Abstract：
:Meta-diamides [3-benzamido-N-(4-(perfluoropropan-2-yl)phenyl)benzamides] are a distinct class of RDL GABA receptor noncompetitive antagonists showing high insecticidal activity against Spodoptera litura. The mode of action of the meta-diamides was demonstrated to be distinct from that of conventional noncompetitive antagonists (NCAs) such as fipronil, picrotoxin, lindane, dieldrin, and α-endosulfan. It was suggested that meta-diamides act at or near G336 in the M3 region of the Drosophila RDL GABA receptor. Although the site of action of the meta-diamides appears to overlap with that of macrocyclic lactones including avermectins and milbemycins, differential effects of mutations on the actions of the meta-diamides and the macrocyclic lactones were observed. Molecular modeling studies revealed that the meta-diamides may bind to an inter-subunit pocket near G336 in the Drosophila RDL GABA receptor better when in the closed state, which is distinct from the NCA-binding site, which is in a channel formed by M2s. In contrast, the macrocyclic lactones were suggested to bind to an inter-subunit pocket near G336 in the Drosophila RDL GABA receptor when in the open state. Furthermore, mechanisms underlying the high selectivity of meta-diamides are discussed. This minireview highlights the unique features of novel meta-diamide insecticides and demonstrates why meta-diamides are anticipated to become prominent insecticides that are effective against pests resistant to cyclodienes and fipronil.
journal_name
Pestic Biochem Physioljournal_title
Pesticide biochemistry and physiologyauthors
Nakao T,Banba Sdoi
10.1016/j.pestbp.2014.09.010subject
Has Abstractpub_date
2015-06-01 00:00:00pages
39-46eissn
0048-3575issn
1095-9939pii
S0048-3575(14)00163-1journal_volume
121pub_type
杂志文章,评审abstract：:A polysaccharide DNPE6(11) was purified from Dendrobium nobile Lindl. (D. nobile Lindl.). Its structural characteristic, antiviral activity, and preliminary mechanism were studied. The structural characteristic analysis indicated that DNPE6(11) was a novel homogenous heteropolysaccharide from D. nobile Lindl. Bioactiv...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2020.104598
更新日期：2020-07-01 00:00:00
abstract：:The mirid bug is frequently controlled by the application of organophosphorus insecticides in the transgenic Bt cotton field of China. A topical bioassay method was performed to evaluate the toxicities of chlorpyrifos and malathion towards field-collected Chinese populations of Apolygus lucorum from transgenic Bt cott...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2016.04.008
更新日期：2016-09-01 00:00:00
abstract：:Paraquat (PQ) as a herbicide and an environmental pollutant with increasing importance due to its toxicity to humans and animals. This study aimed to evaluate the protective and antioxidant activity of quercetin loaded Nanostructured Lipid Carriers (QNLC) against toxicity induced by PQ. Blood lymphocytes were prepared...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2020.104586
更新日期：2020-07-01 00:00:00
abstract：:The two-spotted spider mite Tetranychus urticae is a serious pest of many agricultural crops and ornamental plants. The sublethal effects of a new chemical, spinetoram, on T. urticae were investigated by treating adult females and eggs with LC10 and LC20 in the laboratory. The data were assessed based on age-stage, tw...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2016.02.002
更新日期：2016-09-01 00:00:00
abstract：:Helicoverpa armigera is one of the major crop pests and is less amenable to current pest control approaches. RNA interference (RNAi) is emerging as a potent arsenal for the insect pest control over current methods. Here, we examined the effect on growth and development in H. armigera by targeting various enzymes/prote...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2016.03.006
更新日期：2016-10-01 00:00:00
abstract：:In this study, Piper nigrum essential oil (PNO) has been encapsulated in chitosan nanoparticle (CS NPs) via ionic gelation method with sodium tripolyphosphate (TPP). The successfully loaded Piper nigrum EO was confirmed by UV-Vis spectrophotometry and X-ray diffraction (XRD) techniques. The average particle size of P....
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2020.104566
更新日期：2020-06-01 00:00:00
abstract：:This paper focuses on the DNA insecticides as a novel preparation against gypsy moth (Lymantria dispar) based on DNA fragments of the anti-apoptotic gene of its nuclear polyhedrosis virus. It was found that the external application of a solution with two single-stranded DNA fragments from BIR and RING domains of LdMNP...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2014.05.005
更新日期：2014-07-01 00:00:00
abstract：:In order to find a novel type of fluorescent phloem-mobile insecticides, a facile one-pot solvothermal strategy via fipronil addition-elimination substitution reaction with the corresponding acyl chloride derivatives has been employed to construct series of phenylpyrazole amide derivatives (PAs) fused olefin moieties ...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2019.10.003
更新日期：2020-02-01 00:00:00
abstract：:The effects of s-metolachlor chronic exposure at concentrations of 1.1 μg/L (maximal real environmental concentration in the Czech Republic), 11 μg/L (environmental relevant concentration) and 110 μg/L on early life stages of marbled crayfish (Procambarus virginalis) was evaluated under laboratory conditions. All s-me...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2018.11.007
更新日期：2019-01-01 00:00:00
abstract：:Galectins are a family of β-galactoside binding proteins, and insect galectins play a role in immune responses and may also affect Cry toxin activity. In this study, we aimed to further understand the function and molecular mechanism of Aedes aegypti galectin-6 in modulation of Cry11Aa toxicity. A. aegypti galectin-6 ...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2019.09.010
更新日期：2020-01-01 00:00:00
abstract：:Sodium channel blocker insecticides (SCBIs) are a relatively new class of insecticides, with a mechanism of action different from those of other classes of insecticides that target voltage-gated sodium channels. These compounds have no effect at hyperpolarized membrane potentials, but cause a voltage-dependent, nearly...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2009.09.001
更新日期：2010-06-01 00:00:00
abstract：:The brown planthopper, Nilaparvata lugens (Stål) (Hemiptera: Delphacidae), is a typical pest in which population resurgence can be induced by insecticides. Warmer global temperatures, associated with anthropogenic climate change, are likely to have marked ecological effects on terrestrial ecosystems. However, the effe...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2014.11.010
更新日期：2015-02-01 00:00:00
abstract：:Imidacloprid is very effective in controlling Nilaparvata lugens Stål, which severely damages rice plants. Following heavy imidacloprid use, imidacloprid-resistant N. lugens, which showed cross-resistance to other neonicotinoids, appeared. We used the baculovirus/Sf9 expression system to express CYP6ER1 variants carry...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2020.02.004
更新日期：2020-05-01 00:00:00
abstract：:2-Allylphenol (2-AP) is an effective fungicide against a number of plant pathogens, which can be metabolized and bio-transformed to four chemical compounds by Rhizoctonia cerealis. To determine if its degradation affects antifungal activity, two major metabolites derived from 2-AP including 2-(2-hydroxypropyl) phenol ...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2016.06.006
更新日期：2017-01-01 00:00:00
abstract：:Sanguinarine (Sang) is a natural alkaloid and distributed in several plants of Papaveraceae. The antitumor, antioxidant, antimicrobial and anti-inflammatory effects of Sang were extensively reported, but its speciality and mechanism against Lepidoptera insects were still unknown. In this study, detailed toxicological ...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2019.08.004
更新日期：2019-10-01 00:00:00
abstract：:Biotypes of Echinochloa crus-galli var. formosensis with resistance to cyhalofop-butyl, an acetyl-CoA carboxylase (ACCase) inhibitor, have been found in dry-seeded rice fields in Okayama, Japan. We collected two lines with suspected resistance (Ecf27 and Ecf108) from dry-seeded rice fields and investigated their sensi...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2015.02.007
更新日期：2015-03-01 00:00:00
abstract：:Polyunsaturated fatty acids usually undergo lipid peroxidation induced by reactive oxygen species (ROS). Calcium-independent cellular phospholipase A2 (iPLA2) can maintain fatty acid compositions in phospholipids depending on physiological conditions. An insect iPLA2 (Pi-iPLA2) was predicted from the transciptome of t...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2017.09.010
更新日期：2017-11-01 00:00:00
abstract：:Pyrethrum extract (PY) is a natural insecticide that is extensively used across the world, and its insecticidal activity is attributed to the presence of six active esters known as pyrethrins. PY targets the nervous systems of insects by delaying the closure of voltage-gated sodium ion channels in the nerve cells. How...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2016.09.003
更新日期：2017-04-01 00:00:00
abstract：:Although it is well known that Bacillus thuringiensis Cry toxins kill insect pest by disrupting midgut cells of susceptible larvae through their pore formation activity, it is not clear what intracellular events are triggered after pore formation on the cell membrane of the target cells. Here we analyzed the role of C...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2020.104728
更新日期：2021-01-01 00:00:00
abstract：:The carmine spider mite, Tetranychus cinnabarinus is an important crop and vegetable plants pest mite. As a novel acaricide, cyflumetofen is effective against Tetranychus and Panonychus mites, but its risk and biochemical mechanism of resistance in mites is not clear. In this study, the resistance against cyflumetofen...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2014.04.004
更新日期：2014-05-01 00:00:00
abstract：:The acute toxicity of fipronil and its sublethal effects on detoxification enzymes (carboxylesterases (CarEs), glutathione S-transferases (GSTs), and 7-ethoxycoumarin O-deethylase (ECOD)) in zebrafish (Danio rerio) were investigated. The results indicated that the 24-h LC50 of fipronil for zebrafish was 220.4 μg/L (95...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2014.07.010
更新日期：2014-10-01 00:00:00
abstract：:Chinese sprangletop (Leptochloa chinensis (L.) Nees) is one of the most troublesome grass weeds in rice in China. Seven suspected cyhalofop-butyl-resistant L. chinensis populations were collected from different rice fields with a history of cyhalofop-butyl use. The level of resistance and resistance mechanisms in seve...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2019.05.004
更新日期：2019-07-01 00:00:00
abstract：:Myosoton aquaticum L., a widespread and competitive winter weed of wheat in China, has evolved resistance to many classes of herbicides. In one M. aquaticum population (AH03), collected from Anhui Province, where tribenuron-methyl and florasulam had been used to control this weed resistance to both herbicides had evol...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2018.12.004
更新日期：2019-03-01 00:00:00
abstract：:τ-Fluvalinate (fluvalinate) is a highly selective pyrethroid insecticide compound used for controlling ectoparasitic mites that cause major damages in honey bee colonies. Although honey bees have resistance and low toxicity to this xenobiotic chemical, little is known about the effects of this chemical on sensory modu...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2020.02.005
更新日期：2020-03-01 00:00:00
abstract：:The purpose of this research was to explore the effect of phenazine-1-carboxamide (PCN) on Rhizoctonia solani and to elucidate its mechanisms of action. The toxicity of PCN to R. solani was measured using a growth rate method. The results indicated that PCN inhibited R. solani with a 50% effective concentration (EC50)...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2017.10.006
更新日期：2018-05-01 00:00:00
abstract：:The use of 1,1'-(2,2,2-Trichloro-1,1-ethanediyl)bis(4-chlorobenzene) (DDT) as a pesticide for the control of insects vectors responsible for the spread of many life threatening diseases was officially banned in 1972 by the United States Environmental Protection Agency (USEPA). It was banned throughout the world, in mo...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2019.02.005
更新日期：2019-05-01 00:00:00
abstract：:A series of novel aryloxyphenoxypropionate (APP) herbicides containing benzofuran moiety were designed, synthesized and tested for herbicidal activity. The bioassay results indicated that most of target compounds possessed moderate to good herbicidal activity against monocotyledonous weeds. Compounds 5a-5d and 6a-6d s...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2018.12.011
更新日期：2019-02-01 00:00:00
abstract：:Rotenone, a naturally occurring and commonly used pesticide, has been established as a model for inducing Parkinson's Disease (PD) in rodents. Kolaviron is a biflavonoid complex from Garcinia kola seeds with anti-oxidative and anti-inflammatory properties. Here, we evaluated the ameliorative role of Kolaviron on roten...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2018.01.002
更新日期：2018-02-01 00:00:00
abstract：:Although there have been many reports on the synergistic interactions among the major constituents of plant essential oils regarding insecticidal activity, their underlying mechanism of synergy is poorly understood. In our previous studies, we found each of the two most abundant constituents of rosemary (Rosmarinus of...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2017.01.012
更新日期：2017-08-01 00:00:00
abstract：:We have studied the mode of action of the insecticide spirotetramat in the nematode Caenorhabditis elegans. A combination of symptomology, forward genetics and genome editing show that spirotetramat acts on acetyl-CoA carboxylase (ACC) in C. elegans, as it does in insects. We found C. elegans embryos exposed to spirot...
journal_title：Pesticide biochemistry and physiology
pub_type： 杂志文章
doi：10.1016/j.pestbp.2020.104604
更新日期：2020-10-01 00:00:00
