Abstract:
:Women with chronic hepatitis B should maintain nucleotide analogue treatment to prevent disease progression during pregnancy. The aim of this study was to prospectively evaluate the efficacy and safety of telbivudine used throughout pregnancy for preventing hepatitis B virus (HBV) mother-to-child transmission (MTCT). From January 2012 to June 2014, women who were receiving telbivudine therapy and became pregnant were enrolled in group A at 28 weeks of gestation. Pregnant women with an HBV DNA level >106 IU/mL were enrolled in either group B (telbivudine started at 28 weeks of gestation) or group C (control group without treatment). MTCT was defined as infants who were positive for serum hepatitis B surface antigen at 7 months after birth. There were 41, 179 and 177 pregnant women (397 infants) enrolled in groups A, B and C, respectively. The HBV DNA load at 28 weeks of gestation and delivery was 1.50 ± 0.62 vs 1.45 ± 0.61, 8.05 ± 0.37 vs 4.24 ± 0.89 and 7.94 ± 0.62 vs 7.86 ± 0.73 log10 IU/mL in groups A, B and C, respectively. The rate of MTCT in group C was 4.60%, which was significantly higher than the rates in groups A and B (0% and 0.6%, respectively) (P = .043). The difference between group A and group B was not significant. The rates of neonatal congenital abnormalities were 2.4%, 0.6% and 2.3% in groups A, B and C, respectively, and there were no significant differences (P = .140). Telbivudine used throughout pregnancy may be safe and effective for mothers and infants, but it may not enhance the efficacy of an HBV MTCT block compared with treatment starting at 28 weeks of gestation (NCT02253485).
journal_name
J Viral Hepatjournal_title
Journal of viral hepatitisauthors
Yi W,Li MH,Xie Y,Wu J,Hu YH,Zhang D,Zhang Y,Cao WHdoi
10.1111/jvh.12788subject
Has Abstractpub_date
2017-11-01 00:00:00pages
49-56eissn
1352-0504issn
1365-2893journal_volume
24 Suppl 1pub_type
杂志文章abstract::Several direct-acting antivirals (DAAs) have been approved for the treatment of chronic hepatitis C virus (HCV) infections, opening the door to highly effective interferon-free treatment regimens. Resistance-associated substitutions (RASs) have been reported both in treatment-naïve patients and following treatment wit...
journal_title:Journal of viral hepatitis
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journal_title:Journal of viral hepatitis
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journal_title:Journal of viral hepatitis
pub_type: 临床试验,杂志文章,随机对照试验
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章,多中心研究
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更新日期:2018-12-01 00:00:00
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journal_title:Journal of viral hepatitis
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
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journal_title:Journal of viral hepatitis
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journal_title:Journal of viral hepatitis
pub_type: 临床试验,杂志文章,随机对照试验
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doi:10.1111/j.1365-2893.2005.00710.x
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
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更新日期:2020-03-01 00:00:00
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journal_title:Journal of viral hepatitis
pub_type: 杂志文章
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pub_type: 杂志文章,meta分析,评审
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