Abstract:
BACKGROUND:HLA alloimmunization is caused by sensitization events (SEs), such as transfusion, pregnancy, or previous organ transplantation, and the effects of particular SEs have not been thoroughly studied. Our aim was to evaluate how each SE affected HLA alloimmunization by considering Luminex assays. METHODS:Sera from 722 kidney transplantation candidates were screened per protocol by means of Luminex assays to determine the presence of anti-HLA class I/II antibodies; positive sera underwent single-antigen assay to determine the presence of specific antibodies against HLA A, B, C, DR, DQ, DP loci (positivity if median fluorescence intensity values were >1,000). The effect of each SE was analyzed considering only patients exposed to 1 kind of sensitization. RESULTS:In the 453 candidates with ≥1 SE, anti-HLA class I positivity rates were significantly higher in patients with previous transfusion (18.9%; P = .014), pregnancy (38.3%; P < .001) or transplant (75%; P < .001) compared with those with no SE (similar results for class II). The strength (median fluorescence intensity) of specific antibodies was significantly higher in patients with previous transplantation than in those with previous transfusion for HLA-A (8,017 vs 2,302; P = .02), HLA-B (7,765 vs 2,901; P = .018), and HLA-DR (9,835 vs 2,060; P = .003). Other anti-HLA antibody strengths were similar between patients with previous pregnancy or transplantation. CONCLUSIONS:Presence of any SE analyzed was associated with a higher prevalence of anti-HLA antibodies for class I ± II compared with nonsensitized patients. Transplantation had the strongest immunization effect on both classes, followed by pregnancy and then transfusion.
journal_name
Transplant Procjournal_title
Transplantation proceedingsauthors
Lopes D,Barra T,Malheiro J,Tafulo S,Martins L,Almeida M,Pedroso S,Dias L,Castro Henriques A,Cabrita Adoi
10.1016/j.transproceed.2015.03.014subject
Has Abstractpub_date
2015-05-01 00:00:00pages
894-7issue
4eissn
0041-1345issn
1873-2623pii
S0041-1345(15)00242-0journal_volume
47pub_type
杂志文章abstract:BACKGROUND:Gastrointestinal (GI) complications are common after renal transplantation, mainly owing to immunosuppressive therapy. Assessment of GI transit time can facilitate rational management of these disorders. OBJECTIVE:We evaluate the GI transit parameters in renal transplant recipients taking tacrolimus, azathi...
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更新日期:2012-10-01 00:00:00
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abstract:BACKGROUND:Estimation of glomerular filtration rate (eGFR) after renal transplantation is performed with the use of methods that are standardized for a population of nontransplantation patients with chronic kidney disease. The aim of the study was to compare the performance of GFR estimation formulas in renal transplan...
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pub_type: 杂志文章,多中心研究
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pub_type: 杂志文章,评审
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更新日期:2016-11-01 00:00:00
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更新日期:2006-03-01 00:00:00
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更新日期:2003-08-01 00:00:00
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pub_type: 杂志文章
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更新日期:2014-01-01 00:00:00
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