unit firing intervals at threshold force of the motor units, as noted ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(87)90077-3

    authors： Fuglsang-Frederiksen A,Smith T,Høgenhaven H

    更新日期：1987-03-01 00:00:00

  • Blood oxidative stress in amyotrophic lateral sclerosis.

    abstract：:It has been suggested that amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder resulting in motor neuron death, is associated with oxidative damage induced by free radicals. Our study aimed to get an assessment of the blood oxidative stress status in a population of 167 ALS patients (aged 59+/-13 years),...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0022-510x(00)00365-8

    authors： Bonnefont-Rousselot D,Lacomblez L,Jaudon M,Lepage S,Salachas F,Bensimon G,Bizard C,Doppler V,Delattre J,Meininger V

    更新日期：2000-09-01 00:00:00

  • Novel mutations in the sacsin gene in ataxia patients from Maritime Canada.

    abstract：:We ascertained two families in Eastern Canada segregating a form of ataxia consistent with a recessive mode of inheritance. We performed a whole genome scan using dense SNP genotyping, and despite an absence of shared homozygosity in the families we defined linkage to a small region on chromosome 13. Direct DNA resequ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2009.09.034

    authors： Guernsey DL,Dubé MP,Jiang H,Asselin G,Blowers S,Evans S,Ferguson M,Macgillivray C,Matsuoka M,Nightingale M,Rideout A,Delatycki M,Orr A,Ludman M,Dooley J,Riddell C,Samuels ME

    更新日期：2010-01-15 00:00:00

  • Factors associated with favorable outcome in botulinum toxin A treatment for chronic migraine: A clinic-based prospective study.

    abstract：BACKGROUND:Botulinum toxin A (BTA) responders have elevated levels of calcitonin gene-related and vasoactive intestinal peptides, which are potent vasodilators. We aimed to investigate neurovascular features as a predictor of BTA treatment response in patients with chronic migraine. METHODS:We prospectively recruited ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2016.01.054

    authors： Lee MJ,Lee C,Choi H,Chung CS

    更新日期：2016-04-15 00:00:00

  • Intranasal nerve growth factor attenuates tau phosphorylation in brain after traumatic brain injury in rats.

    abstract：:Traumatic brain injury (TBI) is a considerable cause of mild cognitive impairment and dementia. Intranasal administration of nerve growth factor (NGF) has previously been found to improve cognitive function after TBI, but the mechanism remains unclear. This study aimed to investigate the effects of intranasal NGF on t...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2014.06.037

    authors： Lv Q,Lan W,Sun W,Ye R,Fan X,Ma M,Yin Q,Jiang Y,Xu G,Dai J,Guo R,Liu X

    更新日期：2014-10-15 00:00:00

  • Relationship between gray matter volume and cognitive learning in CIS patients on disease-modifying treatment.

    abstract：BACKGROUND:Repeated administration of Paced Auditory Serial Addition Test (PASAT) results in a considerable learning effect in short- or long-term follow-up studies. However, the relationship between PASAT learning and changes in magnetic resonance imaging (MRI) parameters is yet to be investigated. OBJECTIVES:The aim...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2014.10.002

    authors： Uher T,Benedict RH,Horakova D,Bergsland N,Dusankova JB,Tyblova M,Ramasamy DP,Seidl Z,Vaneckova M,Krasensky J,Havrdova E,Zivadinov R

    更新日期：2014-12-15 00:00:00

  • Optic neuritis in an ethnically diverse population: higher risk of atypical cases in patients of African or African-Caribbean heritage.

    abstract：PURPOSE:To investigate the presence of an ethnicity bias within patients presenting with optic neuritis in London. DESIGN:Observational cross-sectional study. METHODS:The ethnicity profile of all patients attending a neuro-ophthalmology clinic in central London with acute optic neuritis over a 16month period (n=86) w...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2011.08.030

    authors： Storoni M,Pittock SJ,Weinshenker BG,Plant GT

    更新日期：2012-01-15 00:00:00

  • Accumulation of HAX-1 and PARL in brainstem- and cortical-type Lewy bodies in Parkinson's disease and dementia with Lewy bodies.

    abstract：:HS1-associated protein X-1 (HAX-1) and presenilin-associated rhomboid-like protein (PALR) were reported to play an important role in the activation of HtrA2/Omi, which is also designated PARK13, in the mitochondria. To elucidate the role of HAX-1 and PARL in patients with Parkinson's disease (PD) and dementia with Lew...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2020.116928

    authors： Kawamoto Y,Ayaki T,Urushitani M,Ito H,Takahashi R

    更新日期：2020-08-15 00:00:00

  • Usage of SWI (susceptibility weighted imaging) acquired at 7T for qualitative evaluation of temporal lobe epilepsy patients with histopathological and clinical correlation: An initial pilot study.

    abstract：OBJECTIVES:Ultra high field MRI at 7T is able to provide much improved spatial and contrast resolution which may aid in the diagnosis of hippocampal abnormalities. This paper presents a preliminary experience on qualitative evaluation of 7T MRI in temporal lobe epilepsy patients with a focus on comparison to histopatho...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2016.07.066

    authors： Kwan BYM,Salehi F,Ohorodnyk P,Lee DH,Burneo JG,Mirsattari SM,Steven D,Hammond R,Peters TM,Khan AR

    更新日期：2016-10-15 00:00:00

  • Parkinson's disease and mitochondrial gene variations: a review.

    abstract：:Parkinson's disease (PD) is a common disorder of the central nervous system in the elderly. The pathogenesis of PD is a complex process, with genetics as an important contributing factor. This factor may stem from mitochondrial gene variations and mutations as well as from nuclear gene variations and mutations. More r...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2014.07.067

    authors： Andalib S,Vafaee MS,Gjedde A

    更新日期：2014-11-15 00:00:00

  • Bilateral infarction of the anterior cingulate gyri and of the fornices. Report of a case.

    abstract：:A 70-year-old woman had complex behavioural changes of sudden onset. The symptoms consisted of indifference, docility and inappropriate urination, but predominantly in a lack of attention. She was unable to maintain the attention necessary to perform a goal-directed activity and she was distracted by any stimulus, suc...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(81)90107-6

    authors： Laplane D,Degos JD,Baulac M,Gray F

    更新日期：1981-08-01 00:00:00

  • Further studies of mitochondrial and lipid storage myopathies.

    abstract：:Further observations on a family with facioscapulohumeral (FSH) muscular dystrophy due to mitochondrial myopathy, and on a case with lipid storage myopathy are reported. One member of the family with FSH muscular dystrophy died due to a viral pneumonia, during which she developed gross hyperlacticacidaemia and acidosi...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(78)90003-5

    authors： Bradley WG,Tomlinson BE,Hardy M

    更新日期：1978-02-01 00:00:00

  • Zika virus infection and risk of Guillain-Barré syndrome: A meta-analysis.

    abstract：OBJECTIVE:Findings from studies of the association between Zika virus (ZIKV) infection and Guillain-Barré syndrome (GBS) are inconsistent. I conducted a systematic review and meta-analysis to clarify the nature of this association. METHODS:I searched PubMed, Scopus, Cochrane, CINAHL, Web of Science, Scielo, and DOAJ f...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.jns.2019.06.019

    authors： Bautista LE

    更新日期：2019-08-15 00:00:00

  • SiRNA-mediated serotonin transporter knockdown in the dorsal raphe nucleus rescues single prolonged stress-induced hippocampal autophagy in rats.

    abstract：:The neurobiological mechanisms underlying the development of post-traumatic stress disorder (PTSD) remain elusive. One of the hypotheses is the dysfunction of serotonin (5-HT) neurotransmission, which is critically regulated by serotonin transporter (SERT). Therefore, we hypothesized that attenuation of SERT gene expr...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2015.11.056

    authors： Wu ZM,Zheng CH,Zhu ZH,Wu FT,Ni GL,Liang Y

    更新日期：2016-01-15 00:00:00

  • Friedreich ataxia with minimal GAA expansion presenting as adult-onset spastic ataxia.

    abstract：:Around a quarter of Friedreich ataxia (FA) patients, despite being homozygous for GAA expansion within the FRDA gene, show atypical presentations. Our aim is to describe the case of three brothers with long-term follow-up suffering from late onset FA manifested with spastic ataxia. The three patients belong to a famil...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(01)00681-5

    authors： Berciano J,Mateo I,De Pablos C,Polo JM,Combarros O

    更新日期：2002-02-15 00:00:00

  • Regional distribution of glycoasparagine storage material in the brain in aspartylglycosaminuria.

    abstract：:We have studied the regional distribution of glycoasparagine storage material in the brain in aspartylglycosaminuria, a condition characterized by inherited deficiency of lysosomal N-aspartyl-beta-N-acetylglucosamine amidohydrolase. Gaschromatographic measurements of the main accumulating glycoprotein-derived metaboli...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(81)90174-x

    authors： Maury CP,Haltia M,Palo J

    更新日期：1981-05-01 00:00:00

  • Clofibrate-induced muscular syndrome. Report of a case with clinical, electromyographic and pathologic observations.

    abstract：:In this report the clinical features of a case of clofibrate-induced muscular syndrome, as well as the electromyographic, histochemical, light- and electron-microscopic findings are described. The clinical features are similar to those of previously reported cases. Electromyography was consistent with a myopathy. Hist...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(79)90149-7

    authors： Abourizk N,Khalil BA,Bahuth N,Afifi AK

    更新日期：1979-06-01 00:00:00

  • Adjuvant intra-arterial rt-PA injection at the initially deployed solitaire stent enhances the efficacy of mechanical thrombectomy in acute ischemic stroke.

    abstract：BACKGROUND:Both intra-arterial recombinant tissue plasminogen activator (rt-PA) and stent retrieval are effective for treating acute ischemic stroke. The goal of this study was to evaluate the effectiveness of stent retrieval combined with intra-arterial rt-PA administration via micro-catheter (called the complex techn...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2018.01.012

    authors： Yi TY,Chen WH,Wu YM,Zhang MF,Lin DL,Lin XH

    更新日期：2018-03-15 00:00:00

  • Heterozygous UDP-GlcNAc 2-epimerase and N-acetylmannosamine kinase domain mutations in the GNE gene result in a less severe GNE myopathy phenotype compared to homozygous N-acetylmannosamine kinase domain mutations.

    abstract：BACKGROUND:Glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase (GNE) myopathy, also called distal myopathy with rimmed vacuoles (DMRV) or hereditary inclusion body myopathy (HIBM), is a rare, progressive autosomal recessive disorder caused by mutations in the GNE gene. Here, we examined the relationship b...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2012.03.016

    authors： Mori-Yoshimura M,Monma K,Suzuki N,Aoki M,Kumamoto T,Tanaka K,Tomimitsu H,Nakano S,Sonoo M,Shimizu J,Sugie K,Nakamura H,Oya Y,Hayashi YK,Malicdan MC,Noguchi S,Murata M,Nishino I

    更新日期：2012-07-15 00:00:00

  • Enriched environment induces angiogenesis and improves neural function outcomes in rat stroke model.

    abstract：:Increasing evidence shows that exposure to an enriched environment (EE) after cerebral ischemia/reperfusion injury has neuroprotective benefits in animal models, including enhancing functional recovery after ischemic stroke. However, the mechanism underlying this effect remains unclear. To clarify this critical issue,...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2014.10.022

    authors： Yu K,Wu Y,Zhang Q,Xie H,Liu G,Guo Z,Li F,Jia J,Kuang S,Hu R

    更新日期：2014-12-15 00:00:00

  • A multiparametric MRI study of frontal lobe dementia in multiple sclerosis.

    abstract：:Previous studies achieved conflicting results when correlating magnetic resonance imaging (MRI) abnormalities and cognitive impairment in multiple sclerosis (MS) patients. Recently, the estimation of MS lesion load on T1-weighted images and the analysis of magnetization transfer ratio (MTR) histograms, increased the d...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(99)00266-x

    authors： Comi G,Rovaris M,Falautano M,Santuccio G,Martinelli V,Rocca MA,Possa F,Leocani L,Paulesu E,Filippi M

    更新日期：1999-12-15 00:00:00

  • 677C to T mutation in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene and plasma homocyst(e)ine levels in patients with TIA or minor stroke.

    abstract：:It was the aim of this study to determine the associations of clinical and laboratory data with plasma homocyst(e)ine levels in patients with transient ischemic attack (TIA) or minor stroke (MS), with special reference to their 677C to T mutation status in the 5,10-methylenetetrahydrofolate reductase (5,10-MTHFR) gene...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0022-510x(97)00311-0

    authors： Lalouschek W,Aull S,Korninger L,Mannhalter C,Pabinger-Fasching I,Schmid RW,Schnider P,Zeiler K

    更新日期：1998-03-05 00:00:00

  • Fatty acid compositions of erythrocytes, mononuclear cells and blood plasma of patients with myotonic dystrophy.

    abstract：:Fatty acid compositions of erythrocyte membrane phospholipids including phosphatidylethanolamine subclasses, blood plasma and mononuclear cells of 8 patients with myotonic dystrophy (MyD) and 8 normal controls were analyzed by high performance liquid chromatography. Slight changes (decreased C18:2 and increased C16:0)...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(85)90077-2

    authors： Antoku Y,Sakai T,Goto I,Iwashita H,Kuroiwa Y

    更新日期：1985-12-01 00:00:00

  • LINGO1 and risk for essential tremor: results of a meta-analysis of rs9652490 and rs11856808.

    abstract：BACKGROUND/OBJECTIVES:Recently, a genome-wide association study revealed a significant statistical association between LINGO1 rs9652490 and rs11856808 polymorphisms and the risk of developing essential tremor (ET) in Icelandic people. Because the results of further association studies were controversial, we conducted a...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.jns.2012.02.030

    authors： Jiménez-Jiménez FJ,García-Martín E,Lorenzo-Betancor O,Pastor P,Alonso-Navarro H,Agúndez JA

    更新日期：2012-06-15 00:00:00

  • White matter changes and the development of motor phenotypes in de novo Parkinson's Disease.

    abstract：BACKGROUND:Parkinson's Disease (PD) patients are usually divided into Tremor Dominant (TD) and Postural Instability/Gait Difficulty (PIGD) subtypes. The latter is characterized by axial motor symptoms and worse outcomes, possibly also because of comorbid white matter disease. Therefore, the current study investigated t...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2016.06.015

    authors： Moccia M,Tedeschi E,Ugga L,Erro R,Picillo M,Caranci F,Barone P,Brunetti A

    更新日期：2016-08-15 00:00:00