Abstract：
INTRODUCTION:Systemic hyperfibrinolysis (accelerated clot degradation) and fibrinolysis shutdown (impaired clot degradation) are associated with increased mortality compared with physiologic fibrinolysis after trauma. Animal models have not reproduced these changes. We hypothesize rodents have a shutdown phenotype that require an exogenous profibrinolytic to differentiate mechanisms that promote or inhibit fibrinolysis. METHODS:Fibrinolysis resistance was assessed by thrombelastography (TEG) using exogenous tissue plasminogen activator (tPA) titrations in whole blood. There were 3 experimental groups: (1) tissue injury (laparotomy/bowel crush), (2) shock (hemorrhage to mean arterial pressure of 20 mmHg), and (3) control (arterial cannulation and tracheostomy). Baseline and 30-minute postintervention blood samples were collected, and assayed with TEG challenged with taurocholic acid (TUCA). RESULTS:Rats were resistant to exogenous tPA; the percent clot remaining 30 minutes after maximum amplitude (CL30) at 150 ng/mL (P = .511) and 300 ng/mL (P = .931) was similar to baseline, whereas 600 ng/mL (P = .046) provoked fibrinolysis. Using the TUCA challenge, the percent change in CL30 from baseline was increased in tissue injury compared with control (P = .048.), whereas CL30 decreased in shock versus control (P = .048). tPA increased in the shock group compared with tissue injury (P = .009) and control (P = .012). CONCLUSION:Rats have an innate fibrinolysis shutdown phenotype. The TEG TUCA challenge is capable of differentiating changes in clot stability with rats undergoing different procedures. Tissue injury inhibits fibrinolysis, whereas shock promotes tPA-mediated fibrinolysis.
journal_name
Surgeryjournal_title
Surgeryauthors
Moore HB,Moore EE,Lawson PJ,Gonzalez E,Fragoso M,Morton AP,Gamboni F,Chapman MP,Sauaia A,Banerjee A,Silliman CCdoi
10.1016/j.surg.2015.04.008subject
Has Abstractpub_date
2015-08-01 00:00:00pages
386-92issue
2eissn
0039-6060issn
1532-7361pii
S0039-6060(15)00247-0journal_volume
158pub_type
杂志文章相关文献
SURGERY文献大全abstract：BACKGROUND:We sought to determine the long-term effects of ABO-compatible donors (ACD) in adult cardiac transplantation (OHT). METHODS:The United Network for Organ Sharing database was examined for adult OHT from 2000 to 2010. RESULTS:Of 20,353 patients undergoing OHT, 3,046 (15%) were with ACD. Recipients of ACD wer...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2013.04.023
更新日期：2013-08-01 00:00:00
abstract：:Gallstone ileus in association with Crohn's disease of the terminal ileum is a surprisingly uncommon occurrence. The diseased ileal segment may be responsible for gallstone lithogenesis as well as for luminal stenosis that prevents gallstone passage. We report only the third case of gallstone ileus in Crohn's disease ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1990-07-01 00:00:00
abstract：BACKGROUND:Although prophylactic glucocorticoids have been used before liver resection to minimize liver dysfunction, it is unknown whether treatment with glucocorticoids will accelerates recovery from hyperbilirubinemia after liver resection. METHODS:In this open-label, randomized, controlled trial, patients with hyp...
journal_title：Surgery
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.surg.2018.09.002
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:Epithelialization of cutaneous ulcers is a long-lasting process. To study the pathomechanism of impaired epithelialization, we evaluated the role of cell cycle- and apoptosis-related proteins in the regenerating epidermis. We characterized immunohistochemically the expression of cell cycle regulators p63, CD...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2003.223
更新日期：2003-08-01 00:00:00
abstract：BACKGROUND:Persistent elevation of serum parathyroid hormone (PTH), despite normocalcemia, occurs in 8% to 40% of patients after parathyroidectomy. Explanations have included hypocalcemia owing to vitamin D deficiency or bone remineralization, and persistent hyperparathyroidism. METHODS:A retrospective chart review of...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2005.08.026
更新日期：2005-12-01 00:00:00
abstract：BACKGROUND:Upper abdominal surgery is associated with severe postoperative pain and a concomitant reduction in pulmonary function and oxygen saturation. Laparoscopic cholecystectomy is said to result in less postoperative pain compared with open cholecystectomy. METHODS:In a pragmatic, randomized trial, postoperative ...
journal_title：Surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1994-05-01 00:00:00
abstract：BACKGROUND:We have previously shown that in a randomized comparison of laparoscopic (LC) versus small incision (SC) cholecystectomy, postoperative hospital stay is comparable. This randomized prospective study compares the postoperative pain, analgesic and antiemetic consumption, perceived health, and metabolic and res...
journal_title：Surgery
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1067/msy.1998.87552
更新日期：1998-05-01 00:00:00
abstract：:The blood lost through the suture line holes of vessels closed with braided polyester sutures is compared with that lost when a monofilament polypropylene suture is employed. In a retrospective analysis of blood replacement during saphenous vein aortorenal bypasses, twice as much blood replacement was required when th...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1975-08-01 00:00:00
abstract：:In the past 11 years we have operated on three patients with "tiny" parathyroid adenomas (less than 60 mg). Two of these adenomas were virtually indistinguishable visually from the normal glands. (The third adenoma was found only after fixation and permanent sections.) Despite frozen-section diagnoses of "probable hyp...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1986-12-01 00:00:00
abstract：BACKGROUND:Management of critically ill patients is a challenge in low resource settings where there is a paucity of trained staff, infrastructure, resources, and drugs. We aimed to study the characteristics of surgical patients admitted in intensive care unit in a limited resource setting and determine factors associa...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2019.04.010
更新日期：2019-08-01 00:00:00
abstract：BACKGROUND:Anastomotic leakage after gastrointestinal operation is a complication difficult to manage because conservative therapy and/or reoperation may be unsuccessful and carry the risk of increased morbidity and mortality. The endoscopic use of tissue sealants appears to be a promising alternative to avoid operatio...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2014.06.002
更新日期：2015-01-01 00:00:00
abstract：:We performed spirometry on 114 morbidly obese patients considered for gastric bypass surgery to assess its efficacy as a preoperative screening test. One hundred eight subjects underwent surgery, and 61 patients returned for repeat spirometry 1 year later. The average preoperative forced vital capacity (FVC), forced e...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1986-06-01 00:00:00
abstract：BACKGROUND:Surgery for low rectal cancer can be associated with severe bowel dysfunction and impaired quality of life. It is important to determine how patients value the trade-off between anorectal dysfunction versus abdominoperineal resection. Therefore, the objective was to determine patients' preferences for treatm...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2020.07.020
更新日期：2020-08-24 00:00:00
abstract：BACKGROUND:The American Board of Surgery encourages graduating medical students to prepare for surgical residency before day 1. We sought to determine the impact of personalized video feedback on an advance preparation task. METHODS:We conducted a nonrandomized study comparing video feedback versus no feedback. We sen...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2017.11.006
更新日期：2018-04-01 00:00:00
abstract：BACKGROUND:Preoperative noninvasive localization studies of the neck and mediastinum are beneficial before reoperation. However, the role of selective venous sampling (SVS) for parathyroid hormone (PTH) in reoperative parathyroid surgery has never been clearly defined. The purpose of this study was to evaluate the accu...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1067/msy.2002.128477
更新日期：2002-12-01 00:00:00
abstract：BACKGROUND:Estimates of the number of firearm-related injuries widely vary. Although focus has been primarily on deaths, the societal cost of caring for victims of these injuries is largely unknown. Our goal was to estimate the economic impact of nonfatal, firearm-related injuries in the United States based on recent, ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2014.02.011
更新日期：2014-05-01 00:00:00
abstract：:Among 1480 patients treated for cancers of the rectosigmoid over a 30-year period, 24 patients underwent total pelvic exenteration. These patients, 13 men and 11 women, had a median age of 64 years. Pathologic staging revealed 15 Dukes' B and nine Dukes' C lesions. For 17 patients, this operation was the only form of ...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1987-10-01 00:00:00
abstract：:This study examines the effect of pretreatment with 10(8) ultraviolet B-irradiated donor leukocytes (UV-DL) with or without peritransplant cyclosporine (CyA) treatment (20 mg/kg on days 0, +1, and +2 relative to transplantation) on rat cardiac allograft survival across major histocompatibility loci. A single UV-DL pre...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1988-08-01 00:00:00
abstract：BACKGROUND:The aim of this study was to review and discuss our observations on 33 patients who underwent surgical treatment for Caroli's disease (CD), focusing on diagnosis, current surgical management, and long-term outcome. METHODS:Between May 1993 and June 2004, 642 liver resections and 286 liver transplantations i...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2005.05.002
更新日期：2005-11-01 00:00:00
abstract：BACKGROUND:Our ability to predict respiratory compromise during general anesthesia in a child with an anterior mediastinal mass is limited. Two prior reports have found a correlation between adequacy of ventilation during general anesthesia and the tracheal cross-sectional area obtained from computed tomograms (compute...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(05)80360-5
更新日期：1995-09-01 00:00:00
abstract：BACKGROUND:The prognosis of neuroblastoma patients remains unsatisfactory. Therefore, developing an effective treatment strategy is important. Resveratrol, a natural polyphenol, possesses chemopreventive and antitumor effects. We investigated the effects of resveratrol on the proliferation, apoptosis, and cell cycle al...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2004.01.017
更新日期：2004-07-01 00:00:00
abstract：:An analysis is presented of the results of forty-one reconstructions of the superficial femoral artery using a Gore-Tex prosthesis. There were four complications and the results, when the boundary conditions were good, were comparable to those obtained from reconstruction with autogenous vein. Most failures occurred i...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1979-06-01 00:00:00
abstract：BACKGROUND:The liver is a source of systemic proinflammatory mediators in acute pancreatitis. We have investigated the effects of blood from the pancreas and intestine in liver activation and lung inflammation during early stages of experimental acute pancreatitis in a rat model. METHODS:A portosystemic shunt and a me...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/j.surg.2004.06.039
更新日期：2005-02-01 00:00:00
abstract：:A new technique for endarterectomy of the aorta, iliac, femoropopliteal, and three distal vessels of the lower leg is a safe and predictable method of endarterectomy that has proved to be effective. By the use of this technique the superficial femoral artery and its collateral branches are opened, considerably increas...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1985-05-01 00:00:00
abstract：:We will describe the development of new resectional techniques with the use of the ultrasonic scalpel in 33 patients with liver disease. Our experience is presented in the performance of anatomic and nonanatomic liver resections by use of this device. Its saline-cooled tip vibrated at ultrasonic frequencies and select...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1984-02-01 00:00:00
abstract：BACKGROUND:The aim of this prospective study was to elucidate the features, indications, and surgical treatment in patients affected by complications of Crohn's disease. METHODS:Between January 1985 and July 1996, 513 consecutive patients (248 male, 265 female; mean age, 38 years) were operated on for 542 occurrences ...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(97)90071-4
更新日期：1997-10-01 00:00:00
abstract：BACKGROUND:No reports have yet precisely determined corticotropin (ACTH) responsiveness in virilizing adrenocortical adenoma. METHODS:Five women with an androgen-secreting adrenal adenoma were reviewed. Three of them were examined by in vitro steroidogenesis. Two of these 3 patients were studied by immunohistochemistr...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1999-04-01 00:00:00
abstract：:The proliferation of transplantation programs has not been paralleled by a similar increase in the availability of organ donors. Between 1984 and 1987, 104 orthotopic heart transplantations were performed at Loyola University Medical Center. During the same period, 25 patients died while awaiting a donor organ. To red...
journal_title：Surgery
pub_type： 杂志文章
doi：
更新日期：1990-10-01 00:00:00
abstract：:For the surgeon, atherosclerosis is defined by a variety of aneurysmal, occlusive, or ulcerated lesions in major arteries. These end-stage lesions often require operative treatment. However, just as advanced atherosclerosis presents complex clinical phenomena, so its earlier stages display many underlying mechanisms p...
journal_title：Surgery
pub_type： 杂志文章,评审
doi：
更新日期：1978-08-01 00:00:00
abstract：BACKGROUND:An assessment was made of operative risk and outcome after parathyroidectomy for primary hyperparathyroidism. METHODS:A retrospective study was conducted in a single center university hospital in Switzerland. The 173 patients (130 women and 43 men) ranged from 17 to 89 years of age (mean, 62.0 years). No ro...
journal_title：Surgery
pub_type： 杂志文章
doi：10.1016/s0039-6060(05)80058-3
更新日期：1995-04-01 00:00:00
