Abstract：
:Metal oxide nanoparticles, such as copper oxide (CuO), are mass produced for use in a variety of products like coatings and ceramics. Acute exposure to CuO nanoparticles has caused toxicity to many aquatic organisms, yet there is no information on the effect of prolonged CuO nanomaterial exposures. This study examined effects of chronic exposure to CuO nanoparticles on Xenopus laevis growth and development. Experiments included a 14 d subchronic exposure and a 47 d chronic exposure throughout metamorphosis. The subchronic exposure caused mortality in all tested CuO concentrations, and significant growth effects occurred after exposure to 2.5 mg L(-1) CuO. Chronic exposure to 0.3 mg L(-1) CuO elicited significant mortality and affected the rate of metamorphosis. Exposure to lower concentrations of CuO stimulated metamorphosis and growth, indicating that low dose exposure can have hormetic effects.
journal_name
Chemospherejournal_title
Chemosphereauthors
Nations S,Long M,Wages M,Maul JD,Theodorakis CW,Cobb GPdoi
10.1016/j.chemosphere.2015.03.078subject
Has Abstractpub_date
2015-09-01 00:00:00pages
166-74eissn
0045-6535issn
1879-1298pii
S0045-6535(15)00322-7journal_volume
135pub_type
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