Probable role of both sulfhydryls and prostaglandins in gastric mucosal protection induced by S-adenosylmethionine.

Abstract:

:The role of both sulfhydryl groups and endogenous prostaglandins in the protective effect of S-adenosylmethionine against ethanol-induced gastric mucosal damage was studied in rats. Drugs were administered subcutaneously or intragastrically to fasted rats 30 or 60 min before 100% ethanol (1 ml/rat), and mucosal lesions were measured planimetrically 1 h later. The gastric mucosal protection given by S-adenosylmethionine or by 20% ethanol (adaptive protection) was significantly diminished by pretreatment of rats with the sulfhydryl blocker iodoacetamide or with the cyclooxygenase inhibitor indomethacin. The protective effect of S-adenosylmethionine could be totally abolished only by pretreatment with the combination of iodoacetamide and indomethacin. Our present data suggest that endogenous release of prostaglandins and sulfhydryl groups may play a role in the protective actions of both S-adenosylmethionine and 20% ethanol (adaptive protection) against ethanol-induced gastric mucosal damage.

journal_name

Scand J Gastroenterol

authors

Gutiérrez-Cabano CA

doi

10.3109/00365528909089244

subject

Has Abstract

pub_date

1989-10-01 00:00:00

pages

982-6

issue

8

eissn

0036-5521

issn

1502-7708

journal_volume

24

pub_type

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