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Exploiting the human peptidome for novel antimicrobial and anticancer agents.

Abstract：

:Infectious diseases and cancers are leading causes of death and pose major challenges to public health. The human peptidome encompasses millions of compounds that display an enormous structural and functional diversity and represents an excellent source for the discovery of endogenous agents with antimicrobial and/or anticancer activity. Here, we discuss how to exploit the human peptidome for novel antimicrobial and anticancer agents through the generation of peptide libraries from human body fluids and tissues and stepwise purification of bioactive compounds.

journal_name

Bioorg Med Chem

journal_title

Bioorganic & medicinal chemistry

authors

Bosso M,Ständker L,Kirchhoff F,Münch J

doi

10.1016/j.bmc.2017.10.038

subject

Has Abstract

pub_date

2018-06-01 00:00:00

pages

2719-2726

issue

10

eissn

0968-0896

issn

1464-3391

pii

S0968-0896(17)31975-2

journal_volume

26

pub_type

杂志文章,评审

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