Abstract:
:Florfenicol (FLC) and oxytetracycline (OTC) are the two most commonly used antibiotics for bacterial treatment in fish farming in Brazil, and because of their intensive use, the potential harmful effects on aquatic organisms are of great concern. This study evaluated the effects of environmental concentrations of FLC and OTC on the genetic material of juvenile tilapia (Oreochromis niloticus) erythrocytes by using the comet assay and the occurrence of micronuclei (MN) and other erythrocytic nuclear abnormalities (ENAs) after exposure to 96hour. The comet assay showed that fish erythrocytes exhibited significantly higher DNA damage after exposure to environmental concentrations of FLC and OTC. Although MN was not observed, ENAs were significantly higher after exposure to FLC, indicating that ENAs are a better biomarker for FLC than MN. The results showed that environmental concentrations of FLC and OTC were genotoxic to erythrocytes of O. niloticus; however, future studies on DNA damage recovery are needed.
journal_name
Chemospherejournal_title
Chemosphereauthors
Botelho RG,Christofoletti CA,Correia JE,Ansoar Y,Olinda RA,Tornisielo VLdoi
10.1016/j.chemosphere.2015.02.053subject
Has Abstractpub_date
2015-08-01 00:00:00pages
206-12eissn
0045-6535issn
1879-1298pii
S0045-6535(15)00167-8journal_volume
132pub_type
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